ID   MAGBG_HUMAN             Reviewed;         324 AA.
AC   A2A368; A8MU30;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   24-JAN-2024, entry version 100.
DE   RecName: Full=Melanoma-associated antigen B16;
DE   AltName: Full=MAGE-B16 antigen;
GN   Name=MAGEB16;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
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DR   EMBL; AL161722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS43927.1; -.
DR   RefSeq; NP_001093391.1; NM_001099921.1.
DR   RefSeq; XP_011543755.1; XM_011545453.2.
DR   RefSeq; XP_011543756.1; XM_011545454.2.
DR   AlphaFoldDB; A2A368; -.
DR   SMR; A2A368; -.
DR   BioGRID; 126578; 1.
DR   IntAct; A2A368; 1.
DR   STRING; 9606.ENSP00000382871; -.
DR   iPTMnet; A2A368; -.
DR   PhosphoSitePlus; A2A368; -.
DR   BioMuta; MAGEB16; -.
DR   jPOST; A2A368; -.
DR   MassIVE; A2A368; -.
DR   MaxQB; A2A368; -.
DR   PaxDb; 9606-ENSP00000382871; -.
DR   PeptideAtlas; A2A368; -.
DR   ProteomicsDB; 253; -.
DR   Antibodypedia; 64810; 74 antibodies from 12 providers.
DR   DNASU; 139604; -.
DR   Ensembl; ENST00000399985.1; ENSP00000382867.1; ENSG00000189023.11.
DR   Ensembl; ENST00000399987.5; ENSP00000382869.1; ENSG00000189023.11.
DR   Ensembl; ENST00000399988.6; ENSP00000382870.1; ENSG00000189023.11.
DR   Ensembl; ENST00000399989.5; ENSP00000382871.1; ENSG00000189023.11.
DR   GeneID; 139604; -.
DR   KEGG; hsa:139604; -.
DR   MANE-Select; ENST00000399988.6; ENSP00000382870.1; NM_001370158.1; NP_001357087.1.
DR   UCSC; uc010ngt.1; human.
DR   AGR; HGNC:21188; -.
DR   CTD; 139604; -.
DR   DisGeNET; 139604; -.
DR   GeneCards; MAGEB16; -.
DR   HGNC; HGNC:21188; MAGEB16.
DR   HPA; ENSG00000189023; Tissue enriched (testis).
DR   MIM; 300762; gene.
DR   neXtProt; NX_A2A368; -.
DR   OpenTargets; ENSG00000189023; -.
DR   PharmGKB; PA134922508; -.
DR   VEuPathDB; HostDB:ENSG00000189023; -.
DR   eggNOG; KOG4562; Eukaryota.
DR   GeneTree; ENSGT00940000162825; -.
DR   HOGENOM; CLU_039582_1_0_1; -.
DR   InParanoid; A2A368; -.
DR   OMA; IVINECE; -.
DR   OrthoDB; 3128316at2759; -.
DR   PhylomeDB; A2A368; -.
DR   TreeFam; TF328505; -.
DR   PathwayCommons; A2A368; -.
DR   SignaLink; A2A368; -.
DR   BioGRID-ORCS; 139604; 13 hits in 770 CRISPR screens.
DR   GenomeRNAi; 139604; -.
DR   Pharos; A2A368; Tdark.
DR   PRO; PR:A2A368; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; A2A368; Protein.
DR   Bgee; ENSG00000189023; Expressed in primordial germ cell in gonad and 4 other cell types or tissues.
DR   ExpressionAtlas; A2A368; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.1200; MAGE homology domain, winged helix WH1 motif; 1.
DR   Gene3D; 1.10.10.1210; MAGE homology domain, winged helix WH2 motif; 1.
DR   InterPro; IPR037445; MAGE.
DR   InterPro; IPR021072; MAGE_N.
DR   InterPro; IPR041898; MAGE_WH1.
DR   InterPro; IPR041899; MAGE_WH2.
DR   InterPro; IPR002190; MHD_dom.
DR   PANTHER; PTHR11736:SF145; MELANOMA-ASSOCIATED ANTIGEN B16; 1.
DR   PANTHER; PTHR11736; MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN; 1.
DR   Pfam; PF01454; MAGE; 1.
DR   Pfam; PF12440; MAGE_N; 1.
DR   SMART; SM01373; MAGE; 1.
DR   SMART; SM01392; MAGE_N; 1.
DR   PROSITE; PS50838; MAGE; 1.
PE   4: Predicted;
KW   Reference proteome; Tumor antigen.
FT   CHAIN           1..324
FT                   /note="Melanoma-associated antigen B16"
FT                   /id="PRO_0000311928"
FT   DOMAIN          113..312
FT                   /note="MAGE"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          39..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..85
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         38
FT                   /note="L -> F (in dbSNP:rs1410961)"
FT                   /id="VAR_037350"
FT   VARIANT         128
FT                   /note="C -> Y (in dbSNP:rs1410962)"
FT                   /id="VAR_037351"
FT   VARIANT         161
FT                   /note="H -> R (in dbSNP:rs5973488)"
FT                   /id="VAR_037352"
FT   VARIANT         248
FT                   /note="M -> K (in dbSNP:rs4829391)"
FT                   /id="VAR_037354"
FT   VARIANT         248
FT                   /note="M -> V (in dbSNP:rs4829390)"
FT                   /id="VAR_037353"
SQ   SEQUENCE   324 AA;  36178 MW;  86F05F0E6FFD22BD CRC64;
     MSQDQESPRC THDQHLQTFS ETQSLEVAQV SKALEKTLLS SSHPLVPGKL KEAPAAKAES
     PLEVPQSFCS SSIAVTTTSS SESDEASSNQ EEEDSPSSSE DTSDPRNVPA DALDQKVAFL
     VNFMLHKCQM KKPITKADML KIIIKDDESH FSEILLRASE HLEMIFGLDV VEVDPTTHCY
     GLFIKLGLTY DGMLSGEKGV PKTGLLIIVL GVIFMKGNRA TEEEVWEVLN LTGVYSGKKH
     FIFGEPRMLI TKDFVKEKYL EYQQVANSDP ARYEFLWGPR AKAETSKMKV LEFVAKVHGS
     YPHSFPSQYA EALKEEEERA RARI
//