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Protein

REM2- and Rab-like small GTPase 1

Gene

Rsg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi62 – 69GTPBy similarity8
Nucleotide bindingi175 – 178GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation, Exocytosis, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
REM2- and Rab-like small GTPase 1
Gene namesi
Name:Rsg1
Synonyms:Gm723
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1923416. Rsg1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002845391 – 258REM2- and Rab-like small GTPase 1Add BLAST258

Proteomic databases

PaxDbiA2A825.
PRIDEiA2A825.

PTM databases

iPTMnetiA2A825.
PhosphoSitePlusiA2A825.

Expressioni

Gene expression databases

BgeeiENSMUSG00000073733.
CleanExiMM_6330545A04RIK.
ExpressionAtlasiA2A825. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095422.

Structurei

3D structure databases

ProteinModelPortaliA2A825.
SMRiA2A825.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 258Small GTPase-likeAdd BLAST208

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00390000006521.
HOVERGENiHBG106703.
InParanoidiA2A825.
OMAiMVIGSKF.
OrthoDBiEOG091G0LUX.
PhylomeDBiA2A825.
TreeFamiTF329319.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

A2A825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPPMHGSV IVPDWHETVE GKEYLACILR KNRRREFGLL ERPVLPPSVV
60 70 80 90 100
IDTASYKIFV SGKSGVGKTA LVAKLAGLEV PIVHHETTGI QTTVVFWPAK
110 120 130 140 150
LKASDCVVMF RFEFWDCGES ALKKFDHMLP ACKENADAFL FLFSFTDRAS
160 170 180 190 200
FEDLPGQLTR VAGEAPGLVK IVIGSKFDQY MHTDVPARDL TAFRQAWELP
210 220 230 240 250
LFRVKSVPGR RLADGRTLDG RAGLADTAHV LNGLAEQLWH QDQVAAGLLP

SSPESAPG
Length:258
Mass (Da):28,422
Last modified:February 20, 2007 - v1
Checksum:i2AE5CB87F791780A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL607087 Genomic DNA. Translation: CAM16992.1.
CCDSiCCDS38937.1.
RefSeqiNP_001074643.1. NM_001081174.2.
UniGeneiMm.271064.
Mm.458647.

Genome annotation databases

EnsembliENSMUST00000097813; ENSMUSP00000095422; ENSMUSG00000073733.
GeneIDi76166.
KEGGimmu:76166.
UCSCiuc012doa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL607087 Genomic DNA. Translation: CAM16992.1.
CCDSiCCDS38937.1.
RefSeqiNP_001074643.1. NM_001081174.2.
UniGeneiMm.271064.
Mm.458647.

3D structure databases

ProteinModelPortaliA2A825.
SMRiA2A825.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095422.

PTM databases

iPTMnetiA2A825.
PhosphoSitePlusiA2A825.

Proteomic databases

PaxDbiA2A825.
PRIDEiA2A825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097813; ENSMUSP00000095422; ENSMUSG00000073733.
GeneIDi76166.
KEGGimmu:76166.
UCSCiuc012doa.1. mouse.

Organism-specific databases

CTDi79363.
MGIiMGI:1923416. Rsg1.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00390000006521.
HOVERGENiHBG106703.
InParanoidiA2A825.
OMAiMVIGSKF.
OrthoDBiEOG091G0LUX.
PhylomeDBiA2A825.
TreeFamiTF329319.

Miscellaneous databases

PROiA2A825.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073733.
CleanExiMM_6330545A04RIK.
ExpressionAtlasiA2A825. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRSG1_MOUSE
AccessioniPrimary (citable) accession number: A2A825
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.