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Protein

Melanoma-associated antigen B16

Gene

MAGEB16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Keywordsi

Molecular functionTumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen B16
Alternative name(s):
MAGE-B16 antigen
Gene namesi
Name:MAGEB16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000189023.10
HGNCiHGNC:21188 MAGEB16
MIMi300762 gene
neXtProtiNX_A2A368

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189023
PharmGKBiPA134922508

Polymorphism and mutation databases

BioMutaiMAGEB16

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119281 – 324Melanoma-associated antigen B16Add BLAST324

Proteomic databases

MaxQBiA2A368
PaxDbiA2A368
PRIDEiA2A368

PTM databases

iPTMnetiA2A368
PhosphoSitePlusiA2A368

Expressioni

Gene expression databases

BgeeiENSG00000189023
ExpressionAtlasiA2A368 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi126578, 1 interactor
STRINGi9606.ENSP00000382867

Structurei

3D structure databases

ProteinModelPortaliA2A368
SMRiA2A368
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 312MAGEPROSITE-ProRule annotationAdd BLAST200

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00760000118824
HOGENOMiHOG000231161
HOVERGENiHBG006315
InParanoidiA2A368
PhylomeDBiA2A368
TreeFamiTF328505

Family and domain databases

InterProiView protein in InterPro
IPR037445 MAGE
IPR021072 MAGE_N
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
PF12440 MAGE_N, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
SM01392 MAGE_N, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit

Sequencei

Sequence statusi: Complete.

A2A368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQDQESPRC THDQHLQTFS ETQSLEVAQV SKALEKTLLS SSHPLVPGKL
60 70 80 90 100
KEAPAAKAES PLEVPQSFCS SSIAVTTTSS SESDEASSNQ EEEDSPSSSE
110 120 130 140 150
DTSDPRNVPA DALDQKVAFL VNFMLHKCQM KKPITKADML KIIIKDDESH
160 170 180 190 200
FSEILLRASE HLEMIFGLDV VEVDPTTHCY GLFIKLGLTY DGMLSGEKGV
210 220 230 240 250
PKTGLLIIVL GVIFMKGNRA TEEEVWEVLN LTGVYSGKKH FIFGEPRMLI
260 270 280 290 300
TKDFVKEKYL EYQQVANSDP ARYEFLWGPR AKAETSKMKV LEFVAKVHGS
310 320
YPHSFPSQYA EALKEEEERA RARI
Length:324
Mass (Da):36,178
Last modified:March 24, 2009 - v2
Checksum:i86F05F0E6FFD22BD
GO

Sequence cautioni

The sequence CAM20853 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03735038L → F. Corresponds to variant dbSNP:rs1410961Ensembl.1
Natural variantiVAR_037351128C → Y. Corresponds to variant dbSNP:rs1410962Ensembl.1
Natural variantiVAR_037352161H → R. Corresponds to variant dbSNP:rs5973488Ensembl.1
Natural variantiVAR_037354248M → K. Corresponds to variant dbSNP:rs4829391Ensembl.1
Natural variantiVAR_037353248M → V. Corresponds to variant dbSNP:rs4829390Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161722 Genomic DNA Translation: CAM20853.1 Sequence problems.
CCDSiCCDS43927.1
RefSeqiNP_001093391.1, NM_001099921.1
XP_011543755.1, XM_011545453.2
XP_011543756.1, XM_011545454.2
UniGeneiHs.700562

Genome annotation databases

EnsembliENST00000399985; ENSP00000382867; ENSG00000189023
ENST00000399987; ENSP00000382869; ENSG00000189023
ENST00000399988; ENSP00000382870; ENSG00000189023
ENST00000399989; ENSP00000382871; ENSG00000189023
GeneIDi139604
KEGGihsa:139604
UCSCiuc010ngt.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMAGBG_HUMAN
AccessioniPrimary (citable) accession number: A2A368
Secondary accession number(s): A8MU30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 24, 2009
Last modified: December 20, 2017
This is version 73 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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Main funding by: National Institutes of Health