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Protein

Protein tyrosine phosphatase domain-containing protein 1

Gene

PTPDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play roles in cilia formation and/or maintenance.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei190 – 1901Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tyrosine phosphatase domain-containing protein 1 (EC:3.1.3.-)
Gene namesi
Name:PTPDC1
Synonyms:PTP9Q22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:30184. PTPDC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134940207.

Polymorphism and mutation databases

BioMutaiPTPDC1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 754754Protein tyrosine phosphatase domain-containing protein 1PRO_0000312212Add
BLAST

Proteomic databases

EPDiA2A3K4.
MaxQBiA2A3K4.
PaxDbiA2A3K4.
PRIDEiA2A3K4.

PTM databases

DEPODiA2A3K4.
PhosphoSiteiA2A3K4.

Expressioni

Gene expression databases

BgeeiA2A3K4.
CleanExiHS_PTPDC1.
ExpressionAtlasiA2A3K4. baseline and differential.
GenevisibleiA2A3K4. HS.

Organism-specific databases

HPAiHPA016747.
HPA026832.

Interactioni

Protein-protein interaction databases

BioGridi126515. 7 interactions.
IntActiA2A3K4. 1 interaction.
STRINGi9606.ENSP00000288976.

Structurei

3D structure databases

ProteinModelPortaliA2A3K4.
SMRiA2A3K4. Positions 67-244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 23568Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1720. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00390000004113.
HOGENOMiHOG000115791.
HOVERGENiHBG058281.
InParanoidiA2A3K4.
KOiK18078.
OrthoDBiEOG73Z2TK.
PhylomeDBiA2A3K4.
TreeFamiTF313460.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2A3K4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGVLPQNE QPYSTLVNNS ECVANMKGNL ERPTPKYTKV GERLRHVIPG
60 70 80 90 100
HMACSMACGG RACKYENPAR WSEQEQAIKG VYSSWVTDNI LAMARPSSEL
110 120 130 140 150
LEKYHIIDQF LSHGIKTIIN LQRPGEHASC GNPLEQESGF TYLPEAFMEA
160 170 180 190 200
GIYFYNFGWK DYGVASLTTI LDMVKVMTFA LQEGKVAIHC HAGLGRTGVL
210 220 230 240 250
IACYLVFATR MTADQAIIFV RAKRPNSIQT RGQLLCVREF TQFLTPLRNI
260 270 280 290 300
FSCCDPKAHA VTLPQYLIRQ RHLLHGYEAR LLKHVPKIIH LVCKLLLDLA
310 320 330 340 350
ENRPVMMKDV SEGPGLSAEI EKTMSEMVTM QLDKELLRHD SDVSNPPNPT
360 370 380 390 400
AVAADFDNRG MIFSNEQQFD PLWKRRNVEC LQPLTHLKRR LSYSDSDLKR
410 420 430 440 450
AENLLEQGET PQTVPAQILV GHKPRQQKLI SHCYIPQSPE PDLHKEALVR
460 470 480 490 500
STLSFWSQSK FGGLEGLKDN GSPIFHGRII PKEAQQSGAF SADVSGSHSP
510 520 530 540 550
GEPVSPSFAN VHKDPNPAHQ QVSHCQCKTH GVGSPGSVRQ NSRTPRSPLD
560 570 580 590 600
CGSSPKAQFL VEHETQDSKD LSEAASHSAL QSELSAEARR ILAAKALANL
610 620 630 640 650
NESVEKEELK RKVEMWQKEL NSRDGAWERI CGERDPFILC SLMWSWVEQL
660 670 680 690 700
KEPVITKEDV DMLVDRRADA AEALFLLEKG QHQTILCVLH CIVNLQTIPV
710 720 730 740 750
DVEEAFLAHA IKAFTKVNFD SENGPTVYNT LKKIFKHTLE EKRKMTKDGP

KPGL
Length:754
Mass (Da):84,457
Last modified:February 20, 2007 - v1
Checksum:iE669F3AF34CF725F
GO
Isoform 2 (identifier: A2A3K4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MAAGVLPQNEQPYSTLVNNSECVANMKG → MQVQDATRRP...GNPTFPERKR

Show »
Length:806
Mass (Da):90,143
Checksum:iE5252ECA4645EC6D
GO

Sequence cautioni

The sequence BAC04391.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC04421.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271K → T in AAO13168 (Ref. 1) Curated
Sequence conflicti343 – 3431V → F in AAH67120 (PubMed:15489334).Curated
Sequence conflicti518 – 5181A → D in AAO13168 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti571 – 5711L → Q.
Corresponds to variant rs16909677 [ dbSNP | Ensembl ].
VAR_037455

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2828MAAGV…ANMKG → MQVQDATRRPSAVRFLSSFL QGRRHSTSDPVLRLQQARRG SGLGSGSATKLLSSSSLQVM VAVSSVSHAEGNPTFPERKR in isoform 2. CuratedVSP_029736Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY171233 mRNA. Translation: AAO13168.1.
AL360020 Genomic DNA. Translation: CAI14621.2.
AL360020 Genomic DNA. Translation: CAM20720.1.
CH471089 Genomic DNA. Translation: EAW62876.1.
BC067120 mRNA. Translation: AAH67120.1.
AK094631 mRNA. Translation: BAC04391.1. Different initiation.
AK094773 mRNA. Translation: BAC04421.1. Different initiation.
CCDSiCCDS6707.1. [A2A3K4-1]
CCDS6708.1. [A2A3K4-2]
RefSeqiNP_001240758.1. NM_001253829.1.
NP_001240759.1. NM_001253830.1.
NP_689635.3. NM_152422.4. [A2A3K4-2]
NP_818931.1. NM_177995.2. [A2A3K4-1]
XP_005251768.1. XM_005251711.3. [A2A3K4-1]
XP_006717020.1. XM_006716957.2. [A2A3K4-1]
XP_011516542.1. XM_011518240.1. [A2A3K4-1]
XP_011516543.1. XM_011518241.1. [A2A3K4-1]
UniGeneiHs.437943.

Genome annotation databases

EnsembliENST00000288976; ENSP00000288976; ENSG00000158079. [A2A3K4-2]
ENST00000375360; ENSP00000364509; ENSG00000158079. [A2A3K4-1]
GeneIDi138639.
KEGGihsa:138639.
UCSCiuc004auf.2. human. [A2A3K4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY171233 mRNA. Translation: AAO13168.1.
AL360020 Genomic DNA. Translation: CAI14621.2.
AL360020 Genomic DNA. Translation: CAM20720.1.
CH471089 Genomic DNA. Translation: EAW62876.1.
BC067120 mRNA. Translation: AAH67120.1.
AK094631 mRNA. Translation: BAC04391.1. Different initiation.
AK094773 mRNA. Translation: BAC04421.1. Different initiation.
CCDSiCCDS6707.1. [A2A3K4-1]
CCDS6708.1. [A2A3K4-2]
RefSeqiNP_001240758.1. NM_001253829.1.
NP_001240759.1. NM_001253830.1.
NP_689635.3. NM_152422.4. [A2A3K4-2]
NP_818931.1. NM_177995.2. [A2A3K4-1]
XP_005251768.1. XM_005251711.3. [A2A3K4-1]
XP_006717020.1. XM_006716957.2. [A2A3K4-1]
XP_011516542.1. XM_011518240.1. [A2A3K4-1]
XP_011516543.1. XM_011518241.1. [A2A3K4-1]
UniGeneiHs.437943.

3D structure databases

ProteinModelPortaliA2A3K4.
SMRiA2A3K4. Positions 67-244.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126515. 7 interactions.
IntActiA2A3K4. 1 interaction.
STRINGi9606.ENSP00000288976.

PTM databases

DEPODiA2A3K4.
PhosphoSiteiA2A3K4.

Polymorphism and mutation databases

BioMutaiPTPDC1.

Proteomic databases

EPDiA2A3K4.
MaxQBiA2A3K4.
PaxDbiA2A3K4.
PRIDEiA2A3K4.

Protocols and materials databases

DNASUi138639.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288976; ENSP00000288976; ENSG00000158079. [A2A3K4-2]
ENST00000375360; ENSP00000364509; ENSG00000158079. [A2A3K4-1]
GeneIDi138639.
KEGGihsa:138639.
UCSCiuc004auf.2. human. [A2A3K4-1]

Organism-specific databases

CTDi138639.
GeneCardsiPTPDC1.
HGNCiHGNC:30184. PTPDC1.
HPAiHPA016747.
HPA026832.
neXtProtiNX_A2A3K4.
PharmGKBiPA134940207.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1720. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00390000004113.
HOGENOMiHOG000115791.
HOVERGENiHBG058281.
InParanoidiA2A3K4.
KOiK18078.
OrthoDBiEOG73Z2TK.
PhylomeDBiA2A3K4.
TreeFamiTF313460.

Miscellaneous databases

ChiTaRSiPTPDC1. human.
GenomeRNAii138639.
NextBioi83800.
PROiA2A3K4.

Gene expression databases

BgeeiA2A3K4.
CleanExiHS_PTPDC1.
ExpressionAtlasiA2A3K4. baseline and differential.
GenevisibleiA2A3K4. HS.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Guo J.H., Chen L., Yu L.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 331-754 (ISOFORM 1).
    Tissue: Amygdala and Brain.

Entry informationi

Entry nameiPTPC1_HUMAN
AccessioniPrimary (citable) accession number: A2A3K4
Secondary accession number(s): Q5T3M4
, Q6NXE8, Q8IWM1, Q8N1X4, Q8N9F5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 20, 2007
Last modified: May 11, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.