Reviewed, UniProtKB/Swiss-Prot A2A2Z9 (AN18B_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat domain-containing protein 18B

Gene names

Name:

ANKRD18B

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1011 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 5 ANK repeats.

Ontologies

Keywords
Domain	ANK repeat Coiled coil Repeat
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1011	1011	Ankyrin repeat domain-containing protein 18B		PRO_0000317245
Regions
	Repeat	67 – 96	30	ANK 1
	Repeat	100 – 129	30	ANK 2
	Repeat	133 – 162	30	ANK 3
	Repeat	166 – 195	30	ANK 4
	Repeat	199 – 228	30	ANK 5
	Coiled coil	277 – 319	43	Potential
	Coiled coil	385 – 639	255	Potential
	Coiled coil	692 – 722	31	Potential
	Coiled coil	752 – 908	157	Potential

Sequences

	Sequence		Length	Mass (Da)
	A2A2Z9-1 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 9DC98BDDD988B735	FASTA	1,011	118,231
	10 20 30 40 50 60 MRKLLSFGRR LGQALLSSMD QEYAGRGYHI RDWELRKIHR AAIKGDAAEV EHCLTRRFRD 70 80 90 100 110 120 LDVRDRKDRT VLHLACAHGR VQVVTLLLDR KCQINICDRL NRTPLMKAVH CQEEACAIIL 130 140 150 160 170 180 LKRGANPNIK DIYGNTALHY AVYNEGTSLA ERLLSHHANI EALNKEGNTP LLFAINSRRQ 190 200 210 220 230 240 HMVEFLLKNQ ANIHAVDNFK RTALILAVQH NLSSIVTLLL QQNIHISSQD MFGQTAEDYA 250 260 270 280 290 300 FCCDLRSIQQ QILEHKNKML KNHLRNDNQE TAAMKPENLK KRKKRKKLKK RKEGAKAEHN 310 320 330 340 350 360 LKVASEEKQE RLERSENKQP QDSQSYGKKK DEMFGNFMLK RDIAMLKEEL YAIKNDSLRK 370 380 390 400 410 420 EKKYIQEIKS ITEINANFEK SVRLNEEMIT KKVAQYSQQL NDLKAENARL NSKLEKEKHN 430 440 450 460 470 480 KERLEAEVES LHSNLATAIN EYNEILERKD LELVLWRADD VSRHETMGSN ISQLTDKNEL 490 500 510 520 530 540 LTEQVHKARV KFNTLKGKLR ETRDALREKT LALESVQLDL KQAQHRIKEM KQMHPNGEAK 550 560 570 580 590 600 ESQSIGKQNS SEERIRQREL ENLLLERQLE DARKEGDNKE IVINIHRDCL ENGKEDLLEE 610 620 630 640 650 660 RNKELMNEYN YLKEKLLQYE KEKAEREVIV REFQEELVDH LKKFSMSESP LEGTSHCHIN 670 680 690 700 710 720 LDETWTSKKK LFQVEIQPEE KHEEFRKVFE LISLLNYTAD QIRKKNRELE EEATGYKKCL 730 740 750 760 770 780 EMTINMLNAF ANEDFSCHGD LNTDQLKMDI LFKKLKQKFD DLMAEKEAVS SKCVNLAKDN 790 800 810 820 830 840 EVLHQELLSM GKVQEKCEKL EKDKKMLEEK VLNLKTHMEK DMVELGKVQE YKSELDERAM 850 860 870 880 890 900 QAIEKLEEIH LQKQAEYEKQ LEQLNKDNTA SLKKKELTLK DVECKFSKMK TAYEDVTTEL 910 920 930 940 950 960 EEYKEAFAVA LKANSSMSEK ITKSDKKIAV ISTKLFMEKE RMEYFLSTLP MRPDPELPCV 970 980 990 1000 1010 ENLNSIELNR KYIPKMAIRI PTSNPQTSNN CKNSLTELLL RWALAPIYFL L

References

[1]

"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL139008 Genomic DNA. Translation: CAM15100.1.
IPI	IPI00852758.
UniGene	Hs.493710
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A2A2Z9.
Proteomic databases
PRIDE	A2A2Z9.
Genome annotation databases
Ensembl	ENST00000290943; ENSP00000290943; ENSG00000230453; Homo sapiens. [Genome view]
Organism-specific databases
GeneCards	GC09P033518.
HGNC	HGNC:23644. ANKRD18B.
PharmGKB	PA134961354.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG283703.
HOVERGEN	A2A2Z9.
OMA	FSMSESP.
OrthoDB	EOG9909ZH.
Gene expression databases
Bgee	A2A2Z9.
CleanEx	HS_ANKRD18B.
Genevestigator	A2A2Z9.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 5 hits. [Graphical view]
SMART	SM00248. ANK. 5 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 4 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AN18B_HUMAN

Accession

Primary (citable) accession number: A2A2Z9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 20, 2007
Last modified:	December 15, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.