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Protein

TANK-binding kinase 1-binding protein 1

Gene

Tbkbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
TANK-binding kinase 1-binding protein 1
Short name:
TBK1-binding protein 1
Alternative name(s):
Similar to NAP1 TBK1 adapter
Gene namesi
Name:Tbkbp1Imported
Synonyms:Sintbad1 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1920424. Tbkbp1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 611611TANK-binding kinase 1-binding protein 1PRO_0000324655Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei184 – 1841PhosphoserineBy similarity
Modified residuei365 – 3651PhosphoserineBy similarity
Modified residuei372 – 3721PhosphoserineBy similarity
Modified residuei379 – 3791PhosphoserineBy similarity
Modified residuei385 – 3851PhosphoserineBy similarity
Modified residuei400 – 4001PhosphoserineCombined sources
Modified residuei415 – 4151PhosphoserineBy similarity
Modified residuei500 – 5001PhosphoserineBy similarity
Modified residuei530 – 5301PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA2A9T0.
PaxDbiA2A9T0.
PRIDEiA2A9T0.

PTM databases

PhosphoSiteiA2A9T0.

Expressioni

Gene expression databases

BgeeiA2A9T0.
CleanExiMM_TBKBP1.
ExpressionAtlasiA2A9T0. baseline and differential.
GenevisibleiA2A9T0. MM.

Interactioni

Subunit structurei

Homodimer. May form a heterodimer with NAP1. Interacts with TKB1 and IKBKE.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Tbk1Q9WUN22EBI-7987134,EBI-764193

Protein-protein interaction databases

IntActiA2A9T0. 1 interaction.
MINTiMINT-6948061.
STRINGi10090.ENSMUSP00000103240.

Structurei

3D structure databases

ProteinModelPortaliA2A9T0.
SMRiA2A9T0. Positions 286-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 280280HomodimerizationAdd
BLAST
Regioni281 – 33050Interaction with TBK1 and IKBKEAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili48 – 162115Sequence analysisAdd
BLAST
Coiled coili218 – 27760Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi168 – 1736Poly-GlnSequence analysis
Compositional biasi344 – 43289Pro-richSequence analysisAdd
BLAST
Compositional biasi518 – 5214Poly-GluSequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGJJ. Eukaryota.
ENOG410ZK7E. LUCA.
GeneTreeiENSGT00390000008865.
HOGENOMiHOG000154514.
HOVERGENiHBG108550.
InParanoidiA2A9T0.
KOiK12652.
OMAiYGGELYG.
OrthoDBiEOG7KQ21K.
PhylomeDBiA2A9T0.
TreeFamiTF331289.

Family and domain databases

InterProiIPR024581. TBD.
[Graphical view]
PfamiPF12845. TBD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2A9T0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESMFEDDIS ILTQEALGPS EVWLDGPGDP SLGGDMCSAS HFALITAYGD
60 70 80 90 100
IKERLGGLER ENATLRRRLK VYEIKYPLIT DFGEEHGFPL YELKDGSLLE
110 120 130 140 150
VEKVSLQQRL NQFQHELQKS KEQEEQLGEM IQAYEKLCVE KSDLETELGE
160 170 180 190 200
MRALVETHLR QICGLEKQLQ QQQGLRDAAF SSLSPPAVPA SACPDLDLHY
210 220 230 240 250
LALRGGPALG HAGWPGPTSV SVSELERRRL EEALEAAQGE ARGAQLREEQ
260 270 280 290 300
LQAECERLQG ELKQLQETRA QDLASNQSEC DMAWVKRVGD DQVNLALAYT
310 320 330 340 350
ELTEELGRLR ELSSLQGRIL RTLLQEQARN AGQRHSPLSQ RHSPAPACPS
360 370 380 390 400
PSPPARPPPC APCQSPAAQR RSPVPPCPSP QQRRSPASPS CPSPVPQRRS
410 420 430 440 450
PVPPSCQSPS PQRRSPVPPS CPAPQPRPPP PPGERTLAER VYAKPPSHHA
460 470 480 490 500
KAGFQGRRSY SELAEGAAYA GASPAWLQAE AATLPKPRAY GGELYGRPLS
510 520 530 540 550
PRRAFEGIRL RFEKQPSEEE EWAMPASPPS PEAGTIRCAS FCAGFPIPES
560 570 580 590 600
PAATAYAHAE HAQSWPSINL LMETVGSDIR SCPLCQLGFP VGYPDDALIK
610
HIDSHLENSK I
Length:611
Mass (Da):67,001
Last modified:February 20, 2007 - v1
Checksum:iB2AF8DF98F1C6EF9
GO
Isoform 21 Publication (identifier: A2A9T0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-212: Missing.
     364-377: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:596
Mass (Da):65,455
Checksum:i22DF24BC9F366225
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei212 – 2121Missing in isoform 2. 1 PublicationVSP_032344
Alternative sequencei364 – 37714Missing in isoform 2. 1 PublicationVSP_052716Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627445 Genomic DNA. Translation: CAM26991.1.
AL627445 Genomic DNA. Translation: CAM26992.1.
BC057590 mRNA. Translation: AAH57590.1.
RefSeqiNP_932768.2. NM_198100.2.
XP_006534398.1. XM_006534335.1. [A2A9T0-1]
XP_006534399.1. XM_006534336.1. [A2A9T0-1]
XP_006534400.1. XM_006534337.2. [A2A9T0-1]
UniGeneiMm.27882.

Genome annotation databases

EnsembliENSMUST00000066078; ENSMUSP00000065461; ENSMUSG00000038517. [A2A9T0-1]
ENSMUST00000107614; ENSMUSP00000103239; ENSMUSG00000038517. [A2A9T0-1]
GeneIDi73174.
KEGGimmu:73174.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627445 Genomic DNA. Translation: CAM26991.1.
AL627445 Genomic DNA. Translation: CAM26992.1.
BC057590 mRNA. Translation: AAH57590.1.
RefSeqiNP_932768.2. NM_198100.2.
XP_006534398.1. XM_006534335.1. [A2A9T0-1]
XP_006534399.1. XM_006534336.1. [A2A9T0-1]
XP_006534400.1. XM_006534337.2. [A2A9T0-1]
UniGeneiMm.27882.

3D structure databases

ProteinModelPortaliA2A9T0.
SMRiA2A9T0. Positions 286-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2A9T0. 1 interaction.
MINTiMINT-6948061.
STRINGi10090.ENSMUSP00000103240.

PTM databases

PhosphoSiteiA2A9T0.

Proteomic databases

MaxQBiA2A9T0.
PaxDbiA2A9T0.
PRIDEiA2A9T0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066078; ENSMUSP00000065461; ENSMUSG00000038517. [A2A9T0-1]
ENSMUST00000107614; ENSMUSP00000103239; ENSMUSG00000038517. [A2A9T0-1]
GeneIDi73174.
KEGGimmu:73174.

Organism-specific databases

CTDi9755.
MGIiMGI:1920424. Tbkbp1.

Phylogenomic databases

eggNOGiENOG410IGJJ. Eukaryota.
ENOG410ZK7E. LUCA.
GeneTreeiENSGT00390000008865.
HOGENOMiHOG000154514.
HOVERGENiHBG108550.
InParanoidiA2A9T0.
KOiK12652.
OMAiYGGELYG.
OrthoDBiEOG7KQ21K.
PhylomeDBiA2A9T0.
TreeFamiTF331289.

Miscellaneous databases

NextBioi337609.
PROiA2A9T0.
SOURCEiSearch...

Gene expression databases

BgeeiA2A9T0.
CleanExiMM_TBKBP1.
ExpressionAtlasiA2A9T0. baseline and differential.
GenevisibleiA2A9T0. MM.

Family and domain databases

InterProiIPR024581. TBD.
[Graphical view]
PfamiPF12845. TBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6JImported.
    Tissue: BrainImported.
  3. "SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK."
    Ryzhakov G., Randow F.
    EMBO J. 26:3180-3190(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TBK1 AND IKBKE, HOMODIMER.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-400, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung.

Entry informationi

Entry nameiTBKB1_MOUSE
AccessioniPrimary (citable) accession number: A2A9T0
Secondary accession number(s): A2A9S9, Q6PFF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 20, 2007
Last modified: January 20, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.