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A2A468

- A2A468_MOUSE

UniProt

A2A468 - A2A468_MOUSE

Protein
Submitted name:

Nuclear receptor coactivator 3

Gene

Ncoa3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. histone acetyltransferase activity Source: InterPro
    3. ligand-dependent nuclear receptor transcription coactivator activity Source: InterPro
    4. signal transducer activity Source: InterPro

    GO - Biological processi

    1. developmental growth Source: MGI
    2. labyrinthine layer morphogenesis Source: MGI
    3. mammary gland branching involved in thelarche Source: MGI
    4. multicellular organism growth Source: MGI
    5. regulation of transcription, DNA-templated Source: UniProtKB-KW
    6. transcription, DNA-templated Source: UniProtKB-KW
    7. vagina development Source: MGI

    Keywords - Molecular functioni

    ReceptorImported

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Enzyme and pathway databases

    ReactomeiREACT_198602. PPARA activates gene expression.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Nuclear receptor coactivator 3Imported
    Gene namesi
    Name:Ncoa3Imported
    ORF Names:mCG_14623Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1276535. Ncoa3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation
    Contains bHLH (basic helix-loop-helix) domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00530000063109.
    HOGENOMiHOG000230947.
    HOVERGENiHBG052583.
    KOiK11256.
    OrthoDBiEOG72JWFB.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    4.10.630.10. 2 hits.
    InterProiIPR011598. bHLH_dom.
    IPR010011. DUF1518.
    IPR028818. NCOA3.
    IPR009110. Nuc_rcpt_coact.
    IPR014920. Nuc_rcpt_coact_Ncoa-typ.
    IPR017426. Nuclear_rcpt_coactivator.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    IPR014710. RmlC-like_jellyroll.
    IPR014935. SRC-1.
    IPR008955. Src1_rcpt_coact.
    [Graphical view]
    PANTHERiPTHR10684. PTHR10684. 1 hit.
    PTHR10684:SF3. PTHR10684:SF3. 1 hit.
    PfamiPF07469. DUF1518. 1 hit.
    PF08815. Nuc_rec_co-act. 1 hit.
    PF00989. PAS. 1 hit.
    PF08832. SRC-1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038181. Nuclear_receptor_coactivator. 1 hit.
    SMARTiSM00353. HLH. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    SSF55785. SSF55785. 2 hits.
    SSF69125. SSF69125. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2A468-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGLGESSLD PLAAESRKRK LPCDAPGQGL VYSGEKWRRE QESKYIEELA     50
    ELISANLSDI DNFNVKPDKC AILKETVRQI RQIKEQGKTI SSDDDVQKAD 100
    VSSTGQGVID KDSLGPLLLQ ALDGFLFVVN RDGNIVFVSE NVTQYLQYKQ 150
    EDLVNTSVYS ILHEQDRKDF LKHLPKSTVN GVSWTNENQR QKSHTFNCRM 200
    LMKTHDILED VNASPETRQR YETMQCFALS QPRAMLEEGE DLQCCMICVA 250
    RRVTAPFPSS PESFITRHDL SGKVVNIDTN SLRSSMRPGF EDIIRRCIQR 300
    FFSLNDGQSW SQKRHYQEAY VHGHAETPVY RFSLADGTIV SAQTKSKLFR 350
    NPVTNDRHGF ISTHFLQREQ NGYRPNPNPA GQGIRPPAAG CGVSMSPNQN 400
    VQMMGSRTYG VPDPSNTGQM GGARYGASSS VASLTPGQSL QSPSSYQNSS 450
    YGLSMSSPPH GSPGLGPNQQ NIMISPRNRG SPKMASHQFS PAAGAHSPMG 500
    PSGNTGSHSF SSSSLSALQA ISEGVGTSLL STLSSPGPKL DNSPNMNISQ 550
    PSKVSGQDSK SPLGLYCEQN PVESSVCQSN SRDHPSEKES KESSGEVSET 600
    PRGPLESKGH KKLLQLLTCS SDDRGHSSLT NSPLDPNCKD SSVSVTSPSG 650
    VSSSTSGTVS STSNVHGSLL QEKHRILHKL LQNGNSPAEV AKITAEATGK 700
    DTSSTASCGE GTTRQEQLSP KKKENNALLR YLLDRDDPSD VLAKELQPQA 750
    DSGDSKLSQC SCSTNPSSGQ EKDPKIKTET NEEVSGDLDN LDAILGDLTS 800
    SDFYNNPTNG GHPGAKQQMF AGPSSLGLRS PQPVQSVRPP YNRAVSLDSP 850
    VSVGSGPPVK NVSAFPGLPK QPILAGNPRM MDSQENYGAN MGPNRNVPVN 900
    PTSSPGDWGL ANSRASRMEP LASSPLGRTG ADYSATLPRP AMGGSVPTLP 950
    LRSNRLPGAR PSLQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QMLQMRTGEI 1000
    PMGMGVNPYS PAVPSNQPGS WPEGMLSMEQ GPHGSQNRPL LRNSLDDLLG 1050
    PPSNAEGQSD ERALLDQLHT LLSNTDATGL EEIDRALGIP ELVNQGQALE 1100
    SKQDVFQGQE AAVMMDQKAA LYGQTYPAQG PPLQGGFNLQ GQSPSFNSMM 1150
    GQISQQGSFP LQGMHPRAGL VRPRTNTPKQ LRMQLQQRLQ GQQFLNQSRQ 1200
    ALEMKMENPA GTAVMRPMMP QAFFNAQMAA QQKRELMSHH LQQQRMAMMM 1250
    SQPQPQAFSP PPNVTASPSM DGVLAGSAMP QAPPQQFPYP ANYGMGQPPE 1300
    PAFGRGSSPP SAMMSSRMGP SQNAMVQHPQ PTPMYQPSDM KGWPSGNLAR 1350
    NGSFPQQQFA PQGNPAAYNM VHMNSSGGHL GQMAMTPMPM SGMPMGPDQK 1400
    YC 1402
    Length:1,402
    Mass (Da):151,824
    Last modified:February 20, 2007 - v1
    Checksum:i1018880641B43381
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL589873 Genomic DNA. No translation available.
    AL589902 Genomic DNA. No translation available.
    CH466551 Genomic DNA. Translation: EDL06475.1.
    RefSeqiXP_006498951.1. XM_006498888.1.
    UniGeneiMm.469663.

    Genome annotation databases

    EnsembliENSMUST00000109252; ENSMUSP00000104875; ENSMUSG00000027678.
    GeneIDi17979.
    KEGGimmu:17979.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL589873 Genomic DNA. No translation available.
    AL589902 Genomic DNA. No translation available.
    CH466551 Genomic DNA. Translation: EDL06475.1 .
    RefSeqi XP_006498951.1. XM_006498888.1.
    UniGenei Mm.469663.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000109252 ; ENSMUSP00000104875 ; ENSMUSG00000027678 .
    GeneIDi 17979.
    KEGGi mmu:17979.

    Organism-specific databases

    CTDi 8202.
    MGIi MGI:1276535. Ncoa3.

    Phylogenomic databases

    GeneTreei ENSGT00530000063109.
    HOGENOMi HOG000230947.
    HOVERGENi HBG052583.
    KOi K11256.
    OrthoDBi EOG72JWFB.

    Enzyme and pathway databases

    Reactomei REACT_198602. PPARA activates gene expression.

    Miscellaneous databases

    ChiTaRSi NCOA3. mouse.
    NextBioi 35542501.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    4.10.630.10. 2 hits.
    InterProi IPR011598. bHLH_dom.
    IPR010011. DUF1518.
    IPR028818. NCOA3.
    IPR009110. Nuc_rcpt_coact.
    IPR014920. Nuc_rcpt_coact_Ncoa-typ.
    IPR017426. Nuclear_rcpt_coactivator.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    IPR014710. RmlC-like_jellyroll.
    IPR014935. SRC-1.
    IPR008955. Src1_rcpt_coact.
    [Graphical view ]
    PANTHERi PTHR10684. PTHR10684. 1 hit.
    PTHR10684:SF3. PTHR10684:SF3. 1 hit.
    Pfami PF07469. DUF1518. 1 hit.
    PF08815. Nuc_rec_co-act. 1 hit.
    PF00989. PAS. 1 hit.
    PF08832. SRC-1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038181. Nuclear_receptor_coactivator. 1 hit.
    SMARTi SM00353. HLH. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    SSF55785. SSF55785. 2 hits.
    SSF69125. SSF69125. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    3. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    5. Ensembl
      Submitted (JUN-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiA2A468_MOUSE
    AccessioniPrimary (citable) accession number: A2A468
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3