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Protein

CMRF35-like molecule 6

Gene

Cd300c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
CMRF35-like molecule 6
Short name:
CLM-6
Alternative name(s):
CD300 antigen-like family member C
CD_antigen: CD300c
Gene namesi
Name:Cd300c
Synonyms:Clm6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3032626. Cd300c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 188167ExtracellularSequence analysisAdd
BLAST
Transmembranei189 – 20921HelicalSequence analysisAdd
BLAST
Topological domaini210 – 22920CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 229208CMRF35-like molecule 6PRO_0000320129Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 110PROSITE-ProRule annotation
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence analysis
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA2A7V7.
PRIDEiA2A7V7.

Expressioni

Gene expression databases

CleanExiMM_CD300C.

Structurei

3D structure databases

ProteinModelPortaliA2A7V7.
SMRiA2A7V7. Positions 30-134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 126105Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Belongs to the CD300 family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JCC5. Eukaryota.
ENOG4111BBB. LUCA.
HOGENOMiHOG000231065.
HOVERGENiHBG063279.
InParanoidiA2A7V7.
KOiK06719.
PhylomeDBiA2A7V7.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2A7V7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPRVIRLWL PSAVLLSLVP GHFPVRGPST VTGTVGESLS VSCQYEKKLK
60 70 80 90 100
TKKKIWCKWK SNVLCKDIVK TSASEEARNG RVSIRDHPDN LTFTVTLENL
110 120 130 140 150
TLEDAGTYMC MVDIGFFYDA YLQIDKSFKV EVFVVPGKPP FKGSRPGNGI
160 170 180 190 200
NILASPTSSA VHTQPNVTTD DTIPAPSPEL RSLLSSPHFW ILVSLKLPLF
210 220
LSMLGALLWV NRPQRCSGGS SAWPCYENQ
Length:229
Mass (Da):25,336
Last modified:February 20, 2007 - v1
Checksum:i856656FDC5589FD0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411F → V in AAR27943 (PubMed:14662855).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY457052 mRNA. Translation: AAR27943.1.
AL607025 Genomic DNA. Translation: CAM21173.1.
RefSeqiNP_954695.1. NM_199225.1.
UniGeneiMm.351450.

Genome annotation databases

GeneIDi387565.
KEGGimmu:387565.
UCSCiuc007mgc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY457052 mRNA. Translation: AAR27943.1.
AL607025 Genomic DNA. Translation: CAM21173.1.
RefSeqiNP_954695.1. NM_199225.1.
UniGeneiMm.351450.

3D structure databases

ProteinModelPortaliA2A7V7.
SMRiA2A7V7. Positions 30-134.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiA2A7V7.
PRIDEiA2A7V7.

Protocols and materials databases

DNASUi387565.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi387565.
KEGGimmu:387565.
UCSCiuc007mgc.1. mouse.

Organism-specific databases

CTDi10871.
MGIiMGI:3032626. Cd300c.

Phylogenomic databases

eggNOGiENOG410JCC5. Eukaryota.
ENOG4111BBB. LUCA.
HOGENOMiHOG000231065.
HOVERGENiHBG063279.
InParanoidiA2A7V7.
KOiK06719.
PhylomeDBiA2A7V7.

Miscellaneous databases

NextBioi405936.
PROiA2A7V7.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CD300C.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation."
    Chung D.-H., Humphrey M.B., Nakamura M.C., Ginzinger D.G., Seaman W.E., Daws M.R.
    J. Immunol. 171:6541-6548(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiCLM6_MOUSE
AccessioniPrimary (citable) accession number: A2A7V7
Secondary accession number(s): Q6SJQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 20, 2007
Last modified: November 11, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.