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Protein
Submitted name:

PR domain zinc finger protein 16

Gene

Prdm16

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. metal ion binding Source: InterPro
  2. sequence-specific DNA binding Source: MGI
  3. SMAD binding Source: MGI

GO - Biological processi

  1. negative regulation of granulocyte differentiation Source: MGI
  2. negative regulation of transcription, DNA-templated Source: MGI
  3. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  4. negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  5. neurogenesis Source: MGI
  6. palate development Source: MGI
  7. positive regulation of transcription, DNA-templated Source: MGI
  8. somatic stem cell maintenance Source: MGI
  9. tongue development Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
PR domain zinc finger protein 16Imported
Gene namesi
Name:Prdm16Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1917923. Prdm16.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiA2A934.

Expressioni

Gene expression databases

ExpressionAtlasiA2A934. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA2A934.
SMRiA2A934. Positions 74-209, 281-445, 948-1058.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000063676.
HOGENOMiHOG000231144.
HOVERGENiHBG005619.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR030413. Evi1/Prdm16.
IPR030414. PRDM16.
IPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR24393. PTHR24393. 1 hit.
PTHR24393:SF4. PTHR24393:SF4. 1 hit.
PfamiPF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A934-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSKARARKL AKSDGDVVNN MYEPDPDLLA GQSAEEETED GILSPIPMGP
60 70 80 90 100
PSPFPTSEDF TPKEGSPYEA PVYIPEDIPI PPDFELRESS IPGAGLGIWA
110 120 130 140 150
KRKMEIGERF GPYVVTPRAA LKEADFGWEQ MLTDTEVSSQ ESCIKKQISE
160 170 180 190 200
DLGSEKFCVD ANQAGSGSWL KYIRVACSCD DQNLAMCQIN EQIYYKVIKD
210 220 230 240 250
IEPGEELLVH VKEGAYSLGV MAPSLDEDPT FRCDECDELF QCRLDLRRHK
260 270 280 290 300
KYACSSAGAQ LYEGLGEELK PEGLGVGSDG QAHECKDCER MFPNKYSLEQ
310 320 330 340 350
HMIVHTEERE YKCDQCPKAF NWKSNLIRHQ MSHDSGKRFE CENCVKVFTD
360 370 380 390 400
PSNLQRHIRS QHVGARAHAC PDCGKTFATS SGLKQHKHIH STVKPFICEV
410 420 430 440 450
CHKSYTQFSN LCRHKRMHAD CRTQIKCKDC GQMFSTTSSL NKHRRFCEGK
460 470 480 490 500
NHYTPGSIFT PGLPLTPSPM MDKTKPSPTL NHGGLGFSEY FPSRPHPGSL
510 520 530 540 550
PFSAAPPAFP ALTPGFPGIF PPSLYPRPPL LPPTPLLKSP LNHAQDAKLP
560 570 580 590 600
SPLGNPALPL VSAVSNSSQG ATAATGSEEK FDGRLEDAYA EKVKNRSPDM
610 620 630 640 650
SDGSDFEDIN TTTGTDLDTT TGTGSDLDSD LDSDRDKGKD KGKPVESKPE
660 670 680 690 700
FGGASVPPGA MNSVAEVPAF YSQHSFFPPP EEQLLTASGA AGDSIKAIAS
710 720 730 740 750
IAEKYFGPGF MSMQEKKLGS LPYHSVFPFQ FLPNFPHSLY PFTDRALAHN
760 770 780 790 800
LLVKAEPKSP RDALKVGGPS AECPFDLTTK PKEAKPALLA PKVPLIPSSG
810 820 830 840 850
EEQPLDLSIG SRARASQNGG GREPRKNHVY GERKPGVSEG LPKVCPAQLP
860 870 880 890 900
QQPSLHYAKP SPFFMDPIYR VEKRKVADPV GVLKEKYLRP SPLLFHPQMS
910 920 930 940 950
AIETMTEKLE SFAAMKADSG SSLQPLPHHP FNFRSPPPTL SDPILRKGKE
960 970 980 990 1000
RYTCRYCGKI FPRSANLTRH LRTHTGEQPY RCKYCDRSFS ISSNLQRHVR
1010 1020 1030 1040 1050
NIHNKEKPFK CHLCNRCFGQ QTNLDRHLKK HEHEGAPVSQ HSGVLTNHLG
1060 1070 1080 1090 1100
TSASSPTSES DNHALLDEKE DSYFSEIRNF IANSEMNQAS TRMDKRPEIQ
1110 1120 1130 1140 1150
DLDSNPPCPG SASAKPEDVE EEEEEELEEE DDDSLAGKSQ EDTVSPTPEP
1160 1170
QGVYEDEEDE EPPSLTMGFD HTRRHMQ
Length:1,177
Mass (Da):130,340
Last modified:February 5, 2008 - v1
Checksum:iFFBC17FCD168C29F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL611950 Genomic DNA. No translation available.
AL627123 Genomic DNA. No translation available.
AL627127 Genomic DNA. No translation available.
AL627226 Genomic DNA. No translation available.
RefSeqiNP_001171466.1. NM_001177995.1.
UniGeneiMm.257785.

Genome annotation databases

EnsembliENSMUST00000105636; ENSMUSP00000101261; ENSMUSG00000039410.
GeneIDi70673.
KEGGimmu:70673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL611950 Genomic DNA. No translation available.
AL627123 Genomic DNA. No translation available.
AL627127 Genomic DNA. No translation available.
AL627226 Genomic DNA. No translation available.
RefSeqiNP_001171466.1. NM_001177995.1.
UniGeneiMm.257785.

3D structure databases

ProteinModelPortaliA2A934.
SMRiA2A934. Positions 74-209, 281-445, 948-1058.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA2A934.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105636; ENSMUSP00000101261; ENSMUSG00000039410.
GeneIDi70673.
KEGGimmu:70673.

Organism-specific databases

CTDi63976.
MGIiMGI:1917923. Prdm16.

Phylogenomic databases

GeneTreeiENSGT00530000063676.
HOGENOMiHOG000231144.
HOVERGENiHBG005619.

Miscellaneous databases

ChiTaRSiPrdm16. mouse.
NextBioi332055.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiA2A934. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR030413. Evi1/Prdm16.
IPR030414. PRDM16.
IPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR24393. PTHR24393. 1 hit.
PTHR24393:SF4. PTHR24393:SF4. 1 hit.
PfamiPF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2A934_MOUSE
AccessioniPrimary (citable) accession number: A2A934
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: March 4, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.