Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Nuclear receptor coactivator 3

Gene

Ncoa3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. histone acetyltransferase activity Source: MGI
  3. ligand-dependent nuclear receptor binding Source: MGI
  4. ligand-dependent nuclear receptor transcription coactivator activity Source: GO_Central
  5. nuclear hormone receptor binding Source: MGI
  6. protein N-terminus binding Source: MGI
  7. signal transducer activity Source: InterPro
  8. transcription coactivator activity Source: MGI

GO - Biological processi

  1. cellular response to hormone stimulus Source: GO_Central
  2. developmental growth Source: MGI
  3. histone acetylation Source: MGI
  4. intracellular receptor signaling pathway Source: GO_Central
  5. labyrinthine layer morphogenesis Source: MGI
  6. mammary gland branching involved in thelarche Source: MGI
  7. multicellular organism growth Source: MGI
  8. positive regulation of gene expression Source: MGI
  9. positive regulation of keratinocyte differentiation Source: MGI
  10. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  11. regulation of RNA biosynthetic process Source: MGI
  12. transcription, DNA-templated Source: UniProtKB-KW
  13. vagina development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear receptor coactivator 3Imported
Gene namesi
Name:Ncoa3Imported
ORF Names:mCG_14623Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1276535. Ncoa3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. nucleoplasm Source: MGI
  4. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiA2A468.

Expressioni

Gene expression databases

BgeeiA2A468.
ExpressionAtlasiA2A468. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA2A468.
SMRiA2A468. Positions 35-364, 1056-1102.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation
Contains bHLH (basic helix-loop-helix) domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00530000063109.
HOGENOMiHOG000230947.
HOVERGENiHBG052583.
KOiK11256.
OrthoDBiEOG72JWFB.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
4.10.630.10. 2 hits.
InterProiIPR011598. bHLH_dom.
IPR010011. DUF1518.
IPR028818. NCOA3.
IPR009110. Nuc_rcpt_coact.
IPR014920. Nuc_rcpt_coact_Ncoa-typ.
IPR017426. Nuclear_rcpt_coactivator.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR014710. RmlC-like_jellyroll.
IPR014935. SRC-1.
IPR008955. Src1_rcpt_coact.
[Graphical view]
PANTHERiPTHR10684. PTHR10684. 1 hit.
PTHR10684:SF3. PTHR10684:SF3. 1 hit.
PfamiPF07469. DUF1518. 1 hit.
PF08815. Nuc_rec_co-act. 1 hit.
PF00989. PAS. 1 hit.
PF08832. SRC-1. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
SSF69125. SSF69125. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A468-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLGESSLD PLAAESRKRK LPCDAPGQGL VYSGEKWRRE QESKYIEELA
60 70 80 90 100
ELISANLSDI DNFNVKPDKC AILKETVRQI RQIKEQGKTI SSDDDVQKAD
110 120 130 140 150
VSSTGQGVID KDSLGPLLLQ ALDGFLFVVN RDGNIVFVSE NVTQYLQYKQ
160 170 180 190 200
EDLVNTSVYS ILHEQDRKDF LKHLPKSTVN GVSWTNENQR QKSHTFNCRM
210 220 230 240 250
LMKTHDILED VNASPETRQR YETMQCFALS QPRAMLEEGE DLQCCMICVA
260 270 280 290 300
RRVTAPFPSS PESFITRHDL SGKVVNIDTN SLRSSMRPGF EDIIRRCIQR
310 320 330 340 350
FFSLNDGQSW SQKRHYQEAY VHGHAETPVY RFSLADGTIV SAQTKSKLFR
360 370 380 390 400
NPVTNDRHGF ISTHFLQREQ NGYRPNPNPA GQGIRPPAAG CGVSMSPNQN
410 420 430 440 450
VQMMGSRTYG VPDPSNTGQM GGARYGASSS VASLTPGQSL QSPSSYQNSS
460 470 480 490 500
YGLSMSSPPH GSPGLGPNQQ NIMISPRNRG SPKMASHQFS PAAGAHSPMG
510 520 530 540 550
PSGNTGSHSF SSSSLSALQA ISEGVGTSLL STLSSPGPKL DNSPNMNISQ
560 570 580 590 600
PSKVSGQDSK SPLGLYCEQN PVESSVCQSN SRDHPSEKES KESSGEVSET
610 620 630 640 650
PRGPLESKGH KKLLQLLTCS SDDRGHSSLT NSPLDPNCKD SSVSVTSPSG
660 670 680 690 700
VSSSTSGTVS STSNVHGSLL QEKHRILHKL LQNGNSPAEV AKITAEATGK
710 720 730 740 750
DTSSTASCGE GTTRQEQLSP KKKENNALLR YLLDRDDPSD VLAKELQPQA
760 770 780 790 800
DSGDSKLSQC SCSTNPSSGQ EKDPKIKTET NEEVSGDLDN LDAILGDLTS
810 820 830 840 850
SDFYNNPTNG GHPGAKQQMF AGPSSLGLRS PQPVQSVRPP YNRAVSLDSP
860 870 880 890 900
VSVGSGPPVK NVSAFPGLPK QPILAGNPRM MDSQENYGAN MGPNRNVPVN
910 920 930 940 950
PTSSPGDWGL ANSRASRMEP LASSPLGRTG ADYSATLPRP AMGGSVPTLP
960 970 980 990 1000
LRSNRLPGAR PSLQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QMLQMRTGEI
1010 1020 1030 1040 1050
PMGMGVNPYS PAVPSNQPGS WPEGMLSMEQ GPHGSQNRPL LRNSLDDLLG
1060 1070 1080 1090 1100
PPSNAEGQSD ERALLDQLHT LLSNTDATGL EEIDRALGIP ELVNQGQALE
1110 1120 1130 1140 1150
SKQDVFQGQE AAVMMDQKAA LYGQTYPAQG PPLQGGFNLQ GQSPSFNSMM
1160 1170 1180 1190 1200
GQISQQGSFP LQGMHPRAGL VRPRTNTPKQ LRMQLQQRLQ GQQFLNQSRQ
1210 1220 1230 1240 1250
ALEMKMENPA GTAVMRPMMP QAFFNAQMAA QQKRELMSHH LQQQRMAMMM
1260 1270 1280 1290 1300
SQPQPQAFSP PPNVTASPSM DGVLAGSAMP QAPPQQFPYP ANYGMGQPPE
1310 1320 1330 1340 1350
PAFGRGSSPP SAMMSSRMGP SQNAMVQHPQ PTPMYQPSDM KGWPSGNLAR
1360 1370 1380 1390 1400
NGSFPQQQFA PQGNPAAYNM VHMNSSGGHL GQMAMTPMPM SGMPMGPDQK

YC
Length:1,402
Mass (Da):151,824
Last modified:February 19, 2007 - v1
Checksum:i1018880641B43381
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL589873 Genomic DNA. No translation available.
AL589902 Genomic DNA. No translation available.
CH466551 Genomic DNA. Translation: EDL06475.1.
RefSeqiXP_006498951.1. XM_006498888.1.
UniGeneiMm.469663.

Genome annotation databases

EnsembliENSMUST00000109252; ENSMUSP00000104875; ENSMUSG00000027678.
GeneIDi17979.
KEGGimmu:17979.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL589873 Genomic DNA. No translation available.
AL589902 Genomic DNA. No translation available.
CH466551 Genomic DNA. Translation: EDL06475.1.
RefSeqiXP_006498951.1. XM_006498888.1.
UniGeneiMm.469663.

3D structure databases

ProteinModelPortaliA2A468.
SMRiA2A468. Positions 35-364, 1056-1102.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA2A468.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109252; ENSMUSP00000104875; ENSMUSG00000027678.
GeneIDi17979.
KEGGimmu:17979.

Organism-specific databases

CTDi8202.
MGIiMGI:1276535. Ncoa3.

Phylogenomic databases

GeneTreeiENSGT00530000063109.
HOGENOMiHOG000230947.
HOVERGENiHBG052583.
KOiK11256.
OrthoDBiEOG72JWFB.

Miscellaneous databases

ChiTaRSiNcoa3. mouse.
NextBioi35542501.
SOURCEiSearch...

Gene expression databases

BgeeiA2A468.
ExpressionAtlasiA2A468. baseline and differential.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
4.10.630.10. 2 hits.
InterProiIPR011598. bHLH_dom.
IPR010011. DUF1518.
IPR028818. NCOA3.
IPR009110. Nuc_rcpt_coact.
IPR014920. Nuc_rcpt_coact_Ncoa-typ.
IPR017426. Nuclear_rcpt_coactivator.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR014710. RmlC-like_jellyroll.
IPR014935. SRC-1.
IPR008955. Src1_rcpt_coact.
[Graphical view]
PANTHERiPTHR10684. PTHR10684. 1 hit.
PTHR10684:SF3. PTHR10684:SF3. 1 hit.
PfamiPF07469. DUF1518. 1 hit.
PF08815. Nuc_rec_co-act. 1 hit.
PF00989. PAS. 1 hit.
PF08832. SRC-1. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
SSF69125. SSF69125. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiA2A468_MOUSE
AccessioniPrimary (citable) accession number: A2A468
Entry historyi
Integrated into UniProtKB/TrEMBL: February 19, 2007
Last sequence update: February 19, 2007
Last modified: March 31, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.