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Protein

TANK-binding kinase 1-binding protein 1

Gene

Tbkbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
TANK-binding kinase 1-binding protein 1
Short name:
TBK1-binding protein 1
Alternative name(s):
Similar to NAP1 TBK1 adapter
Gene namesi
Name:Tbkbp1Imported
Synonyms:Sintbad1 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1920424. Tbkbp1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003246551 – 611TANK-binding kinase 1-binding protein 1Add BLAST611

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184PhosphoserineBy similarity1
Modified residuei365PhosphoserineBy similarity1
Modified residuei372PhosphoserineBy similarity1
Modified residuei379PhosphoserineBy similarity1
Modified residuei385PhosphoserineBy similarity1
Modified residuei400PhosphoserineCombined sources1
Modified residuei415PhosphoserineBy similarity1
Modified residuei500PhosphoserineBy similarity1
Modified residuei530PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA2A9T0.
PRIDEiA2A9T0.

PTM databases

iPTMnetiA2A9T0.
PhosphoSitePlusiA2A9T0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038517.
CleanExiMM_TBKBP1.
ExpressionAtlasiA2A9T0. baseline and differential.
GenevisibleiA2A9T0. MM.

Interactioni

Subunit structurei

Homodimer. May form a heterodimer with NAP1. Interacts with TKB1 and IKBKE.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Tbk1Q9WUN22EBI-7987134,EBI-764193

Protein-protein interaction databases

IntActiA2A9T0. 1 interactor.
MINTiMINT-6948061.
STRINGi10090.ENSMUSP00000103240.

Structurei

3D structure databases

ProteinModelPortaliA2A9T0.
SMRiA2A9T0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 280HomodimerizationAdd BLAST280
Regioni281 – 330Interaction with TBK1 and IKBKE1 PublicationAdd BLAST50

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili48 – 162Sequence analysisAdd BLAST115
Coiled coili218 – 277Sequence analysisAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi168 – 173Poly-GlnSequence analysis6
Compositional biasi344 – 432Pro-richSequence analysisAdd BLAST89
Compositional biasi518 – 521Poly-GluSequence analysis4

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGJJ. Eukaryota.
ENOG410ZK7E. LUCA.
GeneTreeiENSGT00390000008865.
HOGENOMiHOG000154514.
HOVERGENiHBG108550.
InParanoidiA2A9T0.
KOiK12652.
OMAiYGGELYG.
OrthoDBiEOG091G06LV.
PhylomeDBiA2A9T0.
TreeFamiTF331289.

Family and domain databases

InterProiIPR024581. TBD.
[Graphical view]
PfamiPF12845. TBD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2A9T0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESMFEDDIS ILTQEALGPS EVWLDGPGDP SLGGDMCSAS HFALITAYGD
60 70 80 90 100
IKERLGGLER ENATLRRRLK VYEIKYPLIT DFGEEHGFPL YELKDGSLLE
110 120 130 140 150
VEKVSLQQRL NQFQHELQKS KEQEEQLGEM IQAYEKLCVE KSDLETELGE
160 170 180 190 200
MRALVETHLR QICGLEKQLQ QQQGLRDAAF SSLSPPAVPA SACPDLDLHY
210 220 230 240 250
LALRGGPALG HAGWPGPTSV SVSELERRRL EEALEAAQGE ARGAQLREEQ
260 270 280 290 300
LQAECERLQG ELKQLQETRA QDLASNQSEC DMAWVKRVGD DQVNLALAYT
310 320 330 340 350
ELTEELGRLR ELSSLQGRIL RTLLQEQARN AGQRHSPLSQ RHSPAPACPS
360 370 380 390 400
PSPPARPPPC APCQSPAAQR RSPVPPCPSP QQRRSPASPS CPSPVPQRRS
410 420 430 440 450
PVPPSCQSPS PQRRSPVPPS CPAPQPRPPP PPGERTLAER VYAKPPSHHA
460 470 480 490 500
KAGFQGRRSY SELAEGAAYA GASPAWLQAE AATLPKPRAY GGELYGRPLS
510 520 530 540 550
PRRAFEGIRL RFEKQPSEEE EWAMPASPPS PEAGTIRCAS FCAGFPIPES
560 570 580 590 600
PAATAYAHAE HAQSWPSINL LMETVGSDIR SCPLCQLGFP VGYPDDALIK
610
HIDSHLENSK I
Length:611
Mass (Da):67,001
Last modified:February 20, 2007 - v1
Checksum:iB2AF8DF98F1C6EF9
GO
Isoform 21 Publication (identifier: A2A9T0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-212: Missing.
     364-377: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:596
Mass (Da):65,455
Checksum:i22DF24BC9F366225
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032344212Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_052716364 – 377Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627445 Genomic DNA. Translation: CAM26991.1.
AL627445 Genomic DNA. Translation: CAM26992.1.
BC057590 mRNA. Translation: AAH57590.1.
RefSeqiNP_932768.2. NM_198100.2.
XP_006534398.1. XM_006534335.1. [A2A9T0-1]
XP_006534399.1. XM_006534336.2. [A2A9T0-1]
XP_006534400.1. XM_006534337.2. [A2A9T0-1]
UniGeneiMm.27882.

Genome annotation databases

EnsembliENSMUST00000066078; ENSMUSP00000065461; ENSMUSG00000038517. [A2A9T0-1]
ENSMUST00000107614; ENSMUSP00000103239; ENSMUSG00000038517. [A2A9T0-1]
GeneIDi73174.
KEGGimmu:73174.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627445 Genomic DNA. Translation: CAM26991.1.
AL627445 Genomic DNA. Translation: CAM26992.1.
BC057590 mRNA. Translation: AAH57590.1.
RefSeqiNP_932768.2. NM_198100.2.
XP_006534398.1. XM_006534335.1. [A2A9T0-1]
XP_006534399.1. XM_006534336.2. [A2A9T0-1]
XP_006534400.1. XM_006534337.2. [A2A9T0-1]
UniGeneiMm.27882.

3D structure databases

ProteinModelPortaliA2A9T0.
SMRiA2A9T0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2A9T0. 1 interactor.
MINTiMINT-6948061.
STRINGi10090.ENSMUSP00000103240.

PTM databases

iPTMnetiA2A9T0.
PhosphoSitePlusiA2A9T0.

Proteomic databases

PaxDbiA2A9T0.
PRIDEiA2A9T0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066078; ENSMUSP00000065461; ENSMUSG00000038517. [A2A9T0-1]
ENSMUST00000107614; ENSMUSP00000103239; ENSMUSG00000038517. [A2A9T0-1]
GeneIDi73174.
KEGGimmu:73174.

Organism-specific databases

CTDi9755.
MGIiMGI:1920424. Tbkbp1.

Phylogenomic databases

eggNOGiENOG410IGJJ. Eukaryota.
ENOG410ZK7E. LUCA.
GeneTreeiENSGT00390000008865.
HOGENOMiHOG000154514.
HOVERGENiHBG108550.
InParanoidiA2A9T0.
KOiK12652.
OMAiYGGELYG.
OrthoDBiEOG091G06LV.
PhylomeDBiA2A9T0.
TreeFamiTF331289.

Miscellaneous databases

PROiA2A9T0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038517.
CleanExiMM_TBKBP1.
ExpressionAtlasiA2A9T0. baseline and differential.
GenevisibleiA2A9T0. MM.

Family and domain databases

InterProiIPR024581. TBD.
[Graphical view]
PfamiPF12845. TBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBKB1_MOUSE
AccessioniPrimary (citable) accession number: A2A9T0
Secondary accession number(s): A2A9S9, Q6PFF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.