A2AAJ9 (OBSCN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Obscurin
EC=2.7.11.1

Alternative name(s):
Obscurin-RhoGEF
Obscurin-myosin light chain kinase
Short name=Obscurin-MLCK

Gene names

Name:	Obscn
Synonyms:	Gm878

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	8891 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle By similarity. UniProtKB Q5VST9
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. UniProtKB P28523
Cofactor	Magnesium By similarity. UniProtKB P28523
Sequence similarities	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Contains 1 DH (DBL-homology) domain. Contains 3 fibronectin type-III domains. Contains 55 Ig-like (immunoglobulin-like) domains. Contains 1 IQ domain. Contains 1 PH domain. Contains 2 protein kinase domains. Contains 1 SH3 domain.
Sequence caution	The sequence CAM24490.2 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAM24491.3 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAQ51661.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Differentiation
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Repeat SH3 domain
Ligand	ATP-binding Calmodulin-binding Nucleotide-binding
Molecular function	Developmental protein Kinase Muscle protein Serine/threonine-protein kinase Transferase
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	M band Inferred from direct assay PubMed 18782775. Source: BHF-UCL
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro phospholipid binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.2 (identifier: A2AAJ9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.3 (identifier: A2AAJ9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     7161-7167: VCSHDTS → ERRPSPP
     7168-8891: Missing.

Note: Lacks the kinase domain. No experimental confirmation available.

Isoform 3 Ref.1 Ref.2 (identifier: A2AAJ9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-7306: Missing.
     8384-8389: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 8891	8891	Obscurin		PRO_0000296296
Regions
	Domain	9 – 99	91	Ig-like 1
	Domain	109 – 201	93	Ig-like 2
	Domain	234 – 320	87	Ig-like 3
	Domain	329 – 415	87	Ig-like 4
	Domain	510 – 605	96	Fibronectin type-III 1
	Domain	702 – 793	92	Ig-like 5
	Domain	859 – 951	93	Ig-like 6
	Domain	951 – 1043	93	Ig-like 7
	Domain	1043 – 1135	93	Ig-like 8
	Domain	1135 – 1227	93	Ig-like 9
	Domain	1227 – 1319	93	Ig-like 10
	Domain	1319 – 1407	89	Ig-like 11
	Domain	1411 – 1503	93	Ig-like 12
	Domain	1503 – 1595	93	Ig-like 13
	Domain	1595 – 1687	93	Ig-like 14
	Domain	1687 – 1779	93	Ig-like 15
	Domain	1779 – 1871	93	Ig-like 16
	Domain	1871 – 1963	93	Ig-like 17
	Domain	1963 – 2051	89	Ig-like 18
	Domain	2055 – 2147	93	Ig-like 19
	Domain	2152 – 2241	90	Ig-like 20
	Domain	2242 – 2325	84	Ig-like 21
	Domain	2329 – 2415	87	Ig-like 22
	Domain	2420 – 2504	85	Ig-like 23
	Domain	2598 – 2681	84	Ig-like 24
	Domain	2721 – 2812	92	Ig-like 25
	Domain	2900 – 2984	85	Ig-like 26
	Domain	3078 – 3162	85	Ig-like 27
	Domain	3258 – 3342	85	Ig-like 28
	Domain	3348 – 3431	84	Ig-like 29
	Domain	3527 – 3610	84	Ig-like 30
	Domain	3616 – 3700	85	Ig-like 31
	Domain	3785 – 3876	92	Ig-like 32
	Domain	3881 – 3964	84	Ig-like 33
	Domain	4041 – 4124	84	Ig-like 34
	Domain	4129 – 4212	84	Ig-like 35
	Domain	4218 – 4300	83	Ig-like 36
	Domain	4306 – 4388	83	Ig-like 37
	Domain	4394 – 4476	83	Ig-like 38
	Domain	4482 – 4564	83	Ig-like 39
	Domain	4570 – 4652	83	Ig-like 40
	Domain	4658 – 4740	83	Ig-like 41
	Domain	4745 – 4828	84	Ig-like 42
	Domain	4832 – 4915	84	Ig-like 43
	Domain	4922 – 5006	85	Ig-like 44
	Domain	5012 – 5104	93	Ig-like 45
	Domain	5374 – 5460	87	Ig-like 46
	Domain	5465 – 5556	92	Fibronectin type-III 2
	Domain	5553 – 5650	98	Ig-like 47
	Domain	5812 – 5841	30	IQ
	Domain	5838 – 5921	84	Ig-like 48
	Domain	6068 – 6157	90	Ig-like 49
	Domain	6200 – 6289	90	Ig-like 50
	Domain	6311 – 6407	97	Ig-like 51
	Domain	6540 – 6607	68	SH3
	Domain	6633 – 6817	185	DH
	Domain	6835 – 6944	110	PH
	Domain	6954 – 7037	84	Ig-like 52
	Domain	7048 – 7138	91	Ig-like 53
	Domain	7305 – 7393	89	Ig-like 54
	Domain	7415 – 7668	254	Protein kinase 1
	Domain	8385 – 8469	85	Ig-like 55
	Domain	8479 – 8566	88	Fibronectin type-III 3
	Domain	8595 – 8847	253	Protein kinase 2
	Nucleotide binding	7421 – 7429	9	ATP By similarity UniProtKB P28523
	Nucleotide binding	8601 – 8609	9	ATP By similarity UniProtKB P28523
Sites
	Active site	7534	1	Proton acceptor By similarity UniProtKB P28523
	Active site	8714	1	Proton acceptor By similarity UniProtKB P28523
	Binding site	7444	1	ATP By similarity
	Binding site	8624	1	ATP By similarity
Amino acid modifications
	Disulfide bond	30 ↔ 81		By similarity UniProtKB Q5VST9
	Disulfide bond	257 ↔ 309		By similarity UniProtKB Q5VST9
	Disulfide bond	352 ↔ 402		By similarity UniProtKB Q5VST9
	Disulfide bond	885 ↔ 935		By similarity UniProtKB Q5VST9
	Disulfide bond	977 ↔ 1027		By similarity UniProtKB Q5VST9
