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Protein

PR domain zinc finger protein 16

Gene

Prdm16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. May regulate granulocytes differentiation.4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri230 – 25526C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36124C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri367 – 38923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri395 – 41723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 7; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri951 – 97323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri979 – 100224C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1008 – 103023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • activating transcription factor binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding Source: UniProtKB
  • SMAD binding Source: MGI
  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

  • brown fat cell differentiation Source: UniProtKB
  • negative regulation of granulocyte differentiation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
  • neurogenesis Source: MGI
  • palate development Source: MGI
  • positive regulation of brown fat cell differentiation Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of cellular respiration Source: UniProtKB
  • somatic stem cell maintenance Source: MGI
  • stem cell maintenance Source: MGI
  • tongue development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • white fat cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_278269. PKMTs methylate histone lysines.

Names & Taxonomyi

Protein namesi
Recommended name:
PR domain zinc finger protein 16Curated
Alternative name(s):
PR domain-containing protein 16Curated
Transcription factor MEL1Curated
Short name:
MDS1/EVI1-like gene 11 Publication
Gene namesi
Name:Prdm16Imported
Synonyms:Kiaa1675Curated, Mel11 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1917923. Prdm16.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
  • transcriptional repressor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice die at birth but embryos display altered brown adipose tissue differentiation.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi805 – 8062DL → AS: Loss of interaction with CTBP1 and CTBP2 and loss of repression of WAT-specific genes. 1 Publication
Mutagenesisi996 – 9961R → Q: Loss of DNA-binding activity but no effect on PRDM16-mediated BAT gene transcription activation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12751275PR domain zinc finger protein 16PRO_0000384377Add
BLAST

Proteomic databases

MaxQBiA2A935.
PaxDbiA2A935.
PRIDEiA2A935.

PTM databases

PhosphoSiteiA2A935.

Expressioni

Tissue specificityi

Enriched in BAT compared to WAT. Detected in heart, lung, kidney and brain. Expressed in nuclei of cardiomyocytes.2 Publications

Developmental stagei

Expressed at E12.5, E13.5 and E14.5. Expressed in orofacial tissues, heart, liver, brain and limb bud. At E13.5, expressed throughout the ventricular myocardium, including endocardium and epicardium.2 Publications

Gene expression databases

BgeeiA2A935.
ExpressionAtlasiA2A935. baseline and differential.
GenevestigatoriA2A935.

Interactioni

Subunit structurei

Interacts with CEBPA, CEBPB and CEBPD; the interaction is direct (PubMed:19641492). Interacts with PPARG and PPARA; controls brown adipocytes (PubMed:18719582). Interacts with CTBP1 and CTBP2; represses the expression of WAT-specific genes (PubMed:18483224). Interacts with PPARGC1A and PPARGC1B; interaction with PPARGC1A or PPARGC1B activates the transcription of BAT-specific gene (PubMed:17618855, PubMed:18483224). Interacts with HDAC1, SKI and SMAD2; the interaction with SKI promotes the recruitment of SMAD3-HDAC1 complex on the promoter of TGF-beta target genes (Probable). Interacts with ZNF516; the interaction is direct and may play a role in the transcription of brown adipose tissue-specific gene (PubMed:25578880).By similarity1 Publication5 Publications

Protein-protein interaction databases

BioGridi214194. 5 interactions.
DIPiDIP-60593N.
IntActiA2A935. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliA2A935.
SMRiA2A935. Positions 74-208, 280-444, 947-1057.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 211130SETPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni680 – 1038359Interaction with CTBP1, CTBP2 and ZNF5161 PublicationAdd
BLAST
Regioni740 – 1275536Mediates interaction with SKI and regulation of TGF-beta signalingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi460 – 55899Pro-richAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri230 – 25526C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36124C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri367 – 38923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri395 – 41723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 7; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri951 – 97323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri979 – 100224C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1008 – 103023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00530000063676.
HOGENOMiHOG000231144.
InParanoidiA2A935.
OrthoDBiEOG72G16H.
TreeFamiTF315309.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR030413. Evi1/Prdm16.
IPR030414. PRDM16.
IPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR24393. PTHR24393. 1 hit.
PTHR24393:SF4. PTHR24393:SF4. 1 hit.
PfamiPF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2A935-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSKARARKL AKSDGDVVNN MYEPDPDLLA GQSAEEETED GILSPIPMGP
60 70 80 90 100
PSPFPTSEDF TPKEGSPYEA PVYIPEDIPI PPDFELRESS IPGAGLGIWA
110 120 130 140 150
KRKMEIGERF GPYVVTPRAA LKEADFGWEM LTDTEVSSQE SCIKKQISED
160 170 180 190 200
LGSEKFCVDA NQAGSGSWLK YIRVACSCDD QNLAMCQINE QIYYKVIKDI
210 220 230 240 250
EPGEELLVHV KEGAYSLGVM APSLDEDPTF RCDECDELFQ CRLDLRRHKK
260 270 280 290 300
YACSSAGAQL YEGLGEELKP EGLGVGSDGQ AHECKDCERM FPNKYSLEQH
310 320 330 340 350
MIVHTEEREY KCDQCPKAFN WKSNLIRHQM SHDSGKRFEC ENCVKVFTDP
360 370 380 390 400
SNLQRHIRSQ HVGARAHACP DCGKTFATSS GLKQHKHIHS TVKPFICEVC
410 420 430 440 450
HKSYTQFSNL CRHKRMHADC RTQIKCKDCG QMFSTTSSLN KHRRFCEGKN
460 470 480 490 500
HYTPGSIFTP GLPLTPSPMM DKTKPSPTLN HGGLGFSEYF PSRPHPGSLP
510 520 530 540 550
FSAAPPAFPA LTPGFPGIFP PSLYPRPPLL PPTPLLKSPL NHAQDAKLPS
560 570 580 590 600
PLGNPALPLV SAVSNSSQGA TAATGSEEKF DGRLEDAYAE KVKNRSPDMS
610 620 630 640 650
DGSDFEDINT TTGTDLDTTT GTGSDLDSDL DSDRDKGKDK GKPVESKPEF
660 670 680 690 700
GGASVPPGAM NSVAEVPAFY SQHSFFPPPE EQLLTASGAA GDSIKAIASI
710 720 730 740 750
AEKYFGPGFM SMQEKKLGSL PYHSVFPFQF LPNFPHSLYP FTDRALAHNL
760 770 780 790 800
LVKAEPKSPR DALKVGGPSA ECPFDLTTKP KEAKPALLAP KVPLIPSSGE
810 820 830 840 850
EQPLDLSIGS RARASQNGGG REPRKNHVYG ERKPGVSEGL PKVCPAQLPQ
860 870 880 890 900
QPSLHYAKPS PFFMDPIYRV EKRKVADPVG VLKEKYLRPS PLLFHPQMSA
910 920 930 940 950
IETMTEKLES FAAMKADSGS SLQPLPHHPF NFRSPPPTLS DPILRKGKER
960 970 980 990 1000
YTCRYCGKIF PRSANLTRHL RTHTGEQPYR CKYCDRSFSI SSNLQRHVRN
1010 1020 1030 1040 1050
IHNKEKPFKC HLCNRCFGQQ TNLDRHLKKH EHEGAPVSQH SGVLTNHLGT
1060 1070 1080 1090 1100
SASSPTSESD NHALLDEKED SYFSEIRNFI ANSEMNQAST RMDKRPEIQD
1110 1120 1130 1140 1150
LDSNPPCPGS ASAKPEDVEE EEEEELEEED DDSLAGKSQE DTVSPTPEPQ
1160 1170 1180 1190 1200
GVYEDEEDEE PPSLTMGFDH TRRCVEERGG GLLALEPTPT FGKGLDLRRA
1210 1220 1230 1240 1250
AEEAFEVKDV LNSTLDSEVL KQTLYRQAKN QAYAMMLSLS EDTPLHAPSQ
1260 1270
SSLDAWLNIT GPSSESGAFN PINHL
Length:1,275
Mass (Da):140,858
Last modified:February 5, 2008 - v1
Checksum:i2F1F6B6C3EBFEC10
GO
Isoform 2 (identifier: A2A935-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-129: E → EQ
     868-868: Y → YS
     1174-1176: CVE → HMQ
     1177-1275: Missing.

Note: No experimental confirmation available.

Show »
Length:1,178
Mass (Da):130,427
Checksum:i9B050B76A7B9E29F
GO
Isoform 3 (identifier: A2A935-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     868-868: Y → YS

Note: No experimental confirmation available.

Show »
Length:1,276
Mass (Da):140,945
Checksum:i8A716E6E065ADEA4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81R → K in BAC79382 (PubMed:12816872).Curated
Sequence conflicti510 – 5101A → T in BAC79382 (PubMed:12816872).Curated
Sequence conflicti706 – 7061G → D in BAC79382 (PubMed:12816872).Curated
Sequence conflicti732 – 7321P → L in BAC79382 (PubMed:12816872).Curated
Sequence conflicti760 – 7601R → Q in BAC79382 (PubMed:12816872).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei129 – 1291E → EQ in isoform 2. 1 PublicationVSP_038066
Alternative sequencei868 – 8681Y → YS in isoform 2 and isoform 3. 2 PublicationsVSP_038067
Alternative sequencei1174 – 11763CVE → HMQ in isoform 2. 1 PublicationVSP_038068
Alternative sequencei1177 – 127599Missing in isoform 2. 1 PublicationVSP_038069Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB078338 mRNA. Translation: BAC79382.1.
AL627226
, AL611950, AL627123, AL627127 Genomic DNA. Translation: CAM14956.1.
AL627226
, AL611950, AL627123, AL627127 Genomic DNA. Translation: CAM14959.1.
AL627123
, AL611950, AL627127, AL627226 Genomic DNA. Translation: CAM21844.1.
AL627123
, AL611950, AL627127, AL627226 Genomic DNA. Translation: CAM21845.1.
AL627127
, AL611950, AL627123, AL627226 Genomic DNA. Translation: CAM22275.1.
AL627127
, AL611950, AL627123, AL627226 Genomic DNA. Translation: CAM22278.1.
AL611950
, AL627123, AL627127, AL627226 Genomic DNA. Translation: CAM24998.1.
AL611950
, AL627123, AL627127, AL627226 Genomic DNA. Translation: CAM25001.1.
BC059838 mRNA. Translation: AAH59838.1.
AK173230 mRNA. Translation: BAD32508.1.
CCDSiCCDS38989.1. [A2A935-1]
CCDS71532.1. [A2A935-2]
RefSeqiNP_001277955.1. NM_001291026.1.
NP_001277958.1. NM_001291029.1. [A2A935-2]
NP_081780.3. NM_027504.3. [A2A935-1]
XP_006539236.1. XM_006539173.2. [A2A935-3]
UniGeneiMm.257785.

Genome annotation databases

EnsembliENSMUST00000030902; ENSMUSP00000030902; ENSMUSG00000039410. [A2A935-1]
ENSMUST00000070313; ENSMUSP00000064546; ENSMUSG00000039410. [A2A935-2]
GeneIDi70673.
KEGGimmu:70673.
UCSCiuc008wbu.1. mouse. [A2A935-1]
uc008wbx.1. mouse. [A2A935-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB078338 mRNA. Translation: BAC79382.1.
AL627226
, AL611950, AL627123, AL627127 Genomic DNA. Translation: CAM14956.1.
AL627226
, AL611950, AL627123, AL627127 Genomic DNA. Translation: CAM14959.1.
AL627123
, AL611950, AL627127, AL627226 Genomic DNA. Translation: CAM21844.1.
AL627123
, AL611950, AL627127, AL627226 Genomic DNA. Translation: CAM21845.1.
AL627127
, AL611950, AL627123, AL627226 Genomic DNA. Translation: CAM22275.1.
AL627127
, AL611950, AL627123, AL627226 Genomic DNA. Translation: CAM22278.1.
AL611950
, AL627123, AL627127, AL627226 Genomic DNA. Translation: CAM24998.1.
AL611950
, AL627123, AL627127, AL627226 Genomic DNA. Translation: CAM25001.1.
BC059838 mRNA. Translation: AAH59838.1.
AK173230 mRNA. Translation: BAD32508.1.
CCDSiCCDS38989.1. [A2A935-1]
CCDS71532.1. [A2A935-2]
RefSeqiNP_001277955.1. NM_001291026.1.
NP_001277958.1. NM_001291029.1. [A2A935-2]
NP_081780.3. NM_027504.3. [A2A935-1]
XP_006539236.1. XM_006539173.2. [A2A935-3]
UniGeneiMm.257785.

3D structure databases

ProteinModelPortaliA2A935.
SMRiA2A935. Positions 74-208, 280-444, 947-1057.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214194. 5 interactions.
DIPiDIP-60593N.
IntActiA2A935. 1 interaction.

PTM databases

PhosphoSiteiA2A935.

Proteomic databases

MaxQBiA2A935.
PaxDbiA2A935.
PRIDEiA2A935.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030902; ENSMUSP00000030902; ENSMUSG00000039410. [A2A935-1]
ENSMUST00000070313; ENSMUSP00000064546; ENSMUSG00000039410. [A2A935-2]
GeneIDi70673.
KEGGimmu:70673.
UCSCiuc008wbu.1. mouse. [A2A935-1]
uc008wbx.1. mouse. [A2A935-2]

Organism-specific databases

CTDi63976.
MGIiMGI:1917923. Prdm16.
RougeiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00530000063676.
HOGENOMiHOG000231144.
InParanoidiA2A935.
OrthoDBiEOG72G16H.
TreeFamiTF315309.

Enzyme and pathway databases

ReactomeiREACT_278269. PKMTs methylate histone lysines.

Miscellaneous databases

ChiTaRSiPrdm16. mouse.
NextBioi332055.
PROiA2A935.
SOURCEiSearch...

Gene expression databases

BgeeiA2A935.
ExpressionAtlasiA2A935. baseline and differential.
GenevestigatoriA2A935.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR030413. Evi1/Prdm16.
IPR030414. PRDM16.
IPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR24393. PTHR24393. 1 hit.
PTHR24393:SF4. PTHR24393:SF4. 1 hit.
PfamiPF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation."
    Nishikata I., Sasaki H., Iga M., Tateno Y., Imayoshi S., Asou N., Nakamura T., Morishita K.
    Blood 102:3323-3332(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 570-1275 (ISOFORM 3).
    Tissue: Pancreatic islet.
  5. "PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue."
    Warner D.R., Horn K.H., Mudd L., Webb C.L., Greene R.M., Pisano M.M.
    Biochim. Biophys. Acta 1773:814-820(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SMAD3, DEVELOPMENTAL STAGE.
  6. Cited for: FUNCTION, INTERACTION WITH PPARGC1A AND PPARGC1B, MUTAGENESIS OF ARG-996, TISSUE SPECIFICITY.
  7. "Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex."
    Kajimura S., Seale P., Tomaru T., Erdjument-Bromage H., Cooper M.P., Ruas J.L., Chin S., Tempst P., Lazar M.A., Spiegelman B.M.
    Genes Dev. 22:1397-1409(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CTBP1; CTBP2; PPARGC1A AND PPARGC1B, SUBCELLULAR LOCATION, MUTAGENESIS OF 805-ASP-LEU-806, REGION.
  8. Cited for: FUNCTION, INTERACTION WITH PPARA AND PPARG, DISRUPTION PHENOTYPE.
  9. "Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex."
    Kajimura S., Seale P., Kubota K., Lunsford E., Frangioni J.V., Gygi S.P., Spiegelman B.M.
    Nature 460:1154-1158(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CEBPA; CEBPB AND CEBPD.
  10. Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
  11. "Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat."
    Dempersmier J., Sambeat A., Gulyaeva O., Paul S.M., Hudak C.S., Raposo H.F., Kwan H.Y., Kang C., Wong R.H., Sul H.S.
    Mol. Cell 57:235-246(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZNF516, REGION.

Entry informationi

Entry nameiPRD16_MOUSE
AccessioniPrimary (citable) accession number: A2A935
Secondary accession number(s): Q69ZD6, Q6PB79, Q7TPF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: February 5, 2008
Last modified: May 27, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.