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A2A368

- MAGBG_HUMAN

UniProt

A2A368 - MAGBG_HUMAN

Protein

Melanoma-associated antigen B16

Gene

MAGEB16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 2 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Keywords - Molecular functioni

    Tumor antigen

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melanoma-associated antigen B16
    Alternative name(s):
    MAGE-B16 antigen
    Gene namesi
    Name:MAGEB16
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:21188. MAGEB16.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134922508.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 324324Melanoma-associated antigen B16PRO_0000311928Add
    BLAST

    Proteomic databases

    PaxDbiA2A368.
    PRIDEiA2A368.

    PTM databases

    PhosphoSiteiA2A368.

    Expressioni

    Gene expression databases

    BgeeiA2A368.
    GenevestigatoriA2A368.

    Organism-specific databases

    HPAiHPA055743.

    Structurei

    3D structure databases

    ProteinModelPortaliA2A368.
    SMRiA2A368. Positions 104-315.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini113 – 312200MAGEPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MAGE domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG253567.
    HOGENOMiHOG000231161.
    HOVERGENiHBG006315.
    InParanoidiA2A368.
    OrthoDBiEOG75F4GM.
    PhylomeDBiA2A368.
    TreeFamiTF328505.

    Family and domain databases

    InterProiIPR002190. MAGE.
    IPR021072. Melanoma_ass_antigen_N.
    [Graphical view]
    PANTHERiPTHR11736. PTHR11736. 1 hit.
    PfamiPF01454. MAGE. 1 hit.
    PF12440. MAGE_N. 1 hit.
    [Graphical view]
    PROSITEiPS50838. MAGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2A368-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQDQESPRC THDQHLQTFS ETQSLEVAQV SKALEKTLLS SSHPLVPGKL    50
    KEAPAAKAES PLEVPQSFCS SSIAVTTTSS SESDEASSNQ EEEDSPSSSE 100
    DTSDPRNVPA DALDQKVAFL VNFMLHKCQM KKPITKADML KIIIKDDESH 150
    FSEILLRASE HLEMIFGLDV VEVDPTTHCY GLFIKLGLTY DGMLSGEKGV 200
    PKTGLLIIVL GVIFMKGNRA TEEEVWEVLN LTGVYSGKKH FIFGEPRMLI 250
    TKDFVKEKYL EYQQVANSDP ARYEFLWGPR AKAETSKMKV LEFVAKVHGS 300
    YPHSFPSQYA EALKEEEERA RARI 324
    Length:324
    Mass (Da):36,178
    Last modified:March 24, 2009 - v2
    Checksum:i86F05F0E6FFD22BD
    GO

    Sequence cautioni

    The sequence CAM20853.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti38 – 381L → F.
    Corresponds to variant rs1410961 [ dbSNP | Ensembl ].
    VAR_037350
    Natural varianti128 – 1281C → Y.
    Corresponds to variant rs1410962 [ dbSNP | Ensembl ].
    VAR_037351
    Natural varianti161 – 1611H → R.
    Corresponds to variant rs5973488 [ dbSNP | Ensembl ].
    VAR_037352
    Natural varianti248 – 2481M → K.
    Corresponds to variant rs4829391 [ dbSNP | Ensembl ].
    VAR_037354
    Natural varianti248 – 2481M → V.
    Corresponds to variant rs4829390 [ dbSNP | Ensembl ].
    VAR_037353

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL161722 Genomic DNA. Translation: CAM20853.1. Sequence problems.
    CCDSiCCDS43927.1.
    RefSeqiNP_001093391.1. NM_001099921.1.
    UniGeneiHs.700562.

    Genome annotation databases

    EnsembliENST00000399985; ENSP00000382867; ENSG00000189023.
    ENST00000399987; ENSP00000382869; ENSG00000189023.
    ENST00000399988; ENSP00000382870; ENSG00000189023.
    ENST00000399989; ENSP00000382871; ENSG00000189023.
    GeneIDi139604.
    KEGGihsa:139604.
    UCSCiuc010ngt.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL161722 Genomic DNA. Translation: CAM20853.1 . Sequence problems.
    CCDSi CCDS43927.1.
    RefSeqi NP_001093391.1. NM_001099921.1.
    UniGenei Hs.700562.

    3D structure databases

    ProteinModelPortali A2A368.
    SMRi A2A368. Positions 104-315.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A2A368.

    Proteomic databases

    PaxDbi A2A368.
    PRIDEi A2A368.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000399985 ; ENSP00000382867 ; ENSG00000189023 .
    ENST00000399987 ; ENSP00000382869 ; ENSG00000189023 .
    ENST00000399988 ; ENSP00000382870 ; ENSG00000189023 .
    ENST00000399989 ; ENSP00000382871 ; ENSG00000189023 .
    GeneIDi 139604.
    KEGGi hsa:139604.
    UCSCi uc010ngt.1. human.

    Organism-specific databases

    CTDi 139604.
    GeneCardsi GC0XP035816.
    HGNCi HGNC:21188. MAGEB16.
    HPAi HPA055743.
    MIMi 300762. gene.
    neXtProti NX_A2A368.
    PharmGKBi PA134922508.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253567.
    HOGENOMi HOG000231161.
    HOVERGENi HBG006315.
    InParanoidi A2A368.
    OrthoDBi EOG75F4GM.
    PhylomeDBi A2A368.
    TreeFami TF328505.

    Miscellaneous databases

    GenomeRNAii 139604.
    NextBioi 84002.
    SOURCEi Search...

    Gene expression databases

    Bgeei A2A368.
    Genevestigatori A2A368.

    Family and domain databases

    InterProi IPR002190. MAGE.
    IPR021072. Melanoma_ass_antigen_N.
    [Graphical view ]
    PANTHERi PTHR11736. PTHR11736. 1 hit.
    Pfami PF01454. MAGE. 1 hit.
    PF12440. MAGE_N. 1 hit.
    [Graphical view ]
    PROSITEi PS50838. MAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiMAGBG_HUMAN
    AccessioniPrimary (citable) accession number: A2A368
    Secondary accession number(s): A8MU30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 52 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3