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Protein
Submitted name:

Hepatocyte nuclear factor 4-alpha

Gene

Hnf4a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. fatty acid binding Source: MGI
  3. protein homodimerization activity Source: MGI
  4. receptor binding Source: MGI
  5. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
  6. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  7. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  8. sequence-specific DNA binding Source: MGI
  9. sequence-specific DNA binding transcription factor activity Source: MGI
  10. transcription regulatory region DNA binding Source: MGI
  11. zinc ion binding Source: InterPro

GO - Biological processi

  1. blood coagulation Source: MGI
  2. lipid homeostasis Source: MGI
  3. lipid metabolic process Source: MGI
  4. negative regulation of cell growth Source: MGI
  5. negative regulation of cell proliferation Source: MGI
  6. ornithine metabolic process Source: MGI
  7. positive regulation of transcription, DNA-templated Source: MGI
  8. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  9. regulation of gastrulation Source: MGI
  10. regulation of lipid metabolic process Source: MGI
  11. regulation of transcription, DNA-templated Source: MGI
  12. regulation of transcription from RNA polymerase II promoter Source: MGI
  13. sex differentiation Source: MGI
  14. signal transduction involved in regulation of gene expression Source: MGI
  15. SMAD protein signal transduction Source: MGI
  16. transcription from RNA polymerase II promoter Source: GOC
  17. xenobiotic metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Hepatocyte nuclear factor 4-alphaImported
Gene namesi
Name:Hnf4aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:109128. Hnf4a.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

BgeeiA2A5I4.
ExpressionAtlasiA2A5I4. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA2A5I4.
SMRiA2A5I4. Positions 36-100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118948.
HOGENOMiHOG000197750.
HOVERGENiHBG082808.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00047. STROIDFINGER.
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

A2A5I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSVNAPLGA PVASPYDTSP SEGANLNSSN SLGVSALCAI CGDRATGKHY
60 70 80 90 100
GASSCDGCKG FFRRSVRKNH MYSCRFSRQC VVDKDKRNQC RYCRLKKCFR
Length:100
Mass (Da):10,950
Last modified:February 20, 2007 - v1
Checksum:iA10AC0C1E8D75138
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei100 – 1001Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591488 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000143911; ENSMUSP00000119479; ENSMUSG00000017950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591488 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliA2A5I4.
SMRiA2A5I4. Positions 36-100.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000143911; ENSMUSP00000119479; ENSMUSG00000017950.

Organism-specific databases

MGIiMGI:109128. Hnf4a.

Phylogenomic databases

GeneTreeiENSGT00760000118948.
HOGENOMiHOG000197750.
HOVERGENiHBG082808.

Miscellaneous databases

ChiTaRSiHnf4a. mouse.
NextBioi35542592.
SOURCEiSearch...

Gene expression databases

BgeeiA2A5I4.
ExpressionAtlasiA2A5I4. baseline and differential.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00047. STROIDFINGER.
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2A5I4_MOUSE
AccessioniPrimary (citable) accession number: A2A5I4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: April 1, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.