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A2A5I6

- A2A5I6_MOUSE

UniProt

A2A5I6 - A2A5I6_MOUSE

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Protein
Submitted name:

Hepatocyte nuclear factor 4-alpha

Gene

Hnf4a

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  4. sequence-specific DNA binding Source: MGI
  5. sequence-specific DNA binding transcription factor activity Source: MGI
  6. steroid hormone receptor activity Source: InterPro
  7. zinc ion binding Source: InterPro

GO - Biological processi

  1. lipid metabolic process Source: MGI
  2. positive regulation of transcription, DNA-templated Source: MGI
  3. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  4. regulation of gastrulation Source: MGI
  5. regulation of transcription, DNA-templated Source: MGI
  6. regulation of transcription from RNA polymerase II promoter Source: MGI
  7. sex differentiation Source: MGI
  8. signal transduction involved in regulation of gene expression Source: MGI
  9. SMAD protein signal transduction Source: MGI
  10. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Hepatocyte nuclear factor 4-alphaImported
Gene namesi
Name:Hnf4aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:109128. Hnf4a.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiA2A5I6.

Expressioni

Gene expression databases

ExpressionAtlasiA2A5I6. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA2A5I6.
SMRiA2A5I6. Positions 34-111, 124-191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118948.
HOGENOMiHOG000260822.
HOVERGENiHBG005606.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

A2A5I6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYGQLREMMM LCLTDTSPSE GANLNSSNSL GVSALCAICG DRATGKHYGA
60 70 80 90 100
SSCDGCKGFF RRSVRKNHMY SCRFSRQCVV DKDKRNQCRY CRLKKCFRAG
110 120 130 140 150
MKKEAVQNER DRISTRRSSY EDSSLPSINA LLQAEVLSQQ ITSPISGING
160 170 180 190
DIRAKKIANI TDVCESMKEQ LLVLVEWAKY IPAFCELLLD D
Length:191
Mass (Da):21,447
Last modified:February 20, 2007 - v1
Checksum:i723296901B63F8A4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei191 – 1911Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591488 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000137449; ENSMUSP00000123511; ENSMUSG00000017950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591488 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali A2A5I6.
SMRi A2A5I6. Positions 34-111, 124-191.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A2A5I6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000137449 ; ENSMUSP00000123511 ; ENSMUSG00000017950 .

Organism-specific databases

MGIi MGI:109128. Hnf4a.

Phylogenomic databases

GeneTreei ENSGT00760000118948.
HOGENOMi HOG000260822.
HOVERGENi HBG005606.

Miscellaneous databases

ChiTaRSi Hnf4a. mouse.
NextBioi 35542593.
SOURCEi Search...

Gene expression databases

ExpressionAtlasi A2A5I6. baseline and differential.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2A5I6_MOUSE
AccessioniPrimary (citable) accession number: A2A5I6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 26, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3