UniProtKB - A2ABF8 (A2ABF8_HUMAN)
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Protein
Submitted name:
Histone-lysine N-methyltransferase EHMT2
Gene
EHMT2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- C2H2 zinc finger domain binding Source: Ensembl
- histone methyltransferase activity (H3-K27 specific) Source: Ensembl
- histone methyltransferase activity (H3-K9 specific) Source: Ensembl
- p53 binding Source: InterPro
- promoter-specific chromatin binding Source: Ensembl
- RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
- zinc ion binding Source: InterPro
GO - Biological processi
- behavioral response to cocaine Source: Ensembl
- cellular response to cocaine Source: Ensembl
- DNA methylation on cytosine within a CG sequence Source: Ensembl
- fertilization Source: Ensembl
- long-term memory Source: Ensembl
- negative regulation of autophagosome assembly Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- neuron fate specification Source: Ensembl
- organ growth Source: Ensembl
- phenotypic switching Source: Ensembl
- regulation of DNA methylation Source: Ensembl
- regulation of DNA replication Source: Ensembl
- regulation of histone H3-K4 methylation Source: Ensembl
- regulation of histone H3-K9 methylation Source: Ensembl
- response to ethanol Source: Ensembl
- response to fungicide Source: Ensembl
- response to nutrient levels Source: Ensembl
- spermatid development Source: Ensembl
- synaptonemal complex assembly Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: Histone-lysine N-methyltransferase EHMT2Imported |
Gene namesi | Name:EHMT2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000204371.11. |
HGNCi | HGNC:14129. EHMT2. |
Subcellular locationi
Keywords - Cellular componenti
ChromosomeSAAS annotation, NucleusSAAS annotationInteractioni
GO - Molecular functioni
- C2H2 zinc finger domain binding Source: Ensembl
- p53 binding Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 677 – 910 | ANK_REP_REGIONInterPro annotationAdd BLAST | 234 | |
Repeati | 707 – 739 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 740 – 772 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 773 – 797 | ANKPROSITE-ProRule annotationAdd BLAST | 25 | |
Repeati | 807 – 839 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 873 – 905 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 995 – 1058 | Pre-SETInterPro annotationAdd BLAST | 64 | |
Domaini | 1061 – 1178 | SETInterPro annotationAdd BLAST | 118 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 341 – 387 | Sequence analysisAdd BLAST | 47 |
Keywords - Domaini
ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG1082. Eukaryota. COG0666. LUCA. COG2940. LUCA. |
GeneTreei | ENSGT00780000121845. |
HOGENOMi | HOG000231216. |
HOVERGENi | HBG028394. |
Family and domain databases
CDDi | cd00204. ANK. 2 hits. |
Gene3Di | 1.25.40.20. 1 hit. |
InterProi | View protein in InterPro IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR036770. Ankyrin_rpt-contain_sf. IPR038034. EHMT2. IPR007728. Pre-SET_dom. IPR001214. SET_dom. |
PANTHERi | PTHR22884:SF361. PTHR22884:SF361. 2 hits. |
Pfami | View protein in Pfam PF12796. Ank_2. 3 hits. PF05033. Pre-SET. 1 hit. PF00856. SET. 1 hit. |
PRINTSi | PR01415. ANKYRIN. |
SMARTi | View protein in SMART SM00248. ANK. 6 hits. SM00468. PreSET. 1 hit. SM00317. SET. 1 hit. |
SUPFAMi | SSF48403. SSF48403. 1 hit. |
PROSITEi | View protein in PROSITE PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 5 hits. PS50867. PRE_SET. 1 hit. PS50280. SET. 1 hit. |
i Sequence
Sequence statusi: Complete.
A2ABF8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRGLPRGRGL MRARGRGRAA PPGSRGRGRG GPHRGRGRPR SLLSLPRAQA
60 70 80 90 100
SWTPQLSTGL TSPPVPCLPS QGEAPAEMGA LLLEKETRGA TERVHGSLGD
110 120 130 140 150
TPRSEETLPK ATPDSLEPAG PSSPASVTVT VGDEGADTPV GATPLIGDES
160 170 180 190 200
ENLEGDGDLR GGRILLGHAT KSFPSSPSKG GSCPSRAKMS MTGAGKSPPS
210 220 230 240 250
VQSLAMRLLS MPGAQGAAAA GSEPPPATTS PEGQPKVHRA RKTMSKPGNG
260 270 280 290 300
QPPVPEKRPP EIQHFRMSDD VHSLGKVTSD LAKRRKLNSG GGLSEELGSA
310 320 330 340 350
RRSGEVTLTK GDPGSLEEWE TVVGDDFSLY YDSYSVDERV DSDSKSEVEA
360 370 380 390 400
LTEQLSEEEE EEEEEEEEEE EEEEEEEEEE DEESGNQSDR SGSSGRRKAK
410 420 430 440 450
KKWRKDSPWV KPSRKRRKRE PPRAKEPRGV SNDTSSLETE RGFEELPLCS
460 470 480 490 500
CRMEAPKIDR ISERAGHKCM ATESVDGELS GCNAAILKRE TMRPSSRVAL
510 520 530 540 550
MVLCETHRAR MVKHHCCPGC GYFCTAGTFL ECHPDFRVAH RFHKACVSQL
560 570 580 590 600
NGMVFCPHCG EDASEAQEVT IPRGDGVTPP AGTAAPAPPP LSQDVPGRAD
610 620 630 640 650
TSQPSARMRG HGEPRRPPCD PLADTIDSSG PSLTLPNGGC LSAVGLPLGP
660 670 680 690 700
GREALEKALV IQESERRKKL RFHPRQLYLS VKQGELQKVI LMLLDNLDPN
710 720 730 740 750
FQSDQQSKRT PLHAAAQKGS VEICHVLLQA GANINAVDKQ QRTPLMEAVV
760 770 780 790 800
NNHLEVARYM VQRGGCVYSK EEDGSTCLHH AAKIGNLEMV SLLLSTGQVD
810 820 830 840 850
VNAQDSGGWT PIIWAAEHKH IEVIRMLLTR GADVTLTDNE ENICLHWASF
860 870 880 890 900
TGSAAIAEVL LNARCDLHAV NYHGDTPLHI AARESYHDCV LLFLSRGANP
910 920 930 940 950
ELRNKEGDTA WDLTPERSDV WFALQLNRKL RLGVGNRAIR TEKIICRDVA
960 970 980 990 1000
RGYENVPIPC VNGVDGEPCP EDYKYISENC ETSTMNIDRN ITHLQHCTCV
1010 1020 1030 1040 1050
DDCSSSNCLC GQLSIRCWYD KDGRLLQEFN KIEPPLIFEC NQACSCWRNC
1060 1070 1080 1090 1100
KNRVVQSGIK VRLQLYRTAK MGWGVRALQT IPQGTFICEY VGELISDAEA
1110 1120 1130 1140 1150
DVREDDSYLF DLDNKDGEVY CIDARYYGNI SRFINHLCDP NIIPVRVFML
1160 1170 1180 1190 1200
HQDLRFPRIA FFSSRDIRTG EELGFDYGDR FWDIKSKYFT CQCGSEKCKH
1210 1220 1230
SAEAIALEQS RLARLDPHPE LLPELGSLPP VNT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL662834 Genomic DNA. No translation available. AL671762 Genomic DNA. No translation available. AL844853 Genomic DNA. No translation available. CR388202 Genomic DNA. No translation available. CR388219 Genomic DNA. No translation available. |
RefSeqi | NP_001276342.1. NM_001289413.1. |
UniGenei | Hs.709218. |
Genome annotation databases
Ensembli | ENST00000375528; ENSP00000364678; ENSG00000204371. ENST00000400008; ENSP00000382888; ENSG00000206376. ENST00000428442; ENSP00000400861; ENSG00000227333. ENST00000443951; ENSP00000403402; ENSG00000236759. |
GeneIDi | 10919. |
UCSCi | uc011don.2. human. |
Similar proteinsi
Entry informationi
Entry namei | A2ABF8_HUMAN | |
Accessioni | A2ABF8Primary (citable) accession number: A2ABF8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | March 28, 2018 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |