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Protein

Ankyrin repeat domain-containing protein 18B

Gene

ANKRD18B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 18B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23644. ANKRD18B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10111011Ankyrin repeat domain-containing protein 18BPRO_0000317245Add
BLAST

Proteomic databases

EPDiA2A2Z9.
MaxQBiA2A2Z9.
PaxDbiA2A2Z9.
PRIDEiA2A2Z9.

PTM databases

iPTMnetiA2A2Z9.
PhosphoSiteiA2A2Z9.

Expressioni

Gene expression databases

BgeeiA2A2Z9.
CleanExiHS_ANKRD18B.
ExpressionAtlasiA2A2Z9. baseline and differential.
GenevisibleiA2A2Z9. HS.

Organism-specific databases

HPAiHPA046346.
HPA049923.
HPA051288.

Interactioni

Protein-protein interaction databases

IntActiA2A2Z9. 1 interaction.
STRINGi9606.ENSP00000290943.

Structurei

3D structure databases

ProteinModelPortaliA2A2Z9.
SMRiA2A2Z9. Positions 2-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati67 – 9630ANK 1Add
BLAST
Repeati100 – 12930ANK 2Add
BLAST
Repeati133 – 16230ANK 3Add
BLAST
Repeati166 – 19530ANK 4Add
BLAST
Repeati199 – 22830ANK 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili277 – 31943Sequence analysisAdd
BLAST
Coiled coili385 – 639255Sequence analysisAdd
BLAST
Coiled coili692 – 72231Sequence analysisAdd
BLAST
Coiled coili752 – 908157Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000033931.
HOVERGENiHBG095812.
InParanoidiA2A2Z9.
OMAiMLKQELY.
OrthoDBiEOG7N63KX.
PhylomeDBiA2A2Z9.
TreeFamiTF333496.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR021885. DUF3496.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF12001. DUF3496. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A2Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKLLSFGRR LGQALLSSMD QEYAGRGYHI RDWELRKIHR AAIKGDAAEV
60 70 80 90 100
EHCLTRRFRD LDVRDRKDRT VLHLACAHGR VQVVTLLLDR KCQINICDRL
110 120 130 140 150
NRTPLMKAVH CQEEACAIIL LKRGANPNIK DIYGNTALHY AVYNEGTSLA
160 170 180 190 200
ERLLSHHANI EALNKEGNTP LLFAINSRRQ HMVEFLLKNQ ANIHAVDNFK
210 220 230 240 250
RTALILAVQH NLSSIVTLLL QQNIHISSQD MFGQTAEDYA FCCDLRSIQQ
260 270 280 290 300
QILEHKNKML KNHLRNDNQE TAAMKPENLK KRKKRKKLKK RKEGAKAEHN
310 320 330 340 350
LKVASEEKQE RLERSENKQP QDSQSYGKKK DEMFGNFMLK RDIAMLKEEL
360 370 380 390 400
YAIKNDSLRK EKKYIQEIKS ITEINANFEK SVRLNEEMIT KKVAQYSQQL
410 420 430 440 450
NDLKAENARL NSKLEKEKHN KERLEAEVES LHSNLATAIN EYNEILERKD
460 470 480 490 500
LELVLWRADD VSRHETMGSN ISQLTDKNEL LTEQVHKARV KFNTLKGKLR
510 520 530 540 550
ETRDALREKT LALESVQLDL KQAQHRIKEM KQMHPNGEAK ESQSIGKQNS
560 570 580 590 600
SEERIRQREL ENLLLERQLE DARKEGDNKE IVINIHRDCL ENGKEDLLEE
610 620 630 640 650
RNKELMNEYN YLKEKLLQYE KEKAEREVIV REFQEELVDH LKKFSMSESP
660 670 680 690 700
LEGTSHCHIN LDETWTSKKK LFQVEIQPEE KHEEFRKVFE LISLLNYTAD
710 720 730 740 750
QIRKKNRELE EEATGYKKCL EMTINMLNAF ANEDFSCHGD LNTDQLKMDI
760 770 780 790 800
LFKKLKQKFD DLMAEKEAVS SKCVNLAKDN EVLHQELLSM GKVQEKCEKL
810 820 830 840 850
EKDKKMLEEK VLNLKTHMEK DMVELGKVQE YKSELDERAM QAIEKLEEIH
860 870 880 890 900
LQKQAEYEKQ LEQLNKDNTA SLKKKELTLK DVECKFSKMK TAYEDVTTEL
910 920 930 940 950
EEYKEAFAVA LKANSSMSEK ITKSDKKIAV ISTKLFMEKE RMEYFLSTLP
960 970 980 990 1000
MRPDPELPCV ENLNSIELNR KYIPKMAIRI PTSNPQTSNN CKNSLTELLL
1010
RWALAPIYFL L
Length:1,011
Mass (Da):118,231
Last modified:February 20, 2007 - v1
Checksum:i9DC98BDDD988B735
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139008 Genomic DNA. Translation: CAM15100.1.
UniGeneiHs.493710.

Genome annotation databases

EnsembliENST00000290943; ENSP00000290943; ENSG00000230453.
UCSCiuc064spz.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139008 Genomic DNA. Translation: CAM15100.1.
UniGeneiHs.493710.

3D structure databases

ProteinModelPortaliA2A2Z9.
SMRiA2A2Z9. Positions 2-255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2A2Z9. 1 interaction.
STRINGi9606.ENSP00000290943.

PTM databases

iPTMnetiA2A2Z9.
PhosphoSiteiA2A2Z9.

Proteomic databases

EPDiA2A2Z9.
MaxQBiA2A2Z9.
PaxDbiA2A2Z9.
PRIDEiA2A2Z9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290943; ENSP00000290943; ENSG00000230453.
UCSCiuc064spz.1. human.

Organism-specific databases

GeneCardsiANKRD18B.
HGNCiHGNC:23644. ANKRD18B.
HPAiHPA046346.
HPA049923.
HPA051288.
neXtProtiNX_A2A2Z9.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000033931.
HOVERGENiHBG095812.
InParanoidiA2A2Z9.
OMAiMLKQELY.
OrthoDBiEOG7N63KX.
PhylomeDBiA2A2Z9.
TreeFamiTF333496.

Miscellaneous databases

PROiA2A2Z9.

Gene expression databases

BgeeiA2A2Z9.
CleanExiHS_ANKRD18B.
ExpressionAtlasiA2A2Z9. baseline and differential.
GenevisibleiA2A2Z9. HS.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR021885. DUF3496.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF12001. DUF3496. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAN18B_HUMAN
AccessioniPrimary (citable) accession number: A2A2Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 20, 2007
Last modified: June 8, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.