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A2A6H3

- FBX47_MOUSE

UniProt

A2A6H3 - FBX47_MOUSE

Protein

F-box only protein 47

Gene

Fbxo47

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 2 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.By similarity

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box only protein 47
    Gene namesi
    Name:Fbxo47
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1920223. Fbxo47.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 451451F-box only protein 47PRO_0000307726Add
    BLAST

    Proteomic databases

    PRIDEiA2A6H3.

    PTM databases

    PhosphoSiteiA2A6H3.

    Expressioni

    Gene expression databases

    BgeeiA2A6H3.
    CleanExiMM_FBXO47.
    GenevestigatoriA2A6H3.

    Interactioni

    Subunit structurei

    Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000091471.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 9151F-boxPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 F-box domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG70508.
    GeneTreeiENSGT00390000014175.
    HOGENOMiHOG000261636.
    HOVERGENiHBG051584.
    InParanoidiB2RY07.
    KOiK10321.
    OMAiFTLIPNQ.
    OrthoDBiEOG7M98GB.
    PhylomeDBiA2A6H3.
    TreeFamiTF343134.

    Family and domain databases

    InterProiIPR001810. F-box_dom.
    [Graphical view]
    PfamiPF00646. F-box. 1 hit.
    [Graphical view]
    SUPFAMiSSF81383. SSF81383. 1 hit.
    PROSITEiPS50181. FBOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2A6H3-1 [UniParc]FASTAAdd to Basket

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    MASRVNTSFT LIPKQKCRRS NHHSSYFCNT LDSDPQLLST LGNFKVLPLE    50
    ILHIILRYLS VKDIGMLSMV SKTVSQHIIN YISTSSGSRR LLLQNFHDLD 100
    LPGTKEETAL LEHYRALGLL FKRCTLLLPT KERLKYIHKI LSEVSCFKFS 150
    GCSVPLQCLG LSCYGMFLQT LTAGWDELEC HRVYNFLCEL TNLSRKMQTV 200
    VCNKPGSARK LELRVRLFCR NVLLDHWTHR SDSAFWLTRI LKPWPMVNQA 250
    RLLYIIFGPT SPHDGQVIWQ EMIEGPTDES SLKGLANAIK LLYDTGAKGW 300
    TADDVISLVD ELSVVPREWL LENNARLLIL SGNNICFTFM ASKAVNGRAV 350
    ELARLVVFLA LVCEKELYCM DWTVRMMQKV CKVFSTAAER KSFLQSIANA 400
    FACVTMEMLQ PVMSGDRDDD DRGFLNLFHL LHAQANFHKE VLYLTMNAIS 450
    S 451
    Length:451
    Mass (Da):51,374
    Last modified:September 11, 2007 - v2
    Checksum:i4DD1A55803102DE6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL596446 Genomic DNA. Translation: CAM22785.2.
    BC158049 mRNA. Translation: AAI58050.1.
    CCDSiCCDS36299.1.
    RefSeqiNP_001074904.1. NM_001081435.1.
    XP_006534391.1. XM_006534328.1.
    XP_006534392.1. XM_006534329.1.
    XP_006534393.1. XM_006534330.1.
    XP_006534394.1. XM_006534331.1.
    UniGeneiMm.245939.

    Genome annotation databases

    EnsembliENSMUST00000093939; ENSMUSP00000091471; ENSMUSG00000070336.
    GeneIDi72973.
    KEGGimmu:72973.
    UCSCiuc007lfb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL596446 Genomic DNA. Translation: CAM22785.2 .
    BC158049 mRNA. Translation: AAI58050.1 .
    CCDSi CCDS36299.1.
    RefSeqi NP_001074904.1. NM_001081435.1.
    XP_006534391.1. XM_006534328.1.
    XP_006534392.1. XM_006534329.1.
    XP_006534393.1. XM_006534330.1.
    XP_006534394.1. XM_006534331.1.
    UniGenei Mm.245939.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000091471.

    PTM databases

    PhosphoSitei A2A6H3.

    Proteomic databases

    PRIDEi A2A6H3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000093939 ; ENSMUSP00000091471 ; ENSMUSG00000070336 .
    GeneIDi 72973.
    KEGGi mmu:72973.
    UCSCi uc007lfb.1. mouse.

    Organism-specific databases

    CTDi 494188.
    MGIi MGI:1920223. Fbxo47.

    Phylogenomic databases

    eggNOGi NOG70508.
    GeneTreei ENSGT00390000014175.
    HOGENOMi HOG000261636.
    HOVERGENi HBG051584.
    InParanoidi B2RY07.
    KOi K10321.
    OMAi FTLIPNQ.
    OrthoDBi EOG7M98GB.
    PhylomeDBi A2A6H3.
    TreeFami TF343134.

    Miscellaneous databases

    NextBioi 337257.
    PROi A2A6H3.
    SOURCEi Search...

    Gene expression databases

    Bgeei A2A6H3.
    CleanExi MM_FBXO47.
    Genevestigatori A2A6H3.

    Family and domain databases

    InterProi IPR001810. F-box_dom.
    [Graphical view ]
    Pfami PF00646. F-box. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81383. SSF81383. 1 hit.
    PROSITEi PS50181. FBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiFBX47_MOUSE
    AccessioniPrimary (citable) accession number: A2A6H3
    Secondary accession number(s): B2RY07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3