	Disulfide bond	1069 ↔ 1119		By similarity UniProtKB Q5VST9
	Disulfide bond	1161 ↔ 1211		By similarity UniProtKB Q5VST9
	Disulfide bond	1253 ↔ 1303		By similarity UniProtKB Q5VST9
	Disulfide bond	1345 ↔ 1395		By similarity UniProtKB Q5VST9
	Disulfide bond	1437 ↔ 1487		By similarity UniProtKB Q5VST9
	Disulfide bond	1529 ↔ 1579		By similarity UniProtKB Q5VST9
	Disulfide bond	1621 ↔ 1671		By similarity UniProtKB Q5VST9
	Disulfide bond	1713 ↔ 1763		By similarity UniProtKB Q5VST9
	Disulfide bond	1805 ↔ 1855		By similarity UniProtKB Q5VST9
	Disulfide bond	1897 ↔ 1947		By similarity UniProtKB Q5VST9
	Disulfide bond	1989 ↔ 2039		By similarity UniProtKB Q5VST9
	Disulfide bond	2081 ↔ 2131		By similarity UniProtKB Q5VST9
	Disulfide bond	2263 ↔ 2313		By similarity UniProtKB Q5VST9
	Disulfide bond	2620 ↔ 2669		By similarity UniProtKB Q5VST9
	Disulfide bond	2743 ↔ 2793		By similarity UniProtKB Q5VST9
	Disulfide bond	2922 ↔ 2972		By similarity UniProtKB Q5VST9
	Disulfide bond	3100 ↔ 3150		By similarity UniProtKB Q5VST9
	Disulfide bond	3280 ↔ 3330		By similarity UniProtKB Q5VST9
	Disulfide bond	3369 ↔ 3419		By similarity UniProtKB Q5VST9
	Disulfide bond	3549 ↔ 3599		By similarity UniProtKB Q5VST9
	Disulfide bond	3638 ↔ 3688		By similarity UniProtKB Q5VST9
	Disulfide bond	3815 ↔ 3864		By similarity UniProtKB Q5VST9
	Disulfide bond	3903 ↔ 3952		By similarity UniProtKB Q5VST9
	Disulfide bond	4063 ↔ 4112		By similarity UniProtKB Q5VST9
	Disulfide bond	4151 ↔ 4200		By similarity UniProtKB Q5VST9
	Disulfide bond	4239 ↔ 4288		By similarity UniProtKB Q5VST9
	Disulfide bond	4327 ↔ 4376		By similarity UniProtKB Q5VST9
	Disulfide bond	4415 ↔ 4464		By similarity UniProtKB Q5VST9
	Disulfide bond	4503 ↔ 4552		By similarity UniProtKB Q5VST9
	Disulfide bond	4591 ↔ 4640		By similarity UniProtKB Q5VST9
	Disulfide bond	4679 ↔ 4728		By similarity UniProtKB Q5VST9
	Disulfide bond	4767 ↔ 4816		By similarity UniProtKB Q5VST9
	Disulfide bond	4855 ↔ 4905		By similarity UniProtKB Q5VST9
	Disulfide bond	4944 ↔ 4994		By similarity UniProtKB Q5VST9
	Disulfide bond	5033 ↔ 5085		By similarity UniProtKB Q5VST9
	Disulfide bond	5581 ↔ 5634		By similarity UniProtKB Q5VST9
	Disulfide bond	5859 ↔ 5911		By similarity UniProtKB Q5VST9
	Disulfide bond	6089 ↔ 6141		By similarity UniProtKB Q5VST9
	Disulfide bond	6975 ↔ 7027		By similarity UniProtKB Q5VST9
	Disulfide bond	7069 ↔ 7122		By similarity UniProtKB Q5VST9
	Disulfide bond	8406 ↔ 8458		By similarity UniProtKB Q5VST9
Natural variations
	Alternative sequence	1 – 7306	7306	Missing in isoform 3. Ref.1 Ref.2		VSP_052486
	Alternative sequence	7161 – 7167	7	VCSHDTS → ERRPSPP in isoform 2. Ref.3		VSP_052485
	Alternative sequence	7168 – 8891	1724	Missing in isoform 2. Ref.3		VSP_052487
	Alternative sequence	8384 – 8389	6	Missing in isoform 3. Ref.1 Ref.2		VSP_052488
Experimental info
	Sequence conflict	7654	1	R → Q in AAT80900. Ref.1
	Sequence conflict	8518	1	G → E in AAT80900. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 24, 2007. Version 2. Checksum: 384E04B56A54CAB0	FASTA	8,891	966,372
	10 20 30 40 50 60 MDHSFSGAPR FLTRPKAFVV SVGKDATLSC QIVGNPTPHV SWEKDRQPVE AGARFRLAQD 70 80 90 100 110 120 GDVYRLTILD LALGDSGQYV CRARNAIGEA FAAVGLRVDS EGTCAEQAPH FLLRPTSIRV 130 140 150 160 170 180 REGADATFRC RVGGSPQPAV SWSKDGRRLG PPDAPHVRVE EHGESSALRI RSARPRDGGT 190 200 210 220 230 240 YEVRAENPLG SASAAAALVV DSDAEVAGPP GTSTATLLAH LQQRREAMRA EGIPPSPPGA 250 260 270 280 290 300 GTRTCTVTEG KHARLSCFVT GEPKPETVWK KDGQLVTEGR RHVVYEDEQE NFVLKILFCK 310 320 330 340 350 360 QSDRGLYTCT ASNLVGQTYS SVLVVVREPT VPFKKRLQDL EVREKESATF QCEVAQPATE 370 380 390 400 410 420 AAWFKEETRL WASAKYDIEE EGTERRLTVR NVSADDDAVY ICETTEGSRT VAELSVQGNL 430 440 450 460 470 480 TRKLPRKTAV RTGDTAIFWV ELAVPEGPVR WLRNQEEMVA GGRVAITAEG TCHTLTIFQC 490 500 510 520 530 540 TLEDMGEVAF VSGGCRTTTQ FCVSAPRRPP LYPPADPVVK AKTESSVTLS WSAPPHGDRP 550 560 570 580 590 600 VTIDGYVLEK RKLGAYAWSR CHEAGWLATT EFTITGVAEE GDFQFRVSAI NHFGQGPYLE 610 620 630 640 650 660 FPGTMHLVPM LAVKTPLKAV EAVEGGEVTF SVDLTVASSG EWFLDGEALK ASSIYVIRCD 670 680 690 700 710 720 RTRHMLTIRE VPARLHGAQL KFVANGIETS IQMVVRAALG LPSSKLPAAA AREVLAQLHE 730 740 750 760 770 780 EAQLLAELSD QAAAVTWLKD GRELSLGPKY EMQVSAGRRA LLVRDVAQDD AGLYECVSRG 790 800 810 820 830 840 SRTAYQLLVQ DITDGYRDWG PAGPQKHMCK CAGAKIARYL GSSCYRFLQY DKGVWHWLEA 850 860 870 880 890 900 ALDTRQGKGT SSCSLHEKPK LVFAKGQQAH SEVKAEAGNS ATLSCEVTQA QTEVTWFKDG 910 920 930 940 950 960 KKLSSSSKVR MEASGCSRRL VVQQAGKADA GEYSCEAGGQ KLSFRLDVAE PKLVFAKGQQ 970 980 990 1000 1010 1020 AHSEVKAEAG ASATLSCEVA QAQTEVTWFK DGKKLSSSSK VRMEASGCSR RLVVQQAGKA 1030 1040 1050 1060 1070 1080 DAGEYSCEAG GQKLSFRLDV AEPKMVFAKE QQARSEVKAE AGASATLSCE VAQAQTEVTW 1090 1100 1110 1120 1130 1140 FKDGKKLSSS SKVRMEASGC SRRLVVQQAG KADAGEYSCE AGGQKLSFRL DVTEPKLVFA 1150 1160 1170 1180 1190 1200 KEQQARSEVK AEVGNSATLS CEVAQAQTEV TWFKDGKKLS SSSKVRMEAS GCSRRLVVQQ 1210 1220 1230 1240 1250 1260 