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A2A368

- MAGBG_HUMAN

UniProt

A2A368 - MAGBG_HUMAN

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Protein
Melanoma-associated antigen B16
Gene
MAGEB16
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen B16
Alternative name(s):
MAGE-B16 antigen
Gene namesi
Name:MAGEB16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:21188. MAGEB16.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134922508.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Melanoma-associated antigen B16
PRO_0000311928Add
BLAST

Proteomic databases

PaxDbiA2A368.
PRIDEiA2A368.

PTM databases

PhosphoSiteiA2A368.

Expressioni

Gene expression databases

BgeeiA2A368.
GenevestigatoriA2A368.

Organism-specific databases

HPAiHPA055743.

Structurei

3D structure databases

ProteinModelPortaliA2A368.
SMRiA2A368. Positions 104-315.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 312200MAGE
Add
BLAST

Sequence similaritiesi

Contains 1 MAGE domain.

Phylogenomic databases

eggNOGiNOG253567.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiA2A368.
OrthoDBiEOG75F4GM.
PhylomeDBiA2A368.
TreeFamiTF328505.

Family and domain databases

InterProiIPR002190. MAGE.
IPR021072. Melanoma_ass_antigen_N.
[Graphical view]
PANTHERiPTHR11736. PTHR11736. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A368-1 [UniParc]FASTAAdd to Basket

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MSQDQESPRC THDQHLQTFS ETQSLEVAQV SKALEKTLLS SSHPLVPGKL    50
KEAPAAKAES PLEVPQSFCS SSIAVTTTSS SESDEASSNQ EEEDSPSSSE 100
DTSDPRNVPA DALDQKVAFL VNFMLHKCQM KKPITKADML KIIIKDDESH 150
FSEILLRASE HLEMIFGLDV VEVDPTTHCY GLFIKLGLTY DGMLSGEKGV 200
PKTGLLIIVL GVIFMKGNRA TEEEVWEVLN LTGVYSGKKH FIFGEPRMLI 250
TKDFVKEKYL EYQQVANSDP ARYEFLWGPR AKAETSKMKV LEFVAKVHGS 300
YPHSFPSQYA EALKEEEERA RARI 324
Length:324
Mass (Da):36,178
Last modified:March 24, 2009 - v2
Checksum:i86F05F0E6FFD22BD
GO

Sequence cautioni

The sequence CAM20853.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti38 – 381L → F.
Corresponds to variant rs1410961 [ dbSNP | Ensembl ].
VAR_037350
Natural varianti128 – 1281C → Y.
Corresponds to variant rs1410962 [ dbSNP | Ensembl ].
VAR_037351
Natural varianti161 – 1611H → R.
Corresponds to variant rs5973488 [ dbSNP | Ensembl ].
VAR_037352
Natural varianti248 – 2481M → K.
Corresponds to variant rs4829391 [ dbSNP | Ensembl ].
VAR_037354
Natural varianti248 – 2481M → V.
Corresponds to variant rs4829390 [ dbSNP | Ensembl ].
VAR_037353

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL161722 Genomic DNA. Translation: CAM20853.1. Sequence problems.
CCDSiCCDS43927.1.
RefSeqiNP_001093391.1. NM_001099921.1.
UniGeneiHs.700562.

Genome annotation databases

EnsembliENST00000399985; ENSP00000382867; ENSG00000189023.
ENST00000399987; ENSP00000382869; ENSG00000189023.
ENST00000399988; ENSP00000382870; ENSG00000189023.
ENST00000399989; ENSP00000382871; ENSG00000189023.
GeneIDi139604.
KEGGihsa:139604.
UCSCiuc010ngt.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL161722 Genomic DNA. Translation: CAM20853.1 . Sequence problems.
CCDSi CCDS43927.1.
RefSeqi NP_001093391.1. NM_001099921.1.
UniGenei Hs.700562.

3D structure databases

ProteinModelPortali A2A368.
SMRi A2A368. Positions 104-315.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A2A368.

Proteomic databases

PaxDbi A2A368.
PRIDEi A2A368.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000399985 ; ENSP00000382867 ; ENSG00000189023 .
ENST00000399987 ; ENSP00000382869 ; ENSG00000189023 .
ENST00000399988 ; ENSP00000382870 ; ENSG00000189023 .
ENST00000399989 ; ENSP00000382871 ; ENSG00000189023 .
GeneIDi 139604.
KEGGi hsa:139604.
UCSCi uc010ngt.1. human.

Organism-specific databases

CTDi 139604.
GeneCardsi GC0XP035816.
HGNCi HGNC:21188. MAGEB16.
HPAi HPA055743.
MIMi 300762. gene.
neXtProti NX_A2A368.
PharmGKBi PA134922508.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG253567.
HOGENOMi HOG000231161.
HOVERGENi HBG006315.
InParanoidi A2A368.
OrthoDBi EOG75F4GM.
PhylomeDBi A2A368.
TreeFami TF328505.

Miscellaneous databases

GenomeRNAii 139604.
NextBioi 84002.
SOURCEi Search...

Gene expression databases

Bgeei A2A368.
Genevestigatori A2A368.

Family and domain databases

InterProi IPR002190. MAGE.
IPR021072. Melanoma_ass_antigen_N.
[Graphical view ]
PANTHERi PTHR11736. PTHR11736. 1 hit.
Pfami PF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view ]
PROSITEi PS50838. MAGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMAGBG_HUMAN
AccessioniPrimary (citable) accession number: A2A368
Secondary accession number(s): A8MU30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 24, 2009
Last modified: July 9, 2014
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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