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Protein

Protein SZT2

Gene

Szt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxidative stress. May be involved in superoxide dismutase activity and in neuroprotective effect of peroxisomes, but has no direct dismutase activity when tested in yeast. May enhance epileptogenesis and confer low seizure threshold.2 Publications

GO - Biological processi

  • central nervous system development Source: MGI
  • corpus callosum morphogenesis Source: MGI
  • pigmentation Source: MGI
  • post-embryonic development Source: MGI
  • regulation of superoxide dismutase activity Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SZT2
Alternative name(s):
Seizure threshold 2 protein
Transcript increased in glutamate resistance
Short name:
TIGR
Gene namesi
Name:Szt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:3033336. Szt2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Disruption phenotypei

Mutant mice have a low seizure threshold; STZ2 expression is several fold increased in the brain. Mutations are induced by a chemical mutagen, ethylnitrosourea (ENU) that randomly induces point mutations in DNA. Mutagenesis screen of mice with low electroconvulsive threshold allows to identify STZ2 as regulator of seizure threshold and neuronal excitation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 34313431Protein SZT2PRO_0000399821Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1275 – 12751PhosphoserineBy similarity
Modified residuei1415 – 14151PhosphoserineBy similarity
Modified residuei1640 – 16401PhosphothreonineBy similarity
Modified residuei1650 – 16501PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA2A9C3.
MaxQBiA2A9C3.
PaxDbiA2A9C3.
PeptideAtlasiA2A9C3.
PRIDEiA2A9C3.

PTM databases

iPTMnetiA2A9C3.
PhosphoSiteiA2A9C3.

Expressioni

Tissue specificityi

Mostly expressed in brain, spinal cord and lung.2 Publications

Inductioni

Induced in cells resistant to glutamate toxicity.1 Publication

Gene expression databases

BgeeiA2A9C3.
ExpressionAtlasiA2A9C3. baseline and differential.
GenevisibleiA2A9C3. MM.

Interactioni

Protein-protein interaction databases

BioGridi231000. 1 interaction.
STRINGi10090.ENSMUSP00000074862.

Structurei

3D structure databases

ProteinModelPortaliA2A9C3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3040 – 309152His-richAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IE3I. Eukaryota.
ENOG410XTCX. LUCA.
GeneTreeiENSGT00390000018402.
HOGENOMiHOG000231148.
HOVERGENiHBG080139.
InParanoidiA2A9C3.
OMAiDYRAPFL.
OrthoDBiEOG7CNZDW.
PhylomeDBiA2A9C3.
TreeFamiTF333377.

Family and domain databases

InterProiIPR033228. SZT2.
[Graphical view]
PANTHERiPTHR14918. PTHR14918. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2A9C3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASERPEPEV EEAGQVFLLM KKDYRISRNV RLAWFLNHLH QTVQATPQEL
60 70 80 90 100
LLQSEQELEV LSVLPPGWQP DEPVVPRPFL LVPSTRVTFL AWQYRFVIEL
110 120 130 140 150
DLSPSTGIVD DSTGEILFDE VFHALSRCLG GLLRPFRVPG SCINFQPEIY
160 170 180 190 200
VTIQAYSSII GLQSHQVLVQ GCLLDPSQRE AFLQQVYEQL CLFEDKVATM
210 220 230 240 250
LQQQYEPQGQ AEDQSPESGE SLGRKVGVSM VTADLGLVSM IRQGILALQL
260 270 280 290 300
LPSNSSAGII VITDGVTSVP DVAVCETLLN QLRSGTVACS FVQVGGVYSY
310 320 330 340 350
DCSFGHVPNV ELMKFIAMAT FGSYLSTCPE TEPGNLGLTV YHRAFLLYSF
360 370 380 390 400
LRSGEALNPE YYCGSQHRLF NEHLVSASSN PALALRRKKH TEKEVPADLV
410 420 430 440 450
STVSVRLREG YSVREVTLAK GGSQLEVKLV LLWKHNMRIE YVAVAPWPLE
460 470 480 490 500
PEGPRGTRVE VTMEGGYDIL HDVSCALRQP IRSLYRTHVI RRFWNTLQSI
510 520 530 540 550
NQTDQMLAHL QSFSSVPEHF TLPDSTKSGV PLFYIPPGSS TPVLSLQHSG
560 570 580 590 600
SDSSHAQFAA YWKPVLSMDA NSWQRWLHMH RLVLILEHDT PLPKHLHTPG
610 620 630 640 650
SNGRYSTIQC RISHSSLTSL LRDWSSFVLV EGYSYVKLLS SAPDQPPSSF
660 670 680 690 700
YMVRIISKTP CMVLRLGFPI GTPAQARHKI VSGLKEEILR LRFPHRVQSK
710 720 730 740 750
EPTPKVKRKG LGGVGGSSPS KSPPTLGPQQ ALSDRPCLVV LHKPLDKLLI
760 770 780 790 800
RYEKLPLDYR APFLLTLEPP GPLPLVSGRS ASSSLASLSR YLYHRRWLWS
810 820 830 840 850
VPSGLAPTLP LSATAQLLSV LTEVRLSEGF HFACSGEGII NMVLELPVQN
860 870 880 890 900
EPLGQAAAEE KHTCVVQYIL FPPHSTSTKD SFSTDDDNDV EVEALEGDSE
910 920 930 940 950
LNLVTEVWVE PQYGRVGPGP ENWKHLQDLT YSEIPQALHP RDAACIGSLL
960 970 980 990 1000
TFEYLIQLCQ SKEWGPLPPE PRLSDGLDQR GDTCVHEIPF HFDLLGLLPQ
1010 1020 1030 1040 1050
CQQLQMFFLL LSREPEGVPL AEGPCPTNDM VLCLLHSCLG QELSDREIPL
1060 1070 1080 1090 1100
TPADQAAFLN EVLRRSLRDP GPEGPPVGGH AVAKDRAGNS TQASGDSTLP
1110 1120 1130 1140 1150
SQSVVIPGVL RSSISAQPPQ WHCYARLLGP QHVFLTFLPA TFSDVQHLTA
1160 1170 1180 1190 1200
YGLESSFQEE TKPKLGDWSG APSLKDPGAT GTKATESQVP TLSVTLASDS
1210 1220 1230 1240 1250
AQDSGEPSTP SCQDLAANSG RQAPQTEGAD GPRTRCPVYI YSCSLEALRE
1260 1270 1280 1290 1300
QMVGLQPPQA PRDLIFRAQD LDHPSSSSAW MEPRCKEAAT HCALLQEHAQ
1310 1320 1330 1340 1350
RCFVRGLFRS LQQAQSVTCQ DLLTAVDACE ELLQEIDITS FLLALCGHTW
1360 1370 1380 1390 1400
GLPHAPPSPG PLSPGPFSSS IEEGPEPRER AILVSESSIE TEDLSEPEFQ
1410 1420 1430 1440 1450
SSRVSGNLDP GPEISLTDVC QLRGEAHDAL HSLIQEKFLE ISRLHFRTVP
1460 1470 1480 1490 1500
SNPHYFFYCP PSSRREDEGP RDTVDRKISD LEFSEAELVG EEGDTSACCV
1510 1520 1530 1540 1550
VTESDPELEV EYRESREPDL GPAGLDSASL SDADTVNPDE DSFSILGGDS
1560 1570 1580 1590 1600
PTGPDSLMHD LPPLFLHLTC SVRLRGQHSS VPVCSLPTCL GQVLSSLEGP
1610 1620 1630 1640 1650
PIGGRVPLRD LSITLDVFVL TLPLEVELPP ASDPQHHRST SESSASFPRS
1660 1670 1680 1690 1700
PGQPSSLRSD DGLGPPLPPP EEERHPGLSS LAMPHRLAIE STMNEIRWLL
1710 1720 1730 1740 1750
EDEMVGALRR GGIPQSPALH RAAAHIHSSS GRPTCLRQAP PLSFVFGPER
1760 1770 1780 1790 1800
SLTQFKEEFR RLHLPGHVLL EDPDSGFFFV AAGQQPGVLH GEPPSAAWAW
1810 1820 1830 1840 1850
HNHEDRAEDA EGEVLTASPQ VPGSLEDSEG TPLISLPSLS QGGSQPGPSR
1860 1870 1880 1890 1900
GLSLMSSQGS VDSDHLGYDG GSSGSDSEGP GETLGEKALF TLRTPPGPAP
1910 1920 1930 1940 1950
PQPSLPVLPG PSLPDFWLIV RILQDRVEVY AHARSLSRED GGPGAECRHL
1960 1970 1980 1990 2000
QQFLVRRVGE ICREVNQRLL LQDLHDSHVC NSLLVAESEE DLWRSETPFH
2010 2020 2030 2040 2050
SRQRAVLPSD DFAADESCAP RGYLAATMQF VPGHFSCDVV WGTVIRVHSR
2060 2070 2080 2090 2100
LKMGPSMGVS RAIQALRSVL NAFSVVNRKN MFVYQERATK AVYYLRLLET
2110 2120 2130 2140 2150
SCSDRPWEGD TLPPSLALSR SQEPISSEDS VAPRSPLDMA SSRSSDAVRP
2160 2170 2180 2190 2200
VGQVDRHIQL LVHGVGQAGP EITDELVRVL RRRLDEATLD IITVMLVRNC
2210 2220 2230 2240 2250
KLTPADVEFI QPPGSLPSEV LHLVLPPSCR PCLPALAWYL RQNLLTFLHS
2260 2270 2280 2290 2300
PKYTDSNSRN HFQHPLPAQG GLPDLDIYLY NKPGGQGTGG KGVACITLAF
2310 2320 2330 2340 2350
VEEGGTPISL ASWPPSSPGP PDPLREEEFE QLTQVIRCPN TLDSCSAQDG
2360 2370 2380 2390 2400
SPRLRLDVWE KGNISIVQLE EKLRAAARQA LADAIMELRL LPASLCTEDI
2410 2420 2430 2440 2450
PPGSLKSGPL DTKSPACRAN TFPCTPVSGE PVTPPSKAGR RSFWDMLSKT
2460 2470 2480 2490 2500
EAGDLGSPKT TDDIVLDRPE DTRGRRRHKT ENVRTPGGSE RAPGPDSGAQ
2510 2520 2530 2540 2550
RQRRRTTQLE EGEVGTLHPV FARVIQRWMG FMVQIGCASV SRSSTHMVSR
2560 2570 2580 2590 2600
FLLPSILSEF TTLVISMAGD TSVRVFEQHL GSEPDVFSPC SPGQLGPAPR
2610 2620 2630 2640 2650
PAAQRHLLLL GRNFAQWRRP TQQAAKAVQR FESGGDGSPG RSAPRQRLLL
2660 2670 2680 2690 2700
LEVTDKKLQL LTYNWAPDLG AALGRALIRL VQWQNARAHL ISCLLSQKLG
2710 2720 2730 2740 2750
LFHHCGQLDF PMRDGKEPNP FLLPTMEVET LIRNASPPLS REQGRLSGSS
2760 2770 2780 2790 2800
RGGGPLSLDT FPFDEALRDI TAARPSSTGG PAPRPPDPVT YHGQQFLEIK
2810 2820 2830 2840 2850
MTERKELERQ MKMENLFVTW QQRSAPASMP ISAGELETLK QSSRLVHYCA
2860 2870 2880 2890 2900
TALLFDPAAW LHGPPETCAP SEGQRRPCPE SGSGSREVPT SCESLDVPPP
2910 2920 2930 2940 2950
GAREEPWLKE LSLAFLQQYV QYLQSIGFVL VPLRPPSPAR STSRLRAMAI
2960 2970 2980 2990 3000
LGTEGRGSFS CPKAKAEGSP KSTSTPVTTY HLQRALPGGI ILMELTFQGC
3010 3020 3030 3040 3050
YFCVKQFALE CSRIPMGQAV NSQLSLLFTE ECDKVRDLMH VHSFSYDFHL
3060 3070 3080 3090 3100
RLVHQHVLGA HLALRHGYHL TTFLQHFLAH HPDGPHFGRN HIYQGTLELP
3110 3120 3130 3140 3150
TPLIAAHQLY NYVADHASSY HMKPLRMARP GGPEHNEYAL VSAWHSSGSY
3160 3170 3180 3190 3200
LDSEGLRHQD DFDVSLLVCH SAAPFEEQGE AERHVLRLQF FVVLTSQREL
3210 3220 3230 3240 3250
FPRLTADMRR FRKPSRLPLE PETPGSLVGS PREASGMMLA PGPAPLFPPL
3260 3270 3280 3290 3300
AAEVGMARAR LAQLVRLAGG HCRRDTLWKR LFLLEPPGPD RLRLGGRLAL
3310 3320 3330 3340 3350
AELEELLEAV HAKSIADIDP QLDCFLSMTV SWYQSLIKVL LSRFPQSCRH
3360 3370 3380 3390 3400
FQSPDLGTQY LVVLNQKFTD CFVLVFLDSH LGKTSLTVVF REPFPVQPQD
3410 3420 3430
SESPPAQLVS TYHHLESVIN TACFTLWTRL L
Length:3,431
Mass (Da):377,627
Last modified:February 20, 2007 - v1
Checksum:i2DADDD0F72FC38F7
GO
Isoform 2 (identifier: A2A9C3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2131-2131: Missing.

Show »
Length:3,430
Mass (Da):377,528
Checksum:i933F5956D3382889
GO

Sequence cautioni

The sequence AAH52935.1 differs from that shown.Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAH52935.1 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence GU433214 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti275 – 2751C → S in GU433214 (PubMed:19624305).Curated
Sequence conflicti888 – 8881N → K in GU433214 (PubMed:19624305).Curated
Sequence conflicti1067 – 10671L → C in GU433214 (PubMed:19624305).Curated
Sequence conflicti1192 – 11921L → H in GU433214 (PubMed:19624305).Curated
Sequence conflicti1204 – 12041S → T in GU433214 (PubMed:19624305).Curated
Sequence conflicti1308 – 13081F → S in GU433214 (PubMed:19624305).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2131 – 21311Missing in isoform 2. 1 PublicationVSP_039917

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ998170 mRNA. Translation: ACS91341.1.
GU433214 mRNA. No translation available.
AL627212 Genomic DNA. Translation: CAM15198.1.
BC059842 mRNA. Translation: AAH59842.2.
BC052935 mRNA. Translation: AAH52935.1. Sequence problems.
CCDSiCCDS51283.1. [A2A9C3-1]
RefSeqiNP_937813.3. NM_198170.4. [A2A9C3-1]
UniGeneiMm.415218.

Genome annotation databases

EnsembliENSMUST00000075406; ENSMUSP00000074862; ENSMUSG00000033253. [A2A9C3-1]
GeneIDi230676.
KEGGimmu:230676.
UCSCiuc012djw.2. mouse. [A2A9C3-1]
uc012djx.2. mouse. [A2A9C3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ998170 mRNA. Translation: ACS91341.1.
GU433214 mRNA. No translation available.
AL627212 Genomic DNA. Translation: CAM15198.1.
BC059842 mRNA. Translation: AAH59842.2.
BC052935 mRNA. Translation: AAH52935.1. Sequence problems.
CCDSiCCDS51283.1. [A2A9C3-1]
RefSeqiNP_937813.3. NM_198170.4. [A2A9C3-1]
UniGeneiMm.415218.

3D structure databases

ProteinModelPortaliA2A9C3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231000. 1 interaction.
STRINGi10090.ENSMUSP00000074862.

PTM databases

iPTMnetiA2A9C3.
PhosphoSiteiA2A9C3.

Proteomic databases

EPDiA2A9C3.
MaxQBiA2A9C3.
PaxDbiA2A9C3.
PeptideAtlasiA2A9C3.
PRIDEiA2A9C3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075406; ENSMUSP00000074862; ENSMUSG00000033253. [A2A9C3-1]
GeneIDi230676.
KEGGimmu:230676.
UCSCiuc012djw.2. mouse. [A2A9C3-1]
uc012djx.2. mouse. [A2A9C3-2]

Organism-specific databases

CTDi23334.
MGIiMGI:3033336. Szt2.

Phylogenomic databases

eggNOGiENOG410IE3I. Eukaryota.
ENOG410XTCX. LUCA.
GeneTreeiENSGT00390000018402.
HOGENOMiHOG000231148.
HOVERGENiHBG080139.
InParanoidiA2A9C3.
OMAiDYRAPFL.
OrthoDBiEOG7CNZDW.
PhylomeDBiA2A9C3.
TreeFamiTF333377.

Miscellaneous databases

PROiA2A9C3.
SOURCEiSearch...

Gene expression databases

BgeeiA2A9C3.
ExpressionAtlasiA2A9C3. baseline and differential.
GenevisibleiA2A9C3. MM.

Family and domain databases

InterProiIPR033228. SZT2.
[Graphical view]
PANTHERiPTHR14918. PTHR14918. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "A novel giant peroxisomal superoxide dismutase motif-containing protein."
    Toutzaris D., Lewerenz J., Albrecht P., Jensen L.T., Letz J., Geerts A., Golz S., Methner A.
    Free Radic. Biol. Med. 48:811-820(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INDUCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2675-3431.
    Strain: C57BL/6J and Czech II.
    Tissue: Lung.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Pancreas and Spleen.

Entry informationi

Entry nameiSZT2_MOUSE
AccessioniPrimary (citable) accession number: A2A9C3
Secondary accession number(s): Q6PB77, Q7TSS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: February 20, 2007
Last modified: July 6, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.