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Protein
Submitted name:

Adhesion G protein-coupled receptor B2

Gene

ADGRB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Adhesion G protein-coupled receptor B2Imported
Gene namesi
Name:ADGRB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000121753.12
HGNCiHGNC:944 ADGRB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei884 – 905HelicalSequence analysisAdd BLAST22
Transmembranei917 – 938HelicalSequence analysisAdd BLAST22
Transmembranei950 – 974HelicalSequence analysisAdd BLAST25
Transmembranei986 – 1004HelicalSequence analysisAdd BLAST19
Transmembranei1024 – 1047HelicalSequence analysisAdd BLAST24
Transmembranei1068 – 1090HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121753

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_500264182136 – 1500Sequence analysisAdd BLAST1465

Proteomic databases

PeptideAtlasiA2A3C6
PRIDEiA2A3C6

Expressioni

Gene expression databases

BgeeiENSG00000121753
ExpressionAtlasiA2A3C6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA2A3C6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini469 – 539G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST71
Domaini819 – 871GPSInterPro annotationAdd BLAST53
Domaini880 – 1121G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST242

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00910000144013
HOGENOMiHOG000230916
HOVERGENiHBG004813

Family and domain databases

Gene3Di2.20.100.10, 3 hits
4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR008077 GPCR_2_brain_angio_inhib
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF02793 HRM, 1 hit
PF00090 TSP_1, 3 hits
PRINTSiPR01694 BAIPRECURSOR
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00209 TSP1, 3 hits
SUPFAMiSSF82895 SSF82895, 3 hits
PROSITEiView protein in PROSITE
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50092 TSP1, 3 hits

Sequencei

Sequence statusi: Complete.

A2A3C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLRGPDTH GKGHRMTPAC PLLLSVILSL RLATAFDPAP SACSALASGV
60 70 80 90 100
LYGAFSLQDL FPTIASGCSW TLENPDPTKY SLYLRFNRQE QVCAHFAPRL
110 120 130 140 150
LPLDHYLVNF TCLRPSPEEA VAQAESEVGR PEEEEAEAAA GLELCSGSGP
160 170 180 190 200
FTFLHFDKNF VQLCLSAEPS EAPRLLAPAA LAFRFVEVLL INNNNSSQFT
210 220 230 240 250
CGVLCRWSEE CGRAAGRACG FAQPGCSCPG EAGAGSTTTT SPGPPAAHTL
260 270 280 290 300
SNALVPGGPA PPAEADLHSG SSNDLFTTEM RYGEEPEEEP KVKTQWPRSA
310 320 330 340 350
DEPGLYMAQT VHGVWEEWGS WSLCSRSCGR GSRSRMRTCV PPQHGGKACE
360 370 380 390 400
GPELQTKLCS MAACPVEGQW LEWGPWGPCS TSCANGTQQR SRKCSVAGPA
410 420 430 440 450
WATCTGALTD TRECSNLECP ATDSKWGPWN AWSLCSKTCD TGWQRRFRMC
460 470 480 490 500
QATGTQGYPC EGTGEEVKPC SEKRCPAFHE MCRDEYVMLM TWKKAAAGEI
510 520 530 540 550
IYNKCPPNAS GSASRRCLLS AQGVAYWGLP SFARCISHEY RYLYLSLREH
560 570 580 590 600
LAKGQRMLAG EGMSQVVRSL QELLARRTYY SGDLLFSVDI LRNVTDTFKR
610 620 630 640 650
ATYVPSADDV QRFFQVVSFM VDAENKEKWD DAQQVSPGSV HLLRVVEDFI
660 670 680 690 700
HLVGDALKAF QSSLIVTDNL VISIQREPVS AVSSDITFPM RGRRGMKDWV
710 720 730 740 750
RHSEDRLFLP KEVLSLSSPG KPATSGAAGS PGRGRGPGTV PPGPGHSHQR
760 770 780 790 800
LLPADPDESS YFVIGAVLYR TLGLILPPPR PPLAVTSRVM TVTVRPPTQP
810 820 830 840 850
PAEPLITVEL SYIINGTTDP HCASWDYSRA DASSGDWDTE NCQTLETQAA
860 870 880 890 900
HTRCQCQHLS TFAVLAQPPK DLTLELAGSP SVPLVIGCAV SCMALLTLLA
910 920 930 940 950
IYAAFWRFIK SERSIILLNF CLSILASNIL ILVGQSRVLS KGVCTMTAAF
960 970 980 990 1000
LHFFFLSSFC WVLTEAWQSY LAVIGRMRTR LVRKRFLCLG WGLPALVVAV
1010 1020 1030 1040 1050
SVGFTRTKGY GTSSYCWLSL EGGLLYAFVG PAAVIVLVNM LIGIIVFNKL
1060 1070 1080 1090 1100
MARDGISDKS KKQRAGASLW SSCVVLPLLA LTWMSAVLAM TDRRSVLFQA
1110 1120 1130 1140 1150
LFAVFNSAQG FVITAVHCFL RREVQDVVKC QMGVCRADES EDSPDSCKNG
1160 1170 1180 1190 1200
QLQILSDFEK DVDLACQTVL FKEVNTCNPS TITGTLSRLS LDEDEEPKSC
1210 1220 1230 1240 1250
LVGPEGSLSF SPLPGNILVP MAASPGLGEP PPPQEANPVY MCGEGGLRQL
1260 1270 1280 1290 1300
DLTWLRPTEP GSEGDYMVLP RRTLSLQPGG GGGGGEDAPR ARPEGTPRRA
1310 1320 1330 1340 1350
AKTVAHTEGY PSFLSVDHSG LGLGPAYGSL QNPYGMTFQP PPPTPSARQV
1360 1370 1380 1390 1400
PEPGERSRTM PRTVPGSTMK MGSLERKKLR YSDLDFEKVM HTRKRHSELY
1410 1420 1430 1440 1450
HELNQKFHTF DRYRSQSTAK REKRWSVSSG GAAERSVCTD KPSPGERPSL
1460 1470 1480 1490 1500
SQHRRHQSWS TFKSMTLGSL PPKPRERLTL HRAAAWEPTE PPDGDFQTEV
Length:1,500
Mass (Da):163,786
Last modified:February 20, 2007 - v1
Checksum:i21AC1532E02883AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114488 Genomic DNA No translation available.
AL354919 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000398556; ENSP00000381564; ENSG00000121753
UCSCiuc010ogn.3 human

Similar proteinsi

Entry informationi

Entry nameiA2A3C6_HUMAN
AccessioniPrimary (citable) accession number: A2A3C6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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