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A2AAJ9

- OBSCN_MOUSE

UniProt

A2AAJ9 - OBSCN_MOUSE

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Protein

Obscurin

Gene
Obscn, Gm878
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle By similarity.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Magnesium By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7444 – 74441ATP By similarity
Active sitei7534 – 75341Proton acceptor By similarityBy similarity
Binding sitei8624 – 86241ATP By similarity
Active sitei8714 – 87141Proton acceptor By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7421 – 74299ATP By similarityBy similarity
Nucleotide bindingi8601 – 86099ATP By similarityBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
  3. protein tyrosine kinase activity Source: InterPro
  4. Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Muscle protein, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Differentiation

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_204733. G alpha (12/13) signalling events.
REACT_209641. NRAGE signals death through JNK.
REACT_210090. Rho GTPase cycle.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Obscurin (EC:2.7.11.1)
Alternative name(s):
Obscurin-RhoGEF
Obscurin-myosin light chain kinase
Short name:
Obscurin-MLCK
Gene namesi
Name:Obscn
Synonyms:Gm878
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2681862. Obscn.

Subcellular locationi

GO - Cellular componenti

  1. M band Source: BHF-UCL
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 88918891ObscurinPRO_0000296296Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 81 By similarityBy similarity
Disulfide bondi257 ↔ 309 By similarityBy similarity
Disulfide bondi352 ↔ 402 By similarityBy similarity
Disulfide bondi885 ↔ 935 By similarityBy similarity
Disulfide bondi977 ↔ 1027 By similarityBy similarity
Disulfide bondi1069 ↔ 1119 By similarityBy similarity
Disulfide bondi1161 ↔ 1211 By similarityBy similarity
Disulfide bondi1253 ↔ 1303 By similarityBy similarity
Disulfide bondi1345 ↔ 1395 By similarityBy similarity
Disulfide bondi1437 ↔ 1487 By similarityBy similarity
Disulfide bondi1529 ↔ 1579 By similarityBy similarity
Disulfide bondi1621 ↔ 1671 By similarityBy similarity
Disulfide bondi1713 ↔ 1763 By similarityBy similarity
Disulfide bondi1805 ↔ 1855 By similarityBy similarity
Disulfide bondi1897 ↔ 1947 By similarityBy similarity
Disulfide bondi1989 ↔ 2039 By similarityBy similarity
Disulfide bondi2081 ↔ 2131 By similarityBy similarity
Disulfide bondi2263 ↔ 2313 By similarityBy similarity
Disulfide bondi2620 ↔ 2669 By similarityBy similarity
Disulfide bondi2743 ↔ 2793 By similarityBy similarity
Disulfide bondi2922 ↔ 2972 By similarityBy similarity
Disulfide bondi3100 ↔ 3150 By similarityBy similarity
Disulfide bondi3280 ↔ 3330 By similarityBy similarity
Disulfide bondi3369 ↔ 3419 By similarityBy similarity
Disulfide bondi3549 ↔ 3599 By similarityBy similarity
Disulfide bondi3638 ↔ 3688 By similarityBy similarity
Disulfide bondi3815 ↔ 3864 By similarityBy similarity
Disulfide bondi3903 ↔ 3952 By similarityBy similarity
Disulfide bondi4063 ↔ 4112 By similarityBy similarity
Disulfide bondi4151 ↔ 4200 By similarityBy similarity
Disulfide bondi4239 ↔ 4288 By similarityBy similarity
Disulfide bondi4327 ↔ 4376 By similarityBy similarity
Disulfide bondi4415 ↔ 4464 By similarityBy similarity
Disulfide bondi4503 ↔ 4552 By similarityBy similarity
Disulfide bondi4591 ↔ 4640 By similarityBy similarity
Disulfide bondi4679 ↔ 4728 By similarityBy similarity
Disulfide bondi4767 ↔ 4816 By similarityBy similarity
Disulfide bondi4855 ↔ 4905 By similarityBy similarity
Disulfide bondi4944 ↔ 4994 By similarityBy similarity
Disulfide bondi5033 ↔ 5085 By similarityBy similarity
Disulfide bondi5581 ↔ 5634 By similarityBy similarity
Disulfide bondi5859 ↔ 5911 By similarityBy similarity
Disulfide bondi6089 ↔ 6141 By similarityBy similarity
Disulfide bondi6975 ↔ 7027 By similarityBy similarity
Disulfide bondi7069 ↔ 7122 By similarityBy similarity
Disulfide bondi8406 ↔ 8458 By similarityBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiA2AAJ9.
PaxDbiA2AAJ9.
PRIDEiA2AAJ9.

PTM databases

PhosphoSiteiA2AAJ9.

Expressioni

Gene expression databases

ArrayExpressiA2AAJ9.
BgeeiA2AAJ9.
GenevestigatoriA2AAJ9.

Structurei

3D structure databases

ProteinModelPortaliA2AAJ9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 9991Ig-like 1Add
BLAST
Domaini109 – 20193Ig-like 2Add
BLAST
Domaini234 – 32087Ig-like 3Add
BLAST
Domaini329 – 41587Ig-like 4Add
BLAST
Domaini513 – 61098Fibronectin type-III 1Add
BLAST
Domaini702 – 79392Ig-like 5Add
BLAST
Domaini859 – 95193Ig-like 6Add
BLAST
Domaini951 – 104393Ig-like 7Add
BLAST
Domaini1043 – 113593Ig-like 8Add
BLAST
Domaini1135 – 122793Ig-like 9Add
BLAST
Domaini1227 – 131993Ig-like 10Add
BLAST
Domaini1319 – 140789Ig-like 11Add
BLAST
Domaini1411 – 150393Ig-like 12Add
BLAST
Domaini1503 – 159593Ig-like 13Add
BLAST
Domaini1595 – 168793Ig-like 14Add
BLAST
Domaini1687 – 177993Ig-like 15Add
BLAST
Domaini1779 – 187193Ig-like 16Add
BLAST
Domaini1871 – 196393Ig-like 17Add
BLAST
Domaini1963 – 205189Ig-like 18Add
BLAST
Domaini2055 – 214793Ig-like 19Add
BLAST
Domaini2152 – 224190Ig-like 20Add
BLAST
Domaini2242 – 232584Ig-like 21Add
BLAST
Domaini2329 – 241587Ig-like 22Add
BLAST
Domaini2420 – 250485Ig-like 23Add
BLAST
Domaini2598 – 268184Ig-like 24Add
BLAST
Domaini2721 – 281292Ig-like 25Add
BLAST
Domaini2900 – 298485Ig-like 26Add
BLAST
Domaini3078 – 316285Ig-like 27Add
BLAST
Domaini3258 – 334285Ig-like 28Add
BLAST
Domaini3348 – 343184Ig-like 29Add
BLAST
Domaini3527 – 361084Ig-like 30Add
BLAST
Domaini3616 – 370085Ig-like 31Add
BLAST
Domaini3785 – 387692Ig-like 32Add
BLAST
Domaini3881 – 396484Ig-like 33Add
BLAST
Domaini4041 – 412484Ig-like 34Add
BLAST
Domaini4129 – 421284Ig-like 35Add
BLAST
Domaini4218 – 430083Ig-like 36Add
BLAST
Domaini4306 – 438883Ig-like 37Add
BLAST
Domaini4394 – 447683Ig-like 38Add
BLAST
Domaini4482 – 456483Ig-like 39Add
BLAST
Domaini4570 – 465283Ig-like 40Add
BLAST
Domaini4658 – 474083Ig-like 41Add
BLAST
Domaini4745 – 482884Ig-like 42Add
BLAST
Domaini4832 – 491584Ig-like 43Add
BLAST
Domaini4922 – 500685Ig-like 44Add
BLAST
Domaini5012 – 510493Ig-like 45Add
BLAST
Domaini5374 – 546087Ig-like 46Add
BLAST
Domaini5467 – 556094Fibronectin type-III 2Add
BLAST
Domaini5553 – 565098Ig-like 47Add
BLAST
Domaini5812 – 584130IQAdd
BLAST
Domaini5838 – 592184Ig-like 48Add
BLAST
Domaini6068 – 615790Ig-like 49Add
BLAST
Domaini6200 – 628990Ig-like 50Add
BLAST
Domaini6311 – 640797Ig-like 51Add
BLAST
Domaini6540 – 660768SH3Add
BLAST
Domaini6633 – 6817185DHAdd
BLAST
Domaini6835 – 6944110PHAdd
BLAST
Domaini6954 – 703784Ig-like 52Add
BLAST
Domaini7048 – 713891Ig-like 53Add
BLAST
Domaini7305 – 739389Ig-like 54Add
BLAST
Domaini7415 – 7668254Protein kinase 1Add
BLAST
Domaini8385 – 846985Ig-like 55Add
BLAST
Domaini8479 – 857193Fibronectin type-III 3Add
BLAST
Domaini8595 – 8847253Protein kinase 2Add
BLAST

Sequence similaritiesi

Contains 1 IQ domain.
Contains 1 PH domain.
Contains 1 SH3 domain.

Keywords - Domaini

Immunoglobulin domain, Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000115256.
HOVERGENiHBG108206.
InParanoidiB2FDE7.
PhylomeDBiA2AAJ9.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.10. 69 hits.
InterProiIPR000219. DH-domain.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR000048. IQ_motif_EF-hand-BS.
IPR011009. Kinase-like_dom.
IPR020682. Obscurin-myosin_light-ch_kin.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PANTHERiPTHR19897:SF17. PTHR19897:SF17. 1 hit.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 59 hits.
PF00612. IQ. 1 hit.
PF00069. Pkinase. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 20 hits.
SM00408. IGc2. 42 hits.
SM00015. IQ. 1 hit.
SM00233. PH. 1 hit.
SM00220. S_TKc. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF49265. SSF49265. 3 hits.
SSF50044. SSF50044. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50010. DH_2. 1 hit.
PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 54 hits.
PS50096. IQ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: A2AAJ9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MDHSFSGAPR FLTRPKAFVV SVGKDATLSC QIVGNPTPHV SWEKDRQPVE     50
AGARFRLAQD GDVYRLTILD LALGDSGQYV CRARNAIGEA FAAVGLRVDS 100
EGTCAEQAPH FLLRPTSIRV REGADATFRC RVGGSPQPAV SWSKDGRRLG 150
PPDAPHVRVE EHGESSALRI RSARPRDGGT YEVRAENPLG SASAAAALVV 200
DSDAEVAGPP GTSTATLLAH LQQRREAMRA EGIPPSPPGA GTRTCTVTEG 250
KHARLSCFVT GEPKPETVWK KDGQLVTEGR RHVVYEDEQE NFVLKILFCK 300
QSDRGLYTCT ASNLVGQTYS SVLVVVREPT VPFKKRLQDL EVREKESATF 350
QCEVAQPATE AAWFKEETRL WASAKYDIEE EGTERRLTVR NVSADDDAVY 400
ICETTEGSRT VAELSVQGNL TRKLPRKTAV RTGDTAIFWV ELAVPEGPVR 450
WLRNQEEMVA GGRVAITAEG TCHTLTIFQC TLEDMGEVAF VSGGCRTTTQ 500
FCVSAPRRPP LYPPADPVVK AKTESSVTLS WSAPPHGDRP VTIDGYVLEK 550
RKLGAYAWSR CHEAGWLATT EFTITGVAEE GDFQFRVSAI NHFGQGPYLE 600
FPGTMHLVPM LAVKTPLKAV EAVEGGEVTF SVDLTVASSG EWFLDGEALK 650
ASSIYVIRCD RTRHMLTIRE VPARLHGAQL KFVANGIETS IQMVVRAALG 700
LPSSKLPAAA AREVLAQLHE EAQLLAELSD QAAAVTWLKD GRELSLGPKY 750
EMQVSAGRRA LLVRDVAQDD AGLYECVSRG SRTAYQLLVQ DITDGYRDWG 800
PAGPQKHMCK CAGAKIARYL GSSCYRFLQY DKGVWHWLEA ALDTRQGKGT 850
SSCSLHEKPK LVFAKGQQAH SEVKAEAGNS ATLSCEVTQA QTEVTWFKDG 900
KKLSSSSKVR MEASGCSRRL VVQQAGKADA GEYSCEAGGQ KLSFRLDVAE 950
PKLVFAKGQQ AHSEVKAEAG ASATLSCEVA QAQTEVTWFK DGKKLSSSSK 1000
VRMEASGCSR RLVVQQAGKA DAGEYSCEAG GQKLSFRLDV AEPKMVFAKE 1050
QQARSEVKAE AGASATLSCE VAQAQTEVTW FKDGKKLSSS SKVRMEASGC 1100
SRRLVVQQAG KADAGEYSCE AGGQKLSFRL DVTEPKLVFA KEQQARSEVK 1150
AEVGNSATLS CEVAQAQTEV TWFKDGKKLS SSSKVRMEAS GCSRRLVVQQ 1200
AGKADAGEYS CEAGGQKLSF RLDVAEPKLV FAKEQQARSE VKAEAGNSAT 1250
LSCEVAQAQT EVTWFKDGKK LSSSSKVRME ASGCSRRLVV QQAGKADAGE 1300
YSCEAGGQKL SFHLDVTEPK LVFAKEQQAH SEVKAEAGAS ATLSCEVAQA 1350
QTEVTWFKDG KKLSSSSKVR MEASGCSRRL VVQQAGKADA GEYSCEAEGQ 1400
KLSFRLDVAE PKLVFAKEQQ ARSEVKAEAG ASATLSCEVA QAQTEVTWFK 1450
DGKKLSSSSK VRVEASGCSR RLVVQQAGKA DAGEYSCEAG GQKLSFRLDV 1500
AEPKLVFAKE QQANSEVKAE AGASATLSCE VAQAQTEVTW FKDGKKLSSS 1550
SKVRVEASGC SRRLVVQQAG KADAGEYSCE AGGQKLSFRL DVAEPKLAFA 1600
KEQQAHSEVK AEAGASATLS CEVAQAQTEV TWFKDGKKLS SSSKVRVEAS 1650
GCSRRLVVQQ AGKADAGEYS CEAGGQKLSF RLDVAEPKLA FAKEQQAHSE 1700
VKAEAGASAT LSCEVAQAQT EVTWFKDGKK LSSSSKVRVE ASGCSRRLVV 1750
QQAGKADAGE YSCEAGGQKL SFRLDVAEPK LAFAKEQQAH SEVKAEAGAS 1800
ATLSCEVAQA QTEVTWFKDG KKLSSSSKVR VEASGCSRRL VVQQAGKADA 1850
GEYSCEAGGQ KLFFRLDVAE PKLMFAKEQQ AHSEVKAEAG ASATLSCEVA 1900
QAQTEVTWFK DGKKLSSSSK VRVEASGCSR RLVVQQAGKA DAGEYSCEAG 1950
GQKLSFRLDV AEPKLVFAKE QQAHSEVKAE AGASATLSCE VAQAQTEVTW 2000
FKDGKKLSSS SKVRVEASGC SRRLVVQQVG KADAGEYSCE ARGQKLSFRL 2050
DVADTRLMFA KEQQARTEVK AEAGNSATLS CEVAQAQTEV TWFKDGKKLS 2100
SSSKVRVEAS GCSRRLVVQQ AGKADAGEYS CEAGGQKLSF RLDVAEAESQ 2150
IPERPSRREP LVVKEHETII LTATIAAPSV AAVTWLKDGV EIRRSKRHEA 2200
TSLGDTHTLT VRGAQVLDSA IYSCRVGKEG QDFPVQVEEV AAKFSKPLEP 2250
VEGELGGTVM LVCELSPEQA EVVWRCGNTQ LRPGKRFQMT SEGPRRTLTV 2300
SGLREDDAEE YVCESRDDRT SARLTVKVPR VVKFTSGLSA MVAEEGQEAT 2350
FQCVVSPSDA GVTWYKDGMQ LQPSEKFVMV ESGASRSLTI LGLTLEDAGQ 2400
VTVEAEGASS SAALRVREAP VLFKKKLEPQ TVEERTSVTL EVELTRPWPE 2450
VKWTRNAAVL TPSENVEIRA EGARHCLVLR SVGFADRGFF GCETPDDKTQ 2500
AKLNVEMRQV RLVRGLQEVE AKEQGTASMD VELSHAEVEG SWTRDGLRLQ 2550
PGPKCHLAVQ GPVHILTLSA LQPQDSGLVA FRAEGVHTSA RLIVTELPVS 2600
FTRVLQDVVA TQKEKVTLEC ELSRPVDVRW LKDGVELRAG KAIGIVAQGT 2650
CRSLVIYRCE TGDQGVYVCD ALDAQTSASL RVQGRTYTLI FRRVLAEDAG 2700
EVKFVAENAE SRAHLRVKEL PVTLLRPLRD KIAMEKHRGV LECQVSRASA 2750
QVRWFKGGVE LQSGPKYEVV SDGLYRKLVI NDVQPEDEDT YTCDAGNVKT 2800
SAQFFVEEQS ITIVRGLKDM TVMEPAPAWF ECETSIPSVR PPKWLLGKTV 2850
LQAGGNVGLE QDGTVHRLTL HKTCSTMTGP VHFTIGKSRS SAQLVVSDIP 2900
VVLTRPLEPK AGRELQSVVL SCDFRPAPKA VQWYKDDTPL SPSEKFKMAL 2950
EGQMAELRIL RLTPADAGVY RCQAGSAQSS AEVTVEAREV TVIQPLQDAE 3000
AMEEGRVCFS CELSHKDEDI EWSLNGTPLY NDSFHEISHE GCLHTLVLKS 3050
VRQADTGTVC ATSPKVSVSA RLVVKGKPVV FLKALDDVSA EERGTLTLQC 3100
EVSDPEARVV WRKDGVELGP SDKYDFLHKA GARGLTVHDL SHEDAGLYTC 3150
QVGSKETQSK VSVHDLHVGI TKRLKTVEVL EGESCSFECV LSHESPSDPA 3200
VWTVGGKTVG GSGHFHAVRQ GRKYTLTVKD AALSDAGEVV FSVLGLTSKA 3250
SLIIRERPVD ITKPLEDQRT TLGEDVMLSC ELSRAGTSVR WLKDGKAIRK 3300
SQKYDLLSEG TRAVLVVRKA SLKDSGEYTC ETEASKSTAK LCVEEKANRF 3350
TEELADLQVE EKGRAVFTCK TEHPASVVTW RKGLLELRAS GKHVPSQEGL 3400
TLKLTINALE RTDSDTYTCD IGQARTQARL LVHGQKVRVI EDLEDTAVQE 3450
GSSAKFCCRI APADYGPVHW FLDKTPLHSN ELNEITVQPG GYHVLTLRQL 3500
ALKDSGTVYF EAGDQRTSAA LRVTEKPSIF SRPLTDVTVT EGEDLTLVCE 3550
TTTVDSSVRW TKDGKTLRPS ARCQLSHEGC QAQLLITATT PQDGGRYKCE 3600
IGGASSSSIV RVHALPVRFR ESLKDVEVPE GKAATLRCVL SSVAAPVEWR 3650
HGDDVLKSSN KYSLRQEGAV LELVIRDLQP QDSGQYSCSF GDQTTSATLT 3700
VKTSSAQFVG KLRNKEATEG TTVTLRCELT KEAPVEWKKG TETLRNGDKY 3750
SLKQDGAVCE LQICSLLVAD AGEYSCVCGQ EKTSATLTVK ALLVHFVRRL 3800
RSKEATEGDT TTLQCELSKA APVEWRKGTE TLRDGDRYSL KQDGAVCELQ 3850
IRSLTIADAG EYLCTCGQEK TSATLTVRAL PAKFKDSLKN EEATEGTTAT 3900
LSCELSKAAP VTWKKGPKTL QSGDKYVLRQ DGAVCGLQIH GLTMADAGEY 3950
SCVCGQEKTS ATLTVRGLPA KFIEDLRSQE ATEGATAILR CELSKAAPVE 4000
WRKGSETLKD GDRYTLRQDG AVCELQIRGL AVVDTGTYSL PTKFTEGLRN 4050
EEATEGTMAT LRCQMSKAAP VEWRKGSETL RDGDRYSLRQ DGAMCELQIR 4100
GLTIEDSGEY TCVCGQEKTS ATLSVKALPS RFIEDLRSQE ATEGTMATLR 4150
CQMSKTAPVE WKKGSETLRD GGRYSLRQDG PVCELQICDL AVEDAGEYSC 4200
VCGQEKTSAT LSIKALPPRF IEDLRSQEAT EGTMATLRCQ MSKAAPVEWR 4250
KGSETLGDGG RYSLRQNGAV CELQIHDLAV EDTGEYSCVC GQEKTSATLN 4300
VKALPPRFIE DLRSQEATEG TMATLRCQMS KAAPVEWRKG SETLRDGGRY 4350
SLRQDGAVCE LQIHDLDVED AGQYSCVCGQ EKTSAVLTVD ALPPKFTEGL 4400
KKEEATEGTM VTLRCQMSKE ATVEWRKGAK TLSDGGRYSL RQDGAMCELQ 4450
ICGLAVEDAG EYSCVCGQEK TSATLSVKAL PPRFIEDLRS QEATEGTMAT 4500
LRCQMSKAAP VEWRKGSETL RDGDRYSLRQ DGAVCELQIR DLAVEDAGEY 4550
LCVCGQEKTS ATLSVKALPP RFIEDLRSQE ATEGTMATLR CQMSKAAPVE 4600
WRKGSKTLRD GDRYSLRQDG AMCELQICDL AVEDTGDYSC VCGQEKTSAT 4650
LSVKALPPRF IEDLRSQEAR EGTVATLRCR MSKAAPVEWR KGSETLKDGD 4700
RYSLRQEGNL CELQIRDLAV EDTEEYSCVC GQEKTSATLS VKALPAKFIE 4750
DLRSQEAPES STVTLRCKLS KKASVVWKKG SETLRNGARY SLRQDGAVCE 4800
LEIRDLTVED TGEYSCTCGQ ERTSATLSIM APQVVFQQPL QNLQAEEGSM 4850
ASLRCELSVP NAAMVWSKGG LELQGDTRRE ARQQGCVAEL LLRDLRREDA 4900
GEYSCTCGSQ TTSATLMVTA APVRFLRELQ AQDVDEGATA RLRCELSREA 4950
VSVEWRKGSL QLFPCAKYQM VQEGTTAELL VHGVEQEDAG EYTCDAGHTQ 5000
SIARLSVRAP KPKFKTDLQS TEQEAGGTAR LCCQLSEAEP GTPVQWLKEG 5050
VELHVGSKYE MRRQGAVCEL LIHGLEAKDT GEYACLVGGQ KTLASLRVKE 5100
PEVTIVRGLV DMEVQADEDV EFTCKVSQAG ATDVQWHLQG LPLQSNEVTE 5150
VAVLADGCTH VLQLKGVTLE DAGTVSFHVG GLSSSAQLTV RGDRSGAPEG 5200
CAAQRGPGCP LPVPTVQGLG PGGSLGFGRG SLAVQRDERH HCGAGHTLPA 5250
HSAQGDPGGC WDHHSPSGLM LLRGPAEGHS KNTVLRGLEN VDALEGGEAL 5300
FECQLSQPEV AAHTWLLDDE PVHTSEKVEV VYFENGLRHL LLLKNLKPQD 5350
SCRVTFLAGD VVTSAFLTVR GWRLEVLEPP HDASVKAGMQ VRFTCILSEA 5400
VPVGEATWYI NGAAIQPDDT DWTVTTDGSH HALTLSNAQP QHAGEVTFAA 5450
RDAVASARLS VLALPDPPED AEVVGRSDHS VTLSWVAPMS DGGGGLCGYR 5500
VEMKEASTGQ WQLCHDLVPG PECVVDDLVP GKTYRFRVAA VGPAGAGEPV 5550
HLPQMAPAPA PAPAPAPAPE TRQAVVGEDI CLELEVAADG GEVVWHKGTE 5600
RIQPGGHFEV LSRGQRQMLV IKGFRTEDQG EYRCGPIQGL PSSGAATFNV 5650
VMTSGSGDEV PAQPSLPPEA AQEGDLHLLW EALARKRRMS REPTLDSISE 5700
LPEEDSRVQH LRQEAEETAP DLSEGYSTAD ELARTGEADL SHTSSDDESR 5750
AGTPSLVTYL KKAGGPGISP LASKHEAQVT TSVKPQKQQE PVVPTCPPPG 5800
DLSAADLMDP SLDKAAVKIQ AAFKGYKVRK EMKQQEGPVF SRTFGDTEAQ 5850
VGDVLRLECV LATKTDMRAC WLKDGIELTD GRHYHIDQLK DGTCSLLVTG 5900
LAPTDSGRYT CQVSTKSGRV SHSACVVVSG TESEAESSSG GELDDAFRRA 5950
ARRLHRLFRT KSPAELSEEE LFLSADEGPG EPEEPADWQT YREDENFVCI 6000
RFESLAEARQ AVTCFRNMFA TMGIGVEISL GEQGPRGVEM RIGKVAPTVT 6050
PAVPLAKTPG LQTSDAAPVF LTELQNQDVQ DGYPMSFDCV VTGQPVPSVR 6100
WFKDGKLLEE DDHYMINEDQ QGGHQLIITA VVPADMGVYR CLAENSMGVS 6150
STKAELRVEL TSTDYDTAAD ATETSSYFSA QGYLSSREQE GTESDEGQLP 6200
QVLEELKDLQ VAPGTRLAKF QLKVKGYPAP KLYWFKDGQP LTTSDHIRMT 6250
DKKTLHTLEI VSVTREDSGQ YAAYISNAVG AAYSSARLLV RGPSEPEEKP 6300
ASDVHERLVP PRILEKFTPK KVKRGSSITF SVKVEGHPAP SVHWLKEEAE 6350
KGVLWIGPDT PGYTMASSSK QHSLVLLDVG RQHQGTYTCI ATNPAGQALC 6400
SASLHISGLA KEEEQERVKE ALISSFLQGT SQAVSAQMSE SAGFADLVGQ 6450
SKGESLVAEE AHSHLSLAEV GTEEFLQKLT SQITEMVSAK ISQAKLQVPG 6500
GDSDEETKTP SASPRHGRSR PSSSVQESSS ESEDGDSRGE IFDIYVVTAD 6550
YLPLGAEQDA IILREGQYVE VLDSAHPLRW LVRTKPTKSS PSRQGWVSPA 6600
YLDKRLKLSP EWGPTEAPEF PGEAVSEDEY RTRLSSVIQE LLSSEQAFVG 6650
ELQFLESHHM KHLERSPRVP AAVASQKTVI FRNVQDISHF HSSFLKELQG 6700
CGTDDDVAMC FIKNQEAFEK YLEFLVGRVQ AESVVVSTPV QEFYKKYAEE 6750
TLSAKDPTQP PPPPLQHYLE QPVERVQKYQ ALLKELIRNK ARNRQNCALL 6800
EQAYAVVSAL PQRAENKLHV SLMENYPGTL EALGEPIRQG HFIVWEGAPG 6850
ARMPWKGHNR HVFLFRNYLV ICKPRRDSRT DTFSYVFRNM MKLSSIDLND 6900
QVEGDDRAFE VWHEREDSVR KYLLQARTVI IKNSWVKEIC GIQQRLAQPV 6950
WRPPEFEEEL ADCTAELGET VKLACRVTGT PKPIVSWYKD GKPVEVDPHH 7000
ILIEDPDGSC TLILDNLTGI DSGQYMCFAA SAAGNASTLG KILVQVPPRF 7050
VNKVRATPFV EGEDAQITCT VEGAPYPQIR WYKDGTLLAP GNRYRMLNEP 7100
RSGVLVLVIQ AASKEDLGHY ECELVNRLGS TRGGGELYMQ SPALRARDQH 7150
HREQIVAAVE VCSHDTSVEG SAHSAQDGAD QQAASVLWRL LGSEALGPSP 7200
GDLPNTRQSE PPAFEEAASQ IPGAASGTPG ELPEVSQPGT HKGLEQETTS 7250
SGSQGWTVPI RVEGTAWPGA GTGQLLLDVH SQVIMETTQR TYVCQAPDTG 7300
VTRAPSMQVT IEDVQVQVGD MAQFDAVIEG HPPPIVTWYK GSTQLTSSAR 7350
LSQRQDGTTY SLVLTDVAPH DAGVYTCVAN NAGGQVLCKA ELLVHGGDKL 7400
DAENQVYRRK LHSFYDVQEE IGRGVFGFVK RVQHKGNKMF CAAKFIPLRS 7450
KTRAQAYQER DILATLGHPL VTGLLDQFET RKTLILILEL CSSEELLDRL 7500
FKKGVVTEAE VKVYIQQLVE GLHYLHSHGI LHLDIKPPNI LMVHPAREDI 7550
KICDFGFAQK ITPSEPQYSK YGSPEFVSPE IIEQNPVSEG SDIWAMGVIS 7600
YLSLTCSSPF AGESDRATLL NVLEGRVSWS SPTAAHLSED AKDFIKATLQ 7650
RTPRARPSTS QCLAHPWFLK SMPAEEAHFI NTKQLKFLLA RSRWQRSLMS 7700
YKSILVMRSI PELLQGPPDS PSLGVARHLR GEASGASSSS SSSDNELAPF 7750
ARAKSLPPSP VTHSPLLHPR GFLRPSASLP EETEASMPTA DAAVPASPQS 7800
AGPPASPGCV PRHSVISSLF YQQAGEGAER GNKTSGAKRH PARRRHLLKG 7850
GYIARALPGL REPLMEYSLL EEEAAREEQA SLMTKTPSFE TALRLPSSSV 7900
REVPGRSHSL DNPPVTTGPS PEACKEQLLF PPSTGLTHET TAKDRGHKEG 7950
FLQESVPFPP MSGDSRPGKQ EGSSQDSCRG KPASSCHSEL GSGSQEGCGP 8000
PSSQSLGSLP PQSLKKELST SCGPLFSEQP QAAPFPTQVS PLLGSEKEPQ 8050
DGSLSEGPVP VPSSSPGSAS QVDASLDTEG LSEAGDTCDF TPPPQRPQEQ 8100
ATTRKFSLES RGGYAGVAGY GTFAFGGDAG GMLGQGPLWA RMAWAVSQSS 8150
EEQDEAATES PQPLESLGPI AEASGVPLRT SPSLTPWEEV EQVSLVQIRD 8200
LSGDAEAADT ISLDISEVDP AYLNLSDLYD IKYLPFEFMI FRRVPKPIEQ 8250
PESPGSETEA GQGLADFLEE AAWPWPGELG LRAGLEITEE PEEPGDLEAL 8300
LGEAAVGRKR KWSPSRGLFQ FPGRCLSGEE PVELGLRQRV KASMAHISRI 8350
LKGRPEGPER EGPPRKKAGL ASFRLSGLKG RDQAPSFLRE LSDEAVVLGQ 8400
SVTLACQVLA QPTAQATWSK DGVLLESSGH LLISSTLKNF QLLTILVVKE 8450
EDLGTYTCCV SNPLGTAVTT GVLRKAERPS SSPRPEVGEL YKDAVLLVWK 8500
PVESCGPVTY IVQCCIEGGS WTTLASDISD CCYLTGKLSR GGMYIFRTAC 8550
VSKAGMGPYS SPSEQVLLGG PNHLASEEES SRGRPAQLLP STKTFAFQMQ 8600
IRRGRFSVVR QCREKASGRA LAAKIVPYQP EDKTAVLREY EALKRLHHPH 8650
LAQLHAAYLS PRHLVLILEL CSGPELLPSL AERESYSESD VKDYLWQMLS 8700
ATQYLHAQHI LHLDLRSENM MVTEYNLLKV IDLGNAQSLD QEKVPAPENF 8750
KDYLETMAPE LLEGQGAVPQ TDIWAIGVTA FIMLSGEYPE SSEGTRDLQK 8800
GLRKGLIRLS RCYAGLSGGA VAFLQSSLCA QPWGRPCAST CLQCGWLTEE 8850
GPTGSRPTPV TFPTVRLRAF VREREKRRAL LYKKHNLAQV R 8891
Length:8,891
Mass (Da):966,372
Last modified:July 24, 2007 - v2
Checksum:i384E04B56A54CAB0
GO
Isoform 21 Publication (identifier: A2AAJ9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     7161-7167: VCSHDTS → ERRPSPP
     7168-8891: Missing.

Note: Lacks the kinase domain. No experimental confirmation available.

Show »
Length:7,167
Mass (Da):779,862
Checksum:iB61FCAB243F9EA4F
GO
Isoform 32 Publications (identifier: A2AAJ9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7306: Missing.
     8384-8389: Missing.

Show »
Length:1,579
Mass (Da):171,680
Checksum:i536554014AD05993
GO

Sequence cautioni

The sequence CAM24490.2 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAM24491.3 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAQ51661.2 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 73067306Missing in isoform 3. 2 PublicationsVSP_052486Add
BLAST
Alternative sequencei7161 – 71677VCSHDTS → ERRPSPP in isoform 2. 1 PublicationVSP_052485
Alternative sequencei7168 – 88911724Missing in isoform 2. 1 PublicationVSP_052487Add
BLAST
Alternative sequencei8384 – 83896Missing in isoform 3. 2 PublicationsVSP_052488

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7654 – 76541R → Q in AAT80900. 1 Publication
Sequence conflicti8518 – 85181G → E in AAT80900. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY603754 mRNA. Translation: AAT80900.1.
AL645854, AL662809 Genomic DNA. Translation: CAQ51661.2. Sequence problems.
AL662809, AL645854 Genomic DNA. Translation: CAM24490.2. Sequence problems.
AL662809, AL645854 Genomic DNA. Translation: CAM24491.3. Sequence problems.
BC044882 mRNA. Translation: AAH44882.2.
UniGeneiMm.339542.

Genome annotation databases

UCSCiuc029rlw.1. mouse. [A2AAJ9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY603754 mRNA. Translation: AAT80900.1 .
AL645854 , AL662809 Genomic DNA. Translation: CAQ51661.2 . Sequence problems.
AL662809 , AL645854 Genomic DNA. Translation: CAM24490.2 . Sequence problems.
AL662809 , AL645854 Genomic DNA. Translation: CAM24491.3 . Sequence problems.
BC044882 mRNA. Translation: AAH44882.2 .
UniGenei Mm.339542.

3D structure databases

ProteinModelPortali A2AAJ9.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei A2AAJ9.

Proteomic databases

MaxQBi A2AAJ9.
PaxDbi A2AAJ9.
PRIDEi A2AAJ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc029rlw.1. mouse. [A2AAJ9-1 ]

Organism-specific databases

MGIi MGI:2681862. Obscn.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000115256.
HOVERGENi HBG108206.
InParanoidi B2FDE7.
PhylomeDBi A2AAJ9.

Enzyme and pathway databases

Reactomei REACT_204733. G alpha (12/13) signalling events.
REACT_209641. NRAGE signals death through JNK.
REACT_210090. Rho GTPase cycle.

Miscellaneous databases

PROi A2AAJ9.
SOURCEi Search...

Gene expression databases

ArrayExpressi A2AAJ9.
Bgeei A2AAJ9.
Genevestigatori A2AAJ9.

Family and domain databases

Gene3Di 1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.10. 69 hits.
InterProi IPR000219. DH-domain.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR000048. IQ_motif_EF-hand-BS.
IPR011009. Kinase-like_dom.
IPR020682. Obscurin-myosin_light-ch_kin.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
[Graphical view ]
PANTHERi PTHR19897:SF17. PTHR19897:SF17. 1 hit.
Pfami PF00041. fn3. 2 hits.
PF07679. I-set. 59 hits.
PF00612. IQ. 1 hit.
PF00069. Pkinase. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 3 hits.
SM00409. IG. 20 hits.
SM00408. IGc2. 42 hits.
SM00015. IQ. 1 hit.
SM00233. PH. 1 hit.
SM00220. S_TKc. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF49265. SSF49265. 3 hits.
SSF50044. SSF50044. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEi PS50010. DH_2. 1 hit.
PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 54 hits.
PS50096. IQ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases."
    Sutter S.B., Raeker M.O., Borisov A.B., Russell M.W.
    Dev. Genes Evol. 214:352-359(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6772-8891 (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Salivary gland.
  4. "The mouse kinome: discovery and comparative genomics of all mouse protein kinases."
    Caenepeel S., Charydczak G., Sudarsanam S., Hunter T., Manning G.
    Proc. Natl. Acad. Sci. U.S.A. 101:11707-11712(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiOBSCN_MOUSE
AccessioniPrimary (citable) accession number: A2AAJ9
Secondary accession number(s): A2AB85
, B2FDE7, Q695L2, Q811H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: September 3, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi