ID   FBX47_MOUSE             Reviewed;         451 AA.
AC   A2A6H3; B2RY07;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   24-JAN-2024, entry version 100.
DE   RecName: Full=F-box only protein 47;
GN   Name=Fbxo47;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probably recognizes and binds to some phosphorylated proteins
CC       and promotes their ubiquitination and degradation. {ECO:0000250}.
CC   -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
CC       {ECO:0000250}.
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DR   EMBL; AL596446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC158049; AAI58050.1; -; mRNA.
DR   CCDS; CCDS36299.1; -.
DR   RefSeq; NP_001074904.1; NM_001081435.1.
DR   RefSeq; XP_006534391.1; XM_006534328.3.
DR   RefSeq; XP_006534392.1; XM_006534329.3.
DR   RefSeq; XP_006534393.1; XM_006534330.3.
DR   AlphaFoldDB; A2A6H3; -.
DR   BioGRID; 215685; 2.
DR   STRING; 10090.ENSMUSP00000091471; -.
DR   iPTMnet; A2A6H3; -.
DR   PhosphoSitePlus; A2A6H3; -.
DR   PaxDb; 10090-ENSMUSP00000091471; -.
DR   Antibodypedia; 65659; 81 antibodies from 14 providers.
DR   Ensembl; ENSMUST00000093939.4; ENSMUSP00000091471.4; ENSMUSG00000070336.4.
DR   GeneID; 72973; -.
DR   KEGG; mmu:72973; -.
DR   UCSC; uc007lfb.1; mouse.
DR   AGR; MGI:1920223; -.
DR   CTD; 494188; -.
DR   MGI; MGI:1920223; Fbxo47.
DR   VEuPathDB; HostDB:ENSMUSG00000070336; -.
DR   eggNOG; ENOG502QV8T; Eukaryota.
DR   GeneTree; ENSGT00390000014175; -.
DR   HOGENOM; CLU_048746_0_0_1; -.
DR   InParanoid; A2A6H3; -.
DR   OMA; AFACVTM; -.
DR   OrthoDB; 2912079at2759; -.
DR   PhylomeDB; A2A6H3; -.
DR   TreeFam; TF343134; -.
DR   BioGRID-ORCS; 72973; 3 hits in 77 CRISPR screens.
DR   ChiTaRS; Fbxo47; mouse.
DR   PRO; PR:A2A6H3; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; A2A6H3; Protein.
DR   Bgee; ENSMUSG00000070336; Expressed in spermatid and 53 other cell types or tissues.
DR   CDD; cd22112; F-box_FBXO47; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR038946; FBXO47.
DR   PANTHER; PTHR34098; F-BOX ONLY PROTEIN 47; 1.
DR   PANTHER; PTHR34098:SF1; F-BOX ONLY PROTEIN 47; 1.
DR   Pfam; PF00646; F-box; 1.
DR   SUPFAM; SSF81383; F-box domain; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..451
FT                   /note="F-box only protein 47"
FT                   /id="PRO_0000307726"
FT   DOMAIN          41..91
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
SQ   SEQUENCE   451 AA;  51374 MW;  4DD1A55803102DE6 CRC64;
     MASRVNTSFT LIPKQKCRRS NHHSSYFCNT LDSDPQLLST LGNFKVLPLE ILHIILRYLS
     VKDIGMLSMV SKTVSQHIIN YISTSSGSRR LLLQNFHDLD LPGTKEETAL LEHYRALGLL
     FKRCTLLLPT KERLKYIHKI LSEVSCFKFS GCSVPLQCLG LSCYGMFLQT LTAGWDELEC
     HRVYNFLCEL TNLSRKMQTV VCNKPGSARK LELRVRLFCR NVLLDHWTHR SDSAFWLTRI
     LKPWPMVNQA RLLYIIFGPT SPHDGQVIWQ EMIEGPTDES SLKGLANAIK LLYDTGAKGW
     TADDVISLVD ELSVVPREWL LENNARLLIL SGNNICFTFM ASKAVNGRAV ELARLVVFLA
     LVCEKELYCM DWTVRMMQKV CKVFSTAAER KSFLQSIANA FACVTMEMLQ PVMSGDRDDD
     DRGFLNLFHL LHAQANFHKE VLYLTMNAIS S
//