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Protein

Migration and invasion-inhibitory protein

Gene

Miip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Migration and invasion-inhibitory protein
Alternative name(s):
Invasion-inhibitory protein 45
Short name:
IIp45
Gene namesi
Name:Miip
Synonyms:D4Wsu114e, Iip45
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:106506 Miip

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003243231 – 387Migration and invasion-inhibitory proteinAdd BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei307PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA2A7Y5
PRIDEiA2A7Y5

PTM databases

iPTMnetiA2A7Y5
PhosphoSitePlusiA2A7Y5

Expressioni

Gene expression databases

BgeeiENSMUSG00000029022
ExpressionAtlasiA2A7Y5 baseline and differential
GenevisibleiA2A7Y5 MM

Interactioni

Subunit structurei

Interacts with IGFBP2.By similarity

Protein-protein interaction databases

BioGridi205712, 1 interactor
STRINGi10090.ENSMUSP00000030886

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410II0C Eukaryota
ENOG4111PRQ LUCA
GeneTreeiENSGT00390000003768
HOGENOMiHOG000095519
InParanoidiA2A7Y5
OMAiTPCRLCR
OrthoDBiEOG091G0B37
PhylomeDBiA2A7Y5
TreeFamiTF335829

Family and domain databases

InterProiView protein in InterPro
IPR031466 MIIP
PANTHERiPTHR34831 PTHR34831, 1 hit
PfamiView protein in Pfam
PF15734 MIIP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2A7Y5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPNMAETKDP VRLRLLSLEL LKQLWAGHEA MCRSVVRAAS GSNLDCSSNN
60 70 80 90 100
LEMPLSQETS SASSVAPSSQ DKRHMLDPLD SRRDDTFDVA WYVKFNSRMD
110 120 130 140 150
SFLPATGQHQ EPQEELRPPS VPLLATQGLK GPVSLGGPKG LGPDKTQVPR
160 170 180 190 200
SILSRLSKPS KPRVTSQESA VPESSWHSRP YLGYDWIAGS LDNSSPVTSE
210 220 230 240 250
PEAFFSMLQR FRENNKEDCV CNSPEAVFPG LQESSGVEED HECMYCYRIN
260 270 280 290 300
RRLFPEPVDP GAPCRLCGIP RDEKGPGTLV EPVQVRVSIP LSIMDPPHQY
310 320 330 340 350
RIHRRKSFDA SDTLALPRHC LLGWDILPPK SEKTSVPKSL DLWSSVSYGA
360 370 380
GQRRDLSATS PPCQALPAQV TPPLWSEPQV AQLCPSH
Length:387
Mass (Da):42,828
Last modified:February 20, 2007 - v1
Checksum:i62D3902428FF1F2C
GO
Isoform 2 (identifier: A2A7Y5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     365-387: ALPAQVTPPLWSEPQVAQLCPSH → KPRGQTAQKTTVFYQCQQPPLRRSP

Show »
Length:389
Mass (Da):43,275
Checksum:iA5649C4B585262EC
GO

Sequence cautioni

The sequence AAH17525 differs from that shown. Intron retention.Curated
The sequence AAH17525 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH24069 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032215365 – 387ALPAQ…LCPSH → KPRGQTAQKTTVFYQCQQPP LRRSP in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133976 mRNA Translation: BAE21965.1
AL607066 Genomic DNA No translation available.
BC017525 mRNA Translation: AAH17525.1 Sequence problems.
BC024069 mRNA Translation: AAH24069.1 Different initiation.
CCDSiCCDS18923.2 [A2A7Y5-1]
RefSeqiNP_001020536.2, NM_001025365.2 [A2A7Y5-1]
XP_006539013.1, XM_006538950.3 [A2A7Y5-2]
UniGeneiMm.250504

Genome annotation databases

EnsembliENSMUST00000030886; ENSMUSP00000030886; ENSMUSG00000029022 [A2A7Y5-1]
ENSMUST00000119975; ENSMUSP00000113897; ENSMUSG00000029022 [A2A7Y5-2]
ENSMUST00000172710; ENSMUSP00000134085; ENSMUSG00000029022 [A2A7Y5-1]
GeneIDi28010
KEGGimmu:28010
UCSCiuc008vtd.2 mouse [A2A7Y5-1]
uc008vte.2 mouse [A2A7Y5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMIIP_MOUSE
AccessioniPrimary (citable) accession number: A2A7Y5
Secondary accession number(s): Q3UZ92, Q8CFZ8, Q8VD71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 20, 2007
Last modified: January 31, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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