ID   A2A6U3_MOUSE            Unreviewed;       565 AA.
AC   A2A6U3;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   27-MAR-2024, entry version 126.
DE   SubName: Full=Septin 9 {ECO:0000313|Ensembl:ENSMUSP00000101961.3};
GN   Name=Septin9 {ECO:0000313|Ensembl:ENSMUSP00000101961.3,
GN   ECO:0000313|MGI:MGI:1858222};
GN   Synonyms=Sept9 {ECO:0000313|MGI:MGI:1858222};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000101961.3, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0007829|PubMed:17242355}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA   Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of mouse liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000101961.3, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000101961.3,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4] {ECO:0007829|PubMed:23806337}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA   Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA   Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT   "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT   pathways.";
RL   Mol. Cell 50:919-930(2013).
RN   [5] {ECO:0000313|Ensembl:ENSMUSP00000101961.3}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000101961.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. Septin GTPase family.
CC       {ECO:0000256|RuleBase:RU004560}.
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DR   RefSeq; XP_006533807.1; XM_006533744.1.
DR   AlphaFoldDB; A2A6U3; -.
DR   SMR; A2A6U3; -.
DR   SwissPalm; A2A6U3; -.
DR   jPOST; A2A6U3; -.
DR   MaxQB; A2A6U3; -.
DR   PeptideAtlas; A2A6U3; -.
DR   ProteomicsDB; 322848; -.
DR   Antibodypedia; 32488; 281 antibodies from 31 providers.
DR   DNASU; 53860; -.
DR   Ensembl; ENSMUST00000106354.9; ENSMUSP00000101961.3; ENSMUSG00000059248.14.
DR   GeneID; 53860; -.
DR   AGR; MGI:1858222; -.
DR   CTD; 10801; -.
DR   MGI; MGI:1858222; Septin9.
DR   VEuPathDB; HostDB:ENSMUSG00000059248; -.
DR   GeneTree; ENSGT00940000157195; -.
DR   HOGENOM; CLU_017718_5_0_1; -.
DR   OrthoDB; 5396944at2759; -.
DR   BioGRID-ORCS; 53860; 2 hits in 49 CRISPR screens.
DR   ChiTaRS; Sept9; mouse.
DR   Proteomes; UP000000589; Chromosome 11.
DR   Bgee; ENSMUSG00000059248; Expressed in ectoplacental cone and 236 other cell types or tissues.
DR   ExpressionAtlas; A2A6U3; baseline and differential.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   CDD; cd01850; CDC_Septin; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR030379; G_SEPTIN_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016491; Septin.
DR   PANTHER; PTHR18884; SEPTIN; 1.
DR   PANTHER; PTHR18884:SF47; SEPTIN-9; 1.
DR   Pfam; PF00735; Septin; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51719; G_SEPTIN; 1.
PE   1: Evidence at protein level;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU004560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004560};
KW   Proteomics identification {ECO:0007829|EPD:A2A6U3,
KW   ECO:0007829|MaxQB:A2A6U3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          275..547
FT                   /note="Septin-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51719"
FT   REGION          1..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..49
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..206
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   565 AA;  63773 MW;  A562151D065B010E CRC64;
     MERDRITALK RSFEVEEIEP PNSTPPRRVQ TPLLRATVAS SSQKFQDLGV KNSEPAARLV
     DSLSQRSPKP SLRRVELAGA KAPEPMSRRT EISIDISSKQ VESTASAAGP SRFGLKRAEV
     LGHKTPEPVP RRTEITIVKP QESVLRRVET PASKIPEGSA VPATDAAPKR VEIQVPKPAE
     APNCPLPSQT LENSEAPMSQ LQSRLEPRPS VAEVPYRNQE DSEVTPSCVG DMADNPRDAM
     LKQAPASRNE KAPMEFGYVG IDSILEQMRR KAMKQGFEFN IMVVGQSGLG KSTLINTLFK
     SKISRKSVQP TSEERIPKTI EIKSITHDIE EKGVRMKLTV IDTPGFGDHI NNENCWQPIM
     KFINDQYEKY LQEEVNINRK KRIPDTRVHC CLYFIPATGH SLRPLDIEFM KRLSKVVNIV
     PVIAKADTLT LEERVYFKQR ITADLLSNGI DVYPQKEFDE DAEDRLVNEK FREMIPFAVV
     GSDHEYQVNG KRILGRKTKW GTIEVENTTH CEFAYLRDLL IRTHMQNIKD ITSNIHFEAY
     RVKRLNEGNS AMANGIEKEP EAQEM
//