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Protein
Submitted name:

Protocadherin-15

Gene

PCDH15

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protocadherin-15Imported
Gene namesi
Name:PCDH15Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000150275.17.
HGNCiHGNC:14674. PCDH15.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000150275.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500264215327 – 719Sequence analysisAdd BLAST693

Proteomic databases

PaxDbiA2A3E5.
PeptideAtlasiA2A3E5.
PRIDEiA2A3E5.

Expressioni

Gene expression databases

BgeeiENSG00000150275.
ExpressionAtlasiA2A3E5. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA2A3E5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 145CAInterPro annotationAdd BLAST82
Domaini174 – 263CAInterPro annotationAdd BLAST90
Domaini304 – 393CAInterPro annotationAdd BLAST90

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00890000139339.
HOGENOMiHOG000230918.
HOVERGENiHBG053521.

Family and domain databases

InterProiView protein in InterPro
IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR030718. Protocadherin-15.
PANTHERiPTHR24028:SF11. PTHR24028:SF11. 4 hits.
PfamiView protein in Pfam
PF00028. Cadherin. 1 hit.
PRINTSiPR00205. CADHERIN.
SMARTiView protein in SMART
SM00112. CA. 3 hits.
SUPFAMiSSF49313. SSF49313. 2 hits.
PROSITEiView protein in PROSITE
PS00232. CADHERIN_1. 1 hit.

Sequencei

Sequence statusi: Complete.

A2A3E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRQFYLWTC LASGIILGSL FEICLGQYDD DCKLARGGPP ATIVAIDEES
60 70 80 90 100
RNGTILVDNM LIKGTAGGPD PTIELSLKDN VDYWVLMDPV KQMLFLNSTG
110 120 130 140 150
RVLDRDPPMN IHSIVVQVQC INKKVGTIIY HEVRIVVRDR NDNSPTFKHE
160 170 180 190 200
SYYATVNELT PVGTTIFTGF SGDNGATDID DGPNGQIEYV IQYNPDDPTS
210 220 230 240 250
NDTFEIPLML TGNIVLRKRL NYEDKTRYFV IIQANDRAQN LNERRTTTTT
260 270 280 290 300
LTVDVLDGDD LGPMFLPCVL VPNTRDCRPL TYQAAIPELR TPEELNPIIV
310 320 330 340 350
TPPIQAIDQD RNIQPPSDRP GILYSILVGT PEDYPRFFHM HPRTAELSLL
360 370 380 390 400
EPVNRDFHQK FDLVIKAEQD NGHPLPAFAG LHIEILDENN QSPYFTMPSY
410 420 430 440 450
QGYILESAPV GATISDSLNL TSPLRIVALD KDIEDEEPKK IKKPKVEIRE
460 470 480 490 500
PSEEEEVVVT IEKPPAAEPT YTTWKRARIF PMIFKKVRGL ADKRGIVDLE
510 520 530 540 550
GEEWQRRLEE EDKDYLKLTL DQEEATESTV ESEEESSSDY TEYSEEESEF
560 570 580 590 600
SESETTEEES ESETPSEEEE SSTPESEESE STESEGEKAR KNIVLARRRP
610 620 630 640 650
MVEEVKEVKG RKEEPQEEQK EPKMEEEEHS EEEESGPAPV EESTDPEAQD
660 670 680 690 700
IPEEGSAESA SVEGGVESEE ESESGSSSSS SESQSGGPWG YQVPAYDRSK
710
NANQKKSPGA NSEGYNTAL
Length:719
Mass (Da):80,741
Last modified:February 5, 2008 - v1
Checksum:i64801E4DC8E9C15E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013737 Genomic DNA. No translation available.
AC016817 Genomic DNA. No translation available.
AC024073 Genomic DNA. No translation available.
AC027671 Genomic DNA. No translation available.
AL353784 Genomic DNA. No translation available.
AL360214 Genomic DNA. No translation available.
AL365496 Genomic DNA. No translation available.
AL391356 Genomic DNA. No translation available.
KF455239 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000395440; ENSP00000378827; ENSG00000150275.
UCSCiuc057tib.1. human.

Similar proteinsi

Entry informationi

Entry nameiA2A3E5_HUMAN
AccessioniPrimary (citable) accession number: A2A3E5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 25, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported