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Protein
Submitted name:

Histone-lysine N-methyltransferase EHMT2

Gene

EHMT2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Histone-lysine N-methyltransferase EHMT2Imported
Gene namesi
Name:EHMT2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:14129. EHMT2.

Subcellular locationi

  • Chromosome SAAS annotation
  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

ChromosomeSAAS annotation, NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiA2ABF9.
ExpressionAtlasiA2ABF9. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiA2ABF9. 13 interactions.
STRINGi9606.ENSP00000364687.

Structurei

3D structure databases

SMRiA2ABF9. Positions 979-1249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini711 – 944234ANK_REP_REGIONInterPro annotationAdd
BLAST
Domaini1029 – 109264Pre-SETInterPro annotationAdd
BLAST
Domaini1095 – 1212118SETInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili341 – 38747Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 pre-SET domain.UniRule annotation
Contains 5 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotation, Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG0666. LUCA.
COG2940. LUCA.
GeneTreeiENSGT00780000121845.
HOGENOMiHOG000231216.
HOVERGENiHBG028394.
OMAiQASWAPQ.
OrthoDBiEOG744T8D.
PhylomeDBiA2ABF9.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2ABF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGLPRGRGL MRARGRGRAA PPGSRGRGRG GPHRGRGRPR SLLSLPRAQA
60 70 80 90 100
SWTPQLSTGL TSPPVPCLPS QGEAPAEMGA LLLEKETRGA TERVHGSLGD
110 120 130 140 150
TPRSEETLPK ATPDSLEPAG PSSPASVTVT VGDEGADTPV GATPLIGDES
160 170 180 190 200
ENLEGDGDLR GGRILLGHAT KSFPSSPSKG GSCPSRAKMS MTGAGKSPPS
210 220 230 240 250
VQSLAMRLLS MPGAQGAAAA GSEPPPATTS PEGQPKVHRA RKTMSKPGNG
260 270 280 290 300
QPPVPEKRPP EIQHFRMSDD VHSLGKVTSD LAKRRKLNSG GGLSEELGSA
310 320 330 340 350
RRSGEVTLTK GDPGSLEEWE TVVGDDFSLY YDSYSVDERV DSDSKSEVEA
360 370 380 390 400
LTEQLSEEEE EEEEEEEEEE EEEEEEEEEE DEESGNQSDR SGSSGRRKAK
410 420 430 440 450
KKWRKDSPWV KPSRKRRKRE PPRAKEPRGV NGVGSSGPSE YMEVPLGSLE
460 470 480 490 500
LPSEGTLSPN HAGVSNDTSS LETERGFEEL PLCSCRMEAP KIDRISERAG
510 520 530 540 550
HKCMATESVD GELSGCNAAI LKRETMRPSS RVALMVLCET HRARMVKHHC
560 570 580 590 600
CPGCGYFCTA GTFLECHPDF RVAHRFHKAC VSQLNGMVFC PHCGEDASEA
610 620 630 640 650
QEVTIPRGDG VTPPAGTAAP APPPLSQDVP GRADTSQPSA RMRGHGEPRR
660 670 680 690 700
PPCDPLADTI DSSGPSLTLP NGGCLSAVGL PLGPGREALE KALVIQESER
710 720 730 740 750
RKKLRFHPRQ LYLSVKQGEL QKVILMLLDN LDPNFQSDQQ SKRTPLHAAA
760 770 780 790 800
QKGSVEICHV LLQAGANINA VDKQQRTPLM EAVVNNHLEV ARYMVQRGGC
810 820 830 840 850
VYSKEEDGST CLHHAAKIGN LEMVSLLLST GQVDVNAQDS GGWTPIIWAA
860 870 880 890 900
EHKHIEVIRM LLTRGADVTL TDNEENICLH WASFTGSAAI AEVLLNARCD
910 920 930 940 950
LHAVNYHGDT PLHIAARESY HDCVLLFLSR GANPELRNKE GDTAWDLTPE
960 970 980 990 1000
RSDVWFALQL NRKLRLGVGN RAIRTEKIIC RDVARGYENV PIPCVNGVDG
1010 1020 1030 1040 1050
EPCPEDYKYI SENCETSTMN IDRNITHLQH CTCVDDCSSS NCLCGQLSIR
1060 1070 1080 1090 1100
CWYDKDGRLL QEFNKIEPPL IFECNQACSC WRNCKNRVVQ SGIKVRLQLY
1110 1120 1130 1140 1150
RTAKMGWGVR ALQTIPQGTF ICEYVGELIS DAEADVREDD SYLFDLDNKD
1160 1170 1180 1190 1200
GEVYCIDARY YGNISRFINH LCDPNIIPVR VFMLHQDLRF PRIAFFSSRD
1210 1220 1230 1240 1250
IRTGEELGFD YGDRFWDIKS KYFTCQCGSE KCKHSAEAIA LEQSRLARLD
1260
PHPELLPELG SLPPVNT
Length:1,267
Mass (Da):138,770
Last modified:February 20, 2007 - v1
Checksum:i663CB53F5CBA6B3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662834 Genomic DNA. No translation available.
AL671762 Genomic DNA. No translation available.
AL844853 Genomic DNA. No translation available.
CR388202 Genomic DNA. No translation available.
CR388219 Genomic DNA. No translation available.
RefSeqiXP_005248881.1. XM_005248824.2.
XP_005272824.1. XM_005272767.2.
XP_005274970.1. XM_005274913.2.
XP_005275400.1. XM_005275343.2.
UniGeneiHs.709218.

Genome annotation databases

EnsembliENST00000395728; ENSP00000379078; ENSG00000204371.
ENST00000400006; ENSP00000382886; ENSG00000206376.
ENST00000420930; ENSP00000397323; ENSG00000227333.
ENST00000436403; ENSP00000398286; ENSG00000236759.
GeneIDi10919.
UCSCiuc063niw.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662834 Genomic DNA. No translation available.
AL671762 Genomic DNA. No translation available.
AL844853 Genomic DNA. No translation available.
CR388202 Genomic DNA. No translation available.
CR388219 Genomic DNA. No translation available.
RefSeqiXP_005248881.1. XM_005248824.2.
XP_005272824.1. XM_005272767.2.
XP_005274970.1. XM_005274913.2.
XP_005275400.1. XM_005275343.2.
UniGeneiHs.709218.

3D structure databases

SMRiA2ABF9. Positions 979-1249.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2ABF9. 13 interactions.
STRINGi9606.ENSP00000364687.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395728; ENSP00000379078; ENSG00000204371.
ENST00000400006; ENSP00000382886; ENSG00000206376.
ENST00000420930; ENSP00000397323; ENSG00000227333.
ENST00000436403; ENSP00000398286; ENSG00000236759.
GeneIDi10919.
UCSCiuc063niw.1. human.

Organism-specific databases

CTDi10919.
HGNCiHGNC:14129. EHMT2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG0666. LUCA.
COG2940. LUCA.
GeneTreeiENSGT00780000121845.
HOGENOMiHOG000231216.
HOVERGENiHBG028394.
OMAiQASWAPQ.
OrthoDBiEOG744T8D.
PhylomeDBiA2ABF9.

Miscellaneous databases

ChiTaRSiEHMT2. human.
GenomeRNAii10919.

Gene expression databases

BgeeiA2ABF9.
ExpressionAtlasiA2ABF9. baseline and differential.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  10. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Ensembl
    Submitted (JUN-2015) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiA2ABF9_HUMAN
AccessioniPrimary (citable) accession number: A2ABF9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: June 8, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.