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A2A5I4

- A2A5I4_MOUSE

UniProt

A2A5I4 - A2A5I4_MOUSE

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Protein
Submitted name:

Hepatocyte nuclear factor 4-alpha

Gene

Hnf4a

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  4. sequence-specific DNA binding Source: MGI
  5. sequence-specific DNA binding transcription factor activity Source: MGI
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. lipid metabolic process Source: MGI
  2. positive regulation of transcription, DNA-templated Source: MGI
  3. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  4. regulation of gastrulation Source: MGI
  5. regulation of transcription, DNA-templated Source: MGI
  6. regulation of transcription from RNA polymerase II promoter Source: MGI
  7. sex differentiation Source: MGI
  8. signal transduction involved in regulation of gene expression Source: MGI
  9. SMAD protein signal transduction Source: MGI
  10. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Hepatocyte nuclear factor 4-alphaImported
Gene namesi
Name:Hnf4aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:109128. Hnf4a.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

ExpressionAtlasiA2A5I4. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA2A5I4.
SMRiA2A5I4. Positions 36-100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118948.
HOGENOMiHOG000197750.
HOVERGENiHBG082808.
OMAiYASSHFN.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00047. STROIDFINGER.
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

A2A5I4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSVNAPLGA PVASPYDTSP SEGANLNSSN SLGVSALCAI CGDRATGKHY
60 70 80 90 100
GASSCDGCKG FFRRSVRKNH MYSCRFSRQC VVDKDKRNQC RYCRLKKCFR
Length:100
Mass (Da):10,950
Last modified:February 20, 2007 - v1
Checksum:iA10AC0C1E8D75138
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei100 – 1001Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591488 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000143911; ENSMUSP00000119479; ENSMUSG00000017950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591488 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali A2A5I4.
SMRi A2A5I4. Positions 36-100.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000143911 ; ENSMUSP00000119479 ; ENSMUSG00000017950 .

Organism-specific databases

MGIi MGI:109128. Hnf4a.

Phylogenomic databases

GeneTreei ENSGT00760000118948.
HOGENOMi HOG000197750.
HOVERGENi HBG082808.
OMAi YASSHFN.

Miscellaneous databases

ChiTaRSi HNF4A. mouse.
NextBioi 35542592.
SOURCEi Search...

Gene expression databases

ExpressionAtlasi A2A5I4. baseline and differential.

Family and domain databases

Gene3Di 3.30.50.10. 1 hit.
InterProi IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00047. STROIDFINGER.
SMARTi SM00399. ZnF_C4. 1 hit.
[Graphical view ]
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2A5I4_MOUSE
AccessioniPrimary (citable) accession number: A2A5I4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3