Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Melanoma-associated antigen B16

Gene

MAGEB16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Keywords - Molecular functioni

Tumor antigen

Enzyme and pathway databases

BioCyciZFISH:G66-32555-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen B16
Alternative name(s):
MAGE-B16 antigen
Gene namesi
Name:MAGEB16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:21188. MAGEB16.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189023.
PharmGKBiPA134922508.

Polymorphism and mutation databases

BioMutaiMAGEB16.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119281 – 324Melanoma-associated antigen B16Add BLAST324

Proteomic databases

MaxQBiA2A368.
PaxDbiA2A368.
PRIDEiA2A368.

PTM databases

iPTMnetiA2A368.
PhosphoSitePlusiA2A368.

Expressioni

Gene expression databases

BgeeiENSG00000189023.
ExpressionAtlasiA2A368. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi126578. 1 interactor.
STRINGi9606.ENSP00000382867.

Structurei

3D structure databases

ProteinModelPortaliA2A368.
SMRiA2A368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 312MAGEPROSITE-ProRule annotationAdd BLAST200

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiA2A368.
PhylomeDBiA2A368.
TreeFamiTF328505.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQDQESPRC THDQHLQTFS ETQSLEVAQV SKALEKTLLS SSHPLVPGKL
60 70 80 90 100
KEAPAAKAES PLEVPQSFCS SSIAVTTTSS SESDEASSNQ EEEDSPSSSE
110 120 130 140 150
DTSDPRNVPA DALDQKVAFL VNFMLHKCQM KKPITKADML KIIIKDDESH
160 170 180 190 200
FSEILLRASE HLEMIFGLDV VEVDPTTHCY GLFIKLGLTY DGMLSGEKGV
210 220 230 240 250
PKTGLLIIVL GVIFMKGNRA TEEEVWEVLN LTGVYSGKKH FIFGEPRMLI
260 270 280 290 300
TKDFVKEKYL EYQQVANSDP ARYEFLWGPR AKAETSKMKV LEFVAKVHGS
310 320
YPHSFPSQYA EALKEEEERA RARI
Length:324
Mass (Da):36,178
Last modified:March 24, 2009 - v2
Checksum:i86F05F0E6FFD22BD
GO

Sequence cautioni

The sequence CAM20853 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03735038L → F.Corresponds to variant rs1410961dbSNPEnsembl.1
Natural variantiVAR_037351128C → Y.Corresponds to variant rs1410962dbSNPEnsembl.1
Natural variantiVAR_037352161H → R.Corresponds to variant rs5973488dbSNPEnsembl.1
Natural variantiVAR_037354248M → K.Corresponds to variant rs4829391dbSNPEnsembl.1
Natural variantiVAR_037353248M → V.Corresponds to variant rs4829390dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161722 Genomic DNA. Translation: CAM20853.1. Sequence problems.
CCDSiCCDS43927.1.
RefSeqiNP_001093391.1. NM_001099921.1.
XP_011543755.1. XM_011545453.2.
XP_011543756.1. XM_011545454.2.
UniGeneiHs.700562.

Genome annotation databases

EnsembliENST00000399985; ENSP00000382867; ENSG00000189023.
ENST00000399987; ENSP00000382869; ENSG00000189023.
ENST00000399988; ENSP00000382870; ENSG00000189023.
ENST00000399989; ENSP00000382871; ENSG00000189023.
GeneIDi139604.
KEGGihsa:139604.
UCSCiuc010ngt.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161722 Genomic DNA. Translation: CAM20853.1. Sequence problems.
CCDSiCCDS43927.1.
RefSeqiNP_001093391.1. NM_001099921.1.
XP_011543755.1. XM_011545453.2.
XP_011543756.1. XM_011545454.2.
UniGeneiHs.700562.

3D structure databases

ProteinModelPortaliA2A368.
SMRiA2A368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126578. 1 interactor.
STRINGi9606.ENSP00000382867.

PTM databases

iPTMnetiA2A368.
PhosphoSitePlusiA2A368.

Polymorphism and mutation databases

BioMutaiMAGEB16.

Proteomic databases

MaxQBiA2A368.
PaxDbiA2A368.
PRIDEiA2A368.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399985; ENSP00000382867; ENSG00000189023.
ENST00000399987; ENSP00000382869; ENSG00000189023.
ENST00000399988; ENSP00000382870; ENSG00000189023.
ENST00000399989; ENSP00000382871; ENSG00000189023.
GeneIDi139604.
KEGGihsa:139604.
UCSCiuc010ngt.1. human.

Organism-specific databases

CTDi139604.
GeneCardsiMAGEB16.
HGNCiHGNC:21188. MAGEB16.
MIMi300762. gene.
neXtProtiNX_A2A368.
OpenTargetsiENSG00000189023.
PharmGKBiPA134922508.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiA2A368.
PhylomeDBiA2A368.
TreeFamiTF328505.

Enzyme and pathway databases

BioCyciZFISH:G66-32555-MONOMER.

Miscellaneous databases

GenomeRNAii139604.
PROiA2A368.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000189023.
ExpressionAtlasiA2A368. baseline and differential.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAGBG_HUMAN
AccessioniPrimary (citable) accession number: A2A368
Secondary accession number(s): A8MU30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 24, 2009
Last modified: November 2, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.