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Protein
Submitted name:

Probable ATP-dependent RNA helicase DDX58

Gene

DDX58

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi607ZincPROSITE-ProRule annotation1
Metal bindingi610ZincPROSITE-ProRule annotation1
Metal bindingi661ZincPROSITE-ProRule annotation1
Metal bindingi666ZincPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

LigandMetal-bindingPROSITE-ProRule annotation, ZincPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Probable ATP-dependent RNA helicase DDX58Imported
Gene namesi
Name:DDX58Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000107201.9.
HGNCiHGNC:19102. DDX58.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000107201.

PTM / Processingi

Proteomic databases

MaxQBiA2A376.
PaxDbiA2A376.
PeptideAtlasiA2A376.
PRIDEiA2A376.

Expressioni

Gene expression databases

BgeeiENSG00000107201.
ExpressionAtlasiA2A376. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA2A376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 227Helicase ATP-bindingInterPro annotationAdd BLAST180
Domaini407 – 573Helicase C-terminalInterPro annotationAdd BLAST167
Domaini591 – 722RLR CTRInterPro annotationAdd BLAST132

Phylogenomic databases

eggNOGiKOG0354. Eukaryota.
COG1111. LUCA.
GeneTreeiENSGT00510000046789.
HOGENOMiHOG000230911.
HOVERGENiHBG052325.

Family and domain databases

CDDicd00079. HELICc. 1 hit.
InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR021673. RLR_CTR.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF11648. RIG-I_C-RD. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51789. RLR_CTR. 1 hit.

Sequencei

Sequence statusi: Complete.

A2A376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSDIQIFY QEDPECQNLS ENSCPPSEVS DTNLYSPFKP RNYQLELALP
60 70 80 90 100
AMKGKNTIIC APTGCGKTFV SLLICEHHLK KFPQGQKGKV VFFANQIPVY
110 120 130 140 150
EQQKSVFSKY FERHGYRVTG ISGATAENVP VEQIVENNDI IILTPQILVN
160 170 180 190 200
NLKKGTIPSL SIFTLMIFDE CHNTSKQHPY NMIMFNYLDQ KLGGSSGPLP
210 220 230 240 250
QVIGLTASVG VGDAKNTDEA LDYICKLCAS LDASVIATVK HNLEELEQVV
260 270 280 290 300
YKPQKFFRKV ESRISDKFKY IIAQLMRDTE SLAKRICKDL ENLSQIQNRE
310 320 330 340 350
FGTQKYEQWI VTVQKACMVF QMPDKDEESR ICKALFLYTS HLRKYNDALI
360 370 380 390 400
ISEHARMKDA LDYLKDFFSN VRAAGFDEIE QDLTQRFEEK LQELESVSRD
410 420 430 440 450
PSNENPKLED LCFILQEEYH LNPETITILF VKTRALVDAL KNWIEGNPKL
460 470 480 490 500
SFLKPGILTG RGKTNQNTGM TLPAQKCILD AFKASGDHNI LIATSVADEG
510 520 530 540 550
IDIAQCNLVI LYEYVGNVIK MIQTRGRGRA RGSKCFLLTS NAGVIEKEQI
560 570 580 590 600
NMYKEKMMND SILRLQTWDE AVFREKILHI QTHEKFIRDS QEKPKPVPDK
610 620 630 640 650
ENKKLLCRKC KALACYTADV RVIEECHYTV LGDAFKECFV SRPHPKPKQF
660 670 680 690 700
SSFEKRAKIF CARQNCSHDW GIHVKYKTFE IPVIKIESFV VEDIATGVQT
710 720
LYSKWKDFHF EKIPFDPAEM SK
Length:722
Mass (Da):82,613
Last modified:February 20, 2007 - v1
Checksum:iEE1F232A3B7B7165
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161783 Genomic DNA. No translation available.
AL353671 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000379868; ENSP00000369197; ENSG00000107201.
UCSCiuc064smz.1. human.

Similar proteinsi

Entry informationi

Entry nameiA2A376_HUMAN
AccessioniPrimary (citable) accession number: A2A376
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 25, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported