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Protein
Submitted name:

Axin-2

Gene

Axin2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processWnt signaling pathwayPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Axin-2Imported
Gene namesi
Name:Axin2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1270862. Axin2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiA2ABR0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000000142.
ExpressionAtlasiA2ABR0. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA2ABR0.
SMRiA2ABR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 200RGSInterPro annotationAdd BLAST120
Domaini693 – 775DIXInterPro annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili381 – 408Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000010011.
HOGENOMiHOG000231228.
HOVERGENiHBG004324.

Family and domain databases

CDDicd11582. Axin_TNKS_binding. 1 hit.
Gene3Di1.10.196.10. 2 hits.
InterProiView protein in InterPro
IPR014936. Axin_b-cat-bd.
IPR032101. Axin_TNKS-bd.
IPR001158. DIX.
IPR016137. RGS.
IPR036305. RGS_sf.
IPR024066. RGS_subdom1.
IPR029071. Ubiquitin-rel_dom.
PfamiView protein in Pfam
PF16646. AXIN1_TNKS_BD. 1 hit.
PF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
PRINTSiPR01301. RGSPROTEIN.
SMARTiView protein in SMART
SM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.

Sequencei

Sequence statusi: Complete.

A2ABR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAVLVTLL PDPSSSFRED APRPPVPGEE GETPPCQPSV GKVQSTKPMP
60 70 80 90 100
VSSNARRNED GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE
110 120 130 140 150
REKCVDTLDF WFACNGFRQM NLKDTKTLRV AKAIYKRYIE NNSVVSKQLK
160 170 180 190 200
PATKTYIRDG IKKQQIGSVM FDQAQTEIQA VMEENAYQVF LTSDIYLEYV
210 220 230 240 250
RSGGENTAYM SNGGLGSLKV LCGYLPTLNE EEEWTCADLK CKLSPTVVGL
260 270 280 290 300
SSKTLRATAS VRSTETAENG FRSFKRSDPV NPYHVGSGYV FAPATSANDS
310 320 330 340 350
ELSSDALTDD SMSMTDSSVD GVPPYRMGSK KQLQREMHRS VKANGQVSLP
360 370 380 390 400
HFPRTHRLPK EMTPVEPAAF AAELISRLEK LKLELESRHS LEERLQQIRE
410 420 430 440 450
DEEKEGSEQA LSSRDGAPVQ HPLALLPSGS YEEDPQTILD DHLSRVLKTP
460 470 480 490 500
GCQSPGVGRY SPRSRSPDHH HQHHHHQQCH TLLPTGGKLP PVAACPLLGG
510 520 530 540 550
KSFLTKQTTK HVHHHYIHHH AVPKTKEEIE AEATQRVRCL CPGGTDYYCY
560 570 580 590 600
SKCKSHPKAP EPLPGEQFCA QSIRKSYPLE SACAAPGERV SRHHLLGASG
610 620 630 640 650
HSRSVARAHP FTQDPAMPPL TPPNTLAQLE EACRRLAEVS KPQKQRCCVA
660 670 680 690 700
SQQRDRNHSA AGQAGASPFA NPSLAPEDHK EPKKLASVHA LQASELVVTY
710 720 730 740 750
FFCGEEIPYR RMLKAQSLTL GHFKEQLSKK GNYRYYFKKA SDEFACGAVF
760 770
EEIWDDETVL PMYEGRILGK VERID
Length:775
Mass (Da):86,089
Last modified:February 20, 2007 - v1
Checksum:iFF46A12680497C33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662893 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000106711; ENSMUSP00000102322; ENSMUSG00000000142.

Similar proteinsi

Entry informationi

Entry nameiA2ABR0_MOUSE
AccessioniPrimary (citable) accession number: A2ABR0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 25, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported