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Protein
Submitted name:

ETS translocation variant 4

Gene

Etv4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central

GO - Biological processi

  1. branching involved in mammary gland duct morphogenesis Source: MGI
  2. motor neuron axon guidance Source: MGI
  3. negative regulation of mammary gland epithelial cell proliferation Source: MGI
  4. positive regulation of transcription, DNA-templated Source: MGI
  5. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  6. regulation of branching involved in mammary gland duct morphogenesis Source: MGI
  7. regulation of transcription from RNA polymerase II promoter Source: GO_Central
  8. stem cell differentiation Source: MGI
  9. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
ETS translocation variant 4Imported
Gene namesi
Name:Etv4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:99423. Etv4.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: MGI
  2. nucleolus Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiA2A5C2.
ExpressionAtlasiA2A5C2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA2A5C2.
SMRiA2A5C2. Positions 334-430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.UniRule annotation
Contains 1 ETS DNA-binding domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118907.
HOVERGENiHBG000231.
KOiK15592.
OrthoDBiEOG7K9K2M.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR006715. ETS_PEA3_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF04621. ETS_PEA3_N. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A5C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERRMKGGYL DQRVPYTFCS KSPGNGSLGE ALMVPQGKLM DPGSLPPSDS
60 70 80 90 100
EDLFQDLSHF QETWLAEAQV PDSDEQFVPD FHSENLAFHS PTTRIKKEPQ
110 120 130 140 150
SPRTDPALSC SRKPPLPYHH GEQCLYSRQI AIKSPAPGAP GQSPLQPFSR
160 170 180 190 200
AEQQQSLLRA SSSSQSHPGH GYLGEHSSVF QQPVDMCHSF TSPQGGGREP
210 220 230 240 250
LPAPYQHQLS EPCPPYPQQN FKQEYHDPLY EQAGQPASSQ GGVSGHRYPG
260 270 280 290 300
AGVVIKQERT DFAYDSDVPG CASMYLHPEG FSGPSPGDGV MGYGYEKSLR
310 320 330 340 350
PFPDDVCIVP EKFEGDIKQE GIGAFREGPP YQRRGALQLW QFLVALLDDP
360 370 380 390 400
TNAHFIAWTG RGMEFKLIEP EEVARLWGIQ KNRPAMNYDK LSRSLRYYYE
410 420 430 440 450
KGIMQKVAGE RYVYKFVCEP EALFSLAFPD NQRPALKAEF DRPVSEEDTV
460 470 480
PLSHLDESPA YLPELTGPAP PFGHRGGYSY
Length:480
Mass (Da):53,485
Last modified:February 19, 2007 - v1
Checksum:i7B10D83B54CBC839
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591436 Genomic DNA. No translation available.
RefSeqiXP_006532528.1. XM_006532465.2.
UniGeneiMm.5025.

Genome annotation databases

EnsembliENSMUST00000107176; ENSMUSP00000102794; ENSMUSG00000017724.
GeneIDi18612.
KEGGimmu:18612.
UCSCiuc007lpu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591436 Genomic DNA. No translation available.
RefSeqiXP_006532528.1. XM_006532465.2.
UniGeneiMm.5025.

3D structure databases

ProteinModelPortaliA2A5C2.
SMRiA2A5C2. Positions 334-430.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107176; ENSMUSP00000102794; ENSMUSG00000017724.
GeneIDi18612.
KEGGimmu:18612.
UCSCiuc007lpu.1. mouse.

Organism-specific databases

CTDi2118.
MGIiMGI:99423. Etv4.

Phylogenomic databases

GeneTreeiENSGT00760000118907.
HOVERGENiHBG000231.
KOiK15592.
OrthoDBiEOG7K9K2M.

Miscellaneous databases

ChiTaRSiEtv4. mouse.
NextBioi35542572.
SOURCEiSearch...

Gene expression databases

BgeeiA2A5C2.
ExpressionAtlasiA2A5C2. baseline and differential.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR006715. ETS_PEA3_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF04621. ETS_PEA3_N. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2A5C2_MOUSE
AccessioniPrimary (citable) accession number: A2A5C2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 19, 2007
Last sequence update: February 19, 2007
Last modified: March 31, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.