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Protein

Putative PIP5K1A and PSMD4-like protein

Gene

PIPSL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Has negligeable PIP5 kinase activity. Binds to ubiquitinated proteins.

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative PIP5K1A and PSMD4-like protein
Short name:
PIP5K1A-PSMD4
Gene namesi
Name:PIPSL
Synonyms:PSMD4P2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:23733. PIPSL.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003470571 – 862Putative PIP5K1A and PSMD4-like proteinAdd BLAST862

Proteomic databases

EPDiA2A3N6.
MaxQBiA2A3N6.
PRIDEiA2A3N6.

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Organism-specific databases

HPAiHPA029366.
HPA038807.
HPA039252.

Interactioni

Protein-protein interaction databases

IntActiA2A3N6. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliA2A3N6.
SMRiA2A3N6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 396PIPKPROSITE-ProRule annotationAdd BLAST369
Domaini490 – 673VWFAPROSITE-ProRule annotationAdd BLAST184
Domaini696 – 715UIM 1CuratedAdd BLAST20
Domaini766 – 783UIM 2CuratedAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi723 – 731Poly-Ala9

Sequence similaritiesi

Contains 1 PIPK domain.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiA2A3N6.
PhylomeDBiA2A3N6.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF01504. PIP5K. 1 hit.
PF13519. VWA_2. 1 hit.
[Graphical view]
SMARTiSM00330. PIPKc. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51455. PIPK. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A3N6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEVPYASG MPIKKIGHRS VDSSGGTTSS ALKGAIQLGI THTVGSLSTK
60 70 80 90 100
PESDVLMQDF HMVESIFFPS EGSNLTPAHH YNAFRFKTYA PVAFRYFWEL
110 120 130 140 150
FGIRPDDYLY SLCSEPLIEL CSSGASGSLF YVSSDDEFIV KTVRHKEAEF
160 170 180 190 200
LQKLLPGYYI NLNQNPRTLL PKFYGLYCVQ TGGKNIRIVV MNNLLPRSVK
210 220 230 240 250
MHIKYDLKGS TYRRRASQKE REKPLPTFKD LDFLQDIPDG LFLDADVHNA
260 270 280 290 300
LCKTLQRDCL VLQSFKIMDY SLLMSIHNID HAQREPLSSE TQYSVDTRRP
310 320 330 340 350
APQKALYSTA MESIQGEARR GGTMETDDHM GGIPARNSKG ERLLLYIGII
360 370 380 390 400
DILQSYRFVK KLEHSWKALI HDGDTVSVHR PGFYAEWFQR FMCNTVFKKI
410 420 430 440 450
PLKPSPSKKL RSGSSFSQRA GSSGNSCITY QPLVSGEHKA QVTTKAEVEP
460 470 480 490 500
GVHLGCPDVL PQTPPLEEIS EGSPTPDPSF SPLVEETLQM LTTSVDNSEY
510 520 530 540 550
MGNGDFLPTR LQAQQDAVNT VCHSKTRSNP ENNVGLITLD NDCEVLTTLT
560 570 580 590 600
PDTGRILSKL HTVQPKGKIT FCMGIHVAHL ALKHRQGNNH KIRIIAFVGN
610 620 630 640 650
PVEDNEKNLV KLAKCLKKEK VNVDIINFGE EEVNTEKLTA FVNTLNGKDG
660 670 680 690 700
TGSHLVTVPP GPSLADALIS FPILAGEGGA MMGLGASDFE FGVDPSADPE
710 720 730 740 750
LALVLRVFME EQRQRQEEEA RQAAAASAAE AGIATTGTED SDDALLKMTI
760 770 780 790 800
SQQEFGHTGL PDLSSMTEEE KIVCAMQMSL QGAEFGLAES ADIDASSAMD
810 820 830 840 850
TSEPAKEEDD YDVMQDPEFL QSVLENLPGV DPNNEAIRNA VGSLASQATK
860
DSKKDKKEED KK
Length:862
Mass (Da):95,048
Last modified:February 20, 2007 - v1
Checksum:i3F1F11EC0AB0D704
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365510 Genomic DNA. Translation: CAM19360.1.
UniGeneiHs.149255.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365510 Genomic DNA. Translation: CAM19360.1.
UniGeneiHs.149255.

3D structure databases

ProteinModelPortaliA2A3N6.
SMRiA2A3N6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2A3N6. 2 interactors.

Proteomic databases

EPDiA2A3N6.
MaxQBiA2A3N6.
PRIDEiA2A3N6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiPIPSL.
HGNCiHGNC:23733. PIPSL.
HPAiHPA029366.
HPA038807.
HPA039252.
neXtProtiNX_A2A3N6.
GenAtlasiSearch...

Phylogenomic databases

InParanoidiA2A3N6.
PhylomeDBiA2A3N6.

Miscellaneous databases

PROiA2A3N6.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF01504. PIP5K. 1 hit.
PF13519. VWA_2. 1 hit.
[Graphical view]
SMARTiSM00330. PIPKc. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51455. PIPK. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIPSL_HUMAN
AccessioniPrimary (citable) accession number: A2A3N6
Secondary accession number(s): Q6NUK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

PIPSL gene appeared in hominoids by L1-mediated retrotransposition in a hominoid ancestor of a readthrough, intergenically spliced transcript between the PIP5K1A and PSMD4 genes.

Caution

Could be the product of a pseudogene. Although transcribed, the gene is poorly translated probably due to a deletion in the regulatory region. PubMed:17623810 could not detect the protein by Western blot.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.