Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger MYM-type protein 4

Gene

Zmym4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri362 – 40241MYM-type 1Add
BLAST
Zinc fingeri414 – 45744MYM-type 2Add
BLAST
Zinc fingeri464 – 49936MYM-type 3Add
BLAST
Zinc fingeri510 – 54435MYM-type 4Add
BLAST
Zinc fingeri554 – 59239MYM-type 5Add
BLAST
Zinc fingeri600 – 63132MYM-type 6Add
BLAST
Zinc fingeri708 – 74235MYM-type 7Add
BLAST
Zinc fingeri749 – 78840MYM-type 8Add
BLAST
Zinc fingeri795 – 82935MYM-type 9Add
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MYM-type protein 4
Alternative name(s):
Zinc finger protein 262
Gene namesi
Name:Zmym4
Synonyms:Kiaa0425, Zfp262, Znf262
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1915035. Zmym4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 15491548Zinc finger MYM-type protein 4PRO_0000299018Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei106 – 1061PhosphothreonineBy similarity
Modified residuei109 – 1091PhosphoserineBy similarity
Modified residuei121 – 1211PhosphoserineCombined sources
Cross-linki148 – 148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei161 – 1611PhosphoserineBy similarity
Modified residuei197 – 1971PhosphoserineBy similarity
Modified residuei242 – 2421PhosphoserineBy similarity
Cross-linki250 – 250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki250 – 250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki273 – 273Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki430 – 430Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1065 – 10651PhosphoserineBy similarity
Modified residuei1072 – 10721PhosphoserineBy similarity
Modified residuei1182 – 11821PhosphoserineBy similarity
Modified residuei1257 – 12571PhosphoserineBy similarity
Modified residuei1540 – 15401PhosphoserineBy similarity
Modified residuei1543 – 15431PhosphoserineBy similarity
Modified residuei1548 – 15481PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiA2A791.
MaxQBiA2A791.
PaxDbiA2A791.
PeptideAtlasiA2A791.
PRIDEiA2A791.

PTM databases

iPTMnetiA2A791.
PhosphoSiteiA2A791.

Expressioni

Gene expression databases

BgeeiA2A791.
CleanExiMM_ZMYM4.
ExpressionAtlasiA2A791. baseline and differential.
GenevisibleiA2A791. MM.

Interactioni

Protein-protein interaction databases

BioGridi212440. 1 interaction.
IntActiA2A791. 1 interaction.
STRINGi10090.ENSMUSP00000101714.

Structurei

3D structure databases

ProteinModelPortaliA2A791.
SMRiA2A791. Positions 338-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 9 MYM-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri362 – 40241MYM-type 1Add
BLAST
Zinc fingeri414 – 45744MYM-type 2Add
BLAST
Zinc fingeri464 – 49936MYM-type 3Add
BLAST
Zinc fingeri510 – 54435MYM-type 4Add
BLAST
Zinc fingeri554 – 59239MYM-type 5Add
BLAST
Zinc fingeri600 – 63132MYM-type 6Add
BLAST
Zinc fingeri708 – 74235MYM-type 7Add
BLAST
Zinc fingeri749 – 78840MYM-type 8Add
BLAST
Zinc fingeri795 – 82935MYM-type 9Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IE8I. Eukaryota.
ENOG410XQR6. LUCA.
GeneTreeiENSGT00550000074408.
HOGENOMiHOG000293258.
HOVERGENiHBG106731.
InParanoidiA2A791.
OMAiDNIFTEP.
OrthoDBiEOG75J0M6.
PhylomeDBiA2A791.
TreeFamiTF336988.

Family and domain databases

InterProiIPR021893. DUF3504.
IPR011017. TRASH_dom.
IPR010507. Znf_MYM.
[Graphical view]
PfamiPF12012. DUF3504. 1 hit.
PF06467. zf-FCS. 5 hits.
[Graphical view]
SMARTiSM00746. TRASH. 10 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2A791-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEREVETGP RKRFEQKSDA VFDEIVENCG VMDTEMSEDT DHNLTPTLAS
60 70 80 90 100
MSYGMPNQTG SENSLLDEDD YFLNSGDLAG IPVVSSDNED EQDCSSKDNL
110 120 130 140 150
VSSVHTDGSL EVERRAAHQE SDNENEIQIQ NQLKKDFPKQ FDQVSVFKSI
160 170 180 190 200
RKDFCLVREN SKETFSGKEK NRDLTYHERE KRLDKPHKGL DSRLKSSFFD
210 220 230 240 250
KAANQVEETL HTHLPQNPET NFRDSSYPFA SKESIGSELG NSFASNIRIK
260 270 280 290 300
EEPLDDEYDR AVAPQQGLLD RVKDEPDNAQ EYSHGQQQKT QEGELKISAV
310 320 330 340 350
FSVSGSPLAP QLTTGFQPSL ASPGMNKMLP SVPATAVRVS CSGCKKILQK
360 370 380 390 400
GQTAYQRKGS TQLFCSTLCL TGYTVPPARP PPPLTKKTCS SCSKDILNPK
410 420 430 440 450
DVISAQFENS TTSKDFCSQS CLSTYELKKK PIVTINTNSI STKCSMCQKN
460 470 480 490 500
AVIRHEVNYQ NVVHKLCSDA CFSKFRSANN LTMNCCENCG GYCYSGSGQC
510 520 530 540 550
HVLQIEGQSK KFCSSMCVTS YKQKSAKITP CALCKSLRSS AEMIENTNSL
560 570 580 590 600
GKTELFCSVN CLSAYRVKMV TSAGVQVQCN SCKTSAIPQY HLAMSDGSIR
610 620 630 640 650
NFCSYSCVVA FQNLFNKPTG MNSSVVPLSQ GQVIVSIPTG SSASAGGGST
660 670 680 690 700
PAVSPTSINS SAAAGLQRLA AQSQHVGFAR SVVKLRCQHC NRLFATKPEL
710 720 730 740 750
LDYKGKMFQF CGKNCCDEYK KINNVMAMCE YCKIEKIIKE TVRFSGADKS
760 770 780 790 800
FCSEGCKLLY KHDLGKRWGS HCKMCSYCLQ TSPKLIQNNL GGKVEDFCCE
810 820 830 840 850
ECMSKYTVLF YQMAKCDGCK RQGKLSESLK WRGDIKHFCN LLCILMFCHQ
860 870 880 890 900
QTVCDPPLQN NAVASISMVQ AASAGPPSLR KDSTPVIANV VSLASAPAAQ
910 920 930 940 950
PTANTNSVLQ GAVPTVTAKI IGDASTQTDA LKLPPSQPPR LLKNKALLCK
960 970 980 990 1000
PITQTKATSC KPHTQNKECQ TDTPSEPQVM VVPVPVPVFV PIPLHLYTQY
1010 1020 1030 1040 1050
TPVPFGIPVP MPVPMFIPSS MDNDEKATEG IEDIKEKLAT HPFEADLLEM
1060 1070 1080 1090 1100
AEMIAEDEEK EKTLSQGESQ TSEQELFLDT KIFEKDQGST YSGDLESEAV
1110 1120 1130 1140 1150
STPHSWEEEL NHYALKSNAV QDADSELKPF SKGETEQDLE ADFPSESFDP
1160 1170 1180 1190 1200
LNKGQGIQAR SRTRRRHRDG FPQPRRRGRK KSVVPVEPRS LIQGALQGCS
1210 1220 1230 1240 1250
VSGMTLKYMY GVNAWKNWVQ WKNAKDEQGD LKCGGGELAS ASPCSDSLGS
1260 1270 1280 1290 1300
AQDHALSQES SEQGCKARSV KLKEDILSCT FSELSLGLCQ FIQEVRRPNG
1310 1320 1330 1340 1350
EKYDPDSILY LCLGIQQYLF ENGRIDNIFT EPYSRFMIEL TKLLKIWEPT
1360 1370 1380 1390 1400
ILPNGYMFSR IEEEHLWECK QLGAYSPIVL LNTLLFFNTK YFQLRNVTEH
1410 1420 1430 1440 1450
LKLSFAHVMR RTRTLKYSTK MTYLRFFPPL QKPESEPDKV TIGKRKRNED
1460 1470 1480 1490 1500
DEAPVGVEMA ENTDNPLRCP VRLYEFYLSK CSESVKQRSD VFYLQPERSC
1510 1520 1530 1540
VPNSPMWYST FPIDPGTLDT MLTRILMVRE VHEELAKAKS EDSDAELSD
Length:1,549
Mass (Da):172,438
Last modified:February 20, 2007 - v1
Checksum:i644AF24B4FEB0A62
GO
Isoform 2 (identifier: A2A791-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     524-612: Missing.

Show »
Length:1,460
Mass (Da):162,843
Checksum:i3E9A6B51B6803B9E
GO

Sequence cautioni

The sequence BAC97947.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAM19273.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1357 – 13571M → V in BAC97947 (PubMed:14621295).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei524 – 61289Missing in isoform 2. 1 PublicationVSP_027515Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129137 mRNA. Translation: BAC97947.1. Different initiation.
AL606985, AL606908 Genomic DNA. Translation: CAM15585.1.
AL606908, AL606985 Genomic DNA. Translation: CAM19271.1.
AL606908 Genomic DNA. Translation: CAM19273.1. Sequence problems.
AK148366 mRNA. Translation: BAE28508.1.
BC029670 mRNA. Translation: AAH29670.1.
BC050924 mRNA. Translation: AAH50924.1.
CCDSiCCDS51303.1. [A2A791-1]
RefSeqiNP_001107871.1. NM_001114399.1. [A2A791-1]
XP_006503407.1. XM_006503344.2. [A2A791-2]
UniGeneiMm.165401.

Genome annotation databases

EnsembliENSMUST00000106108; ENSMUSP00000101714; ENSMUSG00000042446. [A2A791-1]
GeneIDi67785.
KEGGimmu:67785.
UCSCiuc008uty.3. mouse. [A2A791-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129137 mRNA. Translation: BAC97947.1. Different initiation.
AL606985, AL606908 Genomic DNA. Translation: CAM15585.1.
AL606908, AL606985 Genomic DNA. Translation: CAM19271.1.
AL606908 Genomic DNA. Translation: CAM19273.1. Sequence problems.
AK148366 mRNA. Translation: BAE28508.1.
BC029670 mRNA. Translation: AAH29670.1.
BC050924 mRNA. Translation: AAH50924.1.
CCDSiCCDS51303.1. [A2A791-1]
RefSeqiNP_001107871.1. NM_001114399.1. [A2A791-1]
XP_006503407.1. XM_006503344.2. [A2A791-2]
UniGeneiMm.165401.

3D structure databases

ProteinModelPortaliA2A791.
SMRiA2A791. Positions 338-370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212440. 1 interaction.
IntActiA2A791. 1 interaction.
STRINGi10090.ENSMUSP00000101714.

PTM databases

iPTMnetiA2A791.
PhosphoSiteiA2A791.

Proteomic databases

EPDiA2A791.
MaxQBiA2A791.
PaxDbiA2A791.
PeptideAtlasiA2A791.
PRIDEiA2A791.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106108; ENSMUSP00000101714; ENSMUSG00000042446. [A2A791-1]
GeneIDi67785.
KEGGimmu:67785.
UCSCiuc008uty.3. mouse. [A2A791-1]

Organism-specific databases

CTDi9202.
MGIiMGI:1915035. Zmym4.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IE8I. Eukaryota.
ENOG410XQR6. LUCA.
GeneTreeiENSGT00550000074408.
HOGENOMiHOG000293258.
HOVERGENiHBG106731.
InParanoidiA2A791.
OMAiDNIFTEP.
OrthoDBiEOG75J0M6.
PhylomeDBiA2A791.
TreeFamiTF336988.

Miscellaneous databases

ChiTaRSiZmym4. mouse.
PROiA2A791.
SOURCEiSearch...

Gene expression databases

BgeeiA2A791.
CleanExiMM_ZMYM4.
ExpressionAtlasiA2A791. baseline and differential.
GenevisibleiA2A791. MM.

Family and domain databases

InterProiIPR021893. DUF3504.
IPR011017. TRASH_dom.
IPR010507. Znf_MYM.
[Graphical view]
PfamiPF12012. DUF3504. 1 hit.
PF06467. zf-FCS. 5 hits.
[Graphical view]
SMARTiSM00746. TRASH. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryonic tail.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-218.
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 253-1549 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Brain and Eye.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121 AND SER-1548, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Lung and Spleen.

Entry informationi

Entry nameiZMYM4_MOUSE
AccessioniPrimary (citable) accession number: A2A791
Secondary accession number(s): Q3UFQ2
, Q6ZQB9, Q80X47, Q8K1H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: February 20, 2007
Last modified: July 6, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.