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Protein

Integrin beta

Gene

Itgb4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotation
Biological processCell adhesionUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
Gene namesi
Name:Itgb4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96613 Itgb4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei712 – 734HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_501456522029 – 1802Integrin betaSequence analysisAdd BLAST1774

Expressioni

Gene expression databases

BgeeiENSMUSG00000020758

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021107

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1127 – 1216Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1220 – 1319Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini1510 – 1605Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini1623 – 1719Fibronectin type-IIIInterPro annotationAdd BLAST97

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
GeneTreeiENSGT00760000119064
HOGENOMiHOG000231105
HOVERGENiHBG006189
KOiK06525

Family and domain databases

CDDicd00063 FN3, 4 hits
Gene3Di2.60.40.10, 4 hits
2.60.40.2030, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR013032 EGF-like_CS
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR012013 Integrin_bsu-4
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF42 PTHR10082:SF42, 1 hit
PfamiView protein in Pfam
PF03160 Calx-beta, 1 hit
PF00041 fn3, 4 hits
PF07965 Integrin_B_tail, 1 hit
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit
PIRSFiPIRSF002513 Integrin_B4, 2 hits
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00237 Calx_beta, 1 hit
SM00060 FN3, 4 hits
SM00187 INB, 1 hit
SM01242 Integrin_B_tail, 1 hit
SUPFAMiSSF141072 SSF141072, 1 hit
SSF49265 SSF49265, 2 hits
SSF53300 SSF53300, 1 hit
SSF69687 SSF69687, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS50853 FN3, 4 hits
PS00243 INTEGRIN_BETA, 2 hits

Sequencei

Sequence statusi: Complete.

A2A864-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPCCSPWV KLLLLAAMLS ASLPGDLANR CKKAQVKSCT ECIRVDKSCA
60 70 80 90 100
YCTDELFKER RCNTQAELLA AGCRGESILV MESSLEITEN TQIDTSLHRS
110 120 130 140 150
QVSPQGLQVR LRPGEERSFV FQVFEPLESP VDLYILMDFS NSMSDDLDNL
160 170 180 190 200
KQMGQNLAKI LRQLTSDYTI GFGKFVDKVS VPQTDMRPEK LKEPWPNSDP
210 220 230 240 250
PFSFKNVISL TENVEEFWNK LQGERISGNL DAPEGGFDAI LQTAVCTRDI
260 270 280 290 300
GWRADSTHLL VFSTESAFHY EADGANVLAG IMNRNDEKCH LDASGAYTQY
310 320 330 340 350
KTQDYPSVPT LVRLLAKHNI IPIFAVTNYS YSYYEKLHKY FPVSSLGVLQ
360 370 380 390 400
EDSSNIVELL EEAFYRIRSN LDIRALDSPR GLRTEVTSDT LQKTETGSFH
410 420 430 440 450
IKRGEVGTYN VHLRAVEDID GTHVCQLAKE DQGGNIHLKP SFSDGLRMDA
460 470 480 490 500
SVICDVCPCE LQKEVRSARC HFRGDFMCGH CVCNEGWSGK TCNCSTGSLS
510 520 530 540 550
DTQPCLREGE DKPCSGHGEC QCGRCVCYGE GRYEGHFCEY DNFQCPRTSG
560 570 580 590 600
FLCNDRGRCS MGECVCEPGW TGRSCDCPLS NATCIDSNGG ICNGRGYCEC
610 620 630 640 650
GRCHCNQQSL YTDTTCEINY SAIRLGLCED LRSCVQCQAW GTGEKKGRAC
660 670 680 690 700
DDCPFKVKMV DELKKEEVVE YCSFRDEDDD CTYSYNVEGD GSPGPNSTVL
710 720 730 740 750
VHKKKDCPPG SFWWLIPLLI FLLLLLALLL LLCWKYCACC KACLGLLPCC
760 770 780 790 800
NRGHMVGFKE DHYMLRENLM ASDHLDTPML RSGNLKGRDT VRWKITNNVQ
810 820 830 840 850
RPGFATHAAS TSPTELVPYG LSLRLGRLCT ENLMKPGTRE CDQLRQEVEE
860 870 880 890 900
NLNEVYRQVS GAHKLQQTKF RQQPNTGKKQ DHTIVDTVLL APRSAKQMLL
910 920 930 940 950
KLTEKQVEQG SFHELKVAPG YYTVTAEQDA RGMVEFQEGV ELVDVRVPLF
960 970 980 990 1000
IRPEDDDEKQ LLVEAIDVPV GTATLGRRLV NITIIKEQAS GVVSFEQPEY
1010 1020 1030 1040 1050
SVSRGDQVAR IPVIRHILDN GKSQVSYSTQ DNTAHGHRDY VPVEGELLFH
1060 1070 1080 1090 1100
PGETWKELQV KLLELQEVDS LLRGRQVRRF QVQLSNPKFG ARLGQPSTTT
1110 1120 1130 1140 1150
VILDETDRSL INQTLSSPPP PHGDLGAPQN PNAKAAGSRK IHFNWLPPPG
1160 1170 1180 1190 1200
KPMGYRVKYW IQGDSESEAH LLDSKVPSVE LTNLYPYCDY EMKVCAYGAQ
1210 1220 1230 1240 1250
GEGPYSSLVS CRTHQEVPSE PGRLAFNVVS STVTQLSWAE PAETNGEITA
1260 1270 1280 1290 1300
YEVCYGLVNE DNRPIGPMKK VLVDNPKNRM LLIENLRESQ PYRYTVKARN
1310 1320 1330 1340 1350
GAGWGPEREA IINLATQPKR PMSIPIIPDI PIVDAQGGED YENFLMYSDD
1360 1370 1380 1390 1400
VLRSPASSQR PSVSDDTEHL VNGRMDFAYP GSANSLHRMT AANVAYGTHL
1410 1420 1430 1440 1450
SPHLSHRVLS TSSTLTRDYH SLTRTEHSHS GTLPRDYSTL TSLSSQGLPP
1460 1470 1480 1490 1500
IWEDGRSRLP LSWTLGSLSR AHMKGVPASR GSPDSIILAG QSAAPSWGTD
1510 1520 1530 1540 1550
SRGAVGVPDT PTRLVFSALG PTSLKVSWQE PQCDRMLLGY SVEYQLLNGG
1560 1570 1580 1590 1600
EMHRLNIPNP GQTSVVVEDL LPNHSYVFRV RAQSQEGWGR EREGVITIES
1610 1620 1630 1640 1650
QVHPQSPLCP LPGSAFTLST PSAPGPLVFT ALSPDSLQLS WERPRRPNGD
1660 1670 1680 1690 1700
ILGYLVTCEM AQGGAPARTF RVDGDNPESR LTVPGLSENV PYKFKVQART
1710 1720 1730 1740 1750
TEGFGPEREG IITIESQVGG PFPQLGSHSG LFQNPVQSEF SSVTSTHSTT
1760 1770 1780 1790 1800
TEPFLMDGLT LGTQRLEAGG SLTRHVTQEF VTRTLTASGS LSTHMDQQFF

QT
Length:1,802
Mass (Da):199,867
Last modified:February 20, 2007 - v1
Checksum:i25A903DCCF04DF23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL607108 Genomic DNA No translation available.
AL645647 Genomic DNA No translation available.
RefSeqiNP_001005608.2, NM_001005608.2
UniGeneiMm.213873

Genome annotation databases

EnsembliENSMUST00000021107; ENSMUSP00000021107; ENSMUSG00000020758
ENSMUST00000169928; ENSMUSP00000127604; ENSMUSG00000020758
GeneIDi192897
KEGGimmu:192897
UCSCiuc007mjg.1 mouse

Similar proteinsi

Entry informationi

Entry nameiA2A864_MOUSE
AccessioniPrimary (citable) accession number: A2A864
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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