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Protein
Submitted name:

Probable ATP-dependent RNA helicase DDX58

Gene

DDX58

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Probable ATP-dependent RNA helicase DDX58Imported
Gene namesi
Name:DDX58Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:19102. DDX58.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiA2A376.
PeptideAtlasiA2A376.

Expressioni

Gene expression databases

BgeeiENSG00000107201.
ExpressionAtlasiA2A376. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369213.

Structurei

3D structure databases

ProteinModelPortaliA2A376.
SMRiA2A376. Positions 37-722.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 227180Helicase ATP-bindingInterPro annotationAdd
BLAST
Domaini407 – 573167Helicase C-terminalInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0354. Eukaryota.
COG1111. LUCA.
GeneTreeiENSGT00510000046789.
HOGENOMiHOG000230911.
HOVERGENiHBG052325.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR021673. RIG-I_C-RD.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF11648. RIG-I_C-RD. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSDIQIFY QEDPECQNLS ENSCPPSEVS DTNLYSPFKP RNYQLELALP
60 70 80 90 100
AMKGKNTIIC APTGCGKTFV SLLICEHHLK KFPQGQKGKV VFFANQIPVY
110 120 130 140 150
EQQKSVFSKY FERHGYRVTG ISGATAENVP VEQIVENNDI IILTPQILVN
160 170 180 190 200
NLKKGTIPSL SIFTLMIFDE CHNTSKQHPY NMIMFNYLDQ KLGGSSGPLP
210 220 230 240 250
QVIGLTASVG VGDAKNTDEA LDYICKLCAS LDASVIATVK HNLEELEQVV
260 270 280 290 300
YKPQKFFRKV ESRISDKFKY IIAQLMRDTE SLAKRICKDL ENLSQIQNRE
310 320 330 340 350
FGTQKYEQWI VTVQKACMVF QMPDKDEESR ICKALFLYTS HLRKYNDALI
360 370 380 390 400
ISEHARMKDA LDYLKDFFSN VRAAGFDEIE QDLTQRFEEK LQELESVSRD
410 420 430 440 450
PSNENPKLED LCFILQEEYH LNPETITILF VKTRALVDAL KNWIEGNPKL
460 470 480 490 500
SFLKPGILTG RGKTNQNTGM TLPAQKCILD AFKASGDHNI LIATSVADEG
510 520 530 540 550
IDIAQCNLVI LYEYVGNVIK MIQTRGRGRA RGSKCFLLTS NAGVIEKEQI
560 570 580 590 600
NMYKEKMMND SILRLQTWDE AVFREKILHI QTHEKFIRDS QEKPKPVPDK
610 620 630 640 650
ENKKLLCRKC KALACYTADV RVIEECHYTV LGDAFKECFV SRPHPKPKQF
660 670 680 690 700
SSFEKRAKIF CARQNCSHDW GIHVKYKTFE IPVIKIESFV VEDIATGVQT
710 720
LYSKWKDFHF EKIPFDPAEM SK
Length:722
Mass (Da):82,613
Last modified:February 20, 2007 - v1
Checksum:iEE1F232A3B7B7165
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161783 Genomic DNA. No translation available.
AL353671 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000379868; ENSP00000369197; ENSG00000107201.
UCSCiuc064smz.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161783 Genomic DNA. No translation available.
AL353671 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliA2A376.
SMRiA2A376. Positions 37-722.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369213.

Proteomic databases

PaxDbiA2A376.
PeptideAtlasiA2A376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379868; ENSP00000369197; ENSG00000107201.
UCSCiuc064smz.1. human.

Organism-specific databases

HGNCiHGNC:19102. DDX58.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0354. Eukaryota.
COG1111. LUCA.
GeneTreeiENSGT00510000046789.
HOGENOMiHOG000230911.
HOVERGENiHBG052325.

Miscellaneous databases

ChiTaRSiDDX58. human.

Gene expression databases

BgeeiENSG00000107201.
ExpressionAtlasiA2A376. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR021673. RIG-I_C-RD.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF11648. RIG-I_C-RD. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA2A376_HUMAN
AccessioniPrimary (citable) accession number: A2A376
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.