PR domain zinc finger protein 16 - Mus musculus (Mouse)

Preferred order of sections

Names and origin

Protein names

Recommended name:
PR domain zinc finger protein 16

Alternative name(s):
PR domain-containing protein 16
Transcription factor MEL1
Short name=MDS1/EVI1-like gene 1

Gene names

Name:	Prdm16
Synonyms:	Kiaa1675, Mel1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1275 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. May regulate granulocytes differentiation. Ref.6 Ref.7 Ref.8 Ref.9
Subunit structure	Interacts with HDAC1, SKI, SMAD2 and SMAD3; the interaction with SKI promotes the recruitment of SMAD3-HDAC1 complex on the promoter of TGF-beta target genes By similarity. Interacts with CEBPA, CEBPB and CEBPD; the interaction is direct. Interacts with PPARG and PPARA; controls brown adipocytes differentiation. Interacts with CTBP1 and CTBP2; represses the expression of WAT-specific genes. Interacts with PPARGC1A and PPARGC1B; interaction with PPARGC1A or PPARGC1B activates the transcription of BAT-specific genes. Interacts with SMAD3. Ref.5 Ref.6 Ref.7 Ref.8 Ref.9
Subcellular location	Nucleus Ref.7.
Tissue specificity	Enriched in BAT compared to WAT. Detected in heart, lung, kidney and brain. Ref.6
Developmental stage	Expressed at E12.5, E13.5 and E14.5. Expressed in orofacial tissues, heart, liver, brain and limb bud. Ref.5
Disruption phenotype	Mice die at birth but embryos display altered brown adipose tissue differentiation. Ref.8
Sequence similarities	Contains 10 C2H2-type zinc fingers. Contains 1 SET domain.

Ontologies

Keywords
Biological process	Differentiation Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brown fat cell differentiation Inferred from direct assay Ref.7 Ref.8 Ref.9. Source: UniProtKB negative regulation of granulocyte differentiation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of transforming growth factor beta receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB neurogenesis Inferred from direct assay PubMed 19050759. Source: MGI palate development Inferred from mutant phenotype PubMed 20007998. Source: MGI positive regulation of transcription, DNA-dependent Inferred from direct assay Ref.7 Ref.9. Source: UniProtKB regulation of cellular respiration Inferred from direct assay Ref.6 Ref.7. Source: UniProtKB somatic stem cell maintenance Inferred from direct assay PubMed 19379700. Source: MGI tongue development Inferred from mutant phenotype PubMed 20007998. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW white fat cell differentiation Inferred from direct assay Ref.7. Source: UniProtKB
Cellular_component	transcriptional repressor complex Inferred from direct assay Ref.7. Source: UniProtKB
Molecular_function	sequence-specific DNA binding Inferred from direct assay Ref.6. Source: UniProtKB transcription coactivator activity Inferred from direct assay Ref.6 Ref.8. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A2A935-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A2A935-2) The sequence of this isoform differs from the canonical sequence as follows: 129-129: E → EQ 868-868: Y → YS 1174-1176: CVE → HMQ 1177-1275: Missing.
Note: No experimental confirmation available.

Isoform 3 (identifier: A2A935-3) The sequence of this isoform differs from the canonical sequence as follows: 868-868: Y → YS
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1275

1275

PR domain zinc finger protein 16

PRO_0000384377

Regions

Domain

83 – 215

133

SET

Zinc finger

230 – 255

26

C2H2-type 1; degenerate

Zinc finger

282 – 304

23

C2H2-type 2

Zinc finger

310 – 332

23

C2H2-type 3

Zinc finger

338 – 361

24

C2H2-type 4

Zinc finger

367 – 389

23

C2H2-type 5

Zinc finger

395 – 417

23

C2H2-type 6

Zinc finger

424 – 446

23

C2H2-type 7; atypical

Zinc finger

951 – 973

23

C2H2-type 8

Zinc finger

979 – 1002

24

C2H2-type 9

Zinc finger

1008 – 1030

23

C2H2-type 10

Region

680 – 1038

359

Interaction with CTBP1 and CTBP2

Region

740 – 1275

536

Mediates interaction with SKI and regulation of TGF-beta signaling By similarity

Compositional bias

460 – 558

99

Pro-rich

Natural variations

Alternative sequence

129

1

E → EQ in isoform 2.

VSP_038066

Alternative sequence

868

1

Y → YS in isoform 2 and isoform 3.

VSP_038067

Alternative sequence

1174 – 1176

3

CVE → HMQ in isoform 2.

VSP_038068

Alternative sequence

1177 – 1275

99

Missing in isoform 2.

VSP_038069

Experimental info

Mutagenesis

805 – 806

2

DL → AS: Loss of interaction with CTBP1 and CTBP2 and loss of repression of WAT-specific genes. Ref.7

Mutagenesis

996

1

R → Q: Loss of DNA-binding activity but no effect on PRDM16-mediated BAT gene transcription activation. Ref.6 Ref.7

Sequence conflict

8

1

R → K in BAC79382. Ref.1

Sequence conflict

510

1

A → T in BAC79382. Ref.1

Sequence conflict

706

1

G → D in BAC79382. Ref.1

Sequence conflict

732

1

P → L in BAC79382. Ref.1

Sequence conflict

760

1

R → Q in BAC79382. Ref.1

Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 2F1F6B6C3EBFEC10 Show »	FASTA	1,275	140,858
10 20 30 40 50 60 MRSKARARKL AKSDGDVVNN MYEPDPDLLA GQSAEEETED GILSPIPMGP PSPFPTSEDF 70 80 90 100 110 120 TPKEGSPYEA PVYIPEDIPI PPDFELRESS IPGAGLGIWA KRKMEIGERF GPYVVTPRAA 130 140 150 160 170 180 LKEADFGWEM LTDTEVSSQE SCIKKQISED LGSEKFCVDA NQAGSGSWLK YIRVACSCDD 190 200 210 220 230 240 QNLAMCQINE QIYYKVIKDI EPGEELLVHV KEGAYSLGVM APSLDEDPTF RCDECDELFQ 250 260 270 280 290 300 CRLDLRRHKK YACSSAGAQL YEGLGEELKP EGLGVGSDGQ AHECKDCERM FPNKYSLEQH 310 320 330 340 350 360 MIVHTEEREY KCDQCPKAFN WKSNLIRHQM SHDSGKRFEC ENCVKVFTDP SNLQRHIRSQ 370 380 390 400 410 420 HVGARAHACP DCGKTFATSS GLKQHKHIHS TVKPFICEVC HKSYTQFSNL CRHKRMHADC 430 440 450 460 470 480 RTQIKCKDCG QMFSTTSSLN KHRRFCEGKN HYTPGSIFTP GLPLTPSPMM DKTKPSPTLN 490 500 510 520 530 540 HGGLGFSEYF PSRPHPGSLP FSAAPPAFPA LTPGFPGIFP PSLYPRPPLL PPTPLLKSPL 550 560 570 580 590 600 NHAQDAKLPS PLGNPALPLV SAVSNSSQGA TAATGSEEKF DGRLEDAYAE KVKNRSPDMS 610 620 630 640 650 660 DGSDFEDINT TTGTDLDTTT GTGSDLDSDL DSDRDKGKDK GKPVESKPEF GGASVPPGAM 670 680 690 700 710 720 NSVAEVPAFY SQHSFFPPPE EQLLTASGAA GDSIKAIASI AEKYFGPGFM SMQEKKLGSL 730 740 750 760 770 780 PYHSVFPFQF LPNFPHSLYP FTDRALAHNL LVKAEPKSPR DALKVGGPSA ECPFDLTTKP 790 800 810 820 830 840 KEAKPALLAP KVPLIPSSGE EQPLDLSIGS RARASQNGGG REPRKNHVYG ERKPGVSEGL 850 860 870 880 890 900 PKVCPAQLPQ QPSLHYAKPS PFFMDPIYRV EKRKVADPVG VLKEKYLRPS PLLFHPQMSA 910 920 930 940 950 960 IETMTEKLES FAAMKADSGS SLQPLPHHPF NFRSPPPTLS DPILRKGKER YTCRYCGKIF 970 980 990 1000 1010 1020 PRSANLTRHL RTHTGEQPYR CKYCDRSFSI SSNLQRHVRN IHNKEKPFKC HLCNRCFGQQ 1030 1040 1050 1060 1070 1080 TNLDRHLKKH EHEGAPVSQH SGVLTNHLGT SASSPTSESD NHALLDEKED SYFSEIRNFI 1090 1100 1110 1120 1130 1140 ANSEMNQAST RMDKRPEIQD LDSNPPCPGS ASAKPEDVEE EEEEELEEED DDSLAGKSQE 1150 1160 1170 1180 1190 1200 DTVSPTPEPQ GVYEDEEDEE PPSLTMGFDH TRRCVEERGG GLLALEPTPT FGKGLDLRRA 1210 1220 1230 1240 1250 1260 AEEAFEVKDV LNSTLDSEVL KQTLYRQAKN QAYAMMLSLS EDTPLHAPSQ SSLDAWLNIT 1270 GPSSESGAFN PINHL « Hide
Isoform 2 [UniParc]. Checksum: 9B050B76A7B9E29F Show »	FASTA	1,178	130,427
10 20 30 40 50 60 MRSKARARKL AKSDGDVVNN MYEPDPDLLA GQSAEEETED GILSPIPMGP PSPFPTSEDF 70 80 90 100 110 120 TPKEGSPYEA PVYIPEDIPI PPDFELRESS IPGAGLGIWA KRKMEIGERF GPYVVTPRAA 130 140 150 160 170 180 LKEADFGWEQ MLTDTEVSSQ ESCIKKQISE DLGSEKFCVD ANQAGSGSWL KYIRVACSCD 190 200 210 220 230 240 DQNLAMCQIN EQIYYKVIKD IEPGEELLVH VKEGAYSLGV MAPSLDEDPT FRCDECDELF 250 260 270 280 290 300 QCRLDLRRHK KYACSSAGAQ LYEGLGEELK PEGLGVGSDG QAHECKDCER MFPNKYSLEQ 310 320 330 340 350 360 HMIVHTEERE YKCDQCPKAF NWKSNLIRHQ MSHDSGKRFE CENCVKVFTD PSNLQRHIRS 370 380 390 400 410 420 QHVGARAHAC PDCGKTFATS SGLKQHKHIH STVKPFICEV CHKSYTQFSN LCRHKRMHAD 430 440 450 460 470 480 CRTQIKCKDC GQMFSTTSSL NKHRRFCEGK NHYTPGSIFT PGLPLTPSPM MDKTKPSPTL 490 500 510 520 530 540 NHGGLGFSEY FPSRPHPGSL PFSAAPPAFP ALTPGFPGIF PPSLYPRPPL LPPTPLLKSP 550 560 570 580 590 600 LNHAQDAKLP SPLGNPALPL VSAVSNSSQG ATAATGSEEK FDGRLEDAYA EKVKNRSPDM 610 620 630 640 650 660 SDGSDFEDIN TTTGTDLDTT TGTGSDLDSD LDSDRDKGKD KGKPVESKPE FGGASVPPGA 670 680 690 700 710 720 MNSVAEVPAF YSQHSFFPPP EEQLLTASGA AGDSIKAIAS IAEKYFGPGF MSMQEKKLGS 730 740 750 760 770 780 LPYHSVFPFQ FLPNFPHSLY PFTDRALAHN LLVKAEPKSP RDALKVGGPS AECPFDLTTK 790 800 810 820 830 840 PKEAKPALLA PKVPLIPSSG EEQPLDLSIG SRARASQNGG GREPRKNHVY GERKPGVSEG 850 860 870 880 890 900 LPKVCPAQLP QQPSLHYAKP SPFFMDPIYS RVEKRKVADP VGVLKEKYLR PSPLLFHPQM 910 920 930 940 950 960 SAIETMTEKL ESFAAMKADS GSSLQPLPHH PFNFRSPPPT LSDPILRKGK ERYTCRYCGK 970 980 990 1000 1010 1020 IFPRSANLTR HLRTHTGEQP YRCKYCDRSF SISSNLQRHV RNIHNKEKPF KCHLCNRCFG 1030 1040 1050 1060 1070 1080 QQTNLDRHLK KHEHEGAPVS QHSGVLTNHL GTSASSPTSE SDNHALLDEK EDSYFSEIRN 1090 1100 1110 1120 1130 1140 FIANSEMNQA STRMDKRPEI QDLDSNPPCP GSASAKPEDV EEEEEEELEE EDDDSLAGKS 1150 1160 1170 QEDTVSPTPE PQGVYEDEED EEPPSLTMGF DHTRRHMQ « Hide
Isoform 3 [UniParc]. Checksum: 8A716E6E065ADEA4 Show »	FASTA	1,276	140,945
10 20 30 40 50 60 MRSKARARKL AKSDGDVVNN MYEPDPDLLA GQSAEEETED GILSPIPMGP PSPFPTSEDF 70 80 90 100 110 120 TPKEGSPYEA PVYIPEDIPI PPDFELRESS IPGAGLGIWA KRKMEIGERF GPYVVTPRAA 130 140 150 160 170 180 LKEADFGWEM LTDTEVSSQE SCIKKQISED LGSEKFCVDA NQAGSGSWLK YIRVACSCDD 190 200 210 220 230 240 QNLAMCQINE QIYYKVIKDI EPGEELLVHV KEGAYSLGVM APSLDEDPTF RCDECDELFQ 250 260 270 280 290 300 CRLDLRRHKK YACSSAGAQL YEGLGEELKP EGLGVGSDGQ AHECKDCERM FPNKYSLEQH 310 320 330 340 350 360 MIVHTEEREY KCDQCPKAFN WKSNLIRHQM SHDSGKRFEC ENCVKVFTDP SNLQRHIRSQ 370 380 390 400 410 420 HVGARAHACP DCGKTFATSS GLKQHKHIHS TVKPFICEVC HKSYTQFSNL CRHKRMHADC 430 440 450 460 470 480 RTQIKCKDCG QMFSTTSSLN KHRRFCEGKN HYTPGSIFTP GLPLTPSPMM DKTKPSPTLN 490 500 510 520 530 540 HGGLGFSEYF PSRPHPGSLP FSAAPPAFPA LTPGFPGIFP PSLYPRPPLL PPTPLLKSPL 550 560 570 580 590 600 NHAQDAKLPS PLGNPALPLV SAVSNSSQGA TAATGSEEKF DGRLEDAYAE KVKNRSPDMS 610 620 630 640 650 660 DGSDFEDINT TTGTDLDTTT GTGSDLDSDL DSDRDKGKDK GKPVESKPEF GGASVPPGAM 670 680 690 700 710 720 NSVAEVPAFY SQHSFFPPPE EQLLTASGAA GDSIKAIASI AEKYFGPGFM SMQEKKLGSL 730 740 750 760 770 780 PYHSVFPFQF LPNFPHSLYP FTDRALAHNL LVKAEPKSPR DALKVGGPSA ECPFDLTTKP 790 800 810 820 830 840 KEAKPALLAP KVPLIPSSGE EQPLDLSIGS RARASQNGGG REPRKNHVYG ERKPGVSEGL 850 860 870 880 890 900 PKVCPAQLPQ QPSLHYAKPS PFFMDPIYSR VEKRKVADPV GVLKEKYLRP SPLLFHPQMS 910 920 930 940 950 960 AIETMTEKLE SFAAMKADSG SSLQPLPHHP FNFRSPPPTL SDPILRKGKE RYTCRYCGKI 970 980 990 1000 1010 1020 FPRSANLTRH LRTHTGEQPY RCKYCDRSFS ISSNLQRHVR NIHNKEKPFK CHLCNRCFGQ 1030 1040 1050 1060 1070 1080 QTNLDRHLKK HEHEGAPVSQ HSGVLTNHLG TSASSPTSES DNHALLDEKE DSYFSEIRNF 1090 1100 1110 1120 1130 1140 IANSEMNQAS TRMDKRPEIQ DLDSNPPCPG SASAKPEDVE EEEEEELEEE DDDSLAGKSQ 1150 1160 1170 1180 1190 1200 EDTVSPTPEP QGVYEDEEDE EPPSLTMGFD HTRRCVEERG GGLLALEPTP TFGKGLDLRR 1210 1220 1230 1240 1250 1260 AAEEAFEVKD VLNSTLDSEV LKQTLYRQAK NQAYAMMLSL SEDTPLHAPS QSSLDAWLNI 1270 TGPSSESGAF NPINHL « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation." Nishikata I., Sasaki H., Iga M., Tateno Y., Imayoshi S., Asou N., Nakamura T., Morishita K. Blood 102:3323-3332(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Placenta.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6. Tissue: Brain.
[4]	"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H. DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 570-1275 (ISOFORM 3). Tissue: Pancreatic islet.
[5]	"PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue." Warner D.R., Horn K.H., Mudd L., Webb C.L., Greene R.M., Pisano M.M. Biochim. Biophys. Acta 1773:814-820(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SMAD3, DEVELOPMENTAL STAGE.
[6]	"Transcriptional control of brown fat determination by PRDM16." Seale P., Kajimura S., Yang W., Chin S., Rohas L.M., Uldry M., Tavernier G., Langin D., Spiegelman B.M. Cell Metab. 6:38-54(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH PPARGC1A AND PPARGC1B, MUTAGENESIS OF ARG-996, TISSUE SPECIFICITY.
[7]	"Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex." Kajimura S., Seale P., Tomaru T., Erdjument-Bromage H., Cooper M.P., Ruas J.L., Chin S., Tempst P., Lazar M.A., Spiegelman B.M. Genes Dev. 22:1397-1409(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CTBP1; CTBP2; PPARGC1A AND PPARGC1B, SUBCELLULAR LOCATION, MUTAGENESIS OF 805-ASP-LEU-806.
[8]	"PRDM16 controls a brown fat/skeletal muscle switch." Seale P., Bjork B., Yang W., Kajimura S., Chin S., Kuang S., Scime A., Devarakonda S., Conroe H.M., Erdjument-Bromage H., Tempst P., Rudnicki M.A., Beier D.R., Spiegelman B.M. Nature 454:961-967(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH PPARA AND PPARG, DISRUPTION PHENOTYPE.
[9]	"Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex." Kajimura S., Seale P., Kubota K., Lunsford E., Frangioni J.V., Gygi S.P., Spiegelman B.M. Nature 460:1154-1158(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CEBPA; CEBPB AND CEBPD.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB078338 mRNA. Translation: BAC79382.1. AL627226 , AL611950, AL627123, AL627127 Genomic DNA. Translation: CAM14956.1. AL627226 , AL611950, AL627123, AL627127 Genomic DNA. Translation: CAM14959.1. AL627123 , AL611950, AL627127, AL627226 Genomic DNA. Translation: CAM21844.1. AL627123 , AL611950, AL627127, AL627226 Genomic DNA. Translation: CAM21845.1. AL627127 , AL611950, AL627123, AL627226 Genomic DNA. Translation: CAM22275.1. AL627127 , AL611950, AL627123, AL627226 Genomic DNA. Translation: CAM22278.1. AL611950 , AL627123, AL627127, AL627226 Genomic DNA. Translation: CAM24998.1. AL611950 , AL627123, AL627127, AL627226 Genomic DNA. Translation: CAM25001.1. BC059838 mRNA. Translation: AAH59838.1. AK173230 mRNA. Translation: BAD32508.1.
IPI	IPI00223243. IPI00648809. IPI00944796.
RefSeq	NP_081780.3. NM_027504.3.
UniGene	Mm.257785.
3D structure databases
ProteinModelPortal	A2A935.
SMR	A2A935. Positions 74-208, 280-444, 947-1057.
ModBase	Search...
Protein-protein interaction databases
IntAct	A2A935. 1 interaction.
PTM databases
PhosphoSite	A2A935.
Proteomic databases
PaxDb	A2A935.
PRIDE	A2A935.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000030902; ENSMUSP00000030902; ENSMUSG00000039410. ENSMUST00000070313; ENSMUSP00000064546; ENSMUSG00000039410.
GeneID	70673.
KEGG	mmu:70673.
UCSC	uc008wbu.1. mouse. uc008wbx.1. mouse.
Organism-specific databases
CTD	63976.
MGI	MGI:1917923. Prdm16.
Rouge	Search...
Phylogenomic databases
eggNOG	COG5048.
GeneTree	ENSGT00530000063676.
HOGENOM	HOG000231144.
InParanoid	Q69ZD6.
OrthoDB	EOG4MSCXH.
Gene expression databases
ArrayExpress	A2A935.
Bgee	A2A935.
Genevestigator	A2A935.
Family and domain databases
Gene3D	3.30.160.60. 8 hits.
InterPro	IPR001214. SET_dom. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF00096. zf-C2H2. 4 hits. [Graphical view]
SMART	SM00317. SET. 1 hit. SM00355. ZnF_C2H2. 10 hits. [Graphical view]
PROSITE	PS50280. SET. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 8 hits. PS50157. ZINC_FINGER_C2H2_2. 10 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PRDM16. mouse.
NextBio	332055.
SOURCE	Search...

Entry information

Entry name

PRD16_MOUSE

Accession

Primary (citable) accession number: A2A935
Secondary accession number(s): Q69ZD6, Q6PB79, Q7TPF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	February 5, 2008
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents