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Protein

Voltage-dependent calcium channel gamma subunit

Gene

Cacng4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma subunitUniRule annotation
Alternative name(s):
Voltage-dependent calcium channel gamma-4 subunitUniRule annotation
Gene namesi
Name:Cacng4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1859167. Cacng4.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2822HelicalUniRule annotationAdd
BLAST
Transmembranei103 – 12523HelicalUniRule annotationAdd
BLAST
Transmembranei137 – 16125HelicalUniRule annotationAdd
BLAST
Transmembranei181 – 20727HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000020723.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.UniRule annotation

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021066.

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IJYN. Eukaryota.
ENOG4111W1R. LUCA.
HOVERGENiHBG003682.
KOiK04869.
OMAiICNGTNL.
OrthoDBiEOG091G0D2Z.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR005423. VDCC_g4su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01603. VDCCGAMMA4.

Sequencei

Sequence statusi: Complete.

A2AAU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRCDRGLQM LLTTAGAFAA FSLMAIAIGT DYWLYSSAHI CNGTNLTMDD
60 70 80 90 100
GPPPRRARGD LTHSGLWRVC CIEGIYRGHC FRINHFPEDN DYDHDSSEYL
110 120 130 140 150
LRIVRASSVF PILSTILLLL GGLCIGAGRI YSRKNNIVLS AGILFVAAGL
160 170 180 190 200
SNIIGIIVYI SSNTGDPSDK RDEDKKNHYN YGWSFYFGAL SFIVAETVGV
210 220 230 240 250
LAVNIYIEKN KELRFKTKRE FLKASSSSPY ARMPSYRYRR RRSRSSSRST
260 270 280 290 300
EASPSRDASP VGLKITGAIP MGELSMYTLS REPLKVTTAA SYSPDQDAGF
310 320
LQMHDFFQQD LKEGFHVSML NRRTTPV
Length:327
Mass (Da):36,535
Last modified:February 5, 2008 - v1
Checksum:i6BFB38B546FBCA86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC138503 mRNA. Translation: AAI38504.1.
BC138506 mRNA. Translation: AAI38507.1.
RefSeqiNP_062304.1. NM_019431.2.
UniGeneiMm.103724.

Genome annotation databases

GeneIDi54377.
KEGGimmu:54377.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC138503 mRNA. Translation: AAI38504.1.
BC138506 mRNA. Translation: AAI38507.1.
RefSeqiNP_062304.1. NM_019431.2.
UniGeneiMm.103724.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021066.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi54377.
KEGGimmu:54377.

Organism-specific databases

CTDi27092.
MGIiMGI:1859167. Cacng4.

Phylogenomic databases

eggNOGiENOG410IJYN. Eukaryota.
ENOG4111W1R. LUCA.
HOVERGENiHBG003682.
KOiK04869.
OMAiICNGTNL.
OrthoDBiEOG091G0D2Z.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020723.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR005423. VDCC_g4su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01603. VDCCGAMMA4.
ProtoNetiSearch...

Entry informationi

Entry nameiA2AAU2_MOUSE
AccessioniPrimary (citable) accession number: A2AAU2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.