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A2A884

- ZEP3_MOUSE

UniProt

A2A884 - ZEP3_MOUSE

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Protein

Transcription factor HIVEP3

Gene
Hivep3, KBP1, Kiaa1555, Krc, Rc, shn3, Zas3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.9 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri185 – 20723C2H2-type 1Add
BLAST
Zinc fingeri213 – 23523C2H2-type 2Add
BLAST
Zinc fingeri636 – 65823C2H2-type 3; degenerateAdd
BLAST
Zinc fingeri1720 – 174223C2H2-type 4Add
BLAST
Zinc fingeri1748 – 177225C2H2-type 5Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: MGI
  2. skeletal muscle cell differentiation Source: MGI
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HIVEP3
Alternative name(s):
Human immunodeficiency virus type I enhancer-binding protein 3 homolog
KB-binding and recognition component
Kappa-B and V(D)J recombination signal sequences-binding protein
Kappa-binding protein 1
Short name:
KBP-1
Recombinant component
Schnurri-3
Zinc finger protein ZAS3
Gene namesi
Name:Hivep3
Synonyms:KBP1, Kiaa1555, Krc, Rc, shn3, Zas3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:106589. Hivep3.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice display adult-onset osteosclerosis with increased bone mass due to increased osteoblast activity; the osteoblasts contain elevated levels of Runx2.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23482348Transcription factor HIVEP3PRO_0000331628Add
BLAST

Post-translational modificationi

Phosphorylated on threonine and serine residues. Phosphorylation by cyclin-dependent kinase CDK1 decreases HIVEP3 DNA binding affinity, and by epidermal growth factor receptor kinase increases its DNA binding affinity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA2A884.
PRIDEiA2A884.

PTM databases

PhosphoSiteiA2A884.

Expressioni

Tissue specificityi

Expressed in macrophages, lymphocytes, brain, thymus, spleen and bone marrow. Expressed in osteoblasts, whole bone and, to a lesser extend, in osteoclasts.4 Publications

Developmental stagei

Expressed in the thymus with increasing level, approximately 4-fold, from E15.5 to E16.5, constant level from E16.5 to birth, then decrease to a low level by P30. Expressed at E13.5 in the dorsal root ganglia of the peripheral nervous system and the trigeminal ganglion of the metencephalon and at relatively low levels in the cerebral cortex; no significant expression was observed prior to E13.5. Expressed in the spinal cord at E19, but weakly detected in the lung and the liver.2 Publications

Inductioni

Upon CD3/CD28 stimulation in CD4 T-cells. Induced by LPS in pre-B-cells.2 Publications

Gene expression databases

ArrayExpressiA2A884.
BgeeiA2A884.
GenevestigatoriA2A884.

Interactioni

Subunit structurei

Interacts with TRAF1 AND TRAF2 as well as with JUN. Forms a multimeric complex with RUNX2 and E3 ubiquitin ligase WWP1.3 Publications

Structurei

3D structure databases

ProteinModelPortaliA2A884.
SMRiA2A884. Positions 184-240, 1719-1775.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1897 – 190041
Repeati1927 – 193042
Repeati1933 – 193643
Repeati1961 – 196444
Repeati2024 – 202745

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni185 – 23551ZAS1Add
BLAST
Regioni204 – 1055852No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUNAdd
BLAST
Regioni257 – 28024Acidic 1Add
BLAST
Regioni844 – 86522Acidic 2Add
BLAST
Regioni1720 – 177253ZAS2Add
BLAST
Regioni1783 – 184159Acidic 3Add
BLAST
Regioni2053 – 2148965 X 4 AA tandem repeats of [ST]-P-X-[RK]Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1409 – 143325 Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi885 – 8917Nuclear localization signal Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi301 – 32727Ser-richAdd
BLAST
Compositional biasi371 – 40737Ser-richAdd
BLAST
Compositional biasi780 – 80223Ser-richAdd
BLAST
Compositional biasi826 – 86237Glu/Pro-richAdd
BLAST
Compositional biasi898 – 93033Ser-richAdd
BLAST
Compositional biasi1873 – 190230Ser-richAdd
BLAST

Domaini

ZAS2 domain binds DNA as dimers, tetramers, and multiple of tetramers and readily forms highly ordred DNA-protein structures.3 Publications

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG296349.
GeneTreeiENSGT00530000063161.
HOGENOMiHOG000155774.
HOVERGENiHBG095595.
InParanoidiA2A884.
KOiK09239.
OMAiMERIPGE.
OrthoDBiEOG7V1FPQ.
PhylomeDBiA2A884.
TreeFamiTF331837.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A884-1 [UniParc]FASTAAdd to Basket

« Hide

MDPDQSIKGT KKADGSPRKR LTKGEAIQTS VSSSAPYPGS GTTAPSESAT     50
QELLATQPFS GPSQEKTGQQ QKPARRPSIE ASVHISQLPQ HPLTPAFMSP 100
GKPEHLLEGS TWQLVDPMRP GPSGSFVAPG LHPQSQLLPS HASILPPEEL 150
PGIPKVFVPR PSQVSLKPAE EAHKKERKPQ KPGKYICQYC SRPCAKPSVL 200
QKHIRSHTGE RPYPCGPCGF SFKTKSNLYK HRKSHAHRIK AGLASGSSSE 250
MYPPGLEMER IPGEEFEEPT EGESTDSEEE TGAASGPSTD VLPKPKHPLL 300
SSSLYSSGSH GSSQERCSLS QSSTGPSLED PAPFAEASSE HPLSHKPEDT 350
HTIKQKLALR LSERKKLIEE QTFLSPGSKG STESGYFSRS ESAEQQVSPP 400
NTNAKSYAEI IFGKCGRIGQ RTSMLASTST QPLLPLSSED KPSLVPLSVP 450
RTQVIEHITK LITINEAVVD TSEIDSVKPR RSSLTRRSSV ESPKSSLYRD 500
SLSSHGEKTK QEQSLLSLQH PPSSTHPVPL LRSHSMPSAA CTISTHHHTF 550
RGSYSFDDHV ADPEVPSRNT PVFTSHPRML KRQPAIELPL GGEYSSEEPG 600
PSSKDPTSKP SDEPEPKESD LTKKTKKGFK TKGANYECTI CGARYKKRDN 650
YEAHKKYYCS ELQITKAHSV GAHEVEKTQA EPEPWSQMMH YKLGATLELT 700
PLRKRRKEKS LGDEEEPPAF GSPGPSETAH NRPLGSTKSP AEASKSAPSL 750
EGPTSFQPRT PKPGAGSEPG KERRTMSKEI SVIQHTSSFE KSDPPEQPSG 800
LEEDKPPAQF SSPPPAPHGR SAHSLQPRLV RQPNIQVPEI LVTEEPDRPD 850
TEPEPPPKEP EKTEEFQWPQ RSQTLAQLPA EKLPPKKKRL RLAEMAQSSG 900
ESSFESSVPL SRSPSQESSI SLSGSSRSAS FDREDHGKAE APGPFSDTRS 950
KTLGSHMLTV PSHHPHAREM RRSASEQSPN VPHSSHMTET RSKSFDYGSL 1000
SPTGPSLAVP AAPPPPAAPP ERRKCFLVRQ ASLNRPPEAE LEAVPKGKQE 1050
SSEEPAASKP STKSSVPQIS VGTTQGGPSG GKSQMQDRPP LGSSPPYTEA 1100
LQVFQPLGTQ LPPPASLFSL QQLLPQEQEQ SSEFFPTQAM AGLLSSPYSM 1150
PPLPPSLFQA PPLPLQPTVL HPSQLHLPQL LPHAADIPFQ QPPSFLPMPC 1200
PAPSTLSGYF LPLQSQFALQ LPGEIESHLP PVKTSLPPLA TGPPGPSSST 1250
EYSSDIQLPP VTPQATSPAP TSAPPLALPA CPDAMVSLVV PVRIQTHMPS 1300
YGSAMYTTLS QILVTQSPGS PASTALTKYE EPSSKSMTVC EADVYEAEPG 1350
PSSISKEQNR GYQTPYLRVP ERKGTSLSSE GILSLEGCSS TASGSKRVLS 1400
PAGSLELTME TQQQKRVKEE EASKADEKLE LVSTCSVVLT STEDRKKTEK 1450
PHVGGQGRSR REAETLSSLS SDVSDPKELS PLSHSTLSHG TAPGSEALKE 1500
YAQPSSKAHR RGLPPMSVKK EDPKEQTDLP PLAPPSSLPL SDTSPKPAKL 1550
QEGTDSKKVL QFPSLHTTTN VSWCYLNYIK PNHIQHADRR SSVYAGWCIS 1600
LYNPNLPGVS TKAALSLLRS KQKVSKETYT MATAPHPEAG RLVPSNSRKP 1650
RMTEVHLPSL VSPESQKDPA RVEKEEKQGK AEEGTPTSKR GEPARVKIFE 1700
GGYKSNEEYI YVRGRGRGRY VCEECGIRCK KPSMLKKHIR THTDVRPYVC 1750
KHCHFAFKTK GNLTKHMKSK AHSKKCQETG VLEELEAEEG TSDDLHQDSE 1800
GQEGAEAVEE HQFSDLEDSD SDSDLDEDEE EEEEEEESQD ELSGPCSEAA 1850
PPCLPPTLQE NSSPVEGPQA PDSTSDEVPQ GSSISEATHL TASSCSTPSR 1900
GTQGLPRLGL APLEKDMSSA PSPKATSPRR PWSPSKEAGS RPSLTRKHSL 1950
TKNDSSPQQC SPAREAQASV TSTPGPQMGP GRDLGPHLCG SPRLELSCLT 2000
PYPIGREAPA GLERATDTGT PRYSPTRRWS LGQAESPPQT VLPGKWALAG 2050
PCSPSADKSG LGLGPVPRAL LQPVPLPHTL LSRSPETCTS AWRKTESRSP 2100
SAGPAPLFPR PFSAPHDFHG HLPSRSEENL FSHLPLHSQL LSRAPCPLIP 2150
IGGIQMVQAR PGAQPTVLPG PCAAWVSGFS GGGSDLTGAR EAQERSRWSP 2200
TESPSASVSP VAKVSKFTLS SELEEERTGR GPGRPPDWEP HRAEAPPGPM 2250
GTHSPCSPQL PQGHQVAPSW RGLLGSPHTL ANLKASSFPP LDRSSSMDCL 2300
AETSTYSPPR SRNLSGEPRT RQGSPELLGR GELRTPLFLP KGSGPPSI 2348
Length:2,348
Mass (Da):253,413
Last modified:February 20, 2007 - v1
Checksum:iE226133774AD50C8
GO

Sequence cautioni

The sequence AAA40039.1 differs from that shown. Reason: Frameshift at positions 1502 and 2242.
The sequence AAR88090.1 differs from that shown. Reason: Frameshift at positions 752, 781, 1045, 1054 and 2242.
The sequence AAA40039.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti131 – 1311L → S in AAR88090. 1 Publication
Sequence conflicti583 – 5842QP → HA in AAR88090. 1 Publication
Sequence conflicti721 – 7222GS → AC in AAR88090. 1 Publication
Sequence conflicti872 – 8721S → T in AAR88090. 1 Publication
Sequence conflicti1129 – 11291E → Q in AAR88090. 1 Publication
Sequence conflicti1507 – 15071K → F in AAA40039. 1 Publication
Sequence conflicti1660 – 16601L → V in AAR88090. 1 Publication
Sequence conflicti1660 – 16601L → V in AAA40039. 1 Publication
Sequence conflicti1880 – 18801Q → E in AAR88090. 1 Publication
Sequence conflicti1880 – 18801Q → E in AAA40039. 1 Publication
Sequence conflicti1944 – 19441L → V in AAR88090. 1 Publication
Sequence conflicti1944 – 19441L → V in AAA40039. 1 Publication
Sequence conflicti1994 – 19941L → P in AAR88090. 1 Publication
Sequence conflicti1994 – 19941L → P in AAA40039. 1 Publication
Sequence conflicti1998 – 19981C → R in AAR88090. 1 Publication
Sequence conflicti1998 – 19981C → R in AAA40039. 1 Publication
Sequence conflicti2014 – 20141R → P in AAA40039. 1 Publication
Sequence conflicti2105 – 21051A → G in AAR88090. 1 Publication
Sequence conflicti2105 – 21051A → G in AAA40039. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL607142 Genomic DNA. Translation: CAM27499.1.
AY454345 mRNA. Translation: AAR88090.1. Frameshift.
AK173200 mRNA. Translation: BAD32478.1.
L07911 mRNA. Translation: AAA40039.1. Sequence problems.
CCDSiCCDS38863.1.
PIRiS41479.
T42717.
RefSeqiNP_034787.2. NM_010657.3.
XP_006502878.1. XM_006502815.1.
XP_006502879.1. XM_006502816.1.
XP_006502880.1. XM_006502817.1.
UniGeneiMm.302758.
Mm.394479.
Mm.422538.
Mm.487430.
Mm.488325.

Genome annotation databases

EnsembliENSMUST00000106307; ENSMUSP00000101914; ENSMUSG00000028634.
ENSMUST00000166542; ENSMUSP00000130249; ENSMUSG00000028634.
GeneIDi16656.
KEGGimmu:16656.
UCSCiuc008una.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL607142 Genomic DNA. Translation: CAM27499.1 .
AY454345 mRNA. Translation: AAR88090.1 . Frameshift.
AK173200 mRNA. Translation: BAD32478.1 .
L07911 mRNA. Translation: AAA40039.1 . Sequence problems.
CCDSi CCDS38863.1.
PIRi S41479.
T42717.
RefSeqi NP_034787.2. NM_010657.3.
XP_006502878.1. XM_006502815.1.
XP_006502879.1. XM_006502816.1.
XP_006502880.1. XM_006502817.1.
UniGenei Mm.302758.
Mm.394479.
Mm.422538.
Mm.487430.
Mm.488325.

3D structure databases

ProteinModelPortali A2A884.
SMRi A2A884. Positions 184-240, 1719-1775.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A2A884.

Proteomic databases

PaxDbi A2A884.
PRIDEi A2A884.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000106307 ; ENSMUSP00000101914 ; ENSMUSG00000028634 .
ENSMUST00000166542 ; ENSMUSP00000130249 ; ENSMUSG00000028634 .
GeneIDi 16656.
KEGGi mmu:16656.
UCSCi uc008una.1. mouse.

Organism-specific databases

CTDi 59269.
MGIi MGI:106589. Hivep3.
Rougei Search...

Phylogenomic databases

eggNOGi NOG296349.
GeneTreei ENSGT00530000063161.
HOGENOMi HOG000155774.
HOVERGENi HBG095595.
InParanoidi A2A884.
KOi K09239.
OMAi MERIPGE.
OrthoDBi EOG7V1FPQ.
PhylomeDBi A2A884.
TreeFami TF331837.

Miscellaneous databases

NextBioi 290349.
PROi A2A884.
SOURCEi Search...

Gene expression databases

ArrayExpressi A2A884.
Bgeei A2A884.
Genevestigatori A2A884.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The mouse DNA binding protein Rc for the kappa B motif of transcription and for the V(D)J recombination signal sequences contains composite DNA-protein interaction domains and belongs to a new family of large transcriptional proteins."
    Wu L.-C., Liu Y., Strandtmann J., Mak C.-H., Lee B., Li Z., Yu C.Y.
    Genomics 35:415-424(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-2341, DOMAIN, FUNCTION, TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Brain.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1281-2348.
    Tissue: Thymus.
  4. "Molecular cloning of a zinc finger protein which binds to the heptamer of the signal sequence for V(D)J recombination."
    Wu L.-C., Mak C.-H., Dear N., Boehm T., Foroni L., Rabbitts T.H.
    Nucleic Acids Res. 21:5067-5073(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1497-2295, FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DOMAIN, REPEAT.
  5. "Regulation by phosphorylation of the zinc finger protein KRC that binds the kappaB motif and V(D)J recombination signal sequences."
    Bachmeyer C., Mak C.H., Yu C.Y., Wu L.-C.
    Nucleic Acids Res. 27:643-648(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
  6. "Downregulation of KRC induces proliferation, anchorage independence, and mitotic cell death in HeLa cells."
    Allen C.E., Wu L.-C.
    Exp. Cell Res. 260:346-356(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "The kappaB and V(D)J recombination signal sequence binding protein KRC regulates transcription of the mouse metastasis-associated gene S100A4/mts1."
    Hjelmsoe I., Allen C.E., Cohn M.A., Tulchinsky E.M., Wu L.-C.
    J. Biol. Chem. 275:913-920(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "The kappa B transcriptional enhancer motif and signal sequences of V(D)J recombination are targets for the zinc finger protein HIVEP3/KRC: a site selection amplification binding study."
    Allen C.E., Mak C.-H., Wu L.-C.
    BMC Immunol. 3:10-10(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAIN ZAS.
  9. "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2."
    Oukka M., Kim S.T., Lugo G., Sun J., Wu L.-C., Glimcher L.H.
    Mol. Cell 9:121-131(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION, INTERACTION WITH TRAF1 AND TRAF2, REGION.
  10. "Embryonic expression and regulation of the large zinc finger protein KRC."
    Hicar M.D., Robinson M.L., Wu L.-C.
    Genesis 33:8-20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DEVELOPMENTAL STAGE.
  11. "Inhibition of NF-kappaB by ZAS3, a zinc-finger protein that also binds to the kappaB motif."
    Hong J.W., Allen C.E., Wu L.-C.
    Proc. Natl. Acad. Sci. U.S.A. 100:12301-12306(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  12. "Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells."
    Oukka M., Wein M.N., Glimcher L.H.
    J. Exp. Med. 199:15-24(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH JUN, INDUCTION.
  13. "Structural characterization of the gene encoding the large zinc finger protein ZAS3: implication to the origin of multiple promoters in eukaryotic genes."
    Hong J.-W., Wu L.-C.
    Biochim. Biophys. Acta 1681:74-87(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE PROMOTER USAGE.
  14. "Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3."
    Jones D.C., Wein M.N., Oukka M., Hofstaetter J.G., Glimcher M.J., Glimcher L.H.
    Science 312:1223-1227(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, INTERACTION WITH RUNX2 AND WWP1.

Entry informationi

Entry nameiZEP3_MOUSE
AccessioniPrimary (citable) accession number: A2A884
Secondary accession number(s): A2MZW0, Q69ZG6, Q6SNP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Hivep3 gene expression is probably controlled by a combination of differential promoter usage, alternative splicing, and possible intergenic splicing.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi