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A2A5C2

- A2A5C2_MOUSE

UniProt

A2A5C2 - A2A5C2_MOUSE

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Protein
Submitted name: ETS translocation variant 4
Gene
Etv4
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. branching involved in mammary gland duct morphogenesis Source: MGI
  2. motor neuron axon guidance Source: MGI
  3. negative regulation of mammary gland epithelial cell proliferation Source: MGI
  4. positive regulation of transcription, DNA-templated Source: MGI
  5. regulation of branching involved in mammary gland duct morphogenesis Source: MGI
  6. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  7. stem cell differentiation Source: MGI
  8. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
ETS translocation variant 4Imported
Gene namesi
Name:Etv4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:99423. Etv4.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: MGI
  2. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

ArrayExpressiA2A5C2.

Structurei

3D structure databases

ProteinModelPortaliA2A5C2.
SMRiA2A5C2. Positions 334-430.

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.UniRule annotation
Contains 1 ETS DNA-binding domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00750000117517.
HOVERGENiHBG000231.
KOiK15592.
OrthoDBiEOG7K9K2M.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR006715. ETS_PEA3_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF04621. ETS_PEA3_N. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A5C2-1 [UniParc]FASTAAdd to Basket

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MERRMKGGYL DQRVPYTFCS KSPGNGSLGE ALMVPQGKLM DPGSLPPSDS    50
EDLFQDLSHF QETWLAEAQV PDSDEQFVPD FHSENLAFHS PTTRIKKEPQ 100
SPRTDPALSC SRKPPLPYHH GEQCLYSRQI AIKSPAPGAP GQSPLQPFSR 150
AEQQQSLLRA SSSSQSHPGH GYLGEHSSVF QQPVDMCHSF TSPQGGGREP 200
LPAPYQHQLS EPCPPYPQQN FKQEYHDPLY EQAGQPASSQ GGVSGHRYPG 250
AGVVIKQERT DFAYDSDVPG CASMYLHPEG FSGPSPGDGV MGYGYEKSLR 300
PFPDDVCIVP EKFEGDIKQE GIGAFREGPP YQRRGALQLW QFLVALLDDP 350
TNAHFIAWTG RGMEFKLIEP EEVARLWGIQ KNRPAMNYDK LSRSLRYYYE 400
KGIMQKVAGE RYVYKFVCEP EALFSLAFPD NQRPALKAEF DRPVSEEDTV 450
PLSHLDESPA YLPELTGPAP PFGHRGGYSY 480
Length:480
Mass (Da):53,485
Last modified:February 20, 2007 - v1
Checksum:i7B10D83B54CBC839
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591436 Genomic DNA. No translation available.
RefSeqiXP_006532528.1. XM_006532465.1.
UniGeneiMm.5025.

Genome annotation databases

EnsembliENSMUST00000107176; ENSMUSP00000102794; ENSMUSG00000017724.
GeneIDi18612.
KEGGimmu:18612.
UCSCiuc007lpu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591436 Genomic DNA. No translation available.
RefSeqi XP_006532528.1. XM_006532465.1.
UniGenei Mm.5025.

3D structure databases

ProteinModelPortali A2A5C2.
SMRi A2A5C2. Positions 334-430.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000107176 ; ENSMUSP00000102794 ; ENSMUSG00000017724 .
GeneIDi 18612.
KEGGi mmu:18612.
UCSCi uc007lpu.1. mouse.

Organism-specific databases

CTDi 2118.
MGIi MGI:99423. Etv4.

Phylogenomic databases

GeneTreei ENSGT00750000117517.
HOVERGENi HBG000231.
KOi K15592.
OrthoDBi EOG7K9K2M.

Miscellaneous databases

ChiTaRSi ETV4. mouse.
NextBioi 35542572.
SOURCEi Search...

Gene expression databases

ArrayExpressi A2A5C2.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR000418. Ets_dom.
IPR006715. ETS_PEA3_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
PF04621. ETS_PEA3_N. 1 hit.
[Graphical view ]
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
[Graphical view ]
PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2A5C2_MOUSE
AccessioniPrimary (citable) accession number: A2A5C2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi