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Protein

Tetratricopeptide repeat protein 24

Gene

TTC24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-33828-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 24
Short name:
TPR repeat protein 24
Gene namesi
Name:TTC24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:32348. TTC24.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187862.
PharmGKBiPA142670676.

Polymorphism and mutation databases

BioMutaiTTC24.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003077711 – 582Tetratricopeptide repeat protein 24Add BLAST582

Proteomic databases

PaxDbiA2A3L6.
PRIDEiA2A3L6.

PTM databases

iPTMnetiA2A3L6.
PhosphoSitePlusiA2A3L6.

Expressioni

Gene expression databases

BgeeiENSG00000187862.
CleanExiHS_TTC24.

Organism-specific databases

HPAiHPA029797.
HPA029798.
HPA029799.

Interactioni

Protein-protein interaction databases

IntActiA2A3L6. 1 interactor.
STRINGi9606.ENSP00000357219.

Structurei

3D structure databases

ProteinModelPortaliA2A3L6.
SMRiA2A3L6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 69TPR 1Add BLAST34
Repeati79 – 112TPR 2Add BLAST34
Repeati117 – 150TPR 3Add BLAST34
Repeati154 – 187TPR 4Add BLAST34
Repeati236 – 271TPR 5Add BLAST36
Repeati273 – 306TPR 6Add BLAST34
Repeati313 – 346TPR 7Add BLAST34
Repeati353 – 386TPR 8Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 28Poly-Lys7

Sequence similaritiesi

Contains 8 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00730000111346.
HOGENOMiHOG000090249.
HOVERGENiHBG094909.
InParanoidiA2A3L6.
OMAiAHCLQEA.
OrthoDBiEOG091G0J79.
PhylomeDBiA2A3L6.
TreeFamiTF328344.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR024812. TPR_24.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10098:SF112. PTHR10098:SF112. 1 hit.
PfamiPF13176. TPR_7. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 7 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A3L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPNPEDVP RRPEPEPSSS NKKKKKRKWL RQEASIQALT RAGHGALQAG
60 70 80 90 100
QNHEALNNFQ RAFLLASKAP QTRDTPVLQA CAFNLGAAYV ETGDPARGLE
110 120 130 140 150
LLLRAHPEEK AQGRRHGDQC FNVALAYHAL GELPQALAWY HRALGHYQPQ
160 170 180 190 200
GDQGEAWAKM GACYQALGQP ELAAHCLQEA SQAYAQERQL RAAALALGAA
210 220 230 240 250
AGCMLKSGRH RVGEVVQVLE KSRRLAERST ERRLLGHLYN DLGLGYSQLQ
260 270 280 290 300
LFPLAVEAFL QALPLCWVPG EQATVLRNLG MAHNALGNYQ EAREFHQKAA
310 320 330 340 350
DLHGSVGQRW EQGRSFGSLA FALSQLGDHK AARDNYLHAL QAARDSGDMK
360 370 380 390 400
GQWQACEGLG AAAARLGQYD QALKYYKEAL AQCQKEPDSV RERLVAKLAD
410 420 430 440 450
TVRTRLAQVG LVQTHTLTSA PGRLQAPGGA SQAEGTPAKA GSSTAGVQHR
460 470 480 490 500
SSSGWEDEEF EEGHQKKKEE RSANVPVRAG PGRPELCFLP GTVNHSHHLA
510 520 530 540 550
SSCPTFTKHT PCRGTVLGKA SIYSPGPRAH LPFVGPGPPR AEYPSILVPN
560 570 580
GPQANRSSRW PRESLSRSRQ RRPMESGICT IV
Length:582
Mass (Da):63,396
Last modified:February 20, 2007 - v1
Checksum:i8614C5FC0D1BB185
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036643231E → G.Corresponds to variant rs6682716dbSNPEnsembl.1
Natural variantiVAR_036644532P → A.Corresponds to variant rs17392348dbSNPEnsembl.1
Natural variantiVAR_036645550N → S.Corresponds to variant rs12090808dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365181 Genomic DNA. Translation: CAI13047.1.
AL365181 Genomic DNA. Translation: CAM15718.1.
CCDSiCCDS53379.1.
RefSeqiNP_001099139.2. NM_001105669.2.
UniGeneiHs.447851.

Genome annotation databases

EnsembliENST00000368236; ENSP00000357219; ENSG00000187862.
ENST00000368237; ENSP00000357220; ENSG00000187862.
GeneIDi164118.
KEGGihsa:164118.
UCSCiuc021pbf.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365181 Genomic DNA. Translation: CAI13047.1.
AL365181 Genomic DNA. Translation: CAM15718.1.
CCDSiCCDS53379.1.
RefSeqiNP_001099139.2. NM_001105669.2.
UniGeneiHs.447851.

3D structure databases

ProteinModelPortaliA2A3L6.
SMRiA2A3L6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2A3L6. 1 interactor.
STRINGi9606.ENSP00000357219.

PTM databases

iPTMnetiA2A3L6.
PhosphoSitePlusiA2A3L6.

Polymorphism and mutation databases

BioMutaiTTC24.

Proteomic databases

PaxDbiA2A3L6.
PRIDEiA2A3L6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368236; ENSP00000357219; ENSG00000187862.
ENST00000368237; ENSP00000357220; ENSG00000187862.
GeneIDi164118.
KEGGihsa:164118.
UCSCiuc021pbf.1. human.

Organism-specific databases

CTDi164118.
GeneCardsiTTC24.
HGNCiHGNC:32348. TTC24.
HPAiHPA029797.
HPA029798.
HPA029799.
neXtProtiNX_A2A3L6.
OpenTargetsiENSG00000187862.
PharmGKBiPA142670676.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00730000111346.
HOGENOMiHOG000090249.
HOVERGENiHBG094909.
InParanoidiA2A3L6.
OMAiAHCLQEA.
OrthoDBiEOG091G0J79.
PhylomeDBiA2A3L6.
TreeFamiTF328344.

Enzyme and pathway databases

BioCyciZFISH:G66-33828-MONOMER.

Miscellaneous databases

GenomeRNAii164118.
PROiA2A3L6.

Gene expression databases

BgeeiENSG00000187862.
CleanExiHS_TTC24.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR024812. TPR_24.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10098:SF112. PTHR10098:SF112. 1 hit.
PfamiPF13176. TPR_7. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 7 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTC24_HUMAN
AccessioniPrimary (citable) accession number: A2A3L6
Secondary accession number(s): Q5T3H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.