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A2A5I6

- A2A5I6_MOUSE

UniProt

A2A5I6 - A2A5I6_MOUSE

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Protein
Submitted name: Hepatocyte nuclear factor 4-alpha
Gene
Hnf4a
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  4. protein binding Source: MGI
  5. sequence-specific DNA binding Source: MGI
  6. sequence-specific DNA binding transcription factor activity Source: MGI
  7. steroid hormone receptor activity Source: InterPro
  8. zinc ion binding Source: InterPro

GO - Biological processi

  1. SMAD protein signal transduction Source: MGI
  2. lipid metabolic process Source: MGI
  3. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  4. positive regulation of transcription, DNA-templated Source: MGI
  5. regulation of gastrulation Source: MGI
  6. regulation of transcription from RNA polymerase II promoter Source: MGI
  7. regulation of transcription, DNA-templated Source: MGI
  8. sex differentiation Source: MGI
  9. signal transduction involved in regulation of gene expression Source: MGI
  10. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotations

Keywords - Ligandi

DNA-bindingSAAS annotations, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Hepatocyte nuclear factor 4-alphaImported
Gene namesi
Name:Hnf4aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:109128. Hnf4a.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

PTM / Processingi

Proteomic databases

PRIDEiA2A5I6.

Expressioni

Gene expression databases

ArrayExpressiA2A5I6.

Structurei

3D structure databases

ProteinModelPortaliA2A5I6.
SMRiA2A5I6. Positions 34-111, 124-191.

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotations

Keywords - Domaini

Zinc-fingerSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00740000115493.
HOGENOMiHOG000260822.
HOVERGENiHBG005606.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

A2A5I6-1 [UniParc]FASTAAdd to Basket

« Hide

MYGQLREMMM LCLTDTSPSE GANLNSSNSL GVSALCAICG DRATGKHYGA    50
SSCDGCKGFF RRSVRKNHMY SCRFSRQCVV DKDKRNQCRY CRLKKCFRAG 100
MKKEAVQNER DRISTRRSSY EDSSLPSINA LLQAEVLSQQ ITSPISGING 150
DIRAKKIANI TDVCESMKEQ LLVLVEWAKY IPAFCELLLD D 191
Length:191
Mass (Da):21,447
Last modified:February 20, 2007 - v1
Checksum:i723296901B63F8A4
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei191 – 1911Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591488 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000137449; ENSMUSP00000123511; ENSMUSG00000017950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591488 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali A2A5I6.
SMRi A2A5I6. Positions 34-111, 124-191.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A2A5I6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000137449 ; ENSMUSP00000123511 ; ENSMUSG00000017950 .

Organism-specific databases

MGIi MGI:109128. Hnf4a.

Phylogenomic databases

GeneTreei ENSGT00740000115493.
HOGENOMi HOG000260822.
HOVERGENi HBG005606.

Miscellaneous databases

ChiTaRSi HNF4A. mouse.
NextBioi 35542593.
SOURCEi Search...

Gene expression databases

ArrayExpressi A2A5I6.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2A5I6_MOUSE
AccessioniPrimary (citable) accession number: A2A5I6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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