Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fanconi anemia core complex-associated protein 100

Gene

Faap100

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-MMU-6783310 Fanconi Anemia Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Fanconi anemia core complex-associated protein 100By similarity
Alternative name(s):
Fanconi anemia-associated protein of 100 kDa
Gene namesi
Name:Faap100By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919135 Faap100

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002891311 – 879Fanconi anemia core complex-associated protein 100Add BLAST879

Proteomic databases

EPDiA2ACJ2
MaxQBiA2ACJ2
PaxDbiA2ACJ2
PRIDEiA2ACJ2

PTM databases

iPTMnetiA2ACJ2
PhosphoSitePlusiA2ACJ2

Expressioni

Gene expression databases

BgeeiENSMUSG00000025384
CleanExiMM_2310003H01RIK
GenevisibleiA2ACJ2 MM

Interactioni

Subunit structurei

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM, FAAP24 and FAAP100. Forms a subcomplex with FANCB and FANCL (By similarity).By similarity

Protein-protein interaction databases

BioGridi215005, 9 interactors
IntActiA2ACJ2, 8 interactors
STRINGi10090.ENSMUSP00000026448

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IEYW Eukaryota
ENOG410YKI3 LUCA
GeneTreeiENSGT00390000016682
HOGENOMiHOG000112640
HOVERGENiHBG107926
InParanoidiA2ACJ2
KOiK10993
OMAiPVLCCVS
OrthoDBiEOG091G0D5C
TreeFamiTF330817

Family and domain databases

InterProiView protein in InterPro
IPR029251 Faap100
PfamiView protein in Pfam
PF15146 FANCAA, 1 hit

Sequencei

Sequence statusi: Complete.

A2ACJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGASSRVHY LSDFCCPLGG RAAGKPFVLR HEAEVFLSTG REFVYVYDQE
60 70 80 90 100
GGLLTAVYQF PDQVWHLQLL AIRRALYVLC ARTGIYCLSL DSLDRSGSQA
110 120 130 140 150
CEDKEEAAPP YPVIHVDPDA CVLPDAALCA FTVLDDMLVT LAQGPTQWKM
160 170 180 190 200
QLFERPCAGE EPLPRGQIGE VELSTCTPPG GVPEKPAAPR FLPVLCCVFP
210 220 230 240 250
PDSRAPHGHP QGCGCFTLEE ALFGLLFGVD ATLLQSPVIL CGLPDGQLCC
260 270 280 290 300
VVLKALVTSG LAPGDPKVLV KILHHLEEPV IFIGALRAEP HEEEAAGELL
310 320 330 340 350
PGQHEHSDCL VALGHQGRTL AIKASWSESG NLVPELREYC LPGPVLCAAC
360 370 380 390 400
DRDGHVYHST PSDLCVVDLT RRDSPWNPEK PDGAIGGLPS VLCPASLNIC
410 420 430 440 450
SALALCVTAR APTGSTELLA LSSKGRLITC SLDLNSEAPV PAKMAMANAG
460 470 480 490 500
QKIKELLLDI GDVSERVSFL KKAVDQRNKA ITSLNEAMNV SCALLSHPEG
510 520 530 540 550
DRPIACTITT SWSRLELRDM LMATCTLENS SSFSLDQGWT LCIQVLTSSS
560 570 580 590 600
ALDLDGTGSA FTYTIPVDRL GPGSRREVTL PLGPSESGVL DLPVTMSCWL
610 620 630 640 650
FYSLREVVGA ALAPSDPLEA PYLEQFPLSL PKQEGVCLPL CKRTVDMLQC
660 670 680 690 700
LRFAGAATHP AQAPCMPGPA CEPVETFLKT CQAPGSEPTG AASLRAKYLP
710 720 730 740 750
PSTASIRVSA GLLRAALEDS HSGFHLCSAT LRWLLAENAA VDVVRAQTLS
760 770 780 790 800
SIQGIAPDGT DVNLTVHEVA VTDLSPAGPI QAVEIQVESS SLANMCRAHH
810 820 830 840 850
AIIRRIQTMV TEQAALGSSP PDLRMQYLQQ IHANHQELLR EVQALRDQLC
860 870
TEDELSSCST AQKLLHIYKQ LRNPSLVLL
Length:879
Mass (Da):94,281
Last modified:February 20, 2007 - v1
Checksum:i83F2DF42485E2F50
GO

Sequence cautioni

The sequence AAH34203 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH48376 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AK148234 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti436S → P in AK148234 (PubMed:16141072).Curated1
Sequence conflicti856S → G in AK148234 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148234 mRNA No translation available.
AL669855 Genomic DNA No translation available.
BC034203 mRNA Translation: AAH34203.1 Different initiation.
BC048376 mRNA Translation: AAH48376.1 Different initiation.
CCDSiCCDS49004.1
RefSeqiNP_082256.2, NM_027980.2
UniGeneiMm.274890

Genome annotation databases

EnsembliENSMUST00000026448; ENSMUSP00000026448; ENSMUSG00000025384
GeneIDi71885
KEGGimmu:71885
UCSCiuc007msm.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFP100_MOUSE
AccessioniPrimary (citable) accession number: A2ACJ2
Secondary accession number(s): Q0P653, Q810W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 20, 2007
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health