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Protein

Fanconi anemia core complex-associated protein 100

Gene

Faap100

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-6783310. Fanconi Anemia Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Fanconi anemia core complex-associated protein 100By similarity
Alternative name(s):
Fanconi anemia-associated protein of 100 kDa
Gene namesi
Name:Faap100By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919135. Faap100.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002891311 – 879Fanconi anemia core complex-associated protein 100Add BLAST879

Proteomic databases

EPDiA2ACJ2.
MaxQBiA2ACJ2.
PaxDbiA2ACJ2.
PRIDEiA2ACJ2.

PTM databases

iPTMnetiA2ACJ2.
PhosphoSitePlusiA2ACJ2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025384.
CleanExiMM_2310003H01RIK.
GenevisibleiA2ACJ2. MM.

Interactioni

Subunit structurei

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM, FAAP24 and FAAP100. Forms a subcomplex with FANCB and FANCL (By similarity).By similarity

Protein-protein interaction databases

BioGridi215005. 8 interactors.
IntActiA2ACJ2. 8 interactors.
STRINGi10090.ENSMUSP00000026448.

Structurei

3D structure databases

ProteinModelPortaliA2ACJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IEYW. Eukaryota.
ENOG410YKI3. LUCA.
GeneTreeiENSGT00390000016682.
HOGENOMiHOG000112640.
HOVERGENiHBG107926.
InParanoidiA2ACJ2.
KOiK10993.
OMAiWHLELLA.
OrthoDBiEOG091G0D5C.
TreeFamiTF330817.

Family and domain databases

InterProiIPR029251. Faap100.
[Graphical view]
PfamiPF15146. FANCAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2ACJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGASSRVHY LSDFCCPLGG RAAGKPFVLR HEAEVFLSTG REFVYVYDQE
60 70 80 90 100
GGLLTAVYQF PDQVWHLQLL AIRRALYVLC ARTGIYCLSL DSLDRSGSQA
110 120 130 140 150
CEDKEEAAPP YPVIHVDPDA CVLPDAALCA FTVLDDMLVT LAQGPTQWKM
160 170 180 190 200
QLFERPCAGE EPLPRGQIGE VELSTCTPPG GVPEKPAAPR FLPVLCCVFP
210 220 230 240 250
PDSRAPHGHP QGCGCFTLEE ALFGLLFGVD ATLLQSPVIL CGLPDGQLCC
260 270 280 290 300
VVLKALVTSG LAPGDPKVLV KILHHLEEPV IFIGALRAEP HEEEAAGELL
310 320 330 340 350
PGQHEHSDCL VALGHQGRTL AIKASWSESG NLVPELREYC LPGPVLCAAC
360 370 380 390 400
DRDGHVYHST PSDLCVVDLT RRDSPWNPEK PDGAIGGLPS VLCPASLNIC
410 420 430 440 450
SALALCVTAR APTGSTELLA LSSKGRLITC SLDLNSEAPV PAKMAMANAG
460 470 480 490 500
QKIKELLLDI GDVSERVSFL KKAVDQRNKA ITSLNEAMNV SCALLSHPEG
510 520 530 540 550
DRPIACTITT SWSRLELRDM LMATCTLENS SSFSLDQGWT LCIQVLTSSS
560 570 580 590 600
ALDLDGTGSA FTYTIPVDRL GPGSRREVTL PLGPSESGVL DLPVTMSCWL
610 620 630 640 650
FYSLREVVGA ALAPSDPLEA PYLEQFPLSL PKQEGVCLPL CKRTVDMLQC
660 670 680 690 700
LRFAGAATHP AQAPCMPGPA CEPVETFLKT CQAPGSEPTG AASLRAKYLP
710 720 730 740 750
PSTASIRVSA GLLRAALEDS HSGFHLCSAT LRWLLAENAA VDVVRAQTLS
760 770 780 790 800
SIQGIAPDGT DVNLTVHEVA VTDLSPAGPI QAVEIQVESS SLANMCRAHH
810 820 830 840 850
AIIRRIQTMV TEQAALGSSP PDLRMQYLQQ IHANHQELLR EVQALRDQLC
860 870
TEDELSSCST AQKLLHIYKQ LRNPSLVLL
Length:879
Mass (Da):94,281
Last modified:February 20, 2007 - v1
Checksum:i83F2DF42485E2F50
GO

Sequence cautioni

The sequence AAH34203 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH48376 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AK148234 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti436S → P in AK148234 (PubMed:16141072).Curated1
Sequence conflicti856S → G in AK148234 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148234 mRNA. No translation available.
AL669855 Genomic DNA. Translation: CAM27039.1.
BC034203 mRNA. Translation: AAH34203.1. Different initiation.
BC048376 mRNA. Translation: AAH48376.1. Different initiation.
CCDSiCCDS49004.1.
RefSeqiNP_082256.2. NM_027980.2.
UniGeneiMm.274890.

Genome annotation databases

EnsembliENSMUST00000026448; ENSMUSP00000026448; ENSMUSG00000025384.
GeneIDi71885.
KEGGimmu:71885.
UCSCiuc007msm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148234 mRNA. No translation available.
AL669855 Genomic DNA. Translation: CAM27039.1.
BC034203 mRNA. Translation: AAH34203.1. Different initiation.
BC048376 mRNA. Translation: AAH48376.1. Different initiation.
CCDSiCCDS49004.1.
RefSeqiNP_082256.2. NM_027980.2.
UniGeneiMm.274890.

3D structure databases

ProteinModelPortaliA2ACJ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215005. 8 interactors.
IntActiA2ACJ2. 8 interactors.
STRINGi10090.ENSMUSP00000026448.

PTM databases

iPTMnetiA2ACJ2.
PhosphoSitePlusiA2ACJ2.

Proteomic databases

EPDiA2ACJ2.
MaxQBiA2ACJ2.
PaxDbiA2ACJ2.
PRIDEiA2ACJ2.

Protocols and materials databases

DNASUi71885.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026448; ENSMUSP00000026448; ENSMUSG00000025384.
GeneIDi71885.
KEGGimmu:71885.
UCSCiuc007msm.2. mouse.

Organism-specific databases

CTDi80233.
MGIiMGI:1919135. Faap100.

Phylogenomic databases

eggNOGiENOG410IEYW. Eukaryota.
ENOG410YKI3. LUCA.
GeneTreeiENSGT00390000016682.
HOGENOMiHOG000112640.
HOVERGENiHBG107926.
InParanoidiA2ACJ2.
KOiK10993.
OMAiWHLELLA.
OrthoDBiEOG091G0D5C.
TreeFamiTF330817.

Enzyme and pathway databases

ReactomeiR-MMU-6783310. Fanconi Anemia Pathway.

Miscellaneous databases

PROiA2ACJ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025384.
CleanExiMM_2310003H01RIK.
GenevisibleiA2ACJ2. MM.

Family and domain databases

InterProiIPR029251. Faap100.
[Graphical view]
PfamiPF15146. FANCAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFP100_MOUSE
AccessioniPrimary (citable) accession number: A2ACJ2
Secondary accession number(s): Q0P653, Q810W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.