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Protein
Submitted name:

Histone-lysine N-methyltransferase EHMT2

Gene

EHMT2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Histone-lysine N-methyltransferase EHMT2Imported
Gene namesi
Name:EHMT2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204371.11.
HGNCiHGNC:14129. EHMT2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ChromosomeSAAS annotation, NucleusSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204371.

PTM / Processingi

Proteomic databases

MaxQBiA2ABF8.

PTM databases

iPTMnetiA2ABF8.

Expressioni

Gene expression databases

BgeeiENSG00000204371.
ExpressionAtlasiA2ABF8. baseline and differential.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini677 – 910ANK_REP_REGIONInterPro annotationAdd BLAST234
Repeati707 – 739ANKPROSITE-ProRule annotationAdd BLAST33
Repeati740 – 772ANKPROSITE-ProRule annotationAdd BLAST33
Repeati773 – 797ANKPROSITE-ProRule annotationAdd BLAST25
Repeati807 – 839ANKPROSITE-ProRule annotationAdd BLAST33
Repeati873 – 905ANKPROSITE-ProRule annotationAdd BLAST33
Domaini995 – 1058Pre-SETInterPro annotationAdd BLAST64
Domaini1061 – 1178SETInterPro annotationAdd BLAST118

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili341 – 387Sequence analysisAdd BLAST47

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG0666. LUCA.
COG2940. LUCA.
GeneTreeiENSGT00780000121845.
HOGENOMiHOG000231216.
HOVERGENiHBG028394.

Family and domain databases

CDDicd00204. ANK. 2 hits.
Gene3Di1.25.40.20. 3 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR036770. Ankyrin_rpt-contain_sf.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
PfamiView protein in Pfam
PF12796. Ank_2. 3 hits.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
PRINTSiPR01415. ANKYRIN.
SMARTiView protein in SMART
SM00248. ANK. 6 hits.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.

Sequencei

Sequence statusi: Complete.

A2ABF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGLPRGRGL MRARGRGRAA PPGSRGRGRG GPHRGRGRPR SLLSLPRAQA
60 70 80 90 100
SWTPQLSTGL TSPPVPCLPS QGEAPAEMGA LLLEKETRGA TERVHGSLGD
110 120 130 140 150
TPRSEETLPK ATPDSLEPAG PSSPASVTVT VGDEGADTPV GATPLIGDES
160 170 180 190 200
ENLEGDGDLR GGRILLGHAT KSFPSSPSKG GSCPSRAKMS MTGAGKSPPS
210 220 230 240 250
VQSLAMRLLS MPGAQGAAAA GSEPPPATTS PEGQPKVHRA RKTMSKPGNG
260 270 280 290 300
QPPVPEKRPP EIQHFRMSDD VHSLGKVTSD LAKRRKLNSG GGLSEELGSA
310 320 330 340 350
RRSGEVTLTK GDPGSLEEWE TVVGDDFSLY YDSYSVDERV DSDSKSEVEA
360 370 380 390 400
LTEQLSEEEE EEEEEEEEEE EEEEEEEEEE DEESGNQSDR SGSSGRRKAK
410 420 430 440 450
KKWRKDSPWV KPSRKRRKRE PPRAKEPRGV SNDTSSLETE RGFEELPLCS
460 470 480 490 500
CRMEAPKIDR ISERAGHKCM ATESVDGELS GCNAAILKRE TMRPSSRVAL
510 520 530 540 550
MVLCETHRAR MVKHHCCPGC GYFCTAGTFL ECHPDFRVAH RFHKACVSQL
560 570 580 590 600
NGMVFCPHCG EDASEAQEVT IPRGDGVTPP AGTAAPAPPP LSQDVPGRAD
610 620 630 640 650
TSQPSARMRG HGEPRRPPCD PLADTIDSSG PSLTLPNGGC LSAVGLPLGP
660 670 680 690 700
GREALEKALV IQESERRKKL RFHPRQLYLS VKQGELQKVI LMLLDNLDPN
710 720 730 740 750
FQSDQQSKRT PLHAAAQKGS VEICHVLLQA GANINAVDKQ QRTPLMEAVV
760 770 780 790 800
NNHLEVARYM VQRGGCVYSK EEDGSTCLHH AAKIGNLEMV SLLLSTGQVD
810 820 830 840 850
VNAQDSGGWT PIIWAAEHKH IEVIRMLLTR GADVTLTDNE ENICLHWASF
860 870 880 890 900
TGSAAIAEVL LNARCDLHAV NYHGDTPLHI AARESYHDCV LLFLSRGANP
910 920 930 940 950
ELRNKEGDTA WDLTPERSDV WFALQLNRKL RLGVGNRAIR TEKIICRDVA
960 970 980 990 1000
RGYENVPIPC VNGVDGEPCP EDYKYISENC ETSTMNIDRN ITHLQHCTCV
1010 1020 1030 1040 1050
DDCSSSNCLC GQLSIRCWYD KDGRLLQEFN KIEPPLIFEC NQACSCWRNC
1060 1070 1080 1090 1100
KNRVVQSGIK VRLQLYRTAK MGWGVRALQT IPQGTFICEY VGELISDAEA
1110 1120 1130 1140 1150
DVREDDSYLF DLDNKDGEVY CIDARYYGNI SRFINHLCDP NIIPVRVFML
1160 1170 1180 1190 1200
HQDLRFPRIA FFSSRDIRTG EELGFDYGDR FWDIKSKYFT CQCGSEKCKH
1210 1220 1230
SAEAIALEQS RLARLDPHPE LLPELGSLPP VNT
Length:1,233
Mass (Da):135,418
Last modified:February 20, 2007 - v1
Checksum:iA44CC4C8F2340F24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662834 Genomic DNA. No translation available.
AL671762 Genomic DNA. No translation available.
AL844853 Genomic DNA. No translation available.
CR388202 Genomic DNA. No translation available.
CR388219 Genomic DNA. No translation available.
RefSeqiNP_001276342.1. NM_001289413.1.
UniGeneiHs.709218.

Genome annotation databases

EnsembliENST00000375528; ENSP00000364678; ENSG00000204371.
ENST00000400008; ENSP00000382888; ENSG00000206376.
ENST00000428442; ENSP00000400861; ENSG00000227333.
ENST00000443951; ENSP00000403402; ENSG00000236759.
GeneIDi10919.
UCSCiuc011don.2. human.

Similar proteinsi

Entry informationi

Entry nameiA2ABF8_HUMAN
AccessioniPrimary (citable) accession number: A2ABF8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 25, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported