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Protein
Submitted name:

Next to BRCA1 gene 1 protein

Gene

Nbr1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Next to BRCA1 gene 1 proteinImported
Gene namesi
Name:Nbr1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:108498 Nbr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiA2A4N7
PeptideAtlasiA2A4N7

Expressioni

Gene expression databases

BgeeiENSMUSG00000017119
ExpressionAtlasiA2A4N7 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA2A4N7
SMRiA2A4N7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 86PB1InterPro annotationAdd BLAST83
Domaini212 – 258ZZ-typeInterPro annotationAdd BLAST47
Domaini910 – 954UBAInterPro annotationAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili296 – 330Sequence analysisAdd BLAST35
Coiled coili695 – 715Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4351 Eukaryota
KOG4582 Eukaryota
ENOG4111TKN LUCA
GeneTreeiENSGT00390000016335
HOGENOMiHOG000220861
HOVERGENiHBG052578

Family and domain databases

CDDicd14947 NBR1_like, 1 hit
cd06396 PB1_NBR1, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR032350 N_BRCA1_central
IPR033513 NBR1
IPR000270 PB1_dom
IPR034852 PB1_NBR1
IPR015940 UBA
IPR009060 UBA-like_sf
IPR000433 Znf_ZZ
PANTHERiPTHR20930:SF2 PTHR20930:SF2, 1 hit
PfamiView protein in Pfam
PF16158 N_BRCA1_IG, 1 hit
PF00564 PB1, 1 hit
PF00569 ZZ, 1 hit
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS50030 UBA, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

A2A4N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPQVTLNVT FKNETQSFLV SDPENTTWAD VEAMVKVSFD LNTIQIKYLD
60 70 80 90 100
EENEEISINS QGEYEEALKM ANIKQGNQLQ MQVHEGYHVV DEALPKNVVE
110 120 130 140 150
NQAAARTGKK PLAHYSSLVR VLGSDMKTTE EPAPEQCSSA PCDTDQPQDK
160 170 180 190 200
PPDWFTSYLE MFREQVVKET VEKLEQRLQE KLVLQKPLLS SSPTEVSMPI
210 220 230 240 250
SEETLFLPEN QFSWHIACSH CQKRIVGVRY QCSLCPSYNI CEDCEAGPYT
260 270 280 290 300
HDTNHVLLKL RRPVVISSEP FFYSKYSAPR LPAALEQVRL QKQVDKNFVK
310 320 330 340 350
AEKQRLRAEK KQRKAEVKEL KKQLKLHRKI HLWNSIHGLQ SPKSPLGRPE
360 370 380 390 400
SLLQSNTLML PLQPCAPVMP TLSAAFVDEN LPDGTHLQPG TKFIKHWRMK
410 420 430 440 450
NTGNVKWNTD TKLKFMWGNL TLASTEKKDV LVPCLKAGHV GVVSVEFIAP
460 470 480 490 500
TLEGTYTSHW RLSHKGQQFG PRVWCSIIVD PFPSSESPDN VEGDRISSSK
510 520 530 540 550
ADDFSCEQEE AFLLAEEEIP LGEVTKQTEG TGASASQKTR RAASERELYI
560 570 580 590 600
PSVDLLTAQD LLSFELLDIN IVQELERVPH NTPVDMTPCM SPLPHDSPLI
610 620 630 640 650
EKPGLGQIQE ESEGAGFKAP PDSTVSAKRK AETPASVEET EEDLSGTQFV
660 670 680 690 700
CETVIRSLTL DAAPDHNPPC RQRSPQMKFA LPEEGPRGDE REEIVHIVEE
710 720 730 740 750
EVVEEEEEVQ DEEVQSQSSA SSEDYIIILP ECFDTSRPLG DSMYSSALSQ
760 770 780 790 800
PGLERGAEGE PGIESGLEPT EARERLPERE SQPQEQSISD ILTTSQPLDT
810 820 830 840 850
VPLVPEVAGL PAALSRSAPC GQCESSGVDS PGVDSPATMH EVPPAPDDIR
860 870 880 890 900
GEPRGSTGLA NSRQRSCDHS RHHNGSSIAG GLVKGALSVA ASAYKALFSG
910 920 930 940 950
PPVTAQPIVS EDQTTALMAH LFEMGFCDRQ LNLRLLRKHN YNILQVVTEL
960
LQVNNNDWYS HRY
Length:963
Mass (Da):107,141
Last modified:February 20, 2007 - v1
Checksum:iC8DFDAA37683BE3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590994 Genomic DNA No translation available.
AL590996 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000107212; ENSMUSP00000102830; ENSMUSG00000017119

Similar proteinsi

Entry informationi

Entry nameiA2A4N7_MOUSE
AccessioniPrimary (citable) accession number: A2A4N7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health