ID A2A934_MOUSE Unreviewed; 1177 AA. AC A2A934; DT 05-FEB-2008, integrated into UniProtKB/TrEMBL. DT 05-FEB-2008, sequence version 1. DT 27-MAR-2024, entry version 119. DE SubName: Full=PR domain containing 16 {ECO:0000313|Ensembl:ENSMUSP00000101261.2}; GN Name=Prdm16 {ECO:0000313|Ensembl:ENSMUSP00000101261.2, GN ECO:0000313|MGI:MGI:1917923}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000101261.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000101261.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000101261.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000101261.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000101261.2}; RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_001171466.1; NM_001177995.1. DR AlphaFoldDB; A2A934; -. DR SMR; A2A934; -. DR jPOST; A2A934; -. DR MaxQB; A2A934; -. DR ProteomicsDB; 351439; -. DR Antibodypedia; 26849; 265 antibodies from 30 providers. DR DNASU; 70673; -. DR Ensembl; ENSMUST00000105636.8; ENSMUSP00000101261.2; ENSMUSG00000039410.17. DR GeneID; 70673; -. DR UCSC; uc008wbw.1; mouse. DR AGR; MGI:1917923; -. DR CTD; 63976; -. DR MGI; MGI:1917923; Prdm16. DR VEuPathDB; HostDB:ENSMUSG00000039410; -. DR GeneTree; ENSGT00940000160951; -. DR OrthoDB; 3039682at2759; -. DR BioGRID-ORCS; 70673; 4 hits in 83 CRISPR screens. DR ChiTaRS; Prdm16; mouse. DR Proteomes; UP000000589; Chromosome 4. DR Bgee; ENSMUSG00000039410; Expressed in manus and 235 other cell types or tissues. DR ExpressionAtlas; A2A934; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW. DR GO; GO:0046974; F:histone H3K9 methyltransferase activity; IEA:InterPro. DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW. DR CDD; cd19213; PR-SET_PRDM16; 1. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 8. DR Gene3D; 2.170.270.10; SET domain; 1. DR InterPro; IPR044410; PRDM16_PR-SET. DR InterPro; IPR001214; SET_dom. DR InterPro; IPR046341; SET_dom_sf. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR24393:SF5; HISTONE-LYSINE N-METHYLTRANSFERASE PRDM16; 1. DR PANTHER; PTHR24393; ZINC FINGER PROTEIN; 1. DR Pfam; PF21549; PRDM2_PR; 1. DR Pfam; PF00096; zf-C2H2; 9. DR SMART; SM00317; SET; 1. DR SMART; SM00355; ZnF_C2H2; 10. DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5. DR SUPFAM; SSF82199; SET domain; 1. DR PROSITE; PS50280; SET; 1. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10. DR Genevisible; A2A934; MM. PE 1: Evidence at protein level; KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042}; KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603}; KW Proteomics identification {ECO:0007829|MaxQB:A2A934, KW ECO:0007829|PeptideAtlas:A2A934}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042}; KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}. FT DOMAIN 82..212 FT /note="SET" FT /evidence="ECO:0000259|PROSITE:PS50280" FT DOMAIN 231..261 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 283..310 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 311..338 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 339..367 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 368..395 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 396..423 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 425..452 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 952..979 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 980..1008 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 1009..1036 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT REGION 1..66 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 593..659 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 790..839 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1028..1066 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1085..1177 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 604..627 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 628..647 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 819..833 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1040..1061 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1117..1136 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1177 AA; 130340 MW; FFBC17FCD168C29F CRC64; MRSKARARKL AKSDGDVVNN MYEPDPDLLA GQSAEEETED GILSPIPMGP PSPFPTSEDF TPKEGSPYEA PVYIPEDIPI PPDFELRESS IPGAGLGIWA KRKMEIGERF GPYVVTPRAA LKEADFGWEQ MLTDTEVSSQ ESCIKKQISE DLGSEKFCVD ANQAGSGSWL KYIRVACSCD DQNLAMCQIN EQIYYKVIKD IEPGEELLVH VKEGAYSLGV MAPSLDEDPT FRCDECDELF QCRLDLRRHK KYACSSAGAQ LYEGLGEELK PEGLGVGSDG QAHECKDCER MFPNKYSLEQ HMIVHTEERE YKCDQCPKAF NWKSNLIRHQ MSHDSGKRFE CENCVKVFTD PSNLQRHIRS QHVGARAHAC PDCGKTFATS SGLKQHKHIH STVKPFICEV CHKSYTQFSN LCRHKRMHAD CRTQIKCKDC GQMFSTTSSL NKHRRFCEGK NHYTPGSIFT PGLPLTPSPM MDKTKPSPTL NHGGLGFSEY FPSRPHPGSL PFSAAPPAFP ALTPGFPGIF PPSLYPRPPL LPPTPLLKSP LNHAQDAKLP SPLGNPALPL VSAVSNSSQG ATAATGSEEK FDGRLEDAYA EKVKNRSPDM SDGSDFEDIN TTTGTDLDTT TGTGSDLDSD LDSDRDKGKD KGKPVESKPE FGGASVPPGA MNSVAEVPAF YSQHSFFPPP EEQLLTASGA AGDSIKAIAS IAEKYFGPGF MSMQEKKLGS LPYHSVFPFQ FLPNFPHSLY PFTDRALAHN LLVKAEPKSP RDALKVGGPS AECPFDLTTK PKEAKPALLA PKVPLIPSSG EEQPLDLSIG SRARASQNGG GREPRKNHVY GERKPGVSEG LPKVCPAQLP QQPSLHYAKP SPFFMDPIYR VEKRKVADPV GVLKEKYLRP SPLLFHPQMS AIETMTEKLE SFAAMKADSG SSLQPLPHHP FNFRSPPPTL SDPILRKGKE RYTCRYCGKI FPRSANLTRH LRTHTGEQPY RCKYCDRSFS ISSNLQRHVR NIHNKEKPFK CHLCNRCFGQ QTNLDRHLKK HEHEGAPVSQ HSGVLTNHLG TSASSPTSES DNHALLDEKE DSYFSEIRNF IANSEMNQAS TRMDKRPEIQ DLDSNPPCPG SASAKPEDVE EEEEEELEEE DDDSLAGKSQ EDTVSPTPEP QGVYEDEEDE EPPSLTMGFD HTRRHMQ //