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A2ABR0 (A2ABR0_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length775 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Sequence similarities

Contains 1 RGS domain. RuleBase RU003298

Contains RGS domain. SAAS SAAS024066

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000102322

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway involved in somitogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

bone mineralization

Inferred from mutant phenotype PubMed 19623616. Source: MGI

cell death

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell proliferation

Inferred from mutant phenotype PubMed 20569694. Source: MGI

cellular response to organic cyclic compound

Inferred from Biological aspect of Ancestor. Source: RefGenome

chondrocyte differentiation involved in endochondral bone morphogenesis

Inferred from mutant phenotype PubMed 19623616. Source: MGI

dorsal/ventral axis specification

Inferred from Biological aspect of Ancestor. Source: RefGenome

intramembranous ossification

Inferred from mutant phenotype PubMed 15790973. Source: MGI

negative regulation of canonical Wnt signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of cell proliferation

Inferred from mutant phenotype PubMed 15790973. Source: MGI

negative regulation of osteoblast differentiation

Inferred from mutant phenotype PubMed 15790973. Source: MGI

positive regulation of GTPase activity

Inferred from Biological aspect of Ancestor. Source: GOC

regulation of Wnt signaling pathway

Inferred from direct assay PubMed 9554852. Source: MGI

regulation of catenin import into nucleus

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of chondrocyte development

Inferred from mutant phenotype PubMed 19623616. Source: MGI

regulation of transcription, DNA-templated

Inferred from Biological aspect of Ancestor. Source: RefGenome

secondary heart field specification

Inferred from genetic interaction PubMed 22711842. Source: MGI

somitogenesis

Inferred from direct assay PubMed 12636920. Source: MGI

termination of G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular_componentbeta-catenin destruction complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell cortex

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytoplasmic membrane-bounded vesicle

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytoplasmic microtubule

Inferred from Biological aspect of Ancestor. Source: RefGenome

nucleus

Inferred from direct assay PubMed 21991325. Source: MGI

plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

postsynaptic density

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionGTPase activator activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

I-SMAD binding

Inferred from physical interaction PubMed 16601693. Source: MGI

armadillo repeat domain binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

beta-catenin binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

protein binding

Inferred from physical interaction PubMed 9554852. Source: MGI

protein kinase binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

signal transducer activity

Inferred from electronic annotation. Source: InterPro

ubiquitin protein ligase binding

Inferred from physical interaction PubMed 16601693. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
A2ABR0 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: FF46A12680497C33

FASTA77586,089
        10         20         30         40         50         60 
MSSAVLVTLL PDPSSSFRED APRPPVPGEE GETPPCQPSV GKVQSTKPMP VSSNARRNED 

        70         80         90        100        110        120 
GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE REKCVDTLDF WFACNGFRQM 

       130        140        150        160        170        180 
NLKDTKTLRV AKAIYKRYIE NNSVVSKQLK PATKTYIRDG IKKQQIGSVM FDQAQTEIQA 

       190        200        210        220        230        240 
VMEENAYQVF LTSDIYLEYV RSGGENTAYM SNGGLGSLKV LCGYLPTLNE EEEWTCADLK 

       250        260        270        280        290        300 
CKLSPTVVGL SSKTLRATAS VRSTETAENG FRSFKRSDPV NPYHVGSGYV FAPATSANDS 

       310        320        330        340        350        360 
ELSSDALTDD SMSMTDSSVD GVPPYRMGSK KQLQREMHRS VKANGQVSLP HFPRTHRLPK 

       370        380        390        400        410        420 
EMTPVEPAAF AAELISRLEK LKLELESRHS LEERLQQIRE DEEKEGSEQA LSSRDGAPVQ 

       430        440        450        460        470        480 
HPLALLPSGS YEEDPQTILD DHLSRVLKTP GCQSPGVGRY SPRSRSPDHH HQHHHHQQCH 

       490        500        510        520        530        540 
TLLPTGGKLP PVAACPLLGG KSFLTKQTTK HVHHHYIHHH AVPKTKEEIE AEATQRVRCL 

       550        560        570        580        590        600 
CPGGTDYYCY SKCKSHPKAP EPLPGEQFCA QSIRKSYPLE SACAAPGERV SRHHLLGASG 

       610        620        630        640        650        660 
HSRSVARAHP FTQDPAMPPL TPPNTLAQLE EACRRLAEVS KPQKQRCCVA SQQRDRNHSA 

       670        680        690        700        710        720 
AGQAGASPFA NPSLAPEDHK EPKKLASVHA LQASELVVTY FFCGEEIPYR RMLKAQSLTL 

       730        740        750        760        770 
GHFKEQLSKK GNYRYYFKKA SDEFACGAVF EEIWDDETVL PMYEGRILGK VERID 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL662893 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalA2ABR0.
SMRA2ABR0. Positions 74-199, 696-775.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEA2ABR0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000106711; ENSMUSP00000102322; ENSMUSG00000000142.

Organism-specific databases

MGIMGI:1270862. Axin2.

Phylogenomic databases

GeneTreeENSGT00390000010011.
HOGENOMHOG000231228.
HOVERGENHBG004324.

Gene expression databases

ArrayExpressA2ABR0.

Family and domain databases

Gene3D1.10.196.10. 2 hits.
InterProIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio35542986.
SOURCESearch...

Entry information

Entry nameA2ABR0_MOUSE
AccessionPrimary (citable) accession number: A2ABR0
Entry history
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)