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Protein

Oxysterol-binding protein-related protein 9

Gene

Osbpl9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 9
Short name:
ORP-9
Short name:
OSBP-related protein 9
Gene namesi
Name:Osbpl9
Synonyms:Orp9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1923784. Osbpl9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 736735Oxysterol-binding protein-related protein 9PRO_0000366289Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei306 – 3061PhosphoserineBy similarity
Modified residuei326 – 3261PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiA2A8Z1.
MaxQBiA2A8Z1.
PaxDbiA2A8Z1.
PRIDEiA2A8Z1.

PTM databases

iPTMnetiA2A8Z1.

Expressioni

Gene expression databases

BgeeiA2A8Z1.
ExpressionAtlasiA2A8Z1. baseline and differential.
GenevisibleiA2A8Z1. MM.

Interactioni

Subunit structurei

Heterodimer with OSBPL11. Interacts with OSBPL10.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124370.

Structurei

3D structure databases

ProteinModelPortaliA2A8Z1.
SMRiA2A8Z1. Positions 7-96, 369-731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 9998PHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the OSBP family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2210. Eukaryota.
ENOG410XRW6. LUCA.
GeneTreeiENSGT00550000074515.
HOGENOMiHOG000233872.
HOVERGENiHBG053376.
InParanoidiA2A8Z1.
OrthoDBiEOG7PK8ZG.
PhylomeDBiA2A8Z1.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 2 hits.
PfamiPF01237. Oxysterol_BP. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2A8Z1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASIVEGPLS KWTNVMKGWQ YRWFVLDYNA GLLSYYTSKD KMMRGSRRGC
60 70 80 90 100
VRLRGAVIGI DDEDDSTFTI TVDQKTFHFQ ARDADEREKW IHALEETILR
110 120 130 140 150
HTLQLQGLDS GFIPSVQDFD KKLTEADAYL QILIEQLKLF DDKLQNCKDD
160 170 180 190 200
EQRKKVETLK DTTNSMVESI KHCIVLLQIA KDQSNAEQHA DGIISTINPV
210 220 230 240 250
DAIYQPSPLE PVISTMPSQT ALPPEPAQLC KSEQRPSSLP VGPVLATLGH
260 270 280 290 300
HQTPTPNSTG SGNSPPSSSL TPPSHVNLSP NTVPEFSYSS SEDEFYDADE
310 320 330 340 350
FHQSGSSPKR LIDSSGSASV LTHSSSGNSL KRPDTTESLN SSMSNGTSDA
360 370 380 390 400
DLFDSHDDRD DDGEAGSVEE HKSVIMHLLS QVRLGMDLTK VVLPTFILER
410 420 430 440 450
RSLLEMYADF FAHPDLFVSI SDQKDPRDRM VQVVKWYLSA FHAGRRGSVA
460 470 480 490 500
KKPYNPILGE IFQCHWTLPN DTEENAELVS EGPVPWVSKN SVTFVAEQVS
510 520 530 540 550
HHPPISAFYA ECFNKKIQFN AHIWTKSKFL GMSIGVHNIG QGCVSCLEYD
560 570 580 590 600
EHYILTFPNG YGRSILTVPW VELGGECNIN CSKTGYSANI VFHTKPFYGG
610 620 630 640 650
KKHRITAEIF SPNDKKSFCS IEGEWNGIMY AKYATGENTV FVDTKKLPII
660 670 680 690 700
KKKVRKLEDQ NEYESRSLWK DVTFNLKIRD IDAATEAKHR LEERQRAEAR
710 720 730
ERKEKEIQWE TRLFHEDGEC WVYDEPLLKR LGAVKH
Length:736
Mass (Da):83,109
Last modified:February 20, 2007 - v1
Checksum:i4F033CB93DFD4305
GO
Isoform 2 (identifier: A2A8Z1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
     98-106: ILRHTLQLQ → MALLLAACG

Show »
Length:639
Mass (Da):71,527
Checksum:i23D14C78040EE1D7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9797Missing in isoform 2. CuratedVSP_036572Add
BLAST
Alternative sequencei98 – 1069ILRHTLQLQ → MALLLAACG in isoform 2. CuratedVSP_036573

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627406, AL627103 Genomic DNA. Translation: CAM16907.1.
AL627406 Genomic DNA. Translation: CAM16910.1.
AL627103, AL627406 Genomic DNA. Translation: CAM23713.1.
CCDSiCCDS51258.1. [A2A8Z1-2]
RefSeqiNP_775485.2. NM_173350.3. [A2A8Z1-2]
XP_006502682.2. XM_006502619.2. [A2A8Z1-1]
UniGeneiMm.366315.

Genome annotation databases

EnsembliENSMUST00000030288; ENSMUSP00000030288; ENSMUSG00000028559. [A2A8Z1-1]
ENSMUST00000084366; ENSMUSP00000081396; ENSMUSG00000028559. [A2A8Z1-2]
GeneIDi100273.
KEGGimmu:100273.
UCSCiuc008uca.2. mouse. [A2A8Z1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627406, AL627103 Genomic DNA. Translation: CAM16907.1.
AL627406 Genomic DNA. Translation: CAM16910.1.
AL627103, AL627406 Genomic DNA. Translation: CAM23713.1.
CCDSiCCDS51258.1. [A2A8Z1-2]
RefSeqiNP_775485.2. NM_173350.3. [A2A8Z1-2]
XP_006502682.2. XM_006502619.2. [A2A8Z1-1]
UniGeneiMm.366315.

3D structure databases

ProteinModelPortaliA2A8Z1.
SMRiA2A8Z1. Positions 7-96, 369-731.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124370.

PTM databases

iPTMnetiA2A8Z1.

Proteomic databases

EPDiA2A8Z1.
MaxQBiA2A8Z1.
PaxDbiA2A8Z1.
PRIDEiA2A8Z1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030288; ENSMUSP00000030288; ENSMUSG00000028559. [A2A8Z1-1]
ENSMUST00000084366; ENSMUSP00000081396; ENSMUSG00000028559. [A2A8Z1-2]
GeneIDi100273.
KEGGimmu:100273.
UCSCiuc008uca.2. mouse. [A2A8Z1-2]

Organism-specific databases

CTDi114883.
MGIiMGI:1923784. Osbpl9.

Phylogenomic databases

eggNOGiKOG2210. Eukaryota.
ENOG410XRW6. LUCA.
GeneTreeiENSGT00550000074515.
HOGENOMiHOG000233872.
HOVERGENiHBG053376.
InParanoidiA2A8Z1.
OrthoDBiEOG7PK8ZG.
PhylomeDBiA2A8Z1.

Miscellaneous databases

ChiTaRSiOsbpl9. mouse.
NextBioi354365.
PROiA2A8Z1.
SOURCEiSearch...

Gene expression databases

BgeeiA2A8Z1.
ExpressionAtlasiA2A8Z1. baseline and differential.
GenevisibleiA2A8Z1. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 2 hits.
PfamiPF01237. Oxysterol_BP. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-326, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiOSBL9_MOUSE
AccessioniPrimary (citable) accession number: A2A8Z1
Secondary accession number(s): A2A9Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 20, 2007
Last modified: May 11, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.