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Protein
Submitted name:

Next to BRCA1 gene 1 protein

Gene

Nbr1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Next to BRCA1 gene 1 proteinImported
Gene namesi
Name:Nbr1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:108498. Nbr1.

PTM / Processingi

Proteomic databases

PaxDbiA2A4N8.
PRIDEiA2A4N8.

Expressioni

Gene expression databases

BgeeiA2A4N8.
ExpressionAtlasiA2A4N8. baseline and differential.
GenevisibleiA2A4N8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099387.

Structurei

3D structure databases

ProteinModelPortaliA2A4N8.
SMRiA2A4N8. Positions 1-86, 368-484, 898-944.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 8683PB1InterPro annotationAdd
BLAST
Domaini212 – 25847ZZ-typeInterPro annotationAdd
BLAST
Domaini898 – 94245UBAInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili296 – 33035Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains PB1 domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG4351. Eukaryota.
KOG4582. Eukaryota.
ENOG4111TKN. LUCA.
GeneTreeiENSGT00390000016335.
HOGENOMiHOG000220861.
HOVERGENiHBG052578.

Family and domain databases

InterProiIPR032350. N_BRCA1_central.
IPR033513. NBR1.
IPR000270. PB1_dom.
IPR015940. UBA.
IPR009060. UBA-like.
IPR000433. Znf_ZZ.
[Graphical view]
PANTHERiPTHR20930:SF2. PTHR20930:SF2. 3 hits.
PfamiPF16158. N_BRCA1_IG. 1 hit.
PF00564. PB1. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50030. UBA. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A4N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPQVTLNVT FKNETQSFLV SDPENTTWAD VEAMVKVSFD LNTIQIKYLD
60 70 80 90 100
EENEEISINS QGEYEEALKM ANIKQGNQLQ MQVHEGYHVV DEALPKNVVE
110 120 130 140 150
NQAAARTGKK PLAHYSSLVR VLGSDMKTTE EPAPEQCSSA PCDTDQPQDK
160 170 180 190 200
PPDWFTSYLE MFREQVVKET VEKLEQRLQE KLVLQKPLLS SSPTEVSMPI
210 220 230 240 250
SEETLFLPEN QFSWHIACSH CQKRIVGVRY QCSLCPSYNI CEDCEAGPYT
260 270 280 290 300
HDTNHVLLKL RRPVVISSEP FFYSKYSAPR LPAALEQVRL QKQVDKNFVK
310 320 330 340 350
AEKQRLRAEK KQRKAEVKEL KKQLKLHRKI HLWNSIHGLQ SPKSPLGRPE
360 370 380 390 400
SLLQSNTLML PLQPCAPVMP TLSAAFVDEN LPDGTHLQPG TKFIKHWRMK
410 420 430 440 450
NTGNVKWNTD TKLKFMWGNL TLASTEKKDV LVPCLKAGHV GVVSVEFIAP
460 470 480 490 500
TLEGTYTSHW RLSHKGQQFG PRVWCSIIVD PFPSSESPDN VEGDRISSSK
510 520 530 540 550
ADDFSCEQEE AFLLAEEEIP LGEVTKQTEG TGASASQKTR RAASERELYI
560 570 580 590 600
PSVDLLTAQD LLSFELLDIN IVQELERVPH NTPVDSTVSA KRKAETPASV
610 620 630 640 650
EETEEDLSGT QFVCETVIRS LTLDAAPDHN PPCRQRSPQR ELQLYSTEGQ
660 670 680 690 700
QPLVLPGFCR KDSSLKFALP EEGPRGDERE EIVHIVEEEV VEEEEEVQDE
710 720 730 740 750
EVQSQSSASS EDYIIILPEC FDTSRPLGDS MYSSALSQPG LERGAEGEPG
760 770 780 790 800
IESGLEPTEA RERLPERESQ PQEQSISDIL TTSQPLDTVP LVPEVAGLPA
810 820 830 840 850
ALSRSAPCGQ CESSGVDSPG VDSPATMHEV PPAPDDIRGE PRGSTGLANS
860 870 880 890 900
RQRSCDHSRH HNGSSIAGGL VKGALSVAAS AYKALFSGPP VTAQPIVSED
910 920 930 940 950
QTTALMAHLF EMGFCDRQLN LRLLRKHNYN ILQVVTELLQ VNNNDWYSHR

Y
Length:951
Mass (Da):106,070
Last modified:February 20, 2007 - v1
Checksum:iDCFF673893F54113
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590994 Genomic DNA. No translation available.
AL590996 Genomic DNA. No translation available.
RefSeqiNP_001239151.1. NM_001252222.1.
UniGeneiMm.489817.
Mm.784.

Genome annotation databases

EnsembliENSMUST00000107213; ENSMUSP00000102831; ENSMUSG00000017119.
GeneIDi17966.
UCSCiuc007lpi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590994 Genomic DNA. No translation available.
AL590996 Genomic DNA. No translation available.
RefSeqiNP_001239151.1. NM_001252222.1.
UniGeneiMm.489817.
Mm.784.

3D structure databases

ProteinModelPortaliA2A4N8.
SMRiA2A4N8. Positions 1-86, 368-484, 898-944.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099387.

Proteomic databases

PaxDbiA2A4N8.
PRIDEiA2A4N8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107213; ENSMUSP00000102831; ENSMUSG00000017119.
GeneIDi17966.
UCSCiuc007lpi.2. mouse.

Organism-specific databases

CTDi4077.
MGIiMGI:108498. Nbr1.

Phylogenomic databases

eggNOGiKOG4351. Eukaryota.
KOG4582. Eukaryota.
ENOG4111TKN. LUCA.
GeneTreeiENSGT00390000016335.
HOGENOMiHOG000220861.
HOVERGENiHBG052578.

Miscellaneous databases

ChiTaRSiNbr1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiA2A4N8.
ExpressionAtlasiA2A4N8. baseline and differential.
GenevisibleiA2A4N8. MM.

Family and domain databases

InterProiIPR032350. N_BRCA1_central.
IPR033513. NBR1.
IPR000270. PB1_dom.
IPR015940. UBA.
IPR009060. UBA-like.
IPR000433. Znf_ZZ.
[Graphical view]
PANTHERiPTHR20930:SF2. PTHR20930:SF2. 3 hits.
PfamiPF16158. N_BRCA1_IG. 1 hit.
PF00564. PB1. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50030. UBA. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2A4N8_MOUSE
AccessioniPrimary (citable) accession number: A2A4N8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: July 6, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.