Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Oxysterol-binding protein-related protein 9

Gene

Osbpl9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-192105 Synthesis of bile acids and bile salts

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 9
Short name:
ORP-9
Short name:
OSBP-related protein 9
Gene namesi
Name:Osbpl9
Synonyms:Orp9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1923784 Osbpl9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003662892 – 736Oxysterol-binding protein-related protein 9Add BLAST735

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei306PhosphoserineBy similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei325PhosphoserineBy similarity1
Modified residuei326PhosphoserineCombined sources1
Modified residuei329PhosphoserineBy similarity1
Modified residuei611PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiA2A8Z1
MaxQBiA2A8Z1
PaxDbiA2A8Z1
PeptideAtlasiA2A8Z1
PRIDEiA2A8Z1

PTM databases

iPTMnetiA2A8Z1
PhosphoSitePlusiA2A8Z1

Expressioni

Gene expression databases

BgeeiENSMUSG00000028559
ExpressionAtlasiA2A8Z1 baseline and differential
GenevisibleiA2A8Z1 MM

Interactioni

Subunit structurei

Heterodimer with OSBPL11. Interacts with OSBPL10.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124370

Structurei

3D structure databases

ProteinModelPortaliA2A8Z1
SMRiA2A8Z1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 99PHPROSITE-ProRule annotationAdd BLAST98

Sequence similaritiesi

Belongs to the OSBP family.Curated

Phylogenomic databases

eggNOGiKOG2210 Eukaryota
ENOG410XRW6 LUCA
GeneTreeiENSGT00550000074515
HOGENOMiHOG000233872
HOVERGENiHBG053376
InParanoidiA2A8Z1
KOiK20465
PhylomeDBiA2A8Z1

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2A8Z1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASIVEGPLS KWTNVMKGWQ YRWFVLDYNA GLLSYYTSKD KMMRGSRRGC
60 70 80 90 100
VRLRGAVIGI DDEDDSTFTI TVDQKTFHFQ ARDADEREKW IHALEETILR
110 120 130 140 150
HTLQLQGLDS GFIPSVQDFD KKLTEADAYL QILIEQLKLF DDKLQNCKDD
160 170 180 190 200
EQRKKVETLK DTTNSMVESI KHCIVLLQIA KDQSNAEQHA DGIISTINPV
210 220 230 240 250
DAIYQPSPLE PVISTMPSQT ALPPEPAQLC KSEQRPSSLP VGPVLATLGH
260 270 280 290 300
HQTPTPNSTG SGNSPPSSSL TPPSHVNLSP NTVPEFSYSS SEDEFYDADE
310 320 330 340 350
FHQSGSSPKR LIDSSGSASV LTHSSSGNSL KRPDTTESLN SSMSNGTSDA
360 370 380 390 400
DLFDSHDDRD DDGEAGSVEE HKSVIMHLLS QVRLGMDLTK VVLPTFILER
410 420 430 440 450
RSLLEMYADF FAHPDLFVSI SDQKDPRDRM VQVVKWYLSA FHAGRRGSVA
460 470 480 490 500
KKPYNPILGE IFQCHWTLPN DTEENAELVS EGPVPWVSKN SVTFVAEQVS
510 520 530 540 550
HHPPISAFYA ECFNKKIQFN AHIWTKSKFL GMSIGVHNIG QGCVSCLEYD
560 570 580 590 600
EHYILTFPNG YGRSILTVPW VELGGECNIN CSKTGYSANI VFHTKPFYGG
610 620 630 640 650
KKHRITAEIF SPNDKKSFCS IEGEWNGIMY AKYATGENTV FVDTKKLPII
660 670 680 690 700
KKKVRKLEDQ NEYESRSLWK DVTFNLKIRD IDAATEAKHR LEERQRAEAR
710 720 730
ERKEKEIQWE TRLFHEDGEC WVYDEPLLKR LGAVKH
Length:736
Mass (Da):83,109
Last modified:February 20, 2007 - v1
Checksum:i4F033CB93DFD4305
GO
Isoform 2 (identifier: A2A8Z1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
     98-106: ILRHTLQLQ → MALLLAACG

Show »
Length:639
Mass (Da):71,527
Checksum:i23D14C78040EE1D7
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0365721 – 97Missing in isoform 2. CuratedAdd BLAST97
Alternative sequenceiVSP_03657398 – 106ILRHTLQLQ → MALLLAACG in isoform 2. Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627406, AL627103 Genomic DNA Translation: CAM16907.1
AL627406 Genomic DNA Translation: CAM16910.1
AL627103, AL627406 Genomic DNA Translation: CAM23713.1
CCDSiCCDS51258.1 [A2A8Z1-2]
RefSeqiNP_775485.2, NM_173350.3 [A2A8Z1-2]
XP_006502682.2, XM_006502619.3 [A2A8Z1-1]
UniGeneiMm.366315

Genome annotation databases

EnsembliENSMUST00000030288; ENSMUSP00000030288; ENSMUSG00000028559 [A2A8Z1-1]
ENSMUST00000084366; ENSMUSP00000081396; ENSMUSG00000028559 [A2A8Z1-2]
GeneIDi100273
KEGGimmu:100273
UCSCiuc008uca.2 mouse [A2A8Z1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiOSBL9_MOUSE
AccessioniPrimary (citable) accession number: A2A8Z1
Secondary accession number(s): A2A9Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 20, 2007
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health