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Protein

Melanoma-associated antigen B4

Gene

Mageb4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen B4Imported
Gene namesi
Name:Mageb4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2148568. Mageb4.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Melanoma-associated antigen B4PRO_0000437174Add
BLAST

Proteomic databases

PaxDbiB7ZWI9.

PTM databases

iPTMnetiQ3UNA3.

Expressioni

Tissue specificityi

Expressed in testis (at protein level).1 Publication

Developmental stagei

Detected between 13.5 and 14.5 dpc in both female and male gonads (at protein level). Increases in the male gonads and intensely expressed before birth (at protein level). In female gonads, remains constant until birth (at protein level). In testis, specifically expressed in premeiotic germ cells (at protein level). In fetal ovary, expressed in both premeiotic germ cells, and germ cells that have gone through the pachytene phase and entered meiotic arrest (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000035427.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094107.

Structurei

3D structure databases

SMRiA2A9R3. Positions 103-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 310200MAGEPROSITE-ProRule annotationAdd
BLAST
Repeati334 – 3481511 PublicationAdd
BLAST
Repeati349 – 3631521 PublicationAdd
BLAST
Repeati364 – 3781531 PublicationAdd
BLAST
Repeati379 – 3921441 PublicationAdd
BLAST
Repeati393 – 4071551 PublicationAdd
BLAST
Repeati408 – 4211461 PublicationAdd
BLAST
Repeati422 – 4361571 PublicationAdd
BLAST
Repeati437 – 4511581 PublicationAdd
BLAST
Repeati452 – 4661591 PublicationAdd
BLAST
Repeati467 – 48014101 PublicationAdd
BLAST
Repeati481 – 49515111 PublicationAdd
BLAST
Repeati496 – 51015121 PublicationAdd
BLAST
Repeati511 – 52515131 PublicationAdd
BLAST
Repeati526 – 53914141 PublicationAdd
BLAST
Repeati540 – 55415151 PublicationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni334 – 55422115 X 15 AA approximate tandem repeats1 PublicationAdd
BLAST

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
OrthoDBiEOG091G0TJ0.
TreeFamiTF328505.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR030084. MAGEB2.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736:SF22. PTHR11736:SF22. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A9R3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGQKSKAR AREKRRLVQD EAQELQDAQA KAGEKGKSPS CSNQDSGDAV
60 70 80 90 100
ASTSTAGFPQ KSKSQGEAPT TTARKGGACR RSRKSTRGPR EESTSCTRVP
110 120 130 140 150
RFSENPQNDL LTRKTGMLMQ YLLCKYKMKQ PASKGEMLKV INRRFKEQLP
160 170 180 190 200
EILKKASERI QLVFGLEVKE IKPNGGYYTL VSKLDPSVGN ALTTSLPFPQ
210 220 230 240 250
NGLLMPLLGV IFLNGNRASE AEIWEFLNVL GIYDGKVHII FGEPRKLITR
260 270 280 290 300
DLVKEKYLVY QKEANSDPPS FEFLWGPRAY AETTKMKILE FLAEVNETVP
310 320 330 340 350
QAFPTHYEEA LRDQEERAQA EAVGSPGTSA KDKAEAKVTL VDSSCKYQAE
360 370 380 390 400
SKVTLVDSSC KDQAESKVTL VDPSCKDNAK SKVTLGSSRK YKAKSKVPLV
410 420 430 440 450
DSSCKDQAES KVTLVDSCKD QAESKVTLVD SSCKDQAESK VTLVDSSCKD
460 470 480 490 500
QAESKVTLVD PSCKDKAKSK VTLGSSHKYK AKSKVTLVDS SCKDQAESKV
510 520 530 540 550
TLVDSSCKDQ AESKVTLVDP SCKDNAKSKV TLGSSRKYKA KSKVPLVDSS

GKDKAV
Length:556
Mass (Da):60,922
Last modified:February 20, 2007 - v1
Checksum:iA2B67EE2398651E0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781A → T in AAI72073 (PubMed:15489334).Curated
Sequence conflicti378 – 3781N → K in BAE25842 (PubMed:16141072).Curated
Sequence conflicti378 – 3781N → K in BAE25844 (PubMed:16141072).Curated
Sequence conflicti444 – 4441V → L in BAE25842 (PubMed:16141072).Curated
Sequence conflicti444 – 4441V → L in BAE25844 (PubMed:16141072).Curated
Sequence conflicti529 – 5335KVTLG → NGHTLA in BAE25842 (PubMed:16141072).Curated
Sequence conflicti529 – 5335KVTLG → NGHTLA in BAE25844 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144342 mRNA. Translation: BAE25842.1.
AK144350 mRNA. Translation: BAE25844.1.
AL627411 Genomic DNA. No translation available.
AL954720 Genomic DNA. No translation available.
CH466576 Genomic DNA. Translation: EDL29148.1.
BC150912 mRNA. Translation: AAI50913.1.
BC172073 mRNA. Translation: AAI72073.1.
RefSeqiNP_001028664.2. NM_001033492.2.
UniGeneiMm.213584.

Genome annotation databases

EnsembliENSMUST00000096378; ENSMUSP00000094107; ENSMUSG00000035427.
ENSMUST00000113969; ENSMUSP00000109602; ENSMUSG00000035427.
GeneIDi434903.
KEGGimmu:434903.
UCSCiuc009tse.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144342 mRNA. Translation: BAE25842.1.
AK144350 mRNA. Translation: BAE25844.1.
AL627411 Genomic DNA. No translation available.
AL954720 Genomic DNA. No translation available.
CH466576 Genomic DNA. Translation: EDL29148.1.
BC150912 mRNA. Translation: AAI50913.1.
BC172073 mRNA. Translation: AAI72073.1.
RefSeqiNP_001028664.2. NM_001033492.2.
UniGeneiMm.213584.

3D structure databases

SMRiA2A9R3. Positions 103-311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094107.

PTM databases

iPTMnetiQ3UNA3.

Proteomic databases

PaxDbiB7ZWI9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096378; ENSMUSP00000094107; ENSMUSG00000035427.
ENSMUST00000113969; ENSMUSP00000109602; ENSMUSG00000035427.
GeneIDi434903.
KEGGimmu:434903.
UCSCiuc009tse.1. mouse.

Organism-specific databases

CTDi4115.
MGIiMGI:2148568. Mageb4.

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
OrthoDBiEOG091G0TJ0.
TreeFamiTF328505.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035427.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR030084. MAGEB2.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736:SF22. PTHR11736:SF22. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAGB4_MOUSE
AccessioniPrimary (citable) accession number: A2A9R3
Secondary accession number(s): B7ZWI9, Q3UNA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 7, 2016
Last sequence update: February 20, 2007
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.