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Protein

F-box only protein 47

Gene

Fbxo47

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 47
Gene namesi
Name:Fbxo47
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1920223. Fbxo47.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451F-box only protein 47PRO_0000307726Add
BLAST

Proteomic databases

PRIDEiA2A6H3.

PTM databases

PhosphoSiteiA2A6H3.

Expressioni

Gene expression databases

BgeeiA2A6H3.
CleanExiMM_FBXO47.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091471.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 9151F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG70508.
GeneTreeiENSGT00390000014175.
HOGENOMiHOG000261636.
HOVERGENiHBG051584.
InParanoidiA2A6H3.
KOiK10321.
OMAiRVYNFLC.
OrthoDBiEOG7M98GB.
PhylomeDBiA2A6H3.
TreeFamiTF343134.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A6H3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRVNTSFT LIPKQKCRRS NHHSSYFCNT LDSDPQLLST LGNFKVLPLE
60 70 80 90 100
ILHIILRYLS VKDIGMLSMV SKTVSQHIIN YISTSSGSRR LLLQNFHDLD
110 120 130 140 150
LPGTKEETAL LEHYRALGLL FKRCTLLLPT KERLKYIHKI LSEVSCFKFS
160 170 180 190 200
GCSVPLQCLG LSCYGMFLQT LTAGWDELEC HRVYNFLCEL TNLSRKMQTV
210 220 230 240 250
VCNKPGSARK LELRVRLFCR NVLLDHWTHR SDSAFWLTRI LKPWPMVNQA
260 270 280 290 300
RLLYIIFGPT SPHDGQVIWQ EMIEGPTDES SLKGLANAIK LLYDTGAKGW
310 320 330 340 350
TADDVISLVD ELSVVPREWL LENNARLLIL SGNNICFTFM ASKAVNGRAV
360 370 380 390 400
ELARLVVFLA LVCEKELYCM DWTVRMMQKV CKVFSTAAER KSFLQSIANA
410 420 430 440 450
FACVTMEMLQ PVMSGDRDDD DRGFLNLFHL LHAQANFHKE VLYLTMNAIS

S
Length:451
Mass (Da):51,374
Last modified:September 11, 2007 - v2
Checksum:i4DD1A55803102DE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596446 Genomic DNA. Translation: CAM22785.2.
BC158049 mRNA. Translation: AAI58050.1.
CCDSiCCDS36299.1.
RefSeqiNP_001074904.1. NM_001081435.1.
XP_006534391.1. XM_006534328.2.
XP_006534392.1. XM_006534329.2.
XP_006534393.1. XM_006534330.2.
XP_006534394.1. XM_006534331.2.
UniGeneiMm.245939.

Genome annotation databases

EnsembliENSMUST00000093939; ENSMUSP00000091471; ENSMUSG00000070336.
GeneIDi72973.
KEGGimmu:72973.
UCSCiuc007lfb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596446 Genomic DNA. Translation: CAM22785.2.
BC158049 mRNA. Translation: AAI58050.1.
CCDSiCCDS36299.1.
RefSeqiNP_001074904.1. NM_001081435.1.
XP_006534391.1. XM_006534328.2.
XP_006534392.1. XM_006534329.2.
XP_006534393.1. XM_006534330.2.
XP_006534394.1. XM_006534331.2.
UniGeneiMm.245939.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091471.

PTM databases

PhosphoSiteiA2A6H3.

Proteomic databases

PRIDEiA2A6H3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093939; ENSMUSP00000091471; ENSMUSG00000070336.
GeneIDi72973.
KEGGimmu:72973.
UCSCiuc007lfb.1. mouse.

Organism-specific databases

CTDi494188.
MGIiMGI:1920223. Fbxo47.

Phylogenomic databases

eggNOGiNOG70508.
GeneTreeiENSGT00390000014175.
HOGENOMiHOG000261636.
HOVERGENiHBG051584.
InParanoidiA2A6H3.
KOiK10321.
OMAiRVYNFLC.
OrthoDBiEOG7M98GB.
PhylomeDBiA2A6H3.
TreeFamiTF343134.

Miscellaneous databases

NextBioi337257.
PROiA2A6H3.
SOURCEiSearch...

Gene expression databases

BgeeiA2A6H3.
CleanExiMM_FBXO47.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiFBX47_MOUSE
AccessioniPrimary (citable) accession number: A2A6H3
Secondary accession number(s): B2RY07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: September 11, 2007
Last modified: June 24, 2015
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.