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Protein

Ankyrin repeat domain-containing protein 18B

Gene

ANKRD18B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 18B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000230453.9.
HGNCiHGNC:23644. ANKRD18B.

Pathology & Biotechi

Organism-specific databases

DisGeNETi441459.
OpenTargetsiENSG00000230453.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172451 – 1011Ankyrin repeat domain-containing protein 18BAdd BLAST1011

Proteomic databases

EPDiA2A2Z9.
MaxQBiA2A2Z9.
PaxDbiA2A2Z9.
PRIDEiA2A2Z9.

PTM databases

iPTMnetiA2A2Z9.
PhosphoSitePlusiA2A2Z9.

Expressioni

Gene expression databases

BgeeiENSG00000230453.
CleanExiHS_ANKRD18B.
ExpressionAtlasiA2A2Z9. baseline and differential.
GenevisibleiA2A2Z9. HS.

Organism-specific databases

HPAiHPA046346.
HPA049923.
HPA051288.

Interactioni

Protein-protein interaction databases

IntActiA2A2Z9. 1 interactor.
STRINGi9606.ENSP00000290943.

Structurei

3D structure databases

ProteinModelPortaliA2A2Z9.
SMRiA2A2Z9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati67 – 96ANK 1Add BLAST30
Repeati100 – 129ANK 2Add BLAST30
Repeati133 – 162ANK 3Add BLAST30
Repeati166 – 195ANK 4Add BLAST30
Repeati199 – 228ANK 5Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili277 – 319Sequence analysisAdd BLAST43
Coiled coili385 – 639Sequence analysisAdd BLAST255
Coiled coili692 – 722Sequence analysisAdd BLAST31
Coiled coili752 – 908Sequence analysisAdd BLAST157

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000033931.
HOVERGENiHBG095812.
InParanoidiA2A2Z9.
OMAiMLKQELY.
OrthoDBiEOG091G077A.
PhylomeDBiA2A2Z9.
TreeFamiTF333496.

Family and domain databases

CDDicd00204. ANK. 2 hits.
Gene3Di1.25.40.20. 2 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR021885. DUF3496.
PfamiView protein in Pfam
PF12796. Ank_2. 2 hits.
PF12001. DUF3496. 1 hit.
SMARTiView protein in SMART
SM00248. ANK. 5 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.

Sequencei

Sequence statusi: Complete.

A2A2Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKLLSFGRR LGQALLSSMD QEYAGRGYHI RDWELRKIHR AAIKGDAAEV
60 70 80 90 100
EHCLTRRFRD LDVRDRKDRT VLHLACAHGR VQVVTLLLDR KCQINICDRL
110 120 130 140 150
NRTPLMKAVH CQEEACAIIL LKRGANPNIK DIYGNTALHY AVYNEGTSLA
160 170 180 190 200
ERLLSHHANI EALNKEGNTP LLFAINSRRQ HMVEFLLKNQ ANIHAVDNFK
210 220 230 240 250
RTALILAVQH NLSSIVTLLL QQNIHISSQD MFGQTAEDYA FCCDLRSIQQ
260 270 280 290 300
QILEHKNKML KNHLRNDNQE TAAMKPENLK KRKKRKKLKK RKEGAKAEHN
310 320 330 340 350
LKVASEEKQE RLERSENKQP QDSQSYGKKK DEMFGNFMLK RDIAMLKEEL
360 370 380 390 400
YAIKNDSLRK EKKYIQEIKS ITEINANFEK SVRLNEEMIT KKVAQYSQQL
410 420 430 440 450
NDLKAENARL NSKLEKEKHN KERLEAEVES LHSNLATAIN EYNEILERKD
460 470 480 490 500
LELVLWRADD VSRHETMGSN ISQLTDKNEL LTEQVHKARV KFNTLKGKLR
510 520 530 540 550
ETRDALREKT LALESVQLDL KQAQHRIKEM KQMHPNGEAK ESQSIGKQNS
560 570 580 590 600
SEERIRQREL ENLLLERQLE DARKEGDNKE IVINIHRDCL ENGKEDLLEE
610 620 630 640 650
RNKELMNEYN YLKEKLLQYE KEKAEREVIV REFQEELVDH LKKFSMSESP
660 670 680 690 700
LEGTSHCHIN LDETWTSKKK LFQVEIQPEE KHEEFRKVFE LISLLNYTAD
710 720 730 740 750
QIRKKNRELE EEATGYKKCL EMTINMLNAF ANEDFSCHGD LNTDQLKMDI
760 770 780 790 800
LFKKLKQKFD DLMAEKEAVS SKCVNLAKDN EVLHQELLSM GKVQEKCEKL
810 820 830 840 850
EKDKKMLEEK VLNLKTHMEK DMVELGKVQE YKSELDERAM QAIEKLEEIH
860 870 880 890 900
LQKQAEYEKQ LEQLNKDNTA SLKKKELTLK DVECKFSKMK TAYEDVTTEL
910 920 930 940 950
EEYKEAFAVA LKANSSMSEK ITKSDKKIAV ISTKLFMEKE RMEYFLSTLP
960 970 980 990 1000
MRPDPELPCV ENLNSIELNR KYIPKMAIRI PTSNPQTSNN CKNSLTELLL
1010
RWALAPIYFL L
Length:1,011
Mass (Da):118,231
Last modified:February 20, 2007 - v1
Checksum:i9DC98BDDD988B735
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139008 Genomic DNA. No translation available.
UniGeneiHs.493710.

Genome annotation databases

EnsembliENST00000290943; ENSP00000290943; ENSG00000230453.
UCSCiuc064spz.1. human.

Similar proteinsi

Entry informationi

Entry nameiAN18B_HUMAN
AccessioniPrimary (citable) accession number: A2A2Z9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 20, 2007
Last modified: September 27, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM