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A2A6H3

- FBX47_MOUSE

UniProt

A2A6H3 - FBX47_MOUSE

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Protein

F-box only protein 47

Gene

Fbxo47

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 47
Gene namesi
Name:Fbxo47
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1920223. Fbxo47.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451F-box only protein 47PRO_0000307726Add
BLAST

Proteomic databases

PRIDEiA2A6H3.

PTM databases

PhosphoSiteiA2A6H3.

Expressioni

Gene expression databases

BgeeiA2A6H3.
CleanExiMM_FBXO47.
GenevestigatoriA2A6H3.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091471.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 9151F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG70508.
GeneTreeiENSGT00390000014175.
HOGENOMiHOG000261636.
HOVERGENiHBG051584.
InParanoidiA2A6H3.
KOiK10321.
OMAiFTLIPNQ.
OrthoDBiEOG7M98GB.
PhylomeDBiA2A6H3.
TreeFamiTF343134.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A6H3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASRVNTSFT LIPKQKCRRS NHHSSYFCNT LDSDPQLLST LGNFKVLPLE
60 70 80 90 100
ILHIILRYLS VKDIGMLSMV SKTVSQHIIN YISTSSGSRR LLLQNFHDLD
110 120 130 140 150
LPGTKEETAL LEHYRALGLL FKRCTLLLPT KERLKYIHKI LSEVSCFKFS
160 170 180 190 200
GCSVPLQCLG LSCYGMFLQT LTAGWDELEC HRVYNFLCEL TNLSRKMQTV
210 220 230 240 250
VCNKPGSARK LELRVRLFCR NVLLDHWTHR SDSAFWLTRI LKPWPMVNQA
260 270 280 290 300
RLLYIIFGPT SPHDGQVIWQ EMIEGPTDES SLKGLANAIK LLYDTGAKGW
310 320 330 340 350
TADDVISLVD ELSVVPREWL LENNARLLIL SGNNICFTFM ASKAVNGRAV
360 370 380 390 400
ELARLVVFLA LVCEKELYCM DWTVRMMQKV CKVFSTAAER KSFLQSIANA
410 420 430 440 450
FACVTMEMLQ PVMSGDRDDD DRGFLNLFHL LHAQANFHKE VLYLTMNAIS

S
Length:451
Mass (Da):51,374
Last modified:September 11, 2007 - v2
Checksum:i4DD1A55803102DE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596446 Genomic DNA. Translation: CAM22785.2.
BC158049 mRNA. Translation: AAI58050.1.
CCDSiCCDS36299.1.
RefSeqiNP_001074904.1. NM_001081435.1.
XP_006534391.1. XM_006534328.1.
XP_006534392.1. XM_006534329.1.
XP_006534393.1. XM_006534330.1.
XP_006534394.1. XM_006534331.1.
UniGeneiMm.245939.

Genome annotation databases

EnsembliENSMUST00000093939; ENSMUSP00000091471; ENSMUSG00000070336.
GeneIDi72973.
KEGGimmu:72973.
UCSCiuc007lfb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596446 Genomic DNA. Translation: CAM22785.2 .
BC158049 mRNA. Translation: AAI58050.1 .
CCDSi CCDS36299.1.
RefSeqi NP_001074904.1. NM_001081435.1.
XP_006534391.1. XM_006534328.1.
XP_006534392.1. XM_006534329.1.
XP_006534393.1. XM_006534330.1.
XP_006534394.1. XM_006534331.1.
UniGenei Mm.245939.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000091471.

PTM databases

PhosphoSitei A2A6H3.

Proteomic databases

PRIDEi A2A6H3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000093939 ; ENSMUSP00000091471 ; ENSMUSG00000070336 .
GeneIDi 72973.
KEGGi mmu:72973.
UCSCi uc007lfb.1. mouse.

Organism-specific databases

CTDi 494188.
MGIi MGI:1920223. Fbxo47.

Phylogenomic databases

eggNOGi NOG70508.
GeneTreei ENSGT00390000014175.
HOGENOMi HOG000261636.
HOVERGENi HBG051584.
InParanoidi A2A6H3.
KOi K10321.
OMAi FTLIPNQ.
OrthoDBi EOG7M98GB.
PhylomeDBi A2A6H3.
TreeFami TF343134.

Miscellaneous databases

NextBioi 337257.
PROi A2A6H3.
SOURCEi Search...

Gene expression databases

Bgeei A2A6H3.
CleanExi MM_FBXO47.
Genevestigatori A2A6H3.

Family and domain databases

InterProi IPR001810. F-box_dom.
[Graphical view ]
Pfami PF00646. F-box. 1 hit.
[Graphical view ]
SUPFAMi SSF81383. SSF81383. 1 hit.
PROSITEi PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiFBX47_MOUSE
AccessioniPrimary (citable) accession number: A2A6H3
Secondary accession number(s): B2RY07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3