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Protein

Fas-binding factor 1

Gene

Fbf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-MMU-5620912. Anchoring of the basal body to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Fas-binding factor 1
Short name:
FBF-1
Gene namesi
Name:Fbf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1922033. Fbf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002976471 – 1173Fas-binding factor 1Add BLAST1173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei172PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA2A870.
PaxDbiA2A870.
PRIDEiA2A870.

PTM databases

iPTMnetiA2A870.
PhosphoSitePlusiA2A870.

Expressioni

Tissue specificityi

Broadly expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000020776.
CleanExiMM_FBF1.
ExpressionAtlasiA2A870. baseline and differential.
GenevisibleiA2A870. MM.

Interactioni

Subunit structurei

Interacts with PARD3 (By similarity). May interact with FAS cytoplasmic domain.By similarity

Protein-protein interaction databases

IntActiA2A870. 1 interactor.
MINTiMINT-144589.
STRINGi10090.ENSMUSP00000099320.

Structurei

3D structure databases

ProteinModelPortaliA2A870.
SMRiA2A870.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili617 – 742Sequence analysisAdd BLAST126
Coiled coili808 – 917Sequence analysisAdd BLAST110
Coiled coili975 – 1057Sequence analysisAdd BLAST83

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFRT. Eukaryota.
ENOG4111RN4. LUCA.
GeneTreeiENSGT00720000108861.
HOGENOMiHOG000060115.
HOVERGENiHBG071428.
InParanoidiA2A870.
KOiK16471.
OMAiGIIEQME.
OrthoDBiEOG091G02RR.
PhylomeDBiA2A870.
TreeFamiTF328742.

Family and domain databases

InterProiIPR033561. FBF1.
[Graphical view]
PANTHERiPTHR33689:SF1. PTHR33689:SF1. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2A870-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGQCCEELQ RAPKPRMALR TKKGLKGSIE DVLGDLLGDD TTPPEKPAEP
60 70 80 90 100
ASHAKDTASS PQWQASKAKF LPKDSVEGLA GADAEASSVS DADPQVFLQN
110 120 130 140 150
MKDLDSMDDD LFGRMKSHQP SGKGAAKGPG KEGPSNHKPA GTLTANEKGY
160 170 180 190 200
TMPTKKPPPS SSKTGLQYKK FSFEDFEDPL AGLLSDEEEE TATKLPAVER
210 220 230 240 250
KPAPKSPGAA AGQGPSVPLT PGDTPIRKKE LLFDEGDDIM TTLGFEDSPK
260 270 280 290 300
AERKKTGDQE GPLPARSKLD ELLGRGTAAK LLTRPGTGER REFQLDKKYQ
310 320 330 340 350
KMGGEESVPA RDKEDSWDDE TLTFGAYKPT VASSEGRQSR RQSVSRFLGE
360 370 380 390 400
GGPDPKGESL GFKQSSPPAS SPIHPRKGGA DWLGLKDNDL DLLSPSPVQK
410 420 430 440 450
AQQEDSPMTP SLLPPTNQPS APEPQSAPTG LPSAAKPPAK GARPSLKASQ
460 470 480 490 500
ASSPKASEEK EDDWLSHVIS QKKSQNLARE ERAGPPKDLA SLGSLGQTPS
510 520 530 540 550
GSLPVAQVLE QAPAGEASKP TTQGMAAVRP GVTGSSMSWS QATTVLPVDD
560 570 580 590 600
PKKGAASASG DFSSREPAVY IPHSQEPTGL SVPIQTLLPE SMMQSLLPGS
610 620 630 640 650
GYQKQLLAAQ GQLQSSTAQL QVELLQSQTK LSELEAQVRK LELERAQHRM
660 670 680 690 700
LLESLQQRHQ ADLELIEDAH RSRIKVLETS YQQREEQLRR EKEVLSAQHA
710 720 730 740 750
SYCREAEQAR AELVAQHQRQ MAMAEQERDQ EVARLRELQQ ASILEMRKDH
760 770 780 790 800
EHQLQRLKML KDQEIDAVTS ATSHTRSLNG IIEQMEKFSS SLNTLSSRVE
810 820 830 840 850
ASHLTTSQQR ELGIRQQDEQ LRALQERLGR QQRDMEEERN RLQEVIGKME
860 870 880 890 900
VRLSEQSRLL EQERWRVAAE KTKAESAQRT LEEQRKIMVQ QIAMEREELE
910 920 930 940 950
RAKSALLEEQ KSVMNKCGEE RRRLAAEWAE YFTQQKLSKE RAEREAERAM
960 970 980 990 1000
HADSQREGTI ISLTKEQAEL TVRACELRAK EEKLLAEREA LERERQELRL
1010 1020 1030 1040 1050
EKDRLHKASL RLQARAQEVE HMSKVASKKY EEGEQALQEA QQMQNEQQGR
1060 1070 1080 1090 1100
LQVVQRQQEW LRQQEQRVHQ EHLSLAQQRL QLDRVRQEVP ASLPGLPPRV
1110 1120 1130 1140 1150
QGPAASSRDA VQAPASSSPQ CSQPAAAQVP THLLAKLLLL KHTAEEDHDF
1160 1170
LENEQFFLET LKKAPYNMAY HSA
Length:1,173
Mass (Da):130,138
Last modified:February 20, 2007 - v1
Checksum:i2332B34E71672160
GO
Isoform 2 (identifier: A2A870-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-784: Missing.

Show »
Length:389
Mass (Da):45,315
Checksum:iA2E3381425BD2BD1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17M → V in AAK28326 (PubMed:10978533).Curated1
Sequence conflicti115M → I in AAK28326 (PubMed:10978533).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0273241 – 784Missing in isoform 2. 2 PublicationsAdd BLAST784

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241249 mRNA. Translation: AAK28326.1.
AK031140 mRNA. Translation: BAC27275.1.
AL607108 Genomic DNA. Translation: CAM24057.1.
AL607108 Genomic DNA. Translation: CAM24058.1.
BC055689 mRNA. Translation: AAH55689.1.
BC137794 mRNA. Translation: AAI37795.1.
CCDSiCCDS25659.1. [A2A870-1]
RefSeqiNP_766159.3. NM_172571.3. [A2A870-1]
XP_006533155.1. XM_006533092.3. [A2A870-1]
XP_006533156.1. XM_006533093.3. [A2A870-1]
XP_006533157.1. XM_006533094.3. [A2A870-1]
XP_011247250.1. XM_011248948.2. [A2A870-1]
UniGeneiMm.35241.

Genome annotation databases

EnsembliENSMUST00000103031; ENSMUSP00000099320; ENSMUSG00000020776. [A2A870-1]
ENSMUST00000106435; ENSMUSP00000102043; ENSMUSG00000020776. [A2A870-1]
GeneIDi217335.
KEGGimmu:217335.
UCSCiuc007mkf.1. mouse. [A2A870-2]
uc007mkg.2. mouse. [A2A870-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241249 mRNA. Translation: AAK28326.1.
AK031140 mRNA. Translation: BAC27275.1.
AL607108 Genomic DNA. Translation: CAM24057.1.
AL607108 Genomic DNA. Translation: CAM24058.1.
BC055689 mRNA. Translation: AAH55689.1.
BC137794 mRNA. Translation: AAI37795.1.
CCDSiCCDS25659.1. [A2A870-1]
RefSeqiNP_766159.3. NM_172571.3. [A2A870-1]
XP_006533155.1. XM_006533092.3. [A2A870-1]
XP_006533156.1. XM_006533093.3. [A2A870-1]
XP_006533157.1. XM_006533094.3. [A2A870-1]
XP_011247250.1. XM_011248948.2. [A2A870-1]
UniGeneiMm.35241.

3D structure databases

ProteinModelPortaliA2A870.
SMRiA2A870.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2A870. 1 interactor.
MINTiMINT-144589.
STRINGi10090.ENSMUSP00000099320.

PTM databases

iPTMnetiA2A870.
PhosphoSitePlusiA2A870.

Proteomic databases

MaxQBiA2A870.
PaxDbiA2A870.
PRIDEiA2A870.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103031; ENSMUSP00000099320; ENSMUSG00000020776. [A2A870-1]
ENSMUST00000106435; ENSMUSP00000102043; ENSMUSG00000020776. [A2A870-1]
GeneIDi217335.
KEGGimmu:217335.
UCSCiuc007mkf.1. mouse. [A2A870-2]
uc007mkg.2. mouse. [A2A870-1]

Organism-specific databases

CTDi85302.
MGIiMGI:1922033. Fbf1.

Phylogenomic databases

eggNOGiENOG410IFRT. Eukaryota.
ENOG4111RN4. LUCA.
GeneTreeiENSGT00720000108861.
HOGENOMiHOG000060115.
HOVERGENiHBG071428.
InParanoidiA2A870.
KOiK16471.
OMAiGIIEQME.
OrthoDBiEOG091G02RR.
PhylomeDBiA2A870.
TreeFamiTF328742.

Enzyme and pathway databases

ReactomeiR-MMU-5620912. Anchoring of the basal body to the plasma membrane.

Miscellaneous databases

PROiA2A870.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020776.
CleanExiMM_FBF1.
ExpressionAtlasiA2A870. baseline and differential.
GenevisibleiA2A870. MM.

Family and domain databases

InterProiIPR033561. FBF1.
[Graphical view]
PANTHERiPTHR33689:SF1. PTHR33689:SF1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFBF1_MOUSE
AccessioniPrimary (citable) accession number: A2A870
Secondary accession number(s): A2A871
, B2RQ77, Q8BSP0, Q99MZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.