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A2A935

- PRD16_MOUSE

UniProt

A2A935 - PRD16_MOUSE

Protein

PR domain zinc finger protein 16

Gene

Prdm16

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. May regulate granulocytes differentiation.4 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri230 – 25526C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri282 – 30423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri310 – 33223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri338 – 36124C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri367 – 38923C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri395 – 41723C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri424 – 44623C2H2-type 7; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri951 – 97323C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri979 – 100224C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1008 – 103023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. sequence-specific DNA binding Source: UniProtKB
    4. SMAD binding Source: MGI
    5. transcription coactivator activity Source: UniProtKB

    GO - Biological processi

    1. brown fat cell differentiation Source: UniProtKB
    2. negative regulation of granulocyte differentiation Source: UniProtKB
    3. negative regulation of transcription, DNA-templated Source: UniProtKB
    4. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    5. negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
    6. neurogenesis Source: MGI
    7. palate development Source: MGI
    8. positive regulation of transcription, DNA-templated Source: UniProtKB
    9. regulation of cellular respiration Source: UniProtKB
    10. somatic stem cell maintenance Source: MGI
    11. tongue development Source: MGI
    12. transcription, DNA-templated Source: UniProtKB-KW
    13. white fat cell differentiation Source: UniProtKB

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PR domain zinc finger protein 16
    Alternative name(s):
    PR domain-containing protein 16
    Transcription factor MEL1
    Short name:
    MDS1/EVI1-like gene 1
    Gene namesi
    Name:Prdm16
    Synonyms:Kiaa1675, Mel1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1917923. Prdm16.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB
    2. transcriptional repressor complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice die at birth but embryos display altered brown adipose tissue differentiation.1 Publication

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi805 – 8062DL → AS: Loss of interaction with CTBP1 and CTBP2 and loss of repression of WAT-specific genes. 1 Publication
    Mutagenesisi996 – 9961R → Q: Loss of DNA-binding activity but no effect on PRDM16-mediated BAT gene transcription activation. 2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12751275PR domain zinc finger protein 16PRO_0000384377Add
    BLAST

    Proteomic databases

    PaxDbiA2A935.
    PRIDEiA2A935.

    PTM databases

    PhosphoSiteiA2A935.

    Expressioni

    Tissue specificityi

    Enriched in BAT compared to WAT. Detected in heart, lung, kidney and brain. Expressed in nuclei of cardiomyocytes.2 Publications

    Developmental stagei

    Expressed at E12.5, E13.5 and E14.5. Expressed in orofacial tissues, heart, liver, brain and limb bud. At E13.5, expressed throughout the ventricular myocardium, including endocardium and epicardium.2 Publications

    Gene expression databases

    BgeeiA2A935.
    GenevestigatoriA2A935.

    Interactioni

    Subunit structurei

    Interacts with HDAC1, SKI, SMAD2 and SMAD3; the interaction with SKI promotes the recruitment of SMAD3-HDAC1 complex on the promoter of TGF-beta target genes By similarity. Interacts with CEBPA, CEBPB and CEBPD; the interaction is direct. Interacts with PPARG and PPARA; controls brown adipocytes differentiation. Interacts with CTBP1 and CTBP2; represses the expression of WAT-specific genes. Interacts with PPARGC1A and PPARGC1B; interaction with PPARGC1A or PPARGC1B activates the transcription of BAT-specific genes. Interacts with SMAD3.By similarity5 Publications

    Protein-protein interaction databases

    BioGridi214194. 5 interactions.
    DIPiDIP-60593N.
    IntActiA2A935. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliA2A935.
    SMRiA2A935. Positions 25-210, 229-496, 947-1057.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini82 – 211130SETPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni680 – 1038359Interaction with CTBP1 and CTBP2Add
    BLAST
    Regioni740 – 1275536Mediates interaction with SKI and regulation of TGF-beta signalingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi460 – 55899Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri230 – 25526C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri282 – 30423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri310 – 33223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri338 – 36124C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri367 – 38923C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri395 – 41723C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri424 – 44623C2H2-type 7; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri951 – 97323C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri979 – 100224C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1008 – 103023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00530000063676.
    HOGENOMiHOG000231144.
    InParanoidiQ69ZD6.
    OrthoDBiEOG72G16H.
    TreeFamiTF315309.

    Family and domain databases

    Gene3Di3.30.160.60. 8 hits.
    InterProiIPR001214. SET_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 4 hits.
    [Graphical view]
    SMARTiSM00317. SET. 1 hit.
    SM00355. ZnF_C2H2. 10 hits.
    [Graphical view]
    PROSITEiPS50280. SET. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A2A935-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRSKARARKL AKSDGDVVNN MYEPDPDLLA GQSAEEETED GILSPIPMGP     50
    PSPFPTSEDF TPKEGSPYEA PVYIPEDIPI PPDFELRESS IPGAGLGIWA 100
    KRKMEIGERF GPYVVTPRAA LKEADFGWEM LTDTEVSSQE SCIKKQISED 150
    LGSEKFCVDA NQAGSGSWLK YIRVACSCDD QNLAMCQINE QIYYKVIKDI 200
    EPGEELLVHV KEGAYSLGVM APSLDEDPTF RCDECDELFQ CRLDLRRHKK 250
    YACSSAGAQL YEGLGEELKP EGLGVGSDGQ AHECKDCERM FPNKYSLEQH 300
    MIVHTEEREY KCDQCPKAFN WKSNLIRHQM SHDSGKRFEC ENCVKVFTDP 350
    SNLQRHIRSQ HVGARAHACP DCGKTFATSS GLKQHKHIHS TVKPFICEVC 400
    HKSYTQFSNL CRHKRMHADC RTQIKCKDCG QMFSTTSSLN KHRRFCEGKN 450
    HYTPGSIFTP GLPLTPSPMM DKTKPSPTLN HGGLGFSEYF PSRPHPGSLP 500
    FSAAPPAFPA LTPGFPGIFP PSLYPRPPLL PPTPLLKSPL NHAQDAKLPS 550
    PLGNPALPLV SAVSNSSQGA TAATGSEEKF DGRLEDAYAE KVKNRSPDMS 600
    DGSDFEDINT TTGTDLDTTT GTGSDLDSDL DSDRDKGKDK GKPVESKPEF 650
    GGASVPPGAM NSVAEVPAFY SQHSFFPPPE EQLLTASGAA GDSIKAIASI 700
    AEKYFGPGFM SMQEKKLGSL PYHSVFPFQF LPNFPHSLYP FTDRALAHNL 750
    LVKAEPKSPR DALKVGGPSA ECPFDLTTKP KEAKPALLAP KVPLIPSSGE 800
    EQPLDLSIGS RARASQNGGG REPRKNHVYG ERKPGVSEGL PKVCPAQLPQ 850
    QPSLHYAKPS PFFMDPIYRV EKRKVADPVG VLKEKYLRPS PLLFHPQMSA 900
    IETMTEKLES FAAMKADSGS SLQPLPHHPF NFRSPPPTLS DPILRKGKER 950
    YTCRYCGKIF PRSANLTRHL RTHTGEQPYR CKYCDRSFSI SSNLQRHVRN 1000
    IHNKEKPFKC HLCNRCFGQQ TNLDRHLKKH EHEGAPVSQH SGVLTNHLGT 1050
    SASSPTSESD NHALLDEKED SYFSEIRNFI ANSEMNQAST RMDKRPEIQD 1100
    LDSNPPCPGS ASAKPEDVEE EEEEELEEED DDSLAGKSQE DTVSPTPEPQ 1150
    GVYEDEEDEE PPSLTMGFDH TRRCVEERGG GLLALEPTPT FGKGLDLRRA 1200
    AEEAFEVKDV LNSTLDSEVL KQTLYRQAKN QAYAMMLSLS EDTPLHAPSQ 1250
    SSLDAWLNIT GPSSESGAFN PINHL 1275
    Length:1,275
    Mass (Da):140,858
    Last modified:February 5, 2008 - v1
    Checksum:i2F1F6B6C3EBFEC10
    GO
    Isoform 2 (identifier: A2A935-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         129-129: E → EQ
         868-868: Y → YS
         1174-1176: CVE → HMQ
         1177-1275: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,178
    Mass (Da):130,427
    Checksum:i9B050B76A7B9E29F
    GO
    Isoform 3 (identifier: A2A935-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         868-868: Y → YS

    Note: No experimental confirmation available.

    Show »
    Length:1,276
    Mass (Da):140,945
    Checksum:i8A716E6E065ADEA4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81R → K in BAC79382. (PubMed:12816872)Curated
    Sequence conflicti510 – 5101A → T in BAC79382. (PubMed:12816872)Curated
    Sequence conflicti706 – 7061G → D in BAC79382. (PubMed:12816872)Curated
    Sequence conflicti732 – 7321P → L in BAC79382. (PubMed:12816872)Curated
    Sequence conflicti760 – 7601R → Q in BAC79382. (PubMed:12816872)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei129 – 1291E → EQ in isoform 2. 1 PublicationVSP_038066
    Alternative sequencei868 – 8681Y → YS in isoform 2 and isoform 3. 2 PublicationsVSP_038067
    Alternative sequencei1174 – 11763CVE → HMQ in isoform 2. 1 PublicationVSP_038068
    Alternative sequencei1177 – 127599Missing in isoform 2. 1 PublicationVSP_038069Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB078338 mRNA. Translation: BAC79382.1.
    AL627226
    , AL611950, AL627123, AL627127 Genomic DNA. Translation: CAM14956.1.
    AL627226
    , AL611950, AL627123, AL627127 Genomic DNA. Translation: CAM14959.1.
    AL627123
    , AL611950, AL627127, AL627226 Genomic DNA. Translation: CAM21844.1.
    AL627123
    , AL611950, AL627127, AL627226 Genomic DNA. Translation: CAM21845.1.
    AL627127
    , AL611950, AL627123, AL627226 Genomic DNA. Translation: CAM22275.1.
    AL627127
    , AL611950, AL627123, AL627226 Genomic DNA. Translation: CAM22278.1.
    AL611950
    , AL627123, AL627127, AL627226 Genomic DNA. Translation: CAM24998.1.
    AL611950
    , AL627123, AL627127, AL627226 Genomic DNA. Translation: CAM25001.1.
    BC059838 mRNA. Translation: AAH59838.1.
    AK173230 mRNA. Translation: BAD32508.1.
    CCDSiCCDS38989.1. [A2A935-1]
    CCDS71532.1. [A2A935-2]
    RefSeqiNP_001277955.1. NM_001291026.1.
    NP_001277958.1. NM_001291029.1. [A2A935-2]
    NP_081780.3. NM_027504.3. [A2A935-1]
    XP_006539236.1. XM_006539173.1. [A2A935-3]
    UniGeneiMm.257785.

    Genome annotation databases

    EnsembliENSMUST00000030902; ENSMUSP00000030902; ENSMUSG00000039410. [A2A935-1]
    ENSMUST00000070313; ENSMUSP00000064546; ENSMUSG00000039410. [A2A935-2]
    GeneIDi70673.
    KEGGimmu:70673.
    UCSCiuc008wbu.1. mouse. [A2A935-1]
    uc008wbx.1. mouse. [A2A935-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB078338 mRNA. Translation: BAC79382.1 .
    AL627226
    , AL611950 , AL627123 , AL627127 Genomic DNA. Translation: CAM14956.1 .
    AL627226
    , AL611950 , AL627123 , AL627127 Genomic DNA. Translation: CAM14959.1 .
    AL627123
    , AL611950 , AL627127 , AL627226 Genomic DNA. Translation: CAM21844.1 .
    AL627123
    , AL611950 , AL627127 , AL627226 Genomic DNA. Translation: CAM21845.1 .
    AL627127
    , AL611950 , AL627123 , AL627226 Genomic DNA. Translation: CAM22275.1 .
    AL627127
    , AL611950 , AL627123 , AL627226 Genomic DNA. Translation: CAM22278.1 .
    AL611950
    , AL627123 , AL627127 , AL627226 Genomic DNA. Translation: CAM24998.1 .
    AL611950
    , AL627123 , AL627127 , AL627226 Genomic DNA. Translation: CAM25001.1 .
    BC059838 mRNA. Translation: AAH59838.1 .
    AK173230 mRNA. Translation: BAD32508.1 .
    CCDSi CCDS38989.1. [A2A935-1 ]
    CCDS71532.1. [A2A935-2 ]
    RefSeqi NP_001277955.1. NM_001291026.1.
    NP_001277958.1. NM_001291029.1. [A2A935-2 ]
    NP_081780.3. NM_027504.3. [A2A935-1 ]
    XP_006539236.1. XM_006539173.1. [A2A935-3 ]
    UniGenei Mm.257785.

    3D structure databases

    ProteinModelPortali A2A935.
    SMRi A2A935. Positions 25-210, 229-496, 947-1057.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 214194. 5 interactions.
    DIPi DIP-60593N.
    IntActi A2A935. 1 interaction.

    PTM databases

    PhosphoSitei A2A935.

    Proteomic databases

    PaxDbi A2A935.
    PRIDEi A2A935.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030902 ; ENSMUSP00000030902 ; ENSMUSG00000039410 . [A2A935-1 ]
    ENSMUST00000070313 ; ENSMUSP00000064546 ; ENSMUSG00000039410 . [A2A935-2 ]
    GeneIDi 70673.
    KEGGi mmu:70673.
    UCSCi uc008wbu.1. mouse. [A2A935-1 ]
    uc008wbx.1. mouse. [A2A935-2 ]

    Organism-specific databases

    CTDi 63976.
    MGIi MGI:1917923. Prdm16.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00530000063676.
    HOGENOMi HOG000231144.
    InParanoidi Q69ZD6.
    OrthoDBi EOG72G16H.
    TreeFami TF315309.

    Miscellaneous databases

    ChiTaRSi PRDM16. mouse.
    NextBioi 332055.
    PROi A2A935.
    SOURCEi Search...

    Gene expression databases

    Bgeei A2A935.
    Genevestigatori A2A935.

    Family and domain databases

    Gene3Di 3.30.160.60. 8 hits.
    InterProi IPR001214. SET_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 4 hits.
    [Graphical view ]
    SMARTi SM00317. SET. 1 hit.
    SM00355. ZnF_C2H2. 10 hits.
    [Graphical view ]
    PROSITEi PS50280. SET. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation."
      Nishikata I., Sasaki H., Iga M., Tateno Y., Imayoshi S., Asou N., Nakamura T., Morishita K.
      Blood 102:3323-3332(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 570-1275 (ISOFORM 3).
      Tissue: Pancreatic islet.
    5. "PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue."
      Warner D.R., Horn K.H., Mudd L., Webb C.L., Greene R.M., Pisano M.M.
      Biochim. Biophys. Acta 1773:814-820(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SMAD3, DEVELOPMENTAL STAGE.
    6. Cited for: FUNCTION, INTERACTION WITH PPARGC1A AND PPARGC1B, MUTAGENESIS OF ARG-996, TISSUE SPECIFICITY.
    7. "Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex."
      Kajimura S., Seale P., Tomaru T., Erdjument-Bromage H., Cooper M.P., Ruas J.L., Chin S., Tempst P., Lazar M.A., Spiegelman B.M.
      Genes Dev. 22:1397-1409(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CTBP1; CTBP2; PPARGC1A AND PPARGC1B, SUBCELLULAR LOCATION, MUTAGENESIS OF 805-ASP-LEU-806.
    8. Cited for: FUNCTION, INTERACTION WITH PPARA AND PPARG, DISRUPTION PHENOTYPE.
    9. "Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex."
      Kajimura S., Seale P., Kubota K., Lunsford E., Frangioni J.V., Gygi S.P., Spiegelman B.M.
      Nature 460:1154-1158(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CEBPA; CEBPB AND CEBPD.
    10. Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPRD16_MOUSE
    AccessioniPrimary (citable) accession number: A2A935
    Secondary accession number(s): Q69ZD6, Q6PB79, Q7TPF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3