AGKADAGEYS CEAGGQKLSF RLDVAEPKLV FAKEQQARSE VKAEAGNSAT LSCEVAQAQT 1270 1280 1290 1300 1310 1320 EVTWFKDGKK LSSSSKVRME ASGCSRRLVV QQAGKADAGE YSCEAGGQKL SFHLDVTEPK 1330 1340 1350 1360 1370 1380 LVFAKEQQAH SEVKAEAGAS ATLSCEVAQA QTEVTWFKDG KKLSSSSKVR MEASGCSRRL 1390 1400 1410 1420 1430 1440 VVQQAGKADA GEYSCEAEGQ KLSFRLDVAE PKLVFAKEQQ ARSEVKAEAG ASATLSCEVA 1450 1460 1470 1480 1490 1500 QAQTEVTWFK DGKKLSSSSK VRVEASGCSR RLVVQQAGKA DAGEYSCEAG GQKLSFRLDV 1510 1520 1530 1540 1550 1560 AEPKLVFAKE QQANSEVKAE AGASATLSCE VAQAQTEVTW FKDGKKLSSS SKVRVEASGC 1570 1580 1590 1600 1610 1620 SRRLVVQQAG KADAGEYSCE AGGQKLSFRL DVAEPKLAFA KEQQAHSEVK AEAGASATLS 1630 1640 1650 1660 1670 1680 CEVAQAQTEV TWFKDGKKLS SSSKVRVEAS GCSRRLVVQQ AGKADAGEYS CEAGGQKLSF 1690 1700 1710 1720 1730 1740 RLDVAEPKLA FAKEQQAHSE VKAEAGASAT LSCEVAQAQT EVTWFKDGKK LSSSSKVRVE 1750 1760 1770 1780 1790 1800 ASGCSRRLVV QQAGKADAGE YSCEAGGQKL SFRLDVAEPK LAFAKEQQAH SEVKAEAGAS 1810 1820 1830 1840 1850 1860 ATLSCEVAQA QTEVTWFKDG KKLSSSSKVR VEASGCSRRL VVQQAGKADA GEYSCEAGGQ 1870 1880 1890 1900 1910 1920 KLFFRLDVAE PKLMFAKEQQ AHSEVKAEAG ASATLSCEVA QAQTEVTWFK DGKKLSSSSK 1930 1940 1950 1960 1970 1980 VRVEASGCSR RLVVQQAGKA DAGEYSCEAG GQKLSFRLDV AEPKLVFAKE QQAHSEVKAE 1990 2000 2010 2020 2030 2040 AGASATLSCE VAQAQTEVTW FKDGKKLSSS SKVRVEASGC SRRLVVQQVG KADAGEYSCE 2050 2060 2070 2080 2090 2100 ARGQKLSFRL DVADTRLMFA KEQQARTEVK AEAGNSATLS CEVAQAQTEV TWFKDGKKLS 2110 2120 2130 2140 2150 2160 SSSKVRVEAS GCSRRLVVQQ AGKADAGEYS CEAGGQKLSF RLDVAEAESQ IPERPSRREP 2170 2180 2190 2200 2210 2220 LVVKEHETII LTATIAAPSV AAVTWLKDGV EIRRSKRHEA TSLGDTHTLT VRGAQVLDSA 2230 2240 2250 2260 2270 2280 IYSCRVGKEG QDFPVQVEEV AAKFSKPLEP VEGELGGTVM LVCELSPEQA EVVWRCGNTQ 2290 2300 2310 2320 2330 2340 LRPGKRFQMT SEGPRRTLTV SGLREDDAEE YVCESRDDRT SARLTVKVPR VVKFTSGLSA 2350 2360 2370 2380 2390 2400 MVAEEGQEAT FQCVVSPSDA GVTWYKDGMQ LQPSEKFVMV ESGASRSLTI LGLTLEDAGQ 2410 2420 2430 2440 2450 2460 VTVEAEGASS SAALRVREAP VLFKKKLEPQ TVEERTSVTL EVELTRPWPE VKWTRNAAVL 2470 2480 2490 2500 2510 2520 TPSENVEIRA EGARHCLVLR SVGFADRGFF GCETPDDKTQ AKLNVEMRQV RLVRGLQEVE 2530 2540 2550 2560 2570 2580 AKEQGTASMD VELSHAEVEG SWTRDGLRLQ PGPKCHLAVQ GPVHILTLSA LQPQDSGLVA 2590 2600 2610 2620 2630 2640 FRAEGVHTSA RLIVTELPVS FTRVLQDVVA TQKEKVTLEC ELSRPVDVRW LKDGVELRAG 2650 2660 2670 2680 2690 2700 KAIGIVAQGT CRSLVIYRCE TGDQGVYVCD ALDAQTSASL RVQGRTYTLI FRRVLAEDAG 2710 2720 2730 2740 2750 2760 EVKFVAENAE SRAHLRVKEL PVTLLRPLRD KIAMEKHRGV LECQVSRASA QVRWFKGGVE 2770 2780 2790 2800 2810 2820 LQSGPKYEVV SDGLYRKLVI NDVQPEDEDT YTCDAGNVKT SAQFFVEEQS ITIVRGLKDM 2830 2840 2850 2860 2870 2880 TVMEPAPAWF ECETSIPSVR PPKWLLGKTV LQAGGNVGLE QDGTVHRLTL HKTCSTMTGP 2890 2900 2910 2920 2930 2940 VHFTIGKSRS SAQLVVSDIP VVLTRPLEPK AGRELQSVVL SCDFRPAPKA VQWYKDDTPL 2950 2960 2970 2980 2990 3000 SPSEKFKMAL EGQMAELRIL RLTPADAGVY RCQAGSAQSS AEVTVEAREV TVIQPLQDAE 3010 3020 3030 3040 3050 3060 AMEEGRVCFS CELSHKDEDI EWSLNGTPLY NDSFHEISHE GCLHTLVLKS VRQADTGTVC 3070 3080 3090 3100 3110 3120 ATSPKVSVSA RLVVKGKPVV FLKALDDVSA EERGTLTLQC EVSDPEARVV WRKDGVELGP 3130 3140 3150 3160 3170 3180 SDKYDFLHKA GARGLTVHDL SHEDAGLYTC QVGSKETQSK VSVHDLHVGI TKRLKTVEVL 3190 3200 3210 3220 3230 3240 EGESCSFECV LSHESPSDPA VWTVGGKTVG GSGHFHAVRQ GRKYTLTVKD AALSDAGEVV 3250 3260 3270 3280 3290 3300 FSVLGLTSKA SLIIRERPVD ITKPLEDQRT TLGEDVMLSC ELSRAGTSVR WLKDGKAIRK 3310 3320 3330 3340 3350 3360 SQKYDLLSEG TRAVLVVRKA SLKDSGEYTC ETEASKSTAK LCVEEKANRF TEELADLQVE 3370 3380 3390 3400 3410 3420 EKGRAVFTCK TEHPASVVTW RKGLLELRAS GKHVPSQEGL TLKLTINALE RTDSDTYTCD 3430 3440 3450 3460 3470 3480 IGQARTQARL LVHGQKVRVI EDLEDTAVQE GSSAKFCCRI APADYGPVHW FLDKTPLHSN 3490 3500 3510 3520 3530 3540 ELNEITVQPG GYHVLTLRQL ALKDSGTVYF EAGDQRTSAA LRVTEKPSIF SRPLTDVTVT 3550 3560 3570 3580 3590 3600 EGEDLTLVCE TTTVDSSVRW TKDGKTLRPS ARCQLSHEGC QAQLLITATT PQDGGRYKCE 3610 3620 3630 3640 3650 3660 IGGASSSSIV RVHALPVRFR ESLKDVEVPE GKAATLRCVL SSVAAPVEWR HGDDVLKSSN 3670 3680 3690 3700 3710 3720 KYSLRQEGAV LELVIRDLQP QDSGQYSCSF GDQTTSATLT VKTSSAQFVG KLRNKEATEG 3730 3740 3750 3760 3770 3780 TTVTLRCELT KEAPVEWKKG TETLRNGDKY SLKQDGAVCE LQICSLLVAD AGEYSCVCGQ 3790 3800 3810 3820 3830 3840 EKTSATLTVK ALLVHFVRRL RSKEATEGDT TTLQCELSKA APVEWRKGTE TLRDGDRYSL 3850 3860 3870 3880 3890 3900 KQDGAVCELQ IRSLTIADAG EYLCTCGQEK TSATLTVRAL PAKFKDSLKN EEATEGTTAT 3910 3920 3930 3940 3950 3960 LSCELSKAAP VTWKKGPKTL QSGDKYVLRQ DGAVCGLQIH GLTMADAGEY SCVCGQEKTS 3970 3980 3990 4000 4010 4020 ATLTVRGLPA KFIEDLRSQE ATEGATAILR CELSKAAPVE WRKGSETLKD GDRYTLRQDG 4030 4040 4050 4060 4070 4080 AVCELQIRGL AVVDTGTYSL PTKFTEGLRN EEATEGTMAT LRCQMSKAAP VEWRKGSETL 4090 4100 4110 4120 4130 4140 RDGDRYSLRQ DGAMCELQIR GLTIEDSGEY TCVCGQEKTS ATLSVKALPS RFIEDLRSQE 4150 4160 4170 4180 4190 4200 ATEGTMATLR CQMSKTAPVE WKKGSETLRD GGRYSLRQDG PVCELQICDL AVEDAGEYSC 4210 4220 4230 4240 4250 4260 VCGQEKTSAT LSIKALPPRF IEDLRSQEAT EGTMATLRCQ MSKAAPVEWR KGSETLGDGG 4270 4280 4290 4300 4310 4320 RYSLRQNGAV CELQIHDLAV EDTGEYSCVC GQEKTSATLN VKALPPRFIE DLRSQEATEG 4330 4340 4350 4360 4370 4380 TMATLRCQMS KAAPVEWRKG SETLRDGGRY SLRQDGAVCE LQIHDLDVED AGQYSCVCGQ 4390 4400 4410 4420 4430 4440 EKTSAVLTVD ALPPKFTEGL KKEEATEGTM VTLRCQMSKE ATVEWRKGAK TLSDGGRYSL 4450 4460 4470 4480 4490 4500 RQDGAMCELQ ICGLAVEDAG EYSCVCGQEK TSATLSVKAL PPRFIEDLRS QEATEGTMAT 4510 4520 4530 4540 4550 4560 LRCQMSKAAP VEWRKGSETL RDGDRYSLRQ DGAVCELQIR DLAVEDAGEY LCVCGQEKTS 4570 4580 4590 4600 4610 4620 ATLSVKALPP RFIEDLRSQE ATEGTMATLR CQMSKAAPVE WRKGSKTLRD GDRYSLRQDG 4630 4640 4650 4660 4670 4680 AMCELQICDL AVEDTGDYSC VCGQEKTSAT LSVKALPPRF IEDLRSQEAR EGTVATLRCR 4690 4700 4710 4720 4730 4740 MSKAAPVEWR KGSETLKDGD RYSLRQEGNL CELQIRDLAV EDTEEYSCVC GQEKTSATLS 4750 4760 4770 4780 4790 4800 VKALPAKFIE DLRSQEAPES STVTLRCKLS KKASVVWKKG SETLRNGARY SLRQDGAVCE 4810 4820 4830 4840 4850 4860 LEIRDLTVED TGEYSCTCGQ ERTSATLSIM APQVVFQQPL QNLQAEEGSM ASLRCELSVP 4870 4880 4890 4900 4910 4920 NAAMVWSKGG LELQGDTRRE ARQQGCVAEL LLRDLRREDA GEYSCTCGSQ TTSATLMVTA 4930 4940 4950 4960 4970 4980 APVRFLRELQ AQDVDEGATA RLRCELSREA VSVEWRKGSL QLFPCAKYQM VQEGTTAELL 4990 5000 5010 5020 5030 5040 VHGVEQEDAG EYTCDAGHTQ SIARLSVRAP KPKFKTDLQS TEQEAGGTAR LCCQLSEAEP 5050 5060 5070 5080 5090 5100 GTPVQWLKEG VELHVGSKYE MRRQGAVCEL LIHGLEAKDT GEYACLVGGQ KTLASLRVKE 5110 5120 5130 5140 5150 5160 PEVTIVRGLV DMEVQADEDV EFTCKVSQAG ATDVQWHLQG LPLQSNEVTE VAVLADGCTH 5170 5180 5190 5200 5210 5220 VLQLKGVTLE DAGTVSFHVG GLSSSAQLTV RGDRSGAPEG CAAQRGPGCP LPVPTVQGLG 5230 5240 5250 5260 5270 5280 PGGSLGFGRG SLAVQRDERH HCGAGHTLPA HSAQGDPGGC WDHHSPSGLM LLRGPAEGHS 5290 5300 5310 5320 5330 5340 KNTVLRGLEN VDALEGGEAL FECQLSQPEV AAHTWLLDDE PVHTSEKVEV VYFENGLRHL 5350 5360 5370 5380 5390 5400 LLLKNLKPQD SCRVTFLAGD VVTSAFLTVR GWRLEVLEPP HDASVKAGMQ VRFTCILSEA 5410 5420 5430 5440 5450 5460 VPVGEATWYI NGAAIQPDDT DWTVTTDGSH HALTLSNAQP QHAGEVTFAA RDAVASARLS 5470 5480 5490 5500 5510 5520 VLALPDPPED AEVVGRSDHS VTLSWVAPMS DGGGGLCGYR VEMKEASTGQ WQLCHDLVPG 5530 5540 5550 5560 5570 5580 PECVVDDLVP GKTYRFRVAA VGPAGAGEPV HLPQMAPAPA PAPAPAPAPE TRQAVVGEDI 5590 5600 5610 5620 5630 5640 CLELEVAADG GEVVWHKGTE RIQPGGHFEV LSRGQRQMLV IKGFRTEDQG EYRCGPIQGL 5650 5660 5670 5680 5690 5700 PSSGAATFNV VMTSGSGDEV PAQPSLPPEA AQEGDLHLLW EALARKRRMS REPTLDSISE 5710 5720 5730 5740 5750 5760 LPEEDSRVQH LRQEAEETAP DLSEGYSTAD ELARTGEADL SHTSSDDESR AGTPSLVTYL 5770 5780 5790 5800 5810 5820 KKAGGPGISP LASKHEAQVT TSVKPQKQQE PVVPTCPPPG DLSAADLMDP SLDKAAVKIQ 5830 5840 5850 5860 5870 5880 AAFKGYKVRK EMKQQEGPVF SRTFGDTEAQ VGDVLRLECV LATKTDMRAC WLKDGIELTD 5890 5900 5910 5920 5930 5940 GRHYHIDQLK DGTCSLLVTG LAPTDSGRYT CQVSTKSGRV SHSACVVVSG TESEAESSSG 5950 5960 5970 5980 5990 6000 GELDDAFRRA ARRLHRLFRT KSPAELSEEE LFLSADEGPG EPEEPADWQT YREDENFVCI 6010 6020 6030 6040 6050 6060 RFESLAEARQ AVTCFRNMFA TMGIGVEISL GEQGPRGVEM RIGKVAPTVT PAVPLAKTPG 6070 6080 6090 6100 6110 6120 LQTSDAAPVF LTELQNQDVQ DGYPMSFDCV VTGQPVPSVR WFKDGKLLEE DDHYMINEDQ 6130 6140 6150 6160 6170 6180 QGGHQLIITA VVPADMGVYR CLAENSMGVS STKAELRVEL TSTDYDTAAD ATETSSYFSA 6190 6200 6210 6220 6230 6240 QGYLSSREQE GTESDEGQLP QVLEELKDLQ VAPGTRLAKF QLKVKGYPAP KLYWFKDGQP 6250 6260 6270 6280 6290 6300 LTTSDHIRMT DKKTLHTLEI VSVTREDSGQ YAAYISNAVG AAYSSARLLV RGPSEPEEKP 6310 6320 6330 6340 6350 6360 ASDVHERLVP PRILEKFTPK KVKRGSSITF SVKVEGHPAP SVHWLKEEAE KGVLWIGPDT 6370 6380 6390 6400 6410 6420 PGYTMASSSK QHSLVLLDVG RQHQGTYTCI ATNPAGQALC SASLHISGLA KEEEQERVKE 6430 6440 6450 6460 6470 6480 ALISSFLQGT SQAVSAQMSE SAGFADLVGQ SKGESLVAEE AHSHLSLAEV GTEEFLQKLT 6490 6500 6510 6520 6530 6540 SQITEMVSAK ISQAKLQVPG GDSDEETKTP SASPRHGRSR PSSSVQESSS ESEDGDSRGE 6550 6560 6570 6580 6590 6600 IFDIYVVTAD YLPLGAEQDA IILREGQYVE VLDSAHPLRW LVRTKPTKSS PSRQGWVSPA 6610 6620 6630 6640 6650 6660 YLDKRLKLSP EWGPTEAPEF PGEAVSEDEY RTRLSSVIQE LLSSEQAFVG ELQFLESHHM 6670 6680 6690 6700 6710 6720 KHLERSPRVP AAVASQKTVI FRNVQDISHF HSSFLKELQG CGTDDDVAMC FIKNQEAFEK 6730 6740 6750 6760 6770 6780 YLEFLVGRVQ AESVVVSTPV QEFYKKYAEE TLSAKDPTQP PPPPLQHYLE QPVERVQKYQ 6790 6800 6810 6820 6830 6840 ALLKELIRNK ARNRQNCALL EQAYAVVSAL PQRAENKLHV SLMENYPGTL EALGEPIRQG 6850 6860 6870 6880 6890 6900 HFIVWEGAPG ARMPWKGHNR HVFLFRNYLV ICKPRRDSRT DTFSYVFRNM MKLSSIDLND 6910 6920 6930 6940 6950 6960 QVEGDDRAFE VWHEREDSVR KYLLQARTVI IKNSWVKEIC GIQQRLAQPV WRPPEFEEEL 6970 6980 6990 7000 7010 7020 ADCTAELGET VKLACRVTGT PKPIVSWYKD GKPVEVDPHH ILIEDPDGSC TLILDNLTGI 7030 7040 7050 7060 7070 7080 DSGQYMCFAA SAAGNASTLG KILVQVPPRF VNKVRATPFV EGEDAQITCT VEGAPYPQIR 7090 7100 7110 7120 7130 7140 WYKDGTLLAP GNRYRMLNEP RSGVLVLVIQ AASKEDLGHY ECELVNRLGS TRGGGELYMQ 7150 7160 7170 7180 7190 7200 SPALRARDQH HREQIVAAVE VCSHDTSVEG SAHSAQDGAD QQAASVLWRL LGSEALGPSP 7210 7220 7230 7240 7250 7260 GDLPNTRQSE PPAFEEAASQ IPGAASGTPG ELPEVSQPGT HKGLEQETTS SGSQGWTVPI 7270 7280 7290 7300 7310 7320 RVEGTAWPGA GTGQLLLDVH SQVIMETTQR TYVCQAPDTG VTRAPSMQVT IEDVQVQVGD 7330 7340 7350 7360 7370 7380 MAQFDAVIEG HPPPIVTWYK GSTQLTSSAR LSQRQDGTTY SLVLTDVAPH DAGVYTCVAN 7390 7400 7410 7420 7430 7440 NAGGQVLCKA ELLVHGGDKL DAENQVYRRK LHSFYDVQEE IGRGVFGFVK RVQHKGNKMF 7450 7460 7470 7480 7490 7500 CAAKFIPLRS KTRAQAYQER DILATLGHPL VTGLLDQFET RKTLILILEL CSSEELLDRL 7510 7520 7530 7540 7550 7560 FKKGVVTEAE VKVYIQQLVE GLHYLHSHGI LHLDIKPPNI LMVHPAREDI KICDFGFAQK 7570 7580 7590 7600 7610 7620 ITPSEPQYSK YGSPEFVSPE IIEQNPVSEG SDIWAMGVIS YLSLTCSSPF AGESDRATLL 7630 7640 7650 7660 7670 7680 NVLEGRVSWS SPTAAHLSED AKDFIKATLQ RTPRARPSTS QCLAHPWFLK SMPAEEAHFI 7690 7700 7710 7720 7730 7740 NTKQLKFLLA RSRWQRSLMS YKSILVMRSI PELLQGPPDS PSLGVARHLR GEASGASSSS 7750 7760 7770 7780 7790 7800 SSSDNELAPF ARAKSLPPSP VTHSPLLHPR GFLRPSASLP EETEASMPTA DAAVPASPQS 7810 7820 7830 7840 7850 7860 AGPPASPGCV PRHSVISSLF YQQAGEGAER GNKTSGAKRH PARRRHLLKG GYIARALPGL 7870 7880 7890 7900 7910 7920 REPLMEYSLL EEEAAREEQA SLMTKTPSFE TALRLPSSSV REVPGRSHSL DNPPVTTGPS 7930 7940 7950 7960 7970 7980 PEACKEQLLF PPSTGLTHET TAKDRGHKEG FLQESVPFPP MSGDSRPGKQ EGSSQDSCRG 7990 8000 8010 8020 8030 8040 KPASSCHSEL GSGSQEGCGP PSSQSLGSLP PQSLKKELST SCGPLFSEQP QAAPFPTQVS 8050 8060 8070 8080 8090 8100 PLLGSEKEPQ DGSLSEGPVP VPSSSPGSAS QVDASLDTEG LSEAGDTCDF TPPPQRPQEQ 8110 8120 8130 8140 8150 8160 ATTRKFSLES RGGYAGVAGY GTFAFGGDAG GMLGQGPLWA RMAWAVSQSS EEQDEAATES 8170 8180 8190 8200 8210 8220 PQPLESLGPI AEASGVPLRT SPSLTPWEEV EQVSLVQIRD LSGDAEAADT ISLDISEVDP 8230 8240 8250 8260 8270 8280 AYLNLSDLYD IKYLPFEFMI FRRVPKPIEQ PESPGSETEA GQGLADFLEE AAWPWPGELG 8290 8300 8310 8320 8330 8340 LRAGLEITEE PEEPGDLEAL LGEAAVGRKR KWSPSRGLFQ FPGRCLSGEE PVELGLRQRV 8350 8360 8370 8380 8390 8400 KASMAHISRI LKGRPEGPER EGPPRKKAGL ASFRLSGLKG RDQAPSFLRE LSDEAVVLGQ 8410 8420 8430 8440 8450 8460 SVTLACQVLA QPTAQATWSK DGVLLESSGH LLISSTLKNF QLLTILVVKE EDLGTYTCCV 8470 8480 8490 8500 8510 8520 SNPLGTAVTT GVLRKAERPS SSPRPEVGEL YKDAVLLVWK PVESCGPVTY IVQCCIEGGS 8530 8540 8550 8560 8570 8580 WTTLASDISD CCYLTGKLSR GGMYIFRTAC VSKAGMGPYS SPSEQVLLGG PNHLASEEES 8590 8600 8610 8620 8630 8640 SRGRPAQLLP STKTFAFQMQ IRRGRFSVVR QCREKASGRA LAAKIVPYQP EDKTAVLREY 8650 8660 8670 8680 8690 8700 EALKRLHHPH LAQLHAAYLS PRHLVLILEL CSGPELLPSL AERESYSESD VKDYLWQMLS 8710 8720 8730 8740 8750 8760 ATQYLHAQHI LHLDLRSENM MVTEYNLLKV IDLGNAQSLD QEKVPAPENF KDYLETMAPE 8770 8780 8790 8800 8810 8820 LLEGQGAVPQ TDIWAIGVTA FIMLSGEYPE SSEGTRDLQK GLRKGLIRLS RCYAGLSGGA 8830 8840 8850 8860 8870 8880 VAFLQSSLCA QPWGRPCAST CLQCGWLTEE GPTGSRPTPV TFPTVRLRAF VREREKRRAL 8890 LYKKHNLAQV R
	Isoform 2 [UniParc]. Checksum: B61FCAB243F9EA4F	FASTA	7,167	779,862
	10 20 30 40 50 60 MDHSFSGAPR FLTRPKAFVV SVGKDATLSC QIVGNPTPHV SWEKDRQPVE AGARFRLAQD 70 80 90 100 110 120 GDVYRLTILD LALGDSGQYV CRARNAIGEA FAAVGLRVDS EGTCAEQAPH FLLRPTSIRV 130 140 150 160 170 180 REGADATFRC RVGGSPQPAV SWSKDGRRLG PPDAPHVRVE EHGESSALRI RSARPRDGGT 190 200 210 220 230 240 YEVRAENPLG SASAAAALVV DSDAEVAGPP GTSTATLLAH LQQRREAMRA EGIPPSPPGA 250 260 270 280 290 300 GTRTCTVTEG KHARLSCFVT GEPKPETVWK KDGQLVTEGR RHVVYEDEQE NFVLKILFCK 310 320 330 340 350 360 QSDRGLYTCT ASNLVGQTYS SVLVVVREPT VPFKKRLQDL EVREKESATF QCEVAQPATE 370 380 390 400 410 420 AAWFKEETRL WASAKYDIEE EGTERRLTVR NVSADDDAVY ICETTEGSRT VAELSVQGNL 430 440 450 460 470 480 TRKLPRKTAV RTGDTAIFWV ELAVPEGPVR WLRNQEEMVA GGRVAITAEG TCHTLTIFQC 490 500 510 520 530 540 TLEDMGEVAF VSGGCRTTTQ FCVSAPRRPP LYPPADPVVK AKTESSVTLS WSAPPHGDRP 550 560 570 580 590 600 VTIDGYVLEK RKLGAYAWSR CHEAGWLATT EFTITGVAEE GDFQFRVSAI NHFGQGPYLE 610 620 630 640 650 660 FPGTMHLVPM LAVKTPLKAV EAVEGGEVTF SVDLTVASSG EWFLDGEALK ASSIYVIRCD 670 680 690 700 710 720 RTRHMLTIRE VPARLHGAQL KFVANGIETS IQMVVRAALG LPSSKLPAAA AREVLAQLHE 730 740 750 760 770 780 EAQLLAELSD QAAAVTWLKD GRELSLGPKY EMQVSAGRRA LLVRDVAQDD AGLYECVSRG 790 800 810 820 830 840 SRTAYQLLVQ DITDGYRDWG PAGPQKHMCK CAGAKIARYL GSSCYRFLQY DKGVWHWLEA 850 860 870 880 890 900 ALDTRQGKGT SSCSLHEKPK LVFAKGQQAH SEVKAEAGNS ATLSCEVTQA QTEVTWFKDG 910 920 930 940 950 960 KKLSSSSKVR MEASGCSRRL VVQQAGKADA GEYSCEAGGQ KLSFRLDVAE PKLVFAKGQQ 970 980 990 1000 1010 1020 AHSEVKAEAG ASATLSCEVA QAQTEVTWFK DGKKLSSSSK VRMEASGCSR RLVVQQAGKA 1030 1040 1050 1060 1070 1080 DAGEYSCEAG GQKLSFRLDV AEPKMVFAKE QQARSEVKAE AGASATLSCE VAQAQTEVTW 1090 1100 1110 1120 1130 1140 FKDGKKLSSS SKVRMEASGC SRRLVVQQAG KADAGEYSCE AGGQKLSFRL DVTEPKLVFA 1150 1160 1170 1180 1190 1200 KEQQARSEVK AEVGNSATLS CEVAQAQTEV TWFKDGKKLS SSSKVRMEAS GCSRRLVVQQ 1210 1220 1230 1240 1250 1260 AGKADAGEYS CEAGGQKLSF RLDVAEPKLV FAKEQQARSE VKAEAGNSAT LSCEVAQAQT 1270 1280 1290 1300 1310 1320 EVTWFKDGKK LSSSSKVRME ASGCSRRLVV QQAGKADAGE YSCEAGGQKL SFHLDVTEPK 1330 1340 1350 1360 1370 1380 LVFAKEQQAH SEVKAEAGAS ATLSCEVAQA QTEVTWFKDG KKLSSSSKVR MEASGCSRRL 1390 1400 1410 1420 1430 1440 VVQQAGKADA GEYSCEAEGQ KLSFRLDVAE PKLVFAKEQQ ARSEVKAEAG ASATLSCEVA 1450 1460 1470 1480 1490 1500 QAQTEVTWFK DGKKLSSSSK VRVEASGCSR RLVVQQAGKA DAGEYSCEAG GQKLSFRLDV 1510 1520 1530 1540 1550 1560 AEPKLVFAKE QQANSEVKAE AGASATLSCE VAQAQTEVTW FKDGKKLSSS SKVRVEASGC 1570 1580 1590 1600 1610 1620 SRRLVVQQAG KADAGEYSCE AGGQKLSFRL DVAEPKLAFA KEQQAHSEVK AEAGASATLS 1630 1640 1650 1660 1670 1680 CEVAQAQTEV TWFKDGKKLS SSSKVRVEAS GCSRRLVVQQ AGKADAGEYS CEAGGQKLSF 1690 1700 1710 1720 1730 1740 RLDVAEPKLA FAKEQQAHSE VKAEAGASAT LSCEVAQAQT EVTWFKDGKK LSSSSKVRVE 1750 1760 1770 1780 1790 1800 ASGCSRRLVV QQAGKADAGE YSCEAGGQKL SFRLDVAEPK LAFAKEQQAH SEVKAEAGAS 1810 1820 1830 1840 1850 1860 ATLSCEVAQA QTEVTWFKDG KKLSSSSKVR VEASGCSRRL VVQQAGKADA GEYSCEAGGQ 1870 1880 1890 1900 1910 1920 KLFFRLDVAE PKLMFAKEQQ AHSEVKAEAG ASATLSCEVA QAQTEVTWFK DGKKLSSSSK 1930 1940 1950 1960 1970 1980 VRVEASGCSR RLVVQQAGKA DAGEYSCEAG GQKLSFRLDV AEPKLVFAKE QQAHSEVKAE 1990 2000 2010 2020 2030 2040 AGASATLSCE VAQAQTEVTW FKDGKKLSSS SKVRVEASGC SRRLVVQQVG KADAGEYSCE 2050 2060 2070 2080 2090 2100 ARGQKLSFRL DVADTRLMFA KEQQARTEVK AEAGNSATLS CEVAQAQTEV TWFKDGKKLS 2110 2120 2130 2140 2150 2160 SSSKVRVEAS GCSRRLVVQQ AGKADAGEYS CEAGGQKLSF RLDVAEAESQ IPERPSRREP 2170 2180 2190 2200 2210 2220 LVVKEHETII LTATIAAPSV AAVTWLKDGV EIRRSKRHEA TSLGDTHTLT VRGAQVLDSA 2230 2240 2250 2260 2270 2280 IYSCRVGKEG QDFPVQVEEV AAKFSKPLEP VEGELGGTVM LVCELSPEQA EVVWRCGNTQ 2290 2300 2310 2320 2330 2340 LRPGKRFQMT SEGPRRTLTV SGLREDDAEE YVCESRDDRT SARLTVKVPR VVKFTSGLSA 2350 2360 2370 2380 2390 2400 MVAEEGQEAT FQCVVSPSDA GVTWYKDGMQ LQPSEKFVMV ESGASRSLTI LGLTLEDAGQ 2410 2420 2430 2440 2450 2460 VTVEAEGASS SAALRVREAP VLFKKKLEPQ TVEERTSVTL EVELTRPWPE VKWTRNAAVL 2470 2480 2490 2500 2510 2520 TPSENVEIRA EGARHCLVLR SVGFADRGFF GCETPDDKTQ AKLNVEMRQV RLVRGLQEVE 2530 2540 2550 2560 2570 2580 AKEQGTASMD VELSHAEVEG SWTRDGLRLQ PGPKCHLAVQ GPVHILTLSA LQPQDSGLVA 2590 2600 2610 2620 2630 2640 FRAEGVHTSA RLIVTELPVS FTRVLQDVVA TQKEKVTLEC ELSRPVDVRW LKDGVELRAG 2650 2660 2670 2680 2690 2700 KAIGIVAQGT CRSLVIYRCE TGDQGVYVCD ALDAQTSASL RVQGRTYTLI FRRVLAEDAG 2710 2720 2730 2740 2750 2760 EVKFVAENAE SRAHLRVKEL PVTLLRPLRD KIAMEKHRGV LECQVSRASA QVRWFKGGVE 2770 2780 2790 2800 2810 2820 LQSGPKYEVV SDGLYRKLVI NDVQPEDEDT YTCDAGNVKT SAQFFVEEQS ITIVRGLKDM 2830 2840 2850 2860 2870 2880 TVMEPAPAWF ECETSIPSVR PPKWLLGKTV LQAGGNVGLE QDGTVHRLTL HKTCSTMTGP 2890 2900 2910 2920 2930 2940 VHFTIGKSRS SAQLVVSDIP VVLTRPLEPK AGRELQSVVL SCDFRPAPKA VQWYKDDTPL 2950 2960 2970 2980 2990 3000 SPSEKFKMAL EGQMAELRIL RLTPADAGVY RCQAGSAQSS AEVTVEAREV TVIQPLQDAE 3010 3020 3030 3040 3050 3060 AMEEGRVCFS CELSHKDEDI EWSLNGTPLY NDSFHEISHE GCLHTLVLKS VRQADTGTVC 3070 3080 3090 3100 3110 3120 ATSPKVSVSA RLVVKGKPVV FLKALDDVSA EERGTLTLQC EVSDPEARVV WRKDGVELGP 3130 3140 3150 3160 3170 3180 SDKYDFLHKA GARGLTVHDL SHEDAGLYTC QVGSKETQSK VSVHDLHVGI TKRLKTVEVL 3190 3200 3210 3220 3230 3240 EGESCSFECV LSHESPSDPA VWTVGGKTVG GSGHFHAVRQ GRKYTLTVKD AALSDAGEVV 3250 3260 3270 3280 3290 3300 FSVLGLTSKA SLIIRERPVD ITKPLEDQRT TLGEDVMLSC ELSRAGTSVR WLKDGKAIRK 3310 3320 3330 3340 3350 3360 SQKYDLLSEG TRAVLVVRKA SLKDSGEYTC ETEASKSTAK LCVEEKANRF TEELADLQVE 3370 3380 3390 3400 3410 3420 EKGRAVFTCK TEHPASVVTW RKGLLELRAS GKHVPSQEGL TLKLTINALE RTDSDTYTCD 3430 3440 3450 3460 3470 3480 IGQARTQARL LVHGQKVRVI EDLEDTAVQE GSSAKFCCRI APADYGPVHW FLDKTPLHSN 3490 3500 3510 3520 3530 3540 ELNEITVQPG GYHVLTLRQL ALKDSGTVYF EAGDQRTSAA LRVTEKPSIF SRPLTDVTVT 3550 3560 3570 3580 3590 3600 EGEDLTLVCE TTTVDSSVRW TKDGKTLRPS ARCQLSHEGC QAQLLITATT PQDGGRYKCE 3610 3620 3630 3640 3650 3660 IGGASSSSIV RVHALPVRFR ESLKDVEVPE GKAATLRCVL SSVAAPVEWR HGDDVLKSSN 3670 3680 3690 3700 3710 3720 KYSLRQEGAV LELVIRDLQP QDSGQYSCSF GDQTTSATLT VKTSSAQFVG KLRNKEATEG 3730 3740 3750 3760 3770 3780 TTVTLRCELT KEAPVEWKKG TETLRNGDKY SLKQDGAVCE LQICSLLVAD AGEYSCVCGQ 3790 3800 3810 3820 3830 3840 EKTSATLTVK ALLVHFVRRL RSKEATEGDT TTLQCELSKA APVEWRKGTE TLRDGDRYSL 3850 3860 3870 3880 3890 3900 KQDGAVCELQ IRSLTIADAG EYLCTCGQEK TSATLTVRAL PAKFKDSLKN EEATEGTTAT 3910 3920 3930 3940 3950 3960 LSCELSKAAP VTWKKGPKTL QSGDKYVLRQ DGAVCGLQIH GLTMADAGEY SCVCGQEKTS 3970 3980 3990 4000 4010 4020 ATLTVRGLPA KFIEDLRSQE ATEGATAILR CELSKAAPVE WRKGSETLKD GDRYTLRQDG 4030 4040 4050 4060 4070 4080 AVCELQIRGL AVVDTGTYSL PTKFTEGLRN EEATEGTMAT LRCQMSKAAP VEWRKGSETL 4090 4100 4110 4120 4130 4140 RDGDRYSLRQ DGAMCELQIR GLTIEDSGEY TCVCGQEKTS ATLSVKALPS RFIEDLRSQE 4150 4160 4170 4180 4190 4200 ATEGTMATLR CQMSKTAPVE WKKGSETLRD GGRYSLRQDG PVCELQICDL AVEDAGEYSC 4210 4220 4230 4240 4250 4260 VCGQEKTSAT LSIKALPPRF IEDLRSQEAT EGTMATLRCQ MSKAAPVEWR KGSETLGDGG 4270 4280 4290 4300 4310 4320 RYSLRQNGAV CELQIHDLAV EDTGEYSCVC GQEKTSATLN VKALPPRFIE DLRSQEATEG 4330 4340 4350 4360 4370 4380 TMATLRCQMS KAAPVEWRKG SETLRDGGRY SLRQDGAVCE LQIHDLDVED AGQYSCVCGQ 4390 4400 4410 4420 4430 4440 EKTSAVLTVD ALPPKFTEGL KKEEATEGTM VTLRCQMSKE ATVEWRKGAK TLSDGGRYSL 4450 4460 4470 4480 4490 4500 RQDGAMCELQ ICGLAVEDAG EYSCVCGQEK TSATLSVKAL PPRFIEDLRS QEATEGTMAT 4510 4520 4530 4540 4550 4560 LRCQMSKAAP VEWRKGSETL RDGDRYSLRQ DGAVCELQIR DLAVEDAGEY LCVCGQEKTS 4570 4580 4590 4600 4610 4620 ATLSVKALPP RFIEDLRSQE ATEGTMATLR CQMSKAAPVE WRKGSKTLRD GDRYSLRQDG 4630 4640 4650 4660 4670 4680 AMCELQICDL AVEDTGDYSC VCGQEKTSAT LSVKALPPRF IEDLRSQEAR EGTVATLRCR 4690 4700 4710 4720 4730 4740 MSKAAPVEWR KGSETLKDGD RYSLRQEGNL CELQIRDLAV EDTEEYSCVC GQEKTSATLS 4750 4760 4770 4780 4790 4800 VKALPAKFIE DLRSQEAPES STVTLRCKLS KKASVVWKKG SETLRNGARY SLRQDGAVCE 4810 4820 4830 4840 4850 4860 LEIRDLTVED TGEYSCTCGQ ERTSATLSIM APQVVFQQPL QNLQAEEGSM ASLRCELSVP 4870 4880 4890 4900 4910 4920 NAAMVWSKGG LELQGDTRRE ARQQGCVAEL LLRDLRREDA GEYSCTCGSQ TTSATLMVTA 4930 4940 4950 4960 4970 4980 APVRFLRELQ AQDVDEGATA RLRCELSREA VSVEWRKGSL QLFPCAKYQM VQEGTTAELL 4990 5000 5010 5020 5030 5040 VHGVEQEDAG EYTCDAGHTQ SIARLSVRAP KPKFKTDLQS TEQEAGGTAR LCCQLSEAEP 5050 5060 5070 5080 5090 5100 GTPVQWLKEG VELHVGSKYE MRRQGAVCEL LIHGLEAKDT GEYACLVGGQ KTLASLRVKE 5110 5120 5130 5140 5150 5160 PEVTIVRGLV DMEVQADEDV EFTCKVSQAG ATDVQWHLQG LPLQSNEVTE VAVLADGCTH 5170 5180 5190 5200 5210 5220 VLQLKGVTLE DAGTVSFHVG GLSSSAQLTV RGDRSGAPEG CAAQRGPGCP LPVPTVQGLG 5230 5240 5250 5260 5270 5280 PGGSLGFGRG SLAVQRDERH HCGAGHTLPA HSAQGDPGGC WDHHSPSGLM LLRGPAEGHS 5290 5300 5310 5320 5330 5340 KNTVLRGLEN VDALEGGEAL FECQLSQPEV AAHTWLLDDE PVHTSEKVEV VYFENGLRHL 5350 5360 5370 5380 5390 5400 LLLKNLKPQD SCRVTFLAGD VVTSAFLTVR GWRLEVLEPP HDASVKAGMQ VRFTCILSEA 5410 5420 5430 5440 5450 5460 VPVGEATWYI NGAAIQPDDT DWTVTTDGSH HALTLSNAQP QHAGEVTFAA RDAVASARLS 5470 5480 5490 5500 5510 5520 VLALPDPPED AEVVGRSDHS VTLSWVAPMS DGGGGLCGYR VEMKEASTGQ WQLCHDLVPG 5530 5540 5550 5560 5570 5580 PECVVDDLVP GKTYRFRVAA VGPAGAGEPV HLPQMAPAPA PAPAPAPAPE TRQAVVGEDI 5590 5600 5610 5620 5630 5640 CLELEVAADG GEVVWHKGTE RIQPGGHFEV LSRGQRQMLV IKGFRTEDQG EYRCGPIQGL 5650 5660 5670 5680 5690 5700 PSSGAATFNV VMTSGSGDEV PAQPSLPPEA AQEGDLHLLW EALARKRRMS REPTLDSISE 5710 5720 5730 5740 5750 5760 LPEEDSRVQH LRQEAEETAP DLSEGYSTAD ELARTGEADL SHTSSDDESR AGTPSLVTYL 5770 5780 5790 5800 5810 5820 KKAGGPGISP LASKHEAQVT TSVKPQKQQE PVVPTCPPPG DLSAADLMDP SLDKAAVKIQ 5830 5840 5850 5860 5870 5880 AAFKGYKVRK EMKQQEGPVF SRTFGDTEAQ VGDVLRLECV LATKTDMRAC WLKDGIELTD 5890 5900 5910 5920 5930 5940 GRHYHIDQLK DGTCSLLVTG LAPTDSGRYT CQVSTKSGRV SHSACVVVSG TESEAESSSG 5950 5960 5970 5980 5990 6000 GELDDAFRRA ARRLHRLFRT KSPAELSEEE LFLSADEGPG EPEEPADWQT YREDENFVCI 6010 6020 6030 6040 6050 6060 RFESLAEARQ AVTCFRNMFA TMGIGVEISL GEQGPRGVEM RIGKVAPTVT PAVPLAKTPG 6070 6080 6090 6100 6110 6120 LQTSDAAPVF LTELQNQDVQ DGYPMSFDCV VTGQPVPSVR WFKDGKLLEE DDHYMINEDQ 6130 6140 6150 6160 6170 6180 QGGHQLIITA VVPADMGVYR CLAENSMGVS STKAELRVEL TSTDYDTAAD ATETSSYFSA 6190 6200 6210 6220 6230 6240 QGYLSSREQE GTESDEGQLP QVLEELKDLQ VAPGTRLAKF QLKVKGYPAP KLYWFKDGQP 6250 6260 6270 6280 6290 6300 LTTSDHIRMT DKKTLHTLEI VSVTREDSGQ YAAYISNAVG AAYSSARLLV RGPSEPEEKP 6310 6320 6330 6340 6350 6360 ASDVHERLVP PRILEKFTPK KVKRGSSITF SVKVEGHPAP SVHWLKEEAE KGVLWIGPDT 6370 6380 6390 6400 6410 6420 PGYTMASSSK QHSLVLLDVG RQHQGTYTCI ATNPAGQALC SASLHISGLA KEEEQERVKE 6430 6440 6450 6460 6470 6480 ALISSFLQGT SQAVSAQMSE SAGFADLVGQ SKGESLVAEE AHSHLSLAEV GTEEFLQKLT 6490 6500 6510 6520 6530 6540 SQITEMVSAK ISQAKLQVPG GDSDEETKTP SASPRHGRSR PSSSVQESSS ESEDGDSRGE 6550 6560 6570 6580 6590 6600 IFDIYVVTAD YLPLGAEQDA IILREGQYVE VLDSAHPLRW LVRTKPTKSS PSRQGWVSPA 6610 6620 6630 6640 6650 6660 YLDKRLKLSP EWGPTEAPEF PGEAVSEDEY RTRLSSVIQE LLSSEQAFVG ELQFLESHHM 6670 6680 6690 6700 6710 6720 KHLERSPRVP AAVASQKTVI FRNVQDISHF HSSFLKELQG CGTDDDVAMC FIKNQEAFEK 6730 6740 6750 6760 6770 6780 YLEFLVGRVQ AESVVVSTPV QEFYKKYAEE TLSAKDPTQP PPPPLQHYLE QPVERVQKYQ 6790 6800 6810 6820 6830 6840 ALLKELIRNK ARNRQNCALL EQAYAVVSAL PQRAENKLHV SLMENYPGTL EALGEPIRQG 6850 6860 6870 6880 6890 6900 HFIVWEGAPG ARMPWKGHNR HVFLFRNYLV ICKPRRDSRT DTFSYVFRNM MKLSSIDLND 6910 6920 6930 6940 6950 6960 QVEGDDRAFE VWHEREDSVR KYLLQARTVI IKNSWVKEIC GIQQRLAQPV WRPPEFEEEL 6970 6980 6990 7000 7010 7020 ADCTAELGET VKLACRVTGT PKPIVSWYKD GKPVEVDPHH ILIEDPDGSC TLILDNLTGI 7030 7040 7050 7060 7070 7080 DSGQYMCFAA SAAGNASTLG KILVQVPPRF VNKVRATPFV EGEDAQITCT VEGAPYPQIR 7090 7100 7110 7120 7130 7140 WYKDGTLLAP GNRYRMLNEP RSGVLVLVIQ AASKEDLGHY ECELVNRLGS TRGGGELYMQ 7150 7160 SPALRARDQH HREQIVAAVE ERRPSPP
	Isoform 3 [UniParc]. Checksum: 536554014AD05993	FASTA	1,579	171,680
	10 20 30 40 50 60 MQVTIEDVQV QVGDMAQFDA VIEGHPPPIV TWYKGSTQLT SSARLSQRQD GTTYSLVLTD 70 80 90 100 110 120 VAPHDAGVYT CVANNAGGQV LCKAELLVHG GDKLDAENQV YRRKLHSFYD VQEEIGRGVF 130 140 150 160 170 180 GFVKRVQHKG NKMFCAAKFI PLRSKTRAQA YQERDILATL GHPLVTGLLD QFETRKTLIL 190 200 210 220 230 240 ILELCSSEEL LDRLFKKGVV TEAEVKVYIQ QLVEGLHYLH SHGILHLDIK PPNILMVHPA 250 260 270 280 290 300 REDIKICDFG FAQKITPSEP QYSKYGSPEF VSPEIIEQNP VSEGSDIWAM GVISYLSLTC 310 320 330 340 350 360 SSPFAGESDR ATLLNVLEGR VSWSSPTAAH LSEDAKDFIK ATLQRTPRAR PSTSQCLAHP 370 380 390 400 410 420 WFLKSMPAEE AHFINTKQLK FLLARSRWQR SLMSYKSILV MRSIPELLQG PPDSPSLGVA 430 440 450 460 470 480 RHLRGEASGA SSSSSSSDNE LAPFARAKSL PPSPVTHSPL LHPRGFLRPS ASLPEETEAS 490 500 510 520 530 540 MPTADAAVPA SPQSAGPPAS PGCVPRHSVI SSLFYQQAGE GAERGNKTSG AKRHPARRRH 550 560 570 580 590 600 LLKGGYIARA LPGLREPLME YSLLEEEAAR EEQASLMTKT PSFETALRLP SSSVREVPGR 610 620 630 640 650 660 SHSLDNPPVT TGPSPEACKE QLLFPPSTGL THETTAKDRG HKEGFLQESV PFPPMSGDSR 670 680 690 700 710 720 PGKQEGSSQD SCRGKPASSC HSELGSGSQE GCGPPSSQSL GSLPPQSLKK ELSTSCGPLF 730 740 750 760 770 780 SEQPQAAPFP TQVSPLLGSE KEPQDGSLSE GPVPVPSSSP GSASQVDASL DTEGLSEAGD 790 800 810 820 830 840 TCDFTPPPQR PQEQATTRKF SLESRGGYAG VAGYGTFAFG GDAGGMLGQG PLWARMAWAV 850 860 870 880 890 900 SQSSEEQDEA ATESPQPLES LGPIAEASGV PLRTSPSLTP WEEVEQVSLV QIRDLSGDAE 910 920 930 940 950 960 AADTISLDIS EVDPAYLNLS DLYDIKYLPF EFMIFRRVPK PIEQPESPGS ETEAGQGLAD 970 980 990 1000 1010 1020 FLEEAAWPWP GELGLRAGLE ITEEPEEPGD LEALLGEAAV GRKRKWSPSR GLFQFPGRCL 1030 1040 1050 1060 1070 1080 SGEEPVELGL RQRVKASMAH ISRILKGRPE GPEREGPPRK KAGLASFRLS GLKGRDQELS 1090 1100 1110 1120 1130 1140 DEAVVLGQSV TLACQVLAQP TAQATWSKDG VLLESSGHLL ISSTLKNFQL LTILVVKEED 1150 1160 1170 1180 1190 1200 LGTYTCCVSN PLGTAVTTGV LRKAERPSSS PRPEVGELYK DAVLLVWKPV ESCGPVTYIV 1210 1220 1230 1240 1250 1260 QCCIEGGSWT TLASDISDCC YLTGKLSRGG MYIFRTACVS KAGMGPYSSP SEQVLLGGPN 1270 1280 1290 1300 1310 1320 HLASEEESSR GRPAQLLPST KTFAFQMQIR RGRFSVVRQC REKASGRALA AKIVPYQPED 1330 1340 1350 1360 1370 1380 KTAVLREYEA LKRLHHPHLA QLHAAYLSPR HLVLILELCS GPELLPSLAE RESYSESDVK 1390 1400 1410 1420 1430 1440 DYLWQMLSAT QYLHAQHILH LDLRSENMMV TEYNLLKVID LGNAQSLDQE KVPAPENFKD 1450 1460 1470 1480 1490 1500 YLETMAPELL EGQGAVPQTD IWAIGVTAFI MLSGEYPESS EGTRDLQKGL RKGLIRLSRC 1510 1520 1530 1540 1550 1560 YAGLSGGAVA FLQSSLCAQP WGRPCASTCL QCGWLTEEGP TGSRPTPVTF PTVRLRAFVR 1570 EREKRRALLY KKHNLAQVR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases." Sutter S.B., Raeker M.O., Borisov A.B., Russell M.W. Dev. Genes Evol. 214:352-359(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6772-8891 (ISOFORM 2). Strain: FVB/N. Tissue: Salivary gland.
[4]	"The mouse kinome: discovery and comparative genomics of all mouse protein kinases." Caenepeel S., Charydczak G., Sudarsanam S., Hunter T., Manning G. Proc. Natl. Acad. Sci. U.S.A. 101:11707-11712(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY603754 mRNA. Translation: AAT80900.1. AL645854, AL662809 Genomic DNA. Translation: CAQ51661.2. Sequence problems. AL662809, AL645854 Genomic DNA. Translation: CAM24490.2. Sequence problems. AL662809, AL645854 Genomic DNA. Translation: CAM24491.3. Sequence problems. BC044882 mRNA. Translation: AAH44882.2.
IPI	IPI00459500. IPI00855152. IPI00915477.
UniGene	Mm.339542.
3D structure databases
ProteinModelPortal	A2AAJ9.
ModBase	Search...
Protein family/group databases
MEROPS	I43.001.
PTM databases
PhosphoSite	A2AAJ9.
Proteomic databases
PaxDb	A2AAJ9.
PRIDE	A2AAJ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000020732; ENSMUSP00000020732; ENSMUSG00000061462.
UCSC	uc007jdb.2. mouse.
Organism-specific databases
MGI	MGI:2681862. Obscn.
Phylogenomic databases
eggNOG	NOG12793.
GeneTree	ENSGT00700000104431.
HOGENOM	HOG000115256.
HOVERGEN	HBG108206.
InParanoid	B2FDE7.
OrthoDB	EOG4NKBW8.
Gene expression databases
ArrayExpress	A2AAJ9.
Bgee	A2AAJ9.
Genevestigator	A2AAJ9.
Family and domain databases
Gene3D	1.20.900.10. 1 hit. 2.30.29.30. 1 hit. 2.60.40.10. 69 hits.
InterPro	IPR000219. DH-domain. IPR003961. Fibronectin_type3. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR000048. IQ_motif_EF-hand-BS. IPR011009. Kinase-like_dom. IPR020675. Myosin_light_ch_kinase-rel. IPR020682. Obscurin-myosin_light-ch_kin. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. IPR001452. SH3_domain. IPR008266. Tyr_kinase_AS. [Graphical view]
PANTHER	PTHR22964. PTHR22964. 1 hit. PTHR22964:SF11. PTHR22964:SF11. 1 hit.
Pfam	PF00041. fn3. 2 hits. PF07679. I-set. 58 hits. PF00612. IQ. 1 hit. PF00069. Pkinase. 2 hits. PF00621. RhoGEF. 1 hit. [Graphical view]
SMART	SM00060. FN3. 3 hits. SM00409. IG. 20 hits. SM00408. IGc2. 42 hits. SM00015. IQ. 1 hit. SM00233. PH. 1 hit. SM00220. S_TKc. 2 hits. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF48065. DH-domain. 1 hit. SSF49265. FN_III-like. 3 hits. SSF56112. Kinase_like. 2 hits. SSF50044. SH3. 1 hit.
PROSITE	PS00741. DH_1. False negative. PS50010. DH_2. 1 hit. PS50853. FN3. 3 hits. PS50835. IG_LIKE. 55 hits. PS50096. IQ. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 2 hits. PS00108. PROTEIN_KINASE_ST. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50002. SH3. False negative. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

OBSCN_MOUSE

Accession

Primary (citable) accession number: A2AAJ9
Secondary accession number(s): A2AB85 , B2FDE7, Q695L2, Q811H7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	April 3, 2013
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program