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A2A468

- A2A468_MOUSE

UniProt

A2A468 - A2A468_MOUSE

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Protein
Submitted name:

Nuclear receptor coactivator 3

Gene
Ncoa3, mCG_14623
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. histone acetyltransferase activity Source: InterPro
  3. ligand-dependent nuclear receptor transcription coactivator activity Source: InterPro
  4. signal transducer activity Source: InterPro

GO - Biological processi

  1. developmental growth Source: MGI
  2. labyrinthine layer morphogenesis Source: MGI
  3. mammary gland branching involved in thelarche Source: MGI
  4. multicellular organism growth Source: MGI
  5. regulation of transcription, DNA-templated Source: UniProtKB-KW
  6. transcription, DNA-templated Source: UniProtKB-KW
  7. vagina development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotations

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear receptor coactivator 3Imported
Gene namesi
Name:Ncoa3Imported
ORF Names:mCG_14623Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1276535. Ncoa3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Family & Domainsi

Sequence similaritiesi

Contains bHLH (basic helix-loop-helix) domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00530000063109.
HOGENOMiHOG000230947.
HOVERGENiHBG052583.
KOiK11256.
OrthoDBiEOG72JWFB.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
4.10.630.10. 2 hits.
InterProiIPR011598. bHLH_dom.
IPR010011. DUF1518.
IPR028818. NCOA3.
IPR009110. Nuc_rcpt_coact.
IPR014920. Nuc_rcpt_coact_Ncoa-typ.
IPR017426. Nuclear_rcpt_coactivator.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR014710. RmlC-like_jellyroll.
IPR014935. SRC-1.
IPR008955. Src1_rcpt_coact.
[Graphical view]
PANTHERiPTHR10684. PTHR10684. 1 hit.
PTHR10684:SF3. PTHR10684:SF3. 1 hit.
PfamiPF07469. DUF1518. 1 hit.
PF08815. Nuc_rec_co-act. 1 hit.
PF00989. PAS. 1 hit.
PF08832. SRC-1. 1 hit.
[Graphical view]
PIRSFiPIRSF038181. Nuclear_receptor_coactivator. 1 hit.
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
SSF69125. SSF69125. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A468-1 [UniParc]FASTAAdd to Basket

« Hide

MSGLGESSLD PLAAESRKRK LPCDAPGQGL VYSGEKWRRE QESKYIEELA     50
ELISANLSDI DNFNVKPDKC AILKETVRQI RQIKEQGKTI SSDDDVQKAD 100
VSSTGQGVID KDSLGPLLLQ ALDGFLFVVN RDGNIVFVSE NVTQYLQYKQ 150
EDLVNTSVYS ILHEQDRKDF LKHLPKSTVN GVSWTNENQR QKSHTFNCRM 200
LMKTHDILED VNASPETRQR YETMQCFALS QPRAMLEEGE DLQCCMICVA 250
RRVTAPFPSS PESFITRHDL SGKVVNIDTN SLRSSMRPGF EDIIRRCIQR 300
FFSLNDGQSW SQKRHYQEAY VHGHAETPVY RFSLADGTIV SAQTKSKLFR 350
NPVTNDRHGF ISTHFLQREQ NGYRPNPNPA GQGIRPPAAG CGVSMSPNQN 400
VQMMGSRTYG VPDPSNTGQM GGARYGASSS VASLTPGQSL QSPSSYQNSS 450
YGLSMSSPPH GSPGLGPNQQ NIMISPRNRG SPKMASHQFS PAAGAHSPMG 500
PSGNTGSHSF SSSSLSALQA ISEGVGTSLL STLSSPGPKL DNSPNMNISQ 550
PSKVSGQDSK SPLGLYCEQN PVESSVCQSN SRDHPSEKES KESSGEVSET 600
PRGPLESKGH KKLLQLLTCS SDDRGHSSLT NSPLDPNCKD SSVSVTSPSG 650
VSSSTSGTVS STSNVHGSLL QEKHRILHKL LQNGNSPAEV AKITAEATGK 700
DTSSTASCGE GTTRQEQLSP KKKENNALLR YLLDRDDPSD VLAKELQPQA 750
DSGDSKLSQC SCSTNPSSGQ EKDPKIKTET NEEVSGDLDN LDAILGDLTS 800
SDFYNNPTNG GHPGAKQQMF AGPSSLGLRS PQPVQSVRPP YNRAVSLDSP 850
VSVGSGPPVK NVSAFPGLPK QPILAGNPRM MDSQENYGAN MGPNRNVPVN 900
PTSSPGDWGL ANSRASRMEP LASSPLGRTG ADYSATLPRP AMGGSVPTLP 950
LRSNRLPGAR PSLQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QMLQMRTGEI 1000
PMGMGVNPYS PAVPSNQPGS WPEGMLSMEQ GPHGSQNRPL LRNSLDDLLG 1050
PPSNAEGQSD ERALLDQLHT LLSNTDATGL EEIDRALGIP ELVNQGQALE 1100
SKQDVFQGQE AAVMMDQKAA LYGQTYPAQG PPLQGGFNLQ GQSPSFNSMM 1150
GQISQQGSFP LQGMHPRAGL VRPRTNTPKQ LRMQLQQRLQ GQQFLNQSRQ 1200
ALEMKMENPA GTAVMRPMMP QAFFNAQMAA QQKRELMSHH LQQQRMAMMM 1250
SQPQPQAFSP PPNVTASPSM DGVLAGSAMP QAPPQQFPYP ANYGMGQPPE 1300
PAFGRGSSPP SAMMSSRMGP SQNAMVQHPQ PTPMYQPSDM KGWPSGNLAR 1350
NGSFPQQQFA PQGNPAAYNM VHMNSSGGHL GQMAMTPMPM SGMPMGPDQK 1400
YC 1402
Length:1,402
Mass (Da):151,824
Last modified:February 20, 2007 - v1
Checksum:i1018880641B43381
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL589873 Genomic DNA. No translation available.
AL589902 Genomic DNA. No translation available.
CH466551 Genomic DNA. Translation: EDL06475.1.
RefSeqiXP_006498951.1. XM_006498888.1.
UniGeneiMm.469663.

Genome annotation databases

EnsembliENSMUST00000109252; ENSMUSP00000104875; ENSMUSG00000027678.
GeneIDi17979.
KEGGimmu:17979.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL589873 Genomic DNA. No translation available.
AL589902 Genomic DNA. No translation available.
CH466551 Genomic DNA. Translation: EDL06475.1 .
RefSeqi XP_006498951.1. XM_006498888.1.
UniGenei Mm.469663.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000109252 ; ENSMUSP00000104875 ; ENSMUSG00000027678 .
GeneIDi 17979.
KEGGi mmu:17979.

Organism-specific databases

CTDi 8202.
MGIi MGI:1276535. Ncoa3.

Phylogenomic databases

GeneTreei ENSGT00530000063109.
HOGENOMi HOG000230947.
HOVERGENi HBG052583.
KOi K11256.
OrthoDBi EOG72JWFB.

Enzyme and pathway databases

Reactomei REACT_198602. PPARA activates gene expression.

Miscellaneous databases

ChiTaRSi NCOA3. mouse.
NextBioi 35542501.
SOURCEi Search...

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
4.10.630.10. 2 hits.
InterProi IPR011598. bHLH_dom.
IPR010011. DUF1518.
IPR028818. NCOA3.
IPR009110. Nuc_rcpt_coact.
IPR014920. Nuc_rcpt_coact_Ncoa-typ.
IPR017426. Nuclear_rcpt_coactivator.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR014710. RmlC-like_jellyroll.
IPR014935. SRC-1.
IPR008955. Src1_rcpt_coact.
[Graphical view ]
PANTHERi PTHR10684. PTHR10684. 1 hit.
PTHR10684:SF3. PTHR10684:SF3. 1 hit.
Pfami PF07469. DUF1518. 1 hit.
PF08815. Nuc_rec_co-act. 1 hit.
PF00989. PAS. 1 hit.
PF08832. SRC-1. 1 hit.
[Graphical view ]
PIRSFi PIRSF038181. Nuclear_receptor_coactivator. 1 hit.
SMARTi SM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
SSF69125. SSF69125. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiA2A468_MOUSE
AccessioniPrimary (citable) accession number: A2A468
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi