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A2AAJ9 (OBSCN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Obscurin

EC=2.7.11.1
Alternative name(s):
Obscurin-RhoGEF
Obscurin-myosin light chain kinase
Short name=Obscurin-MLCK
Gene names
Name:Obscn
Synonyms:Gm878
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length8891 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle By similarity. UniProtKB Q5VST9

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. UniProtKB P28523

Cofactor

Magnesium By similarity. UniProtKB P28523

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

Contains 1 DH (DBL-homology) domain.

Contains 3 fibronectin type-III domains.

Contains 55 Ig-like (immunoglobulin-like) domains.

Contains 1 IQ domain.

Contains 1 PH domain.

Contains 2 protein kinase domains.

Contains 1 SH3 domain.

Sequence caution

The sequence CAM24490.2 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAM24491.3 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAQ51661.2 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.2 (identifier: A2AAJ9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.3 (identifier: A2AAJ9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     7161-7167: VCSHDTS → ERRPSPP
     7168-8891: Missing.
Note: Lacks the kinase domain. No experimental confirmation available.
Isoform 3 Ref.1 Ref.2 (identifier: A2AAJ9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-7306: Missing.
     8384-8389: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 88918891Obscurin
PRO_0000296296

Regions

Domain9 – 9991Ig-like 1
Domain109 – 20193Ig-like 2
Domain234 – 32087Ig-like 3
Domain329 – 41587Ig-like 4
Domain513 – 61098Fibronectin type-III 1
Domain702 – 79392Ig-like 5
Domain859 – 95193Ig-like 6
Domain951 – 104393Ig-like 7
Domain1043 – 113593Ig-like 8
Domain1135 – 122793Ig-like 9
Domain1227 – 131993Ig-like 10
Domain1319 – 140789Ig-like 11
Domain1411 – 150393Ig-like 12
Domain1503 – 159593Ig-like 13
Domain1595 – 168793Ig-like 14
Domain1687 – 177993Ig-like 15
Domain1779 – 187193Ig-like 16
Domain1871 – 196393Ig-like 17
Domain1963 – 205189Ig-like 18
Domain2055 – 214793Ig-like 19
Domain2152 – 224190Ig-like 20
Domain2242 – 232584Ig-like 21
Domain2329 – 241587Ig-like 22
Domain2420 – 250485Ig-like 23
Domain2598 – 268184Ig-like 24
Domain2721 – 281292Ig-like 25
Domain2900 – 298485Ig-like 26
Domain3078 – 316285Ig-like 27
Domain3258 – 334285Ig-like 28
Domain3348 – 343184Ig-like 29
Domain3527 – 361084Ig-like 30
Domain3616 – 370085Ig-like 31
Domain3785 – 387692Ig-like 32
Domain3881 – 396484Ig-like 33
Domain4041 – 412484Ig-like 34
Domain4129 – 421284Ig-like 35
Domain4218 – 430083Ig-like 36
Domain4306 – 438883Ig-like 37
Domain4394 – 447683Ig-like 38
Domain4482 – 456483Ig-like 39
Domain4570 – 465283Ig-like 40
Domain4658 – 474083Ig-like 41
Domain4745 – 482884Ig-like 42
Domain4832 – 491584Ig-like 43
Domain4922 – 500685Ig-like 44
Domain5012 – 510493Ig-like 45
Domain5374 – 546087Ig-like 46
Domain5467 – 556094Fibronectin type-III 2
Domain5553 – 565098Ig-like 47
Domain5812 – 584130IQ
Domain5838 – 592184Ig-like 48
Domain6068 – 615790Ig-like 49
Domain6200 – 628990Ig-like 50
Domain6311 – 640797Ig-like 51
Domain6540 – 660768SH3
Domain6633 – 6817185DH
Domain6835 – 6944110PH
Domain6954 – 703784Ig-like 52
Domain7048 – 713891Ig-like 53
Domain7305 – 739389Ig-like 54
Domain7415 – 7668254Protein kinase 1
Domain8385 – 846985Ig-like 55
Domain8479 – 857193Fibronectin type-III 3
Domain8595 – 8847253Protein kinase 2
Nucleotide binding7421 – 74299ATP By similarity UniProtKB P28523
Nucleotide binding8601 – 86099ATP By similarity UniProtKB P28523

Sites

Active site75341Proton acceptor By similarity UniProtKB P28523
Active site87141Proton acceptor By similarity UniProtKB P28523
Binding site74441ATP By similarity
Binding site86241ATP By similarity

Amino acid modifications

Disulfide bond30 ↔ 81 By similarity UniProtKB Q5VST9
Disulfide bond257 ↔ 309 By similarity UniProtKB Q5VST9
Disulfide bond352 ↔ 402 By similarity UniProtKB Q5VST9
Disulfide bond885 ↔ 935 By similarity UniProtKB Q5VST9
Disulfide bond977 ↔ 1027 By similarity UniProtKB Q5VST9
Disulfide bond1069 ↔ 1119 By similarity UniProtKB Q5VST9
Disulfide bond1161 ↔ 1211 By similarity UniProtKB Q5VST9
Disulfide bond1253 ↔ 1303 By similarity UniProtKB Q5VST9
Disulfide bond1345 ↔ 1395 By similarity UniProtKB Q5VST9
Disulfide bond1437 ↔ 1487 By similarity UniProtKB Q5VST9
Disulfide bond1529 ↔ 1579 By similarity UniProtKB Q5VST9
Disulfide bond1621 ↔ 1671 By similarity UniProtKB Q5VST9
Disulfide bond1713 ↔ 1763 By similarity UniProtKB Q5VST9
Disulfide bond1805 ↔ 1855 By similarity UniProtKB Q5VST9
Disulfide bond1897 ↔ 1947 By similarity UniProtKB Q5VST9
Disulfide bond1989 ↔ 2039 By similarity UniProtKB Q5VST9
Disulfide bond2081 ↔ 2131 By similarity UniProtKB Q5VST9
Disulfide bond2263 ↔ 2313 By similarity UniProtKB Q5VST9
Disulfide bond2620 ↔ 2669 By similarity UniProtKB Q5VST9
Disulfide bond2743 ↔ 2793 By similarity UniProtKB Q5VST9
Disulfide bond2922 ↔ 2972 By similarity UniProtKB Q5VST9
Disulfide bond3100 ↔ 3150 By similarity UniProtKB Q5VST9
Disulfide bond3280 ↔ 3330 By similarity UniProtKB Q5VST9
Disulfide bond3369 ↔ 3419 By similarity UniProtKB Q5VST9
Disulfide bond3549 ↔ 3599 By similarity UniProtKB Q5VST9
Disulfide bond3638 ↔ 3688 By similarity UniProtKB Q5VST9
Disulfide bond3815 ↔ 3864 By similarity UniProtKB Q5VST9
Disulfide bond3903 ↔ 3952 By similarity UniProtKB Q5VST9
Disulfide bond4063 ↔ 4112 By similarity UniProtKB Q5VST9
Disulfide bond4151 ↔ 4200 By similarity UniProtKB Q5VST9
Disulfide bond4239 ↔ 4288 By similarity UniProtKB Q5VST9
Disulfide bond4327 ↔ 4376 By similarity UniProtKB Q5VST9
Disulfide bond4415 ↔ 4464 By similarity UniProtKB Q5VST9
Disulfide bond4503 ↔ 4552 By similarity UniProtKB Q5VST9
Disulfide bond4591 ↔ 4640 By similarity UniProtKB Q5VST9
Disulfide bond4679 ↔ 4728 By similarity UniProtKB Q5VST9
Disulfide bond4767 ↔ 4816 By similarity UniProtKB Q5VST9
Disulfide bond4855 ↔ 4905 By similarity UniProtKB Q5VST9
Disulfide bond4944 ↔ 4994 By similarity UniProtKB Q5VST9
Disulfide bond5033 ↔ 5085 By similarity UniProtKB Q5VST9
Disulfide bond5581 ↔ 5634 By similarity UniProtKB Q5VST9
Disulfide bond5859 ↔ 5911 By similarity UniProtKB Q5VST9
Disulfide bond6089 ↔ 6141 By similarity UniProtKB Q5VST9
Disulfide bond6975 ↔ 7027 By similarity UniProtKB Q5VST9
Disulfide bond7069 ↔ 7122 By similarity UniProtKB Q5VST9
Disulfide bond8406 ↔ 8458 By similarity UniProtKB Q5VST9

Natural variations

Alternative sequence1 – 73067306Missing in isoform 3. Ref.1 Ref.2
VSP_052486
Alternative sequence7161 – 71677VCSHDTS → ERRPSPP in isoform 2. Ref.3
VSP_052485
Alternative sequence7168 – 88911724Missing in isoform 2. Ref.3
VSP_052487
Alternative sequence8384 – 83896Missing in isoform 3. Ref.1 Ref.2
VSP_052488

Experimental info

Sequence conflict76541R → Q in AAT80900. Ref.1
Sequence conflict85181G → E in AAT80900. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: 384E04B56A54CAB0

FASTA8,891966,372
        10         20         30         40         50         60 
MDHSFSGAPR FLTRPKAFVV SVGKDATLSC QIVGNPTPHV SWEKDRQPVE AGARFRLAQD 

        70         80         90        100        110        120 
GDVYRLTILD LALGDSGQYV CRARNAIGEA FAAVGLRVDS EGTCAEQAPH FLLRPTSIRV 

       130        140        150        160        170        180 
REGADATFRC RVGGSPQPAV SWSKDGRRLG PPDAPHVRVE EHGESSALRI RSARPRDGGT 

       190        200        210        220        230        240 
YEVRAENPLG SASAAAALVV DSDAEVAGPP GTSTATLLAH LQQRREAMRA EGIPPSPPGA 

       250        260        270        280        290        300 
GTRTCTVTEG KHARLSCFVT GEPKPETVWK KDGQLVTEGR RHVVYEDEQE NFVLKILFCK 

       310        320        330        340        350        360 
QSDRGLYTCT ASNLVGQTYS SVLVVVREPT VPFKKRLQDL EVREKESATF QCEVAQPATE 

       370        380        390        400        410        420 
AAWFKEETRL WASAKYDIEE EGTERRLTVR NVSADDDAVY ICETTEGSRT VAELSVQGNL 

