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A2ABR0

- A2ABR0_MOUSE

UniProt

A2ABR0 - A2ABR0_MOUSE

Protein
Submitted name:

Axin-2

Gene

Axin2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. armadillo repeat domain binding Source: RefGenome
    2. beta-catenin binding Source: RefGenome
    3. GTPase activator activity Source: RefGenome
    4. I-SMAD binding Source: MGI
    5. protein binding Source: MGI
    6. protein kinase binding Source: RefGenome
    7. signal transducer activity Source: InterPro
    8. ubiquitin protein ligase binding Source: MGI

    GO - Biological processi

    1. bone mineralization Source: MGI
    2. cell death Source: RefGenome
    3. cell proliferation Source: MGI
    4. cellular response to organic cyclic compound Source: RefGenome
    5. chondrocyte differentiation involved in endochondral bone morphogenesis Source: MGI
    6. dorsal/ventral axis specification Source: RefGenome
    7. intramembranous ossification Source: MGI
    8. negative regulation of canonical Wnt signaling pathway Source: RefGenome
    9. negative regulation of cell proliferation Source: MGI
    10. negative regulation of osteoblast differentiation Source: MGI
    11. positive regulation of GTPase activity Source: GOC
    12. regulation of catenin import into nucleus Source: RefGenome
    13. regulation of chondrocyte development Source: MGI
    14. regulation of transcription, DNA-templated Source: RefGenome
    15. regulation of Wnt signaling pathway Source: MGI
    16. secondary heart field specification Source: MGI
    17. somitogenesis Source: MGI
    18. termination of G-protein coupled receptor signaling pathway Source: InterPro
    19. Wnt signaling pathway involved in somitogenesis Source: RefGenome

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Axin-2Imported
    Gene namesi
    Name:Axin2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1270862. Axin2.

    Subcellular locationi

    GO - Cellular componenti

    1. beta-catenin destruction complex Source: RefGenome
    2. cell cortex Source: RefGenome
    3. cytoplasmic membrane-bounded vesicle Source: RefGenome
    4. cytoplasmic microtubule Source: RefGenome
    5. nucleus Source: MGI
    6. plasma membrane Source: RefGenome
    7. postsynaptic density Source: RefGenome

    PTM / Processingi

    Proteomic databases

    PRIDEiA2ABR0.

    Expressioni

    Gene expression databases

    ArrayExpressiA2ABR0.

    Structurei

    3D structure databases

    ProteinModelPortaliA2ABR0.
    SMRiA2ABR0. Positions 74-199, 696-775.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 RGS domain.UniRule annotation
    Contains RGS domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000010011.
    HOGENOMiHOG000231228.
    HOVERGENiHBG004324.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00021. DAX. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2ABR0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSAVLVTLL PDPSSSFRED APRPPVPGEE GETPPCQPSV GKVQSTKPMP    50
    VSSNARRNED GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE 100
    REKCVDTLDF WFACNGFRQM NLKDTKTLRV AKAIYKRYIE NNSVVSKQLK 150
    PATKTYIRDG IKKQQIGSVM FDQAQTEIQA VMEENAYQVF LTSDIYLEYV 200
    RSGGENTAYM SNGGLGSLKV LCGYLPTLNE EEEWTCADLK CKLSPTVVGL 250
    SSKTLRATAS VRSTETAENG FRSFKRSDPV NPYHVGSGYV FAPATSANDS 300
    ELSSDALTDD SMSMTDSSVD GVPPYRMGSK KQLQREMHRS VKANGQVSLP 350
    HFPRTHRLPK EMTPVEPAAF AAELISRLEK LKLELESRHS LEERLQQIRE 400
    DEEKEGSEQA LSSRDGAPVQ HPLALLPSGS YEEDPQTILD DHLSRVLKTP 450
    GCQSPGVGRY SPRSRSPDHH HQHHHHQQCH TLLPTGGKLP PVAACPLLGG 500
    KSFLTKQTTK HVHHHYIHHH AVPKTKEEIE AEATQRVRCL CPGGTDYYCY 550
    SKCKSHPKAP EPLPGEQFCA QSIRKSYPLE SACAAPGERV SRHHLLGASG 600
    HSRSVARAHP FTQDPAMPPL TPPNTLAQLE EACRRLAEVS KPQKQRCCVA 650
    SQQRDRNHSA AGQAGASPFA NPSLAPEDHK EPKKLASVHA LQASELVVTY 700
    FFCGEEIPYR RMLKAQSLTL GHFKEQLSKK GNYRYYFKKA SDEFACGAVF 750
    EEIWDDETVL PMYEGRILGK VERID 775
    Length:775
    Mass (Da):86,089
    Last modified:February 20, 2007 - v1
    Checksum:iFF46A12680497C33
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL662893 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000106711; ENSMUSP00000102322; ENSMUSG00000000142.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL662893 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali A2ABR0.
    SMRi A2ABR0. Positions 74-199, 696-775.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A2ABR0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000106711 ; ENSMUSP00000102322 ; ENSMUSG00000000142 .

    Organism-specific databases

    MGIi MGI:1270862. Axin2.

    Phylogenomic databases

    GeneTreei ENSGT00390000010011.
    HOGENOMi HOG000231228.
    HOVERGENi HBG004324.

    Miscellaneous databases

    NextBioi 35542986.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A2ABR0.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00021. DAX. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiA2ABR0_MOUSE
    AccessioniPrimary (citable) accession number: A2ABR0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3