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Protein
Submitted name:

Axin-2

Gene

Axin2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. armadillo repeat domain binding Source: GO_Central
  2. beta-catenin binding Source: GO_Central
  3. enzyme binding Source: MGI
  4. GTPase activator activity Source: GO_Central
  5. I-SMAD binding Source: MGI
  6. protein kinase binding Source: GO_Central
  7. ubiquitin protein ligase binding Source: MGI

GO - Biological processi

  1. bone mineralization Source: MGI
  2. cell death Source: GO_Central
  3. cell proliferation Source: MGI
  4. cellular protein localization Source: MGI
  5. cellular response to organic cyclic compound Source: GO_Central
  6. chondrocyte differentiation involved in endochondral bone morphogenesis Source: MGI
  7. dorsal/ventral axis specification Source: GO_Central
  8. intramembranous ossification Source: MGI
  9. maintenance of DNA repeat elements Source: MGI
  10. mRNA stabilization Source: MGI
  11. negative regulation of canonical Wnt signaling pathway Source: MGI
  12. negative regulation of catenin import into nucleus Source: MGI
  13. negative regulation of cell proliferation Source: MGI
  14. negative regulation of osteoblast differentiation Source: MGI
  15. odontogenesis Source: MGI
  16. positive regulation of cell death Source: MGI
  17. positive regulation of epithelial to mesenchymal transition Source: MGI
  18. positive regulation of GTPase activity Source: GOC
  19. positive regulation of protein phosphorylation Source: MGI
  20. regulation of catenin import into nucleus Source: GO_Central
  21. regulation of centromeric sister chromatid cohesion Source: MGI
  22. regulation of chondrocyte development Source: MGI
  23. regulation of mismatch repair Source: MGI
  24. regulation of Wnt signaling pathway Source: MGI
  25. secondary heart field specification Source: MGI
  26. somitogenesis Source: MGI
  27. termination of G-protein coupled receptor signaling pathway Source: InterPro
  28. Wnt signaling pathway involved in somitogenesis Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Axin-2Imported
Gene namesi
Name:Axin2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1270862. Axin2.

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: GO_Central
  2. centrosome Source: MGI
  3. cytoplasm Source: MGI
  4. cytoplasmic membrane-bounded vesicle Source: GO_Central
  5. cytoplasmic microtubule Source: GO_Central
  6. nucleus Source: MGI
  7. plasma membrane Source: GO_Central
  8. postsynaptic density Source: GO_Central
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiA2ABR0.

Expressioni

Gene expression databases

ExpressionAtlasiA2ABR0. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA2ABR0.
SMRiA2ABR0. Positions 74-199, 696-775.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 RGS domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000010011.
HOGENOMiHOG000231228.
HOVERGENiHBG004324.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2ABR0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSAVLVTLL PDPSSSFRED APRPPVPGEE GETPPCQPSV GKVQSTKPMP
60 70 80 90 100
VSSNARRNED GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE
110 120 130 140 150
REKCVDTLDF WFACNGFRQM NLKDTKTLRV AKAIYKRYIE NNSVVSKQLK
160 170 180 190 200
PATKTYIRDG IKKQQIGSVM FDQAQTEIQA VMEENAYQVF LTSDIYLEYV
210 220 230 240 250
RSGGENTAYM SNGGLGSLKV LCGYLPTLNE EEEWTCADLK CKLSPTVVGL
260 270 280 290 300
SSKTLRATAS VRSTETAENG FRSFKRSDPV NPYHVGSGYV FAPATSANDS
310 320 330 340 350
ELSSDALTDD SMSMTDSSVD GVPPYRMGSK KQLQREMHRS VKANGQVSLP
360 370 380 390 400
HFPRTHRLPK EMTPVEPAAF AAELISRLEK LKLELESRHS LEERLQQIRE
410 420 430 440 450
DEEKEGSEQA LSSRDGAPVQ HPLALLPSGS YEEDPQTILD DHLSRVLKTP
460 470 480 490 500
GCQSPGVGRY SPRSRSPDHH HQHHHHQQCH TLLPTGGKLP PVAACPLLGG
510 520 530 540 550
KSFLTKQTTK HVHHHYIHHH AVPKTKEEIE AEATQRVRCL CPGGTDYYCY
560 570 580 590 600
SKCKSHPKAP EPLPGEQFCA QSIRKSYPLE SACAAPGERV SRHHLLGASG
610 620 630 640 650
HSRSVARAHP FTQDPAMPPL TPPNTLAQLE EACRRLAEVS KPQKQRCCVA
660 670 680 690 700
SQQRDRNHSA AGQAGASPFA NPSLAPEDHK EPKKLASVHA LQASELVVTY
710 720 730 740 750
FFCGEEIPYR RMLKAQSLTL GHFKEQLSKK GNYRYYFKKA SDEFACGAVF
760 770
EEIWDDETVL PMYEGRILGK VERID
Length:775
Mass (Da):86,089
Last modified:February 20, 2007 - v1
Checksum:iFF46A12680497C33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662893 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000106711; ENSMUSP00000102322; ENSMUSG00000000142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662893 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliA2ABR0.
SMRiA2ABR0. Positions 74-199, 696-775.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA2ABR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106711; ENSMUSP00000102322; ENSMUSG00000000142.

Organism-specific databases

MGIiMGI:1270862. Axin2.

Phylogenomic databases

GeneTreeiENSGT00390000010011.
HOGENOMiHOG000231228.
HOVERGENiHBG004324.

Miscellaneous databases

NextBioi35542986.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiA2ABR0. baseline and differential.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2ABR0_MOUSE
AccessioniPrimary (citable) accession number: A2ABR0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: February 4, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.