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Protein
Submitted name:

Adhesion G protein-coupled receptor B2

Gene

ADGRB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Adhesion G protein-coupled receptor B2Imported
Gene namesi
Name:ADGRB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000121753.12
HGNCiHGNC:944 ADGRB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei924 – 945HelicalSequence analysisAdd BLAST22
Transmembranei957 – 978HelicalSequence analysisAdd BLAST22
Transmembranei990 – 1014HelicalSequence analysisAdd BLAST25
Transmembranei1026 – 1044HelicalSequence analysisAdd BLAST19
Transmembranei1064 – 1091HelicalSequence analysisAdd BLAST28
Transmembranei1112 – 1130HelicalSequence analysisAdd BLAST19
Transmembranei1142 – 1162HelicalSequence analysisAdd BLAST21
Transmembranei1169 – 1189HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121753

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500264261121 – 1554Sequence analysisAdd BLAST1534

Proteomic databases

PeptideAtlasiA2A3C2
PRIDEiA2A3C2

Expressioni

Gene expression databases

BgeeiENSG00000121753
ExpressionAtlasiA2A3C2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA2A3C2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini509 – 579G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST71
Domaini859 – 911GPSInterPro annotationAdd BLAST53
Domaini920 – 1194G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST275

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IEA0 Eukaryota
ENOG4111FBM LUCA
GeneTreeiENSGT00910000144013
HOGENOMiHOG000230916
HOVERGENiHBG004813

Family and domain databases

Gene3Di2.20.100.10, 4 hits
4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR008077 GPCR_2_brain_angio_inhib
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF00090 TSP_1, 4 hits
PRINTSiPR01694 BAIPRECURSOR
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00209 TSP1, 4 hits
SUPFAMiSSF82895 SSF82895, 4 hits
PROSITEiView protein in PROSITE
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50092 TSP1, 4 hits

Sequencei

Sequence statusi: Complete.

A2A3C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPACPLLLS VILSLRLATA FDPAPSACSA LASGVLYGAF SLQDLFPTIA
60 70 80 90 100
SGCSWTLENP DPTKYSLYLR FNRQEQVCAH FAPRLLPLDH YLVNFTCLRP
110 120 130 140 150
SPEEAVAQAE SEVGRPEEEE AEAAAGLELC SGSGPFTFLH FDKNFVQLCL
160 170 180 190 200
SAEPSEAPRL LAPAALAFRF VEVLLINNNN SSQFTCGVLC RWSEECGRAA
210 220 230 240 250
GRACGFAQPG CSCPGEAGAG STTTTSPGPP AAHTLSNALV PGGPAPPAEA
260 270 280 290 300
DLHSGSSNDL FTTEMRYGEE PEEEPKVKTQ WPRSADEPGL YMAQTGDPAA
310 320 330 340 350
EEWSPWSVCS LTCGQGLQVR TRSCVSSPYG TLCSGPLRET RPCNNSATCP
360 370 380 390 400
VHGVWEEWGS WSLCSRSCGR GSRSRMRTCV PPQHGGKACE GPELQTKLCS
410 420 430 440 450
MAACPVEGQW LEWGPWGPCS TSCANGTQQR SRKCSVAGPA WATCTGALTD
460 470 480 490 500
TRECSNLECP ATDSKWGPWN AWSLCSKTCD TGWQRRFRMC QATGTQGYPC
510 520 530 540 550
EGTGEEVKPC SEKRCPAFHE MCRDEYVMLM TWKKAAAGEI IYNKCPPNAS
560 570 580 590 600
GSASRRCLLS AQGVAYWGLP SFARCISHEY RYLYLSLREH LAKGQRMLAG
610 620 630 640 650
EGMSQVVRSL QELLARRTYY SGDLLFSVDI LRNVTDTFKR ATYVPSADDV
660 670 680 690 700
QRFFQVVSFM VDAENKEKWD DAQQVSPGSV HLLRVVEDFI HLVGDALKAF
710 720 730 740 750
QSSLIVTDNL VISIQREPVS AVSSDITFPM RGRRGMKDWV RHSEDRLFLP
760 770 780 790 800
KEVLSLSSPG KPATSGAAGS PGRGRGPGTV PPGPGHSHQR LLPADPDESS
810 820 830 840 850
YFVIGAVLYR TLGLILPPPR PPLAVTSRVM TVTVRPPTQP PAEPLITVEL
860 870 880 890 900
SYIINGTTDP HCASWDYSRA DASSGDWDTE NCQTLETQAA HTRCQCQHLS
910 920 930 940 950
TFAVLAQPPK DLTLELAGSP SVPLVIGCAV SCMALLTLLA IYAAFWRFIK
960 970 980 990 1000
SERSIILLNF CLSILASNIL ILVGQSRVLS KGVCTMTAAF LHFFFLSSFC
1010 1020 1030 1040 1050
WVLTEAWQSY LAVIGRMRTR LVRKRFLCLG WGLPALVVAV SVGFTRTKGY
1060 1070 1080 1090 1100
GTSSYCWLSL EGGLLYAFVG PAAVIVLVNM LIGIIVFNKL MARDGISDKS
1110 1120 1130 1140 1150
KKQRAGSERC PWASLLLPCS ACGAVPSPLL SSASARNAMA SLWSSCVVLP
1160 1170 1180 1190 1200
LLALTWMSAV LAMTDRRSVL FQALFAVFNS AQGFVITAVH CFLRREVQDV
1210 1220 1230 1240 1250
VKCQMGVCRA DESEDSPDSC KNGQLQILSD FEKDVDLACQ TVLFKEVNTC
1260 1270 1280 1290 1300
NPSTITGTLS RLSLDEDEEP KSCLVGPEGS LSFSPLPGNI LVPMAASPGL
1310 1320 1330 1340 1350
GEPPPPQEAN PVYMCGEGGL RQLDLTWLRP TEPGSEGDYM VLPRRTLSLQ
1360 1370 1380 1390 1400
PGGGGGGGED APRARPEGTP RRAAKTVAHT EGYPSFLSVD HSGLGLGPAY
1410 1420 1430 1440 1450
GSLQNPYGMT FQPPPPTPSA RQVPEPGERS RTMPRTVPGS TMKMGSLERK
1460 1470 1480 1490 1500
KLRYSDLDFE KVMHTRKRHS ELYHELNQKF HTFDRYRSQS TAKDKPSPGE
1510 1520 1530 1540 1550
RPSLSQHRRH QSWSTFKSMT LGSLPPKPRE RLTLHRAAAW EPTEPPDGDF

QTEV
Length:1,554
Mass (Da):169,222
Last modified:February 20, 2007 - v1
Checksum:i61C391B8D722EF95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114488 Genomic DNA No translation available.
AL354919 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000398538; ENSP00000381548; ENSG00000121753
UCSCiuc057ego.1 human

Similar proteinsi

Entry informationi

Entry nameiA2A3C2_HUMAN
AccessioniPrimary (citable) accession number: A2A3C2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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