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Protein

Protein TANC2

Gene

Tanc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • in utero embryonic development Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TANC2
Alternative name(s):
Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2
Gene namesi
Name:Tanc2
Synonyms:Kiaa1148
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2444121. Tanc2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003338121 – 1994Protein TANC2Add BLAST1994

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei169PhosphoserineBy similarity1
Modified residuei238PhosphoserineBy similarity1
Modified residuei294PhosphoserineBy similarity1
Modified residuei400PhosphoserineBy similarity1
Modified residuei1446PhosphoserineBy similarity1
Modified residuei1462PhosphoserineBy similarity1
Modified residuei1534PhosphoserineBy similarity1
Modified residuei1549PhosphoserineBy similarity1
Modified residuei1567Asymmetric dimethylarginineCombined sources1
Modified residuei1580Asymmetric dimethylarginineCombined sources1
Modified residuei1583PhosphoserineCombined sources1
Modified residuei1726PhosphoserineBy similarity1
Modified residuei1828PhosphoserineCombined sources1
Modified residuei1831PhosphoserineCombined sources1
Glycosylationi1932N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

MaxQBiA2A690.
PaxDbiA2A690.
PeptideAtlasiA2A690.
PRIDEiA2A690.

PTM databases

iPTMnetiA2A690.
PhosphoSitePlusiA2A690.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053580.
ExpressionAtlasiA2A690. baseline and differential.
GenevisibleiA2A690. MM.

Interactioni

Protein-protein interaction databases

BioGridi218515. 2 interactors.
STRINGi10090.ENSMUSP00000097904.

Structurei

3D structure databases

ProteinModelPortaliA2A690.
SMRiA2A690.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati846 – 878ANK 1Add BLAST33
Repeati884 – 913ANK 2Add BLAST30
Repeati917 – 946ANK 3Add BLAST30
Repeati950 – 979ANK 4Add BLAST30
Repeati990 – 1019ANK 5Add BLAST30
Repeati1033 – 1062ANK 6Add BLAST30
Repeati1066 – 1095ANK 7Add BLAST30
Repeati1099 – 1128ANK 8Add BLAST30
Repeati1132 – 1161ANK 9Add BLAST30
Repeati1165 – 1194ANK 10Add BLAST30
Repeati1198 – 1227ANK 11Add BLAST30
Repeati1244 – 1277TPR 1Add BLAST34
Repeati1291 – 1324TPR 2Add BLAST34
Repeati1325 – 1358TPR 3Add BLAST34

Sequence similaritiesi

Belongs to the TANC family.Curated
Contains 11 ANK repeats.PROSITE-ProRule annotation
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000231045.
HOVERGENiHBG061464.
InParanoidiA2A690.
OMAiLQGYILH.
OrthoDBiEOG091G00QZ.
PhylomeDBiA2A690.
TreeFamiTF323159.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR027417. P-loop_NTPase.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
PF13181. TPR_8. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 11 hits.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2A690-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRNSLKMLL TGGKSSRKNR SSDGGSEEPP DRRQSSVDSR QSRSGQGGIS
60 70 80 90 100
TESDCAFEPD YAVPPLPVSE GDVEQELGPP PSVDEAANTL MTRLGFLLGE
110 120 130 140 150
KVTEVQPSDQ YSMEVQDENQ TSAITQRISP CSTLTSSTAS PPASSPCSTL
160 170 180 190 200
PPVSTNAAAK DCSYGAVTSP TSTLESRDSG IIATLTNYSE NMERTKYVGE
210 220 230 240 250
GSKELGSGGN LKPWQSQKSS MDSCLYRVDE NMAASTYSLN KIPERNLETV
260 270 280 290 300
LSQSVQSIPL YLMPRPNSVA ATSSAHLEDL AYLDEQRHTP LRTSLRMPRQ
310 320 330 340 350
SLSGARTQQD LRVRFAPYRP PDISLKPLLF EVPSITTESV FVGRDWVFHE
360 370 380 390 400
IDAQLQSSNA SVNQGVVIVG NIGFGKTAII SRLVALSCHG TRMRQIASDS
410 420 430 440 450
PHASPKHVDA NRELPLTQAP SAHSSITSGS CPGTPEMRRR QEEAMRRLAS
460 470 480 490 500
QVVAYHYCQA DNAYTCLVPE FVHNVAALLC RSPQLTAYRE QLLREPHLQS
510 520 530 540 550
MLSLRSCVQD PMASFRRGVL EPLENLHKER KIPDEDFIIL IDGLNEAEFH
560 570 580 590 600
KPDYGDTIVS FLSKMIGNFP SWLKLIVTVR TSLQEITKLL PFHRIFLDRL
610 620 630 640 650
EENEAIDQDL QAYILHRIHS SSEIQNNISL NGKMDNTTFG KLSSHLKTLS
660 670 680 690 700
QGSYLYLKLT FDLIEKGYLV LKSSSYKVVP VSLSEVYLLQ CNMKFPTQSS
710 720 730 740 750
FDRVMPLLNV AVASLHPLTD EHIFQAINAG SIEGTLEWED FQQRMENLSM
760 770 780 790 800
FLIKRRDMTR MFVHPSFREW LIWREEGEKT KFLCDPRSGH TLLAFWFSRQ
810 820 830 840 850
EGKLNRQQTI ELGHHILKAH IFKGLSKKVG VSSSILQGLW ISYSTEGLSM
860 870 880 890 900
ALASLRNLYT PNIKVSRLLI LGGANINYRT EVLNNAPILC VQSHLGYTEM
910 920 930 940 950
VALLLEFGAN VDASSESGLT PLGYAAAAGF LSIVVLLCKK RAKVDHLDKN
960 970 980 990 1000
GQCALVHAAL RGHLEVVKFL IQCDWTMAGQ QQGVFKKSHA IQQALIAAAS
1010 1020 1030 1040 1050
MGYTEIVSYL LDLPEKDEEE VERAQINSFD SLWGETALTA AAGRGKLDVC
1060 1070 1080 1090 1100
RLLLEQGAAV AQPNRRGAVP LFSTVRQGHW QIVDLLLTHG ADVNMADKQG
1110 1120 1130 1140 1150
RTPLMMAASE GHLGTVDFLL AQGASIALMD KEGLTALSWA CLKGHLSVVR
1160 1170 1180 1190 1200
SLVDNGAATD HADKNGRTPL DLAAFYGDAE VVQFLVDHGA MIEHVDYSGM
1210 1220 1230 1240 1250
RPLDRAVGCR NTSVVVTLLK KGAKIGPATW AMATSKPDIM IILLSKLMEE
1260 1270 1280 1290 1300
GDMFYKKGKV KEAAQRYQYA LKKFPREGFG EDLKTFRELK VSLLLNLSRC
1310 1320 1330 1340 1350
RRKMNDFGMA EEFATKALEL KPKSYEAYYA RARAKRSSRQ FAAALEDLKE
1360 1370 1380 1390 1400
AIKLCPNNRE IQRLLMRVEE ECRQMQQQQQ QQPPPPPQQP PQELPEEETE
1410 1420 1430 1440 1450
PEPQHEDIYS VQDIFEEEYL EQDVENVSIG LQTEARPSQG LPVIQSPPSS
1460 1470 1480 1490 1500
PAHRDSAYIS SSPLGSHQVF DFRSNSSVGS PTRQGYQSTS PALSPTHQNS
1510 1520 1530 1540 1550
HYRPSPPHTS PAHQGASYRF SPPPVGGQSK EYPSPPPSPL RRGPQYRASP
1560 1570 1580 1590 1600
PAESMSVYRS QSGSPVRYQQ ETNVSQLPGR PKSPLSKMAQ RPYQMPQLPV
1610 1620 1630 1640 1650
AVPQQGLRLQ PAKAQIVRSN QPSSAVHSST VIPTGAYGQV AHSMASKYQS
1660 1670 1680 1690 1700
SQGDMGVSQS RLVYQGSIGG IVGDGRPVQH VQASLSAGAI CQHGGLTKED
1710 1720 1730 1740 1750
LPQRPSSAYR GGMRYSQTPQ IGRSQSASYY PVCHSKLDLE RSSSQLGSPD
1760 1770 1780 1790 1800
VSHLIRRPIS VNPNEIKPHP PTPRPLLHSQ SVGLRFSPSS NSISSTSNLT
1810 1820 1830 1840 1850
PTFRPSSSIQ QMEIPLKPAY DRSCDELSPV SPTQGGYPSE PTRSRTTPFM
1860 1870 1880 1890 1900
GIIDKTARTQ QYPHLHQQNR TWAVSSVDTV LSPTSPGNLP QPESFSPPSS
1910 1920 1930 1940 1950
ISNIAFYNKT NNAQNGHLLE DDYYSPHGML ANGSRGDLLE RVSQASSYPD
1960 1970 1980 1990
VKVARTLPVA QAYQDNLYRQ LSRDSRQGQT SPIKPKRPFV ESNV
Length:1,994
Mass (Da):220,263
Last modified:February 20, 2007 - v1
Checksum:iA6A3B4F264CE3341
GO
Isoform 2 (identifier: A2A690-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1225-1225: I → IGCQTLPSRPR

Show »
Length:2,004
Mass (Da):221,360
Checksum:iCFBE24661B3E1555
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0335511225I → IGCQTLPSRPR in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596246 Genomic DNA. Translation: CAM16873.1.
AL596246, AL627312, AL645524 Genomic DNA. Translation: CAM16880.1.
AL627312, AL596246, AL645524 Genomic DNA. Translation: CAM19362.1.
AL645524, AL596246, AL627312 Genomic DNA. Translation: CAM22186.1.
AK173111 mRNA. Translation: BAD32389.1.
BC089352 mRNA. Translation: AAH89352.1.
AK162382 mRNA. Translation: BAE36883.1.
CCDSiCCDS36357.1. [A2A690-1]
RefSeqiNP_851416.2. NM_181071.3. [A2A690-1]
UniGeneiMm.22501.

Genome annotation databases

EnsembliENSMUST00000100330; ENSMUSP00000097904; ENSMUSG00000053580. [A2A690-1]
GeneIDi77097.
KEGGimmu:77097.
UCSCiuc007lxm.1. mouse. [A2A690-1]
uc007lxo.1. mouse. [A2A690-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596246 Genomic DNA. Translation: CAM16873.1.
AL596246, AL627312, AL645524 Genomic DNA. Translation: CAM16880.1.
AL627312, AL596246, AL645524 Genomic DNA. Translation: CAM19362.1.
AL645524, AL596246, AL627312 Genomic DNA. Translation: CAM22186.1.
AK173111 mRNA. Translation: BAD32389.1.
BC089352 mRNA. Translation: AAH89352.1.
AK162382 mRNA. Translation: BAE36883.1.
CCDSiCCDS36357.1. [A2A690-1]
RefSeqiNP_851416.2. NM_181071.3. [A2A690-1]
UniGeneiMm.22501.

3D structure databases

ProteinModelPortaliA2A690.
SMRiA2A690.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218515. 2 interactors.
STRINGi10090.ENSMUSP00000097904.

PTM databases

iPTMnetiA2A690.
PhosphoSitePlusiA2A690.

Proteomic databases

MaxQBiA2A690.
PaxDbiA2A690.
PeptideAtlasiA2A690.
PRIDEiA2A690.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100330; ENSMUSP00000097904; ENSMUSG00000053580. [A2A690-1]
GeneIDi77097.
KEGGimmu:77097.
UCSCiuc007lxm.1. mouse. [A2A690-1]
uc007lxo.1. mouse. [A2A690-2]

Organism-specific databases

CTDi26115.
MGIiMGI:2444121. Tanc2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000231045.
HOVERGENiHBG061464.
InParanoidiA2A690.
OMAiLQGYILH.
OrthoDBiEOG091G00QZ.
PhylomeDBiA2A690.
TreeFamiTF323159.

Miscellaneous databases

ChiTaRSiTanc2. mouse.
PROiA2A690.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053580.
ExpressionAtlasiA2A690. baseline and differential.
GenevisibleiA2A690. MM.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR027417. P-loop_NTPase.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
PF13181. TPR_8. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 11 hits.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTANC2_MOUSE
AccessioniPrimary (citable) accession number: A2A690
Secondary accession number(s): A2A683
, Q3TRZ3, Q5EBP6, Q69ZQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.