       430        440        450        460        470        480 
TRKLPRKTAV RTGDTAIFWV ELAVPEGPVR WLRNQEEMVA GGRVAITAEG TCHTLTIFQC 

       490        500        510        520        530        540 
TLEDMGEVAF VSGGCRTTTQ FCVSAPRRPP LYPPADPVVK AKTESSVTLS WSAPPHGDRP 

       550        560        570        580        590        600 
VTIDGYVLEK RKLGAYAWSR CHEAGWLATT EFTITGVAEE GDFQFRVSAI NHFGQGPYLE 

       610        620        630        640        650        660 
FPGTMHLVPM LAVKTPLKAV EAVEGGEVTF SVDLTVASSG EWFLDGEALK ASSIYVIRCD 

       670        680        690        700        710        720 
RTRHMLTIRE VPARLHGAQL KFVANGIETS IQMVVRAALG LPSSKLPAAA AREVLAQLHE 

       730        740        750        760        770        780 
EAQLLAELSD QAAAVTWLKD GRELSLGPKY EMQVSAGRRA LLVRDVAQDD AGLYECVSRG 

       790        800        810        820        830        840 
SRTAYQLLVQ DITDGYRDWG PAGPQKHMCK CAGAKIARYL GSSCYRFLQY DKGVWHWLEA 

       850        860        870        880        890        900 
ALDTRQGKGT SSCSLHEKPK LVFAKGQQAH SEVKAEAGNS ATLSCEVTQA QTEVTWFKDG 

       910        920        930        940        950        960 
KKLSSSSKVR MEASGCSRRL VVQQAGKADA GEYSCEAGGQ KLSFRLDVAE PKLVFAKGQQ 

       970        980        990       1000       1010       1020 
AHSEVKAEAG ASATLSCEVA QAQTEVTWFK DGKKLSSSSK VRMEASGCSR RLVVQQAGKA 

      1030       1040       1050       1060       1070       1080 
DAGEYSCEAG GQKLSFRLDV AEPKMVFAKE QQARSEVKAE AGASATLSCE VAQAQTEVTW 

      1090       1100       1110       1120       1130       1140 
FKDGKKLSSS SKVRMEASGC SRRLVVQQAG KADAGEYSCE AGGQKLSFRL DVTEPKLVFA 

      1150       1160       1170       1180       1190       1200 
KEQQARSEVK AEVGNSATLS CEVAQAQTEV TWFKDGKKLS SSSKVRMEAS GCSRRLVVQQ 

      1210       1220       1230       1240       1250       1260 
AGKADAGEYS CEAGGQKLSF RLDVAEPKLV FAKEQQARSE VKAEAGNSAT LSCEVAQAQT 

      1270       1280       1290       1300       1310       1320 
EVTWFKDGKK LSSSSKVRME ASGCSRRLVV QQAGKADAGE YSCEAGGQKL SFHLDVTEPK 

      1330       1340       1350       1360       1370       1380 
LVFAKEQQAH SEVKAEAGAS ATLSCEVAQA QTEVTWFKDG KKLSSSSKVR MEASGCSRRL 

      1390       1400       1410       1420       1430       1440 
VVQQAGKADA GEYSCEAEGQ KLSFRLDVAE PKLVFAKEQQ ARSEVKAEAG ASATLSCEVA 

      1450       1460       1470       1480       1490       1500 
QAQTEVTWFK DGKKLSSSSK VRVEASGCSR RLVVQQAGKA DAGEYSCEAG GQKLSFRLDV 

      1510       1520       1530       1540       1550       1560 
AEPKLVFAKE QQANSEVKAE AGASATLSCE VAQAQTEVTW FKDGKKLSSS SKVRVEASGC 

      1570       1580       1590       1600       1610       1620 
SRRLVVQQAG KADAGEYSCE AGGQKLSFRL DVAEPKLAFA KEQQAHSEVK AEAGASATLS 

      1630       1640       1650       1660       1670       1680 
CEVAQAQTEV TWFKDGKKLS SSSKVRVEAS GCSRRLVVQQ AGKADAGEYS CEAGGQKLSF 

      1690       1700       1710       1720       1730       1740 
RLDVAEPKLA FAKEQQAHSE VKAEAGASAT LSCEVAQAQT EVTWFKDGKK LSSSSKVRVE 

      1750       1760       1770       1780       1790       1800 
ASGCSRRLVV QQAGKADAGE YSCEAGGQKL SFRLDVAEPK LAFAKEQQAH SEVKAEAGAS 

      1810       1820       1830       1840       1850       1860 
ATLSCEVAQA QTEVTWFKDG KKLSSSSKVR VEASGCSRRL VVQQAGKADA GEYSCEAGGQ 

      1870       1880       1890       1900       1910       1920 
KLFFRLDVAE PKLMFAKEQQ AHSEVKAEAG ASATLSCEVA QAQTEVTWFK DGKKLSSSSK 

      1930       1940       1950       1960       1970       1980 
VRVEASGCSR RLVVQQAGKA DAGEYSCEAG GQKLSFRLDV AEPKLVFAKE QQAHSEVKAE 

      1990       2000       2010       2020       2030       2040 
AGASATLSCE VAQAQTEVTW FKDGKKLSSS SKVRVEASGC SRRLVVQQVG KADAGEYSCE 

      2050       2060       2070       2080       2090       2100 
ARGQKLSFRL DVADTRLMFA KEQQARTEVK AEAGNSATLS CEVAQAQTEV TWFKDGKKLS 

      2110       2120       2130       2140       2150       2160 
SSSKVRVEAS GCSRRLVVQQ AGKADAGEYS CEAGGQKLSF RLDVAEAESQ IPERPSRREP 

      2170       2180       2190       2200       2210       2220 
LVVKEHETII LTATIAAPSV AAVTWLKDGV EIRRSKRHEA TSLGDTHTLT VRGAQVLDSA 

      2230       2240       2250       2260       2270       2280 
IYSCRVGKEG QDFPVQVEEV AAKFSKPLEP VEGELGGTVM LVCELSPEQA EVVWRCGNTQ 

      2290       2300       2310       2320       2330       2340 
LRPGKRFQMT SEGPRRTLTV SGLREDDAEE YVCESRDDRT SARLTVKVPR VVKFTSGLSA 

      2350       2360       2370       2380       2390       2400 
MVAEEGQEAT FQCVVSPSDA GVTWYKDGMQ LQPSEKFVMV ESGASRSLTI LGLTLEDAGQ 

      2410       2420       2430       2440       2450       2460 
VTVEAEGASS SAALRVREAP VLFKKKLEPQ TVEERTSVTL EVELTRPWPE VKWTRNAAVL 

      2470       2480       2490       2500       2510       2520 
TPSENVEIRA EGARHCLVLR SVGFADRGFF GCETPDDKTQ AKLNVEMRQV RLVRGLQEVE 

      2530       2540       2550       2560       2570       2580 
AKEQGTASMD VELSHAEVEG SWTRDGLRLQ PGPKCHLAVQ GPVHILTLSA LQPQDSGLVA 

      2590       2600       2610       2620       2630       2640 
FRAEGVHTSA RLIVTELPVS FTRVLQDVVA TQKEKVTLEC ELSRPVDVRW LKDGVELRAG 

      2650       2660       2670       2680       2690       2700 
KAIGIVAQGT CRSLVIYRCE TGDQGVYVCD ALDAQTSASL RVQGRTYTLI FRRVLAEDAG 

      2710       2720       2730       2740       2750       2760 
EVKFVAENAE SRAHLRVKEL PVTLLRPLRD KIAMEKHRGV LECQVSRASA QVRWFKGGVE 

      2770       2780       2790       2800       2810       2820 
LQSGPKYEVV SDGLYRKLVI NDVQPEDEDT YTCDAGNVKT SAQFFVEEQS ITIVRGLKDM 

      2830       2840       2850       2860       2870       2880 
TVMEPAPAWF ECETSIPSVR PPKWLLGKTV LQAGGNVGLE QDGTVHRLTL HKTCSTMTGP 

      2890       2900       2910       2920       2930       2940 
VHFTIGKSRS SAQLVVSDIP VVLTRPLEPK AGRELQSVVL SCDFRPAPKA VQWYKDDTPL 

      2950       2960       2970       2980       2990       3000 
SPSEKFKMAL EGQMAELRIL RLTPADAGVY RCQAGSAQSS AEVTVEAREV TVIQPLQDAE 

      3010       3020       3030       3040       3050       3060 
AMEEGRVCFS CELSHKDEDI EWSLNGTPLY NDSFHEISHE GCLHTLVLKS VRQADTGTVC 

      3070       3080       3090       3100       3110       3120 
ATSPKVSVSA RLVVKGKPVV FLKALDDVSA EERGTLTLQC EVSDPEARVV WRKDGVELGP 

      3130       3140       3150       3160       3170       3180 
SDKYDFLHKA GARGLTVHDL SHEDAGLYTC QVGSKETQSK VSVHDLHVGI TKRLKTVEVL 

      3190       3200       3210       3220       3230       3240 
EGESCSFECV LSHESPSDPA VWTVGGKTVG GSGHFHAVRQ GRKYTLTVKD AALSDAGEVV 

      3250       3260       3270       3280       3290       3300 
FSVLGLTSKA SLIIRERPVD ITKPLEDQRT TLGEDVMLSC ELSRAGTSVR WLKDGKAIRK 

      3310       3320       3330       3340       3350       3360 
SQKYDLLSEG TRAVLVVRKA SLKDSGEYTC ETEASKSTAK LCVEEKANRF TEELADLQVE 

      3370       3380       3390       3400       3410       3420 
EKGRAVFTCK TEHPASVVTW RKGLLELRAS GKHVPSQEGL TLKLTINALE RTDSDTYTCD 

      3430       3440       3450       3460       3470       3480 
IGQARTQARL LVHGQKVRVI EDLEDTAVQE GSSAKFCCRI APADYGPVHW FLDKTPLHSN 

      3490       3500       3510       3520       3530       3540 
ELNEITVQPG GYHVLTLRQL ALKDSGTVYF EAGDQRTSAA LRVTEKPSIF SRPLTDVTVT 

      3550       3560       3570       3580       3590       3600 
EGEDLTLVCE TTTVDSSVRW TKDGKTLRPS ARCQLSHEGC QAQLLITATT PQDGGRYKCE 

      3610       3620       3630       3640       3650       3660 
IGGASSSSIV RVHALPVRFR ESLKDVEVPE GKAATLRCVL SSVAAPVEWR HGDDVLKSSN 

      3670       3680       3690       3700       3710       3720 
KYSLRQEGAV LELVIRDLQP QDSGQYSCSF GDQTTSATLT VKTSSAQFVG KLRNKEATEG 

      3730       3740       3750       3760       3770       3780 
TTVTLRCELT KEAPVEWKKG TETLRNGDKY SLKQDGAVCE LQICSLLVAD AGEYSCVCGQ 

      3790       3800       3810       3820       3830       3840 
EKTSATLTVK ALLVHFVRRL RSKEATEGDT TTLQCELSKA APVEWRKGTE TLRDGDRYSL 

      3850       3860       3870       3880       3890       3900 
KQDGAVCELQ IRSLTIADAG EYLCTCGQEK TSATLTVRAL PAKFKDSLKN EEATEGTTAT 

      3910       3920       3930       3940       3950       3960 
LSCELSKAAP VTWKKGPKTL QSGDKYVLRQ DGAVCGLQIH GLTMADAGEY SCVCGQEKTS 

      3970       3980       3990       4000       4010       4020 
ATLTVRGLPA KFIEDLRSQE ATEGATAILR CELSKAAPVE WRKGSETLKD GDRYTLRQDG 

      4030       4040       4050       4060       4070       4080 
AVCELQIRGL AVVDTGTYSL PTKFTEGLRN EEATEGTMAT LRCQMSKAAP VEWRKGSETL 

      4090       4100       4110       4120       4130       4140 
RDGDRYSLRQ DGAMCELQIR GLTIEDSGEY TCVCGQEKTS ATLSVKALPS RFIEDLRSQE 

      4150       4160       4170       4180       4190       4200 
ATEGTMATLR CQMSKTAPVE WKKGSETLRD GGRYSLRQDG PVCELQICDL AVEDAGEYSC 

      4210       4220       4230       4240       4250       4260 
VCGQEKTSAT LSIKALPPRF IEDLRSQEAT EGTMATLRCQ MSKAAPVEWR KGSETLGDGG 

      4270       4280       4290       4300       4310       4320 
RYSLRQNGAV CELQIHDLAV EDTGEYSCVC GQEKTSATLN VKALPPRFIE DLRSQEATEG 

      4330       4340       4350       4360       4370       4380 
TMATLRCQMS KAAPVEWRKG SETLRDGGRY SLRQDGAVCE LQIHDLDVED AGQYSCVCGQ 

      4390       4400       4410       4420       4430       4440 
EKTSAVLTVD ALPPKFTEGL KKEEATEGTM VTLRCQMSKE ATVEWRKGAK TLSDGGRYSL 

      4450       4460       4470       4480       4490       4500 
RQDGAMCELQ ICGLAVEDAG EYSCVCGQEK TSATLSVKAL PPRFIEDLRS QEATEGTMAT 

      4510       4520       4530       4540       4550       4560 
LRCQMSKAAP VEWRKGSETL RDGDRYSLRQ DGAVCELQIR DLAVEDAGEY LCVCGQEKTS 

      4570       4580       4590       4600       4610       4620 
ATLSVKALPP RFIEDLRSQE ATEGTMATLR CQMSKAAPVE WRKGSKTLRD GDRYSLRQDG 

      4630       4640       4650       4660       4670       4680 
AMCELQICDL AVEDTGDYSC VCGQEKTSAT LSVKALPPRF IEDLRSQEAR EGTVATLRCR 

      4690       4700       4710       4720       4730       4740 
MSKAAPVEWR KGSETLKDGD RYSLRQEGNL CELQIRDLAV EDTEEYSCVC GQEKTSATLS 

      4750       4760       4770       4780       4790       4800 
VKALPAKFIE DLRSQEAPES STVTLRCKLS KKASVVWKKG SETLRNGARY SLRQDGAVCE 

      4810       4820       4830       4840       4850       4860 
LEIRDLTVED TGEYSCTCGQ ERTSATLSIM APQVVFQQPL QNLQAEEGSM ASLRCELSVP 

      4870       4880       4890       4900       4910       4920 
NAAMVWSKGG LELQGDTRRE ARQQGCVAEL LLRDLRREDA GEYSCTCGSQ TTSATLMVTA 

      4930       4940       4950       4960       4970       4980 
APVRFLRELQ AQDVDEGATA RLRCELSREA VSVEWRKGSL QLFPCAKYQM VQEGTTAELL 

      4990       5000       5010       5020       5030       5040 
VHGVEQEDAG EYTCDAGHTQ SIARLSVRAP KPKFKTDLQS TEQEAGGTAR LCCQLSEAEP 

      5050       5060       5070       5080       5090       5100 
GTPVQWLKEG VELHVGSKYE MRRQGAVCEL LIHGLEAKDT GEYACLVGGQ KTLASLRVKE 

      5110       5120       5130       5140       5150       5160 
PEVTIVRGLV DMEVQADEDV EFTCKVSQAG ATDVQWHLQG LPLQSNEVTE VAVLADGCTH 

      5170       5180       5190       5200       5210       5220 
VLQLKGVTLE DAGTVSFHVG GLSSSAQLTV RGDRSGAPEG CAAQRGPGCP LPVPTVQGLG 

      5230       5240       5250       5260       5270       5280 
PGGSLGFGRG SLAVQRDERH HCGAGHTLPA HSAQGDPGGC WDHHSPSGLM LLRGPAEGHS 

      5290       5300       5310       5320       5330       5340 
KNTVLRGLEN VDALEGGEAL FECQLSQPEV AAHTWLLDDE PVHTSEKVEV VYFENGLRHL 

      5350       5360       5370       5380       5390       5400 
LLLKNLKPQD SCRVTFLAGD VVTSAFLTVR GWRLEVLEPP HDASVKAGMQ VRFTCILSEA 

      5410       5420       5430       5440       5450       5460 
VPVGEATWYI NGAAIQPDDT DWTVTTDGSH HALTLSNAQP QHAGEVTFAA RDAVASARLS 

      5470       5480       5490       5500       5510       5520 
VLALPDPPED AEVVGRSDHS VTLSWVAPMS DGGGGLCGYR VEMKEASTGQ WQLCHDLVPG 

      5530       5540       5550       5560       5570       5580 
PECVVDDLVP GKTYRFRVAA VGPAGAGEPV HLPQMAPAPA PAPAPAPAPE TRQAVVGEDI 

      5590       5600       5610       5620       5630       5640 
CLELEVAADG GEVVWHKGTE RIQPGGHFEV LSRGQRQMLV IKGFRTEDQG EYRCGPIQGL 

      5650       5660       5670       5680       5690       5700 
PSSGAATFNV VMTSGSGDEV PAQPSLPPEA AQEGDLHLLW EALARKRRMS REPTLDSISE 

      5710       5720       5730       5740       5750       5760 
LPEEDSRVQH LRQEAEETAP DLSEGYSTAD ELARTGEADL SHTSSDDESR AGTPSLVTYL 

      5770       5780       5790       5800       5810       5820 
KKAGGPGISP LASKHEAQVT TSVKPQKQQE PVVPTCPPPG DLSAADLMDP SLDKAAVKIQ 

      5830       5840       5850       5860       5870       5880 
AAFKGYKVRK EMKQQEGPVF SRTFGDTEAQ VGDVLRLECV LATKTDMRAC WLKDGIELTD 

      5890       5900       5910       5920       5930       5940 
GRHYHIDQLK DGTCSLLVTG LAPTDSGRYT CQVSTKSGRV SHSACVVVSG TESEAESSSG 

      5950       5960       5970       5980       5990       6000 
GELDDAFRRA ARRLHRLFRT KSPAELSEEE LFLSADEGPG EPEEPADWQT YREDENFVCI 

      6010       6020       6030       6040       6050       6060 
RFESLAEARQ AVTCFRNMFA TMGIGVEISL GEQGPRGVEM RIGKVAPTVT PAVPLAKTPG 

      6070       6080       6090       6100       6110       6120 
LQTSDAAPVF LTELQNQDVQ DGYPMSFDCV VTGQPVPSVR WFKDGKLLEE DDHYMINEDQ 

      6130       6140       6150       6160       6170       6180 
QGGHQLIITA VVPADMGVYR CLAENSMGVS STKAELRVEL TSTDYDTAAD ATETSSYFSA 

      6190       6200       6210       6220       6230       6240 
QGYLSSREQE GTESDEGQLP QVLEELKDLQ VAPGTRLAKF QLKVKGYPAP KLYWFKDGQP 

      6250       6260       6270       6280       6290       6300 
LTTSDHIRMT DKKTLHTLEI VSVTREDSGQ YAAYISNAVG AAYSSARLLV RGPSEPEEKP 

      6310       6320       6330       6340       6350       6360 
ASDVHERLVP PRILEKFTPK KVKRGSSITF SVKVEGHPAP SVHWLKEEAE KGVLWIGPDT 

      6370       6380       6390       6400       6410       6420 
PGYTMASSSK QHSLVLLDVG RQHQGTYTCI ATNPAGQALC SASLHISGLA KEEEQERVKE 

      6430       6440       6450       6460       6470       6480 
ALISSFLQGT SQAVSAQMSE SAGFADLVGQ SKGESLVAEE AHSHLSLAEV GTEEFLQKLT 

      6490       6500       6510       6520       6530       6540 
SQITEMVSAK ISQAKLQVPG GDSDEETKTP SASPRHGRSR PSSSVQESSS ESEDGDSRGE 

      6550       6560       6570       6580       6590       6600 
IFDIYVVTAD YLPLGAEQDA IILREGQYVE VLDSAHPLRW LVRTKPTKSS PSRQGWVSPA 

      6610       6620       6630       6640       6650       6660 
YLDKRLKLSP EWGPTEAPEF PGEAVSEDEY RTRLSSVIQE LLSSEQAFVG ELQFLESHHM 

      6670       6680       6690       6700       6710       6720 
KHLERSPRVP AAVASQKTVI FRNVQDISHF HSSFLKELQG CGTDDDVAMC FIKNQEAFEK 

      6730       6740       6750       6760       6770       6780 
YLEFLVGRVQ AESVVVSTPV QEFYKKYAEE TLSAKDPTQP PPPPLQHYLE QPVERVQKYQ 

      6790       6800       6810       6820       6830       6840 
ALLKELIRNK ARNRQNCALL EQAYAVVSAL PQRAENKLHV SLMENYPGTL EALGEPIRQG 

      6850       6860       6870       6880       6890       6900 
HFIVWEGAPG ARMPWKGHNR HVFLFRNYLV ICKPRRDSRT DTFSYVFRNM MKLSSIDLND 

      6910       6920       6930       6940       6950       6960 
QVEGDDRAFE VWHEREDSVR KYLLQARTVI IKNSWVKEIC GIQQRLAQPV WRPPEFEEEL 

      6970       6980       6990       7000       7010       7020 
ADCTAELGET VKLACRVTGT PKPIVSWYKD GKPVEVDPHH ILIEDPDGSC TLILDNLTGI 

      7030       7040       7050       7060       7070       7080 
DSGQYMCFAA SAAGNASTLG KILVQVPPRF VNKVRATPFV EGEDAQITCT VEGAPYPQIR 

      7090       7100       7110       7120       7130       7140 
WYKDGTLLAP GNRYRMLNEP RSGVLVLVIQ AASKEDLGHY ECELVNRLGS TRGGGELYMQ 

      7150       7160       7170       7180       7190       7200 
SPALRARDQH HREQIVAAVE VCSHDTSVEG SAHSAQDGAD QQAASVLWRL LGSEALGPSP 

      7210       7220       7230       7240       7250       7260 
GDLPNTRQSE PPAFEEAASQ IPGAASGTPG ELPEVSQPGT HKGLEQETTS SGSQGWTVPI 

      7270       7280       7290       7300       7310       7320 
RVEGTAWPGA GTGQLLLDVH SQVIMETTQR TYVCQAPDTG VTRAPSMQVT IEDVQVQVGD 

      7330       7340       7350       7360       7370       7380 
MAQFDAVIEG HPPPIVTWYK GSTQLTSSAR LSQRQDGTTY SLVLTDVAPH DAGVYTCVAN 

      7390       7400       7410       7420       7430       7440 
NAGGQVLCKA ELLVHGGDKL DAENQVYRRK LHSFYDVQEE IGRGVFGFVK RVQHKGNKMF 

      7450       7460       7470       7480       7490       7500 
CAAKFIPLRS KTRAQAYQER DILATLGHPL VTGLLDQFET RKTLILILEL CSSEELLDRL 

      7510       7520       7530       7540       7550       7560 
FKKGVVTEAE VKVYIQQLVE GLHYLHSHGI LHLDIKPPNI LMVHPAREDI KICDFGFAQK 

      7570       7580       7590       7600       7610       7620 
ITPSEPQYSK YGSPEFVSPE IIEQNPVSEG SDIWAMGVIS YLSLTCSSPF AGESDRATLL 

      7630       7640       7650       7660       7670       7680 
NVLEGRVSWS SPTAAHLSED AKDFIKATLQ RTPRARPSTS QCLAHPWFLK SMPAEEAHFI 

      7690       7700       7710       7720       7730       7740 
NTKQLKFLLA RSRWQRSLMS YKSILVMRSI PELLQGPPDS PSLGVARHLR GEASGASSSS 

      7750       7760       7770       7780       7790       7800 
SSSDNELAPF ARAKSLPPSP VTHSPLLHPR GFLRPSASLP EETEASMPTA DAAVPASPQS 

      7810       7820       7830       7840       7850       7860 
AGPPASPGCV PRHSVISSLF YQQAGEGAER GNKTSGAKRH PARRRHLLKG GYIARALPGL 

      7870       7880       7890       7900       7910       7920 
REPLMEYSLL EEEAAREEQA SLMTKTPSFE TALRLPSSSV REVPGRSHSL DNPPVTTGPS 

      7930       7940       7950       7960       7970       7980 
PEACKEQLLF PPSTGLTHET TAKDRGHKEG FLQESVPFPP MSGDSRPGKQ EGSSQDSCRG 

      7990       8000       8010       8020       8030       8040 
KPASSCHSEL GSGSQEGCGP PSSQSLGSLP PQSLKKELST SCGPLFSEQP QAAPFPTQVS 

      8050       8060       8070       8080       8090       8100 
PLLGSEKEPQ DGSLSEGPVP VPSSSPGSAS QVDASLDTEG LSEAGDTCDF TPPPQRPQEQ 

      8110       8120       8130       8140       8150       8160 
ATTRKFSLES RGGYAGVAGY GTFAFGGDAG GMLGQGPLWA RMAWAVSQSS EEQDEAATES 

      8170       8180       8190       8200       8210       8220 
PQPLESLGPI AEASGVPLRT SPSLTPWEEV EQVSLVQIRD LSGDAEAADT ISLDISEVDP 

      8230       8240       8250       8260       8270       8280 
AYLNLSDLYD IKYLPFEFMI FRRVPKPIEQ PESPGSETEA GQGLADFLEE AAWPWPGELG 

      8290       8300       8310       8320       8330       8340 
LRAGLEITEE PEEPGDLEAL LGEAAVGRKR KWSPSRGLFQ FPGRCLSGEE PVELGLRQRV 

      8350       8360       8370       8380       8390       8400 
KASMAHISRI LKGRPEGPER EGPPRKKAGL ASFRLSGLKG RDQAPSFLRE LSDEAVVLGQ 

      8410       8420       8430       8440       8450       8460 
SVTLACQVLA QPTAQATWSK DGVLLESSGH LLISSTLKNF QLLTILVVKE EDLGTYTCCV 

      8470       8480       8490       8500       8510       8520 
SNPLGTAVTT GVLRKAERPS SSPRPEVGEL YKDAVLLVWK PVESCGPVTY IVQCCIEGGS 

      8530       8540       8550       8560       8570       8580 
WTTLASDISD CCYLTGKLSR GGMYIFRTAC VSKAGMGPYS SPSEQVLLGG PNHLASEEES 

      8590       8600       8610       8620       8630       8640 
SRGRPAQLLP STKTFAFQMQ IRRGRFSVVR QCREKASGRA LAAKIVPYQP EDKTAVLREY 

      8650       8660       8670       8680       8690       8700 
EALKRLHHPH LAQLHAAYLS PRHLVLILEL CSGPELLPSL AERESYSESD VKDYLWQMLS 

      8710       8720       8730       8740       8750       8760 
ATQYLHAQHI LHLDLRSENM MVTEYNLLKV IDLGNAQSLD QEKVPAPENF KDYLETMAPE 

      8770       8780       8790       8800       8810       8820 
LLEGQGAVPQ TDIWAIGVTA FIMLSGEYPE SSEGTRDLQK GLRKGLIRLS RCYAGLSGGA 

      8830       8840       8850       8860       8870       8880 
VAFLQSSLCA QPWGRPCAST CLQCGWLTEE GPTGSRPTPV TFPTVRLRAF VREREKRRAL 

      8890 
LYKKHNLAQV R 

« Hide

Isoform 2 [UniParc].

Checksum: B61FCAB243F9EA4F
Show »

FASTA7,167779,862
Isoform 3 [UniParc].

Checksum: 536554014AD05993
Show »

FASTA1,579171,680

References

« Hide 'large scale' references
[1]"Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases."
Sutter S.B., Raeker M.O., Borisov A.B., Russell M.W.
Dev. Genes Evol. 214:352-359(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6772-8891 (ISOFORM 2).
Strain: FVB/N.
Tissue: Salivary gland.
[4]"The mouse kinome: discovery and comparative genomics of all mouse protein kinases."
Caenepeel S., Charydczak G., Sudarsanam S., Hunter T., Manning G.
Proc. Natl. Acad. Sci. U.S.A. 101:11707-11712(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY603754 mRNA. Translation: AAT80900.1.
AL645854, AL662809 Genomic DNA. Translation: CAQ51661.2. Sequence problems.
AL662809, AL645854 Genomic DNA. Translation: CAM24490.2. Sequence problems.
AL662809, AL645854 Genomic DNA. Translation: CAM24491.3. Sequence problems.
BC044882 mRNA. Translation: AAH44882.2.
UniGeneMm.339542.

3D structure databases

ProteinModelPortalA2AAJ9.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI43.001.

PTM databases

PhosphoSiteA2AAJ9.

Proteomic databases

PaxDbA2AAJ9.
PRIDEA2AAJ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc029rlw.1. mouse. [A2AAJ9-1]

Organism-specific databases

MGIMGI:2681862. Obscn.

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000115256.
HOVERGENHBG108206.
InParanoidB2FDE7.
PhylomeDBA2AAJ9.

Gene expression databases

ArrayExpressA2AAJ9.
BgeeA2AAJ9.
GenevestigatorA2AAJ9.

Family and domain databases

Gene3D1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.10. 69 hits.
InterProIPR000219. DH-domain.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR000048. IQ_motif_EF-hand-BS.
IPR011009. Kinase-like_dom.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamPF00041. fn3. 2 hits.
PF07679. I-set. 59 hits.
PF00612. IQ. 1 hit.
PF00069. Pkinase. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 3 hits.
SM00409. IG. 20 hits.
SM00408. IGc2. 42 hits.
SM00015. IQ. 1 hit.
SM00233. PH. 1 hit.
SM00220. S_TKc. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF48065. SSF48065. 1 hit.
SSF49265. SSF49265. 3 hits.
SSF50044. SSF50044. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEPS50010. DH_2. 1 hit.
PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 54 hits.
PS50096. IQ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROA2AAJ9.
SOURCESearch...

Entry information

Entry nameOBSCN_MOUSE
AccessionPrimary (citable) accession number: A2AAJ9
Secondary accession number(s): A2AB85 expand/collapse secondary AC list , B2FDE7, Q695L2, Q811H7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot