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A2A5I6

- A2A5I6_MOUSE

UniProt

A2A5I6 - A2A5I6_MOUSE

Protein
Submitted name:

Hepatocyte nuclear factor 4-alpha

Gene

Hnf4a

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: MGI
    3. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
    4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
    5. sequence-specific DNA binding Source: MGI
    6. sequence-specific DNA binding transcription factor activity Source: MGI
    7. steroid hormone receptor activity Source: InterPro
    8. zinc ion binding Source: InterPro

    GO - Biological processi

    1. lipid metabolic process Source: MGI
    2. positive regulation of transcription, DNA-templated Source: MGI
    3. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    4. regulation of gastrulation Source: MGI
    5. regulation of transcription, DNA-templated Source: MGI
    6. regulation of transcription from RNA polymerase II promoter Source: MGI
    7. sex differentiation Source: MGI
    8. signal transduction involved in regulation of gene expression Source: MGI
    9. SMAD protein signal transduction Source: MGI
    10. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Keywords - Ligandi

    DNA-bindingSAAS annotation, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Hepatocyte nuclear factor 4-alphaImported
    Gene namesi
    Name:Hnf4aImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:109128. Hnf4a.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    NucleusSAAS annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiA2A5I6.

    Expressioni

    Gene expression databases

    ArrayExpressiA2A5I6.

    Structurei

    3D structure databases

    ProteinModelPortaliA2A5I6.
    SMRiA2A5I6. Positions 34-111, 124-191.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family.UniRule annotation
    Contains nuclear receptor DNA-binding domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115493.
    HOGENOMiHOG000260822.
    HOVERGENiHBG005606.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    A2A5I6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYGQLREMMM LCLTDTSPSE GANLNSSNSL GVSALCAICG DRATGKHYGA    50
    SSCDGCKGFF RRSVRKNHMY SCRFSRQCVV DKDKRNQCRY CRLKKCFRAG 100
    MKKEAVQNER DRISTRRSSY EDSSLPSINA LLQAEVLSQQ ITSPISGING 150
    DIRAKKIANI TDVCESMKEQ LLVLVEWAKY IPAFCELLLD D 191
    Length:191
    Mass (Da):21,447
    Last modified:February 20, 2007 - v1
    Checksum:i723296901B63F8A4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei191 – 1911Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591488 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000137449; ENSMUSP00000123511; ENSMUSG00000017950.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591488 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali A2A5I6.
    SMRi A2A5I6. Positions 34-111, 124-191.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A2A5I6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000137449 ; ENSMUSP00000123511 ; ENSMUSG00000017950 .

    Organism-specific databases

    MGIi MGI:109128. Hnf4a.

    Phylogenomic databases

    GeneTreei ENSGT00740000115493.
    HOGENOMi HOG000260822.
    HOVERGENi HBG005606.

    Miscellaneous databases

    ChiTaRSi HNF4A. mouse.
    NextBioi 35542593.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A2A5I6.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiA2A5I6_MOUSE
    AccessioniPrimary (citable) accession number: A2A5I6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3