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Protein

Calmodulin-binding transcription activator 1

Gene

Camta1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi63 – 188126CG-1PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • sequence-specific DNA binding Source: MGI

GO - Biological processi

  • neuromuscular process controlling balance Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-binding transcription activator 1Imported
Gene namesi
Name:Camta1Imported
Synonyms:Kiaa0833Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2140230. Camta1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotationBy similarity
  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16821682Calmodulin-binding transcription activator 1PRO_0000355043Add
BLAST

Proteomic databases

MaxQBiA2A891.
PaxDbiA2A891.
PRIDEiA2A891.

PTM databases

PhosphoSiteiA2A891.

Expressioni

Gene expression databases

BgeeiA2A891.
ExpressionAtlasiA2A891. baseline and differential.
GenevisibleiA2A891. MM.

Interactioni

Subunit structurei

May interact with calmodulin.By similarity

Protein-protein interaction databases

IntActiA2A891. 1 interaction.
STRINGi10090.ENSMUSP00000054804.

Structurei

3D structure databases

ProteinModelPortaliA2A891.
SMRiA2A891. Positions 874-956.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini875 – 95581IPT/TIGAdd
BLAST
Repeati1066 – 109530ANK 1Sequence analysisAdd
BLAST
Repeati1111 – 114131ANK 2Sequence analysisAdd
BLAST
Repeati1145 – 117430ANK 3Sequence analysisAdd
BLAST
Domaini1549 – 158537IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini1586 – 160823IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini1609 – 163123IQ 3PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi112 – 1198Nuclear localization signalPROSITE-ProRule annotationBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1006 – 103328Gly-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the CAMTA family.Sequence analysis
Contains 3 ANK repeats.PROSITE-ProRule annotation
Contains 1 CG-1 DNA-binding domain.PROSITE-ProRule annotation
Contains 1 IPT/TIG domain.Sequence analysis
Contains 3 IQ domains.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0520. Eukaryota.
ENOG410XS5M. LUCA.
GeneTreeiENSGT00390000001446.
HOVERGENiHBG080107.
InParanoidiA2A891.
OMAiAYMHVAE.
OrthoDBiEOG74R1PX.
PhylomeDBiA2A891.
TreeFamiTF323452.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005559. CG-1_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PfamiPF03859. CG-1. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM01076. CG-1. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS51437. CG_1. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: A2A891-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWRAEGKWLP KTSRKSVSQS VFCGTSTYCV LNTVPPIEDD HGNSNSSHVK
60 70 80 90 100
IFLPKKLLEC LPKCSSLPKE RHRWNTNEEI AAYLITFEKH EEWLTTSPKT
110 120 130 140 150
RPQNGSMILY NRKKVKYRKD GYCWKKRKDG KTTREDHMKL KVQGVECLYG
160 170 180 190 200
CYVHSSIIPT FHRRCYWLLQ NPDIVLVHYL NVPAIEDCGK PCGPILCSIN
210 220 230 240 250
TDKKEWAKWT KEELIGQLKP MFHGIKWTCS NGNSSSGFSV EQLVQQILDS
260 270 280 290 300
HQTKPQPRTH NCLCTGSLGA GSSVHHKCNS AKHRIISPKV EPRAGGYGGH
310 320 330 340 350
SEVQHNDVSE GKHEPSHGRS TSREKRNGKV AKPALLHQNS TEVSSTNQVE
360 370 380 390 400
VPDTTQSSPV SISSGLNSDP DMVDSPVVTG VSSMAVASVM GGLSQSATVF
410 420 430 440 450
MSEVTNEAVY TMSPTAGPNH HLLSPDASQG LVLAVSSDGH KFAFPTTGSS
460 470 480 490 500
DSLSMLPANV SEELVLSTTL DGGRKIPETA MNFDPDCFLN NPKQGQTYGG
510 520 530 540 550
GGLKAEMVST NIRHSPPAER SFGFTSVLTK EIKTEDTSFE QQMAKEAAYS
560 570 580 590 600
SSAAAAASSS LTLTAAGSSL LPSGGGLSPS TTLEQMDFSA IDSNKDYASS
610 620 630 640 650
FSQTGHSPHI HQTPSPSFFL QDASKPLPLE QNTHSSLSES GAAFVMPTVK
660 670 680 690 700
TEASSQTSSC SGHVETRIES TSSLHLMQFQ ANFQAMAAEG EVTMETSQAA
710 720 730 740 750
EGNEVLLKSG ELQACGSEHY LQPETNGVIR SAGGVPLLPS NVVQGLYPVA
760 770 780 790 800
QPSLGNSSNM ELSLDHFDIS FSNQFSDLIN DFISVEGGSG TIYGHQLVSG
810 820 830 840 850
DSAALSQSED GARAPFTQAE MCIPCCSPQQ GSLQLSSAEG GPSTMAYMHV
860 870 880 890 900
AEVVSAASAQ GALGMLQQSG RVFMVTDYSP EWSYPEGGVK VLITGPWQEA
910 920 930 940 950
SNNYSCLFDQ ISVPASLIQP GVLRCYCPAH DTGLVTLQVA FNNQIISNSV
960 970 980 990 1000
VFEYKARALP TLPSSQHDWL SLDDNQFRMS ILERLEQMER RMAEMTGSQQ
1010 1020 1030 1040 1050
HKQASGGGGS GSGSGSGAGG GQAQCASGAG TLGSCFESRV VVVCEKMMSR
1060 1070 1080 1090 1100
ACWAKSKHLI HSKTFRGMTL LHLAAAQGYA TLIQTLIKWR TKHADSIDLE
1110 1120 1130 1140 1150
LEVDPLNVDH FSCTPLMWAC ALGHLEAAVV LYKWDRRAIS IPDSLGRLPL
1160 1170 1180 1190 1200
GIARSRGHVK LAECLEHLQR DEQAQLGQAS RIHCAPSEEP TTDSWMAQWQ
1210 1220 1230 1240 1250
REAMSPPEIP KGVTVIASTN PELRRPRSEP SNYYSTEGHK DYPAPKKHKL
1260 1270 1280 1290 1300
NPESFQARQE KLLCTALSLE QPNIRKQSPR SKQPSPETIS PSEGVREYSR
1310 1320 1330 1340 1350
EAAPPTPETA ASQASASQPV VKWSAKDLYI GVSTVQVTGN PKGTSVVKDA
1360 1370 1380 1390 1400
APSQVRPREP MSVLMLANRE VVNTEMGAYR DRTEHEDCPQ PMDDIQVNMM
1410 1420 1430 1440 1450
TLAEHIIEAT PDRIKQENFV PMESSALERT DPATISSTMS WLASYLADAD
1460 1470 1480 1490 1500
RLPSAAHIRS AYTEPLTPSS NASLSPAGSP VSEVAFEKPS LPSAADWSEF
1510 1520 1530 1540 1550
LSASTSEKVE SELAQLTLSD HEQRELYEAA RLVQTAFRKY KGRPLREQQE
1560 1570 1580 1590 1600
VAAAVIQRCY RKYKQLTWIA LKYALYKKMT QAAILIQSKF RSYYEQKRFQ
1610 1620 1630 1640 1650
QSRRAAVLIQ NFYRSYKKCG RRRPARRTAV IVQQKLRSSL LTKKQDQAAR
1660 1670 1680
KIMRFLRRCR HSPLVDHRLY KRSERIEKGQ GT
Note: Gene prediction based on EST data.Curated
Length:1,682
Mass (Da):184,319
Last modified:February 5, 2008 - v1
Checksum:i3F96253C6CF119C6
GO
Isoform 2 (identifier: A2A891-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1566-1572: Missing.

Show »
Length:1,675
Mass (Da):183,493
Checksum:iC811D17DE9DB7D26
GO
Isoform 3 (identifier: A2A891-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-978: Missing.
     1222-1334: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:591
Mass (Da):66,116
Checksum:i18DEB1C54B8316DB
GO
Isoform 4 (identifier: A2A891-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-978: Missing.
     1222-1334: Missing.
     1566-1572: Missing.
     1662-1682: SPLVDHRLYKRSERIEKGQGT → RVKELKKAKELEDIQQHPLAM

Note: No experimental confirmation available.Curated
Show »
Length:584
Mass (Da):65,325
Checksum:iD71B213119E7D3BF
GO
Isoform 5 (identifier: A2A891-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1459-1472: Missing.
     1566-1572: Missing.
     1662-1682: SPLVDHRLYKRSERIEKGQGT → RVKELKKAKELEDIQQHPLAM

Note: No experimental confirmation available.Curated
Show »
Length:1,661
Mass (Da):182,052
Checksum:i42F3C95AD83F2CC1
GO

Sequence cautioni

The sequence CAM24788.2 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1394 – 13941D → G in CAQ51627 (PubMed:19468303).Curated
Sequence conflicti1394 – 13941D → G in CAQ51628 (PubMed:19468303).Curated
Sequence conflicti1394 – 13941D → G in CAQ51883 (PubMed:19468303).Curated
Sequence conflicti1394 – 13941D → G in CAQ51884 (PubMed:19468303).Curated
Sequence conflicti1482 – 14821S → N in CAQ51627 (PubMed:19468303).Curated
Sequence conflicti1482 – 14821S → N in CAQ51628 (PubMed:19468303).Curated
Sequence conflicti1482 – 14821S → N in CAQ51883 (PubMed:19468303).Curated
Sequence conflicti1482 – 14821S → N in CAQ51884 (PubMed:19468303).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 978978Missing in isoform 3 and isoform 4. CuratedVSP_052987Add
BLAST
Alternative sequencei1222 – 1334113Missing in isoform 3 and isoform 4. CuratedVSP_052988Add
BLAST
Alternative sequencei1459 – 147214Missing in isoform 5. CuratedVSP_052989Add
BLAST
Alternative sequencei1566 – 15727Missing in isoform 2, isoform 4 and isoform 5. CuratedVSP_052990
Alternative sequencei1662 – 168221SPLVD…KGQGT → RVKELKKAKELEDIQQHPLA M in isoform 4 and isoform 5. CuratedVSP_052991Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606986
, AL606967, AL607143, AL611931, AL732550 Genomic DNA. Translation: CAM18834.1.
AL606986
, AL606967, AL607143, AL611931, AL732550 Genomic DNA. Translation: CAM18835.1.
AL606967
, AL606986, AL607143, AL611931, AL732550 Genomic DNA. Translation: CAM20269.1.
AL606967
, AL606986, AL607143, AL611931, AL732550 Genomic DNA. Translation: CAM20270.1.
AL732550
, AL606967, AL606986, AL607143, AL611931 Genomic DNA. Translation: CAM24365.1.
AL732550
, AL606967, AL606986, AL607143, AL611931 Genomic DNA. Translation: CAM24366.1.
AL607143
, AL606967, AL606986, AL611931, AL732550 Genomic DNA. Translation: CAM24783.1.
AL607143
, AL606967, AL606986, AL611931, AL732550 Genomic DNA. Translation: CAM24784.1.
AL607143 Genomic DNA. Translation: CAM24788.2. Sequence problems.
AL607143 Genomic DNA. Translation: CAM24789.1.
AL607143 Genomic DNA. Translation: CAM24790.1.
AL611931
, AL606967, AL606986, AL607143, AL732550 Genomic DNA. Translation: CAM25054.1.
AL611931
, AL606967, AL606986, AL607143, AL732550 Genomic DNA. Translation: CAM25055.1.
CU442759, CU207342, CU407306 Genomic DNA. Translation: CAQ51627.1.
CU442759, CU207342, CU407306 Genomic DNA. Translation: CAQ51628.1.
CU407306, CU207342, CU442759 Genomic DNA. Translation: CAQ51883.1.
CU407306, CU207342, CU442759 Genomic DNA. Translation: CAQ51884.1.
AK122383 mRNA. Translation: BAC65665.1.
CCDSiCCDS38981.1. [A2A891-1]
RefSeqiNP_001075026.1. NM_001081557.3. [A2A891-1]
UniGeneiMm.318846.

Genome annotation databases

EnsembliENSMUST00000049790; ENSMUSP00000054804; ENSMUSG00000014592. [A2A891-1]
ENSMUST00000097774; ENSMUSP00000095381; ENSMUSG00000014592. [A2A891-2]
ENSMUST00000105668; ENSMUSP00000101293; ENSMUSG00000014592. [A2A891-3]
ENSMUST00000105670; ENSMUSP00000101295; ENSMUSG00000014592. [A2A891-4]
ENSMUST00000169423; ENSMUSP00000127916; ENSMUSG00000014592. [A2A891-1]
GeneIDi100072.
KEGGimmu:100072.
UCSCiuc008vyk.2. mouse. [A2A891-4]
uc008vym.2. mouse. [A2A891-3]
uc008vyn.2. mouse. [A2A891-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606986
, AL606967, AL607143, AL611931, AL732550 Genomic DNA. Translation: CAM18834.1.
AL606986
, AL606967, AL607143, AL611931, AL732550 Genomic DNA. Translation: CAM18835.1.
AL606967
, AL606986, AL607143, AL611931, AL732550 Genomic DNA. Translation: CAM20269.1.
AL606967
, AL606986, AL607143, AL611931, AL732550 Genomic DNA. Translation: CAM20270.1.
AL732550
, AL606967, AL606986, AL607143, AL611931 Genomic DNA. Translation: CAM24365.1.
AL732550
, AL606967, AL606986, AL607143, AL611931 Genomic DNA. Translation: CAM24366.1.
AL607143
, AL606967, AL606986, AL611931, AL732550 Genomic DNA. Translation: CAM24783.1.
AL607143
, AL606967, AL606986, AL611931, AL732550 Genomic DNA. Translation: CAM24784.1.
AL607143 Genomic DNA. Translation: CAM24788.2. Sequence problems.
AL607143 Genomic DNA. Translation: CAM24789.1.
AL607143 Genomic DNA. Translation: CAM24790.1.
AL611931
, AL606967, AL606986, AL607143, AL732550 Genomic DNA. Translation: CAM25054.1.
AL611931
, AL606967, AL606986, AL607143, AL732550 Genomic DNA. Translation: CAM25055.1.
CU442759, CU207342, CU407306 Genomic DNA. Translation: CAQ51627.1.
CU442759, CU207342, CU407306 Genomic DNA. Translation: CAQ51628.1.
CU407306, CU207342, CU442759 Genomic DNA. Translation: CAQ51883.1.
CU407306, CU207342, CU442759 Genomic DNA. Translation: CAQ51884.1.
AK122383 mRNA. Translation: BAC65665.1.
CCDSiCCDS38981.1. [A2A891-1]
RefSeqiNP_001075026.1. NM_001081557.3. [A2A891-1]
UniGeneiMm.318846.

3D structure databases

ProteinModelPortaliA2A891.
SMRiA2A891. Positions 874-956.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2A891. 1 interaction.
STRINGi10090.ENSMUSP00000054804.

PTM databases

PhosphoSiteiA2A891.

Proteomic databases

MaxQBiA2A891.
PaxDbiA2A891.
PRIDEiA2A891.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049790; ENSMUSP00000054804; ENSMUSG00000014592. [A2A891-1]
ENSMUST00000097774; ENSMUSP00000095381; ENSMUSG00000014592. [A2A891-2]
ENSMUST00000105668; ENSMUSP00000101293; ENSMUSG00000014592. [A2A891-3]
ENSMUST00000105670; ENSMUSP00000101295; ENSMUSG00000014592. [A2A891-4]
ENSMUST00000169423; ENSMUSP00000127916; ENSMUSG00000014592. [A2A891-1]
GeneIDi100072.
KEGGimmu:100072.
UCSCiuc008vyk.2. mouse. [A2A891-4]
uc008vym.2. mouse. [A2A891-3]
uc008vyn.2. mouse. [A2A891-1]

Organism-specific databases

CTDi23261.
MGIiMGI:2140230. Camta1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0520. Eukaryota.
ENOG410XS5M. LUCA.
GeneTreeiENSGT00390000001446.
HOVERGENiHBG080107.
InParanoidiA2A891.
OMAiAYMHVAE.
OrthoDBiEOG74R1PX.
PhylomeDBiA2A891.
TreeFamiTF323452.

Miscellaneous databases

NextBioi354243.
PROiA2A891.
SOURCEiSearch...

Gene expression databases

BgeeiA2A891.
ExpressionAtlasiA2A891. baseline and differential.
GenevisibleiA2A891. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005559. CG-1_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PfamiPF03859. CG-1. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM01076. CG-1. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS51437. CG_1. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 160-1682 (ISOFORM 1).
    Tissue: BrainImported.

Entry informationi

Entry nameiCMTA1_MOUSE
AccessioniPrimary (citable) accession number: A2A891
Secondary accession number(s): A2A892
, A2A896, A2A897, A2A898, B2KGR3, B2KGR4, Q80TQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: February 5, 2008
Last modified: May 11, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.