##gff-version 3
A2A935	UniProtKB	Chain	1	1275	.	.	.	ID=PRO_0000384377;Note=Histone-lysine N-methyltransferase PRDM16	
A2A935	UniProtKB	Domain	82	211	.	.	.	Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190	
A2A935	UniProtKB	Zinc finger	230	255	.	.	.	Note=C2H2-type 1%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042	
A2A935	UniProtKB	Zinc finger	282	304	.	.	.	Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042	
A2A935	UniProtKB	Zinc finger	310	332	.	.	.	Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042	
A2A935	UniProtKB	Zinc finger	338	361	.	.	.	Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042	
A2A935	UniProtKB	Zinc finger	367	389	.	.	.	Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042	
A2A935	UniProtKB	Zinc finger	395	417	.	.	.	Note=C2H2-type 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042	
A2A935	UniProtKB	Zinc finger	424	446	.	.	.	Note=C2H2-type 7%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042	
A2A935	UniProtKB	Zinc finger	951	973	.	.	.	Note=C2H2-type 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042	
A2A935	UniProtKB	Zinc finger	979	1002	.	.	.	Note=C2H2-type 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042	
A2A935	UniProtKB	Zinc finger	1008	1030	.	.	.	Note=C2H2-type 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042	
A2A935	UniProtKB	Region	1	66	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
A2A935	UniProtKB	Region	592	658	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
A2A935	UniProtKB	Region	680	1038	.	.	.	Note=Interaction with CTBP1%2C CTBP2 and ZNF516;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18483224;Dbxref=PMID:18483224	
A2A935	UniProtKB	Region	740	1275	.	.	.	Note=Mediates interaction with SKI and regulation of TGF-beta signaling;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9HAZ2	
A2A935	UniProtKB	Region	789	838	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
A2A935	UniProtKB	Region	1027	1065	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
A2A935	UniProtKB	Region	1084	1169	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
A2A935	UniProtKB	Compositional bias	603	626	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
A2A935	UniProtKB	Compositional bias	627	646	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
A2A935	UniProtKB	Compositional bias	818	832	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
A2A935	UniProtKB	Compositional bias	1039	1060	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
A2A935	UniProtKB	Compositional bias	1116	1135	.	.	.	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
A2A935	UniProtKB	Alternative sequence	129	129	.	.	.	ID=VSP_038066;Note=In isoform 2. E->EQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334	
A2A935	UniProtKB	Alternative sequence	868	868	.	.	.	ID=VSP_038067;Note=In isoform 2 and isoform 3. Y->YS;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15368895,ECO:0000303|PubMed:15489334;Dbxref=PMID:15368895,PMID:15489334	
A2A935	UniProtKB	Alternative sequence	1174	1176	.	.	.	ID=VSP_038068;Note=In isoform 2. CVE->HMQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334	
A2A935	UniProtKB	Alternative sequence	1177	1275	.	.	.	ID=VSP_038069;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334	
A2A935	UniProtKB	Mutagenesis	805	806	.	.	.	Note=Loss of interaction with CTBP1 and CTBP2 and loss of repression of WAT-specific genes. DL->AS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18483224;Dbxref=PMID:18483224	
A2A935	UniProtKB	Mutagenesis	996	996	.	.	.	Note=Loss of DNA-binding activity but no effect on PRDM16-mediated BAT gene transcription activation. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17618855;Dbxref=PMID:17618855	
A2A935	UniProtKB	Sequence conflict	8	8	.	.	.	Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305	
A2A935	UniProtKB	Sequence conflict	510	510	.	.	.	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305	
A2A935	UniProtKB	Sequence conflict	706	706	.	.	.	Note=G->D;Ontology_term=ECO:0000305;evidence=ECO:0000305	
A2A935	UniProtKB	Sequence conflict	732	732	.	.	.	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305	
A2A935	UniProtKB	Sequence conflict	760	760	.	.	.	Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305