ID FRMD3_HUMAN Reviewed; 597 AA. AC A2A2Y4; A8MQB0; B4DN14; Q53EP2; Q5JV59; Q5VZA1; Q86WP8; Q8IZ44; Q8N3Y5; AC Q8N9L2; DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 20-FEB-2007, sequence version 1. DT 24-JAN-2024, entry version 132. DE RecName: Full=FERM domain-containing protein 3; DE AltName: Full=Band 4.1-like protein 4O; DE AltName: Full=Ovary type protein 4.1; DE Short=4.1O; GN Name=FRMD3; Synonyms=EPB41L4O; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), TISSUE SPECIFICITY, AND RP DEVELOPMENTAL STAGE. RC TISSUE=Fetal brain; RX PubMed=12601556; DOI=10.1007/s100380300015; RA Ni X., Ji C., Cao G., Cheng H., Guo L., Gu S., Ying K., Zhao R.C., Mao Y.; RT "Molecular cloning and characterization of the protein 4.1O gene, a novel RT member of the protein 4.1 family with focal expression in ovary."; RL J. Hum. Genet. 48:101-106(2003). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE RP [LARGE SCALE MRNA] OF 34-597 (ISOFORM 2). RC TISSUE=Cerebellum; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., RA Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4). RC TISSUE=Brain, and Placenta; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-597 (ISOFORM 1). RC TISSUE=Kidney; RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.; RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases. RN [8] RP FUNCTION. RX PubMed=17260017; DOI=10.1038/sj.onc.1210225; RA Haase D., Meister M., Muley T., Hess J., Teurich S., Schnabel P., RA Hartenstein B., Angel P.; RT "FRMD3, a novel putative tumour suppressor in NSCLC."; RL Oncogene 26:4464-4468(2007). CC -!- FUNCTION: Putative tumor suppressor gene that may be implicated in the CC origin and progression of lung cancer. {ECO:0000269|PubMed:17260017}. CC -!- INTERACTION: CC A2A2Y4; Q96FZ5: CMTM7; NbExp=3; IntAct=EBI-6911547, EBI-2807956; CC A2A2Y4; O43169: CYB5B; NbExp=3; IntAct=EBI-6911547, EBI-1058710; CC A2A2Y4; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-6911547, EBI-10266796; CC A2A2Y4; Q8IXM6: NRM; NbExp=3; IntAct=EBI-6911547, EBI-10262547; CC A2A2Y4; Q5VZY2: PLPP4; NbExp=3; IntAct=EBI-6911547, EBI-10485931; CC A2A2Y4; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-6911547, EBI-10329948; CC A2A2Y4; Q8N6R1: SERP2; NbExp=3; IntAct=EBI-6911547, EBI-749270; CC A2A2Y4; Q96G79: SLC35A4; NbExp=3; IntAct=EBI-6911547, EBI-12363689; CC A2A2Y4; Q5SNT2-2: TMEM201; NbExp=3; IntAct=EBI-6911547, EBI-11994282; CC A2A2Y4; A2RU14: TMEM218; NbExp=3; IntAct=EBI-6911547, EBI-10173151; CC A2A2Y4; Q5BJF2: TMEM97; NbExp=3; IntAct=EBI-6911547, EBI-12111910; CC A2A2Y4; O95159: ZFPL1; NbExp=3; IntAct=EBI-6911547, EBI-718439; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane CC protein {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Name=1; CC IsoId=A2A2Y4-1; Sequence=Displayed; CC Name=2; CC IsoId=A2A2Y4-2; Sequence=VSP_031167; CC Name=3; CC IsoId=A2A2Y4-3; Sequence=VSP_031163, VSP_031165, VSP_031167; CC Name=4; CC IsoId=A2A2Y4-4; Sequence=VSP_031162, VSP_031166, VSP_031167; CC Name=5; CC IsoId=A2A2Y4-5; Sequence=VSP_031164; CC -!- TISSUE SPECIFICITY: Ovary-specific. {ECO:0000269|PubMed:12601556}. CC -!- DEVELOPMENTAL STAGE: Expressed in skeletal muscle, lower levels in CC thymus and brain. {ECO:0000269|PubMed:12601556}. CC -!- SEQUENCE CAUTION: CC Sequence=BAC04321.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC Sequence=EAW62650.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY137774; AAN52119.1; -; mRNA. DR EMBL; AK094281; BAC04321.1; ALT_INIT; mRNA. DR EMBL; AK297722; BAG60076.1; -; mRNA. DR EMBL; EF560742; ABQ59052.1; -; mRNA. DR EMBL; AL161786; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL137847; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL450026; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471089; EAW62647.1; -; Genomic_DNA. DR EMBL; CH471089; EAW62649.1; -; Genomic_DNA. DR EMBL; CH471089; EAW62650.1; ALT_INIT; Genomic_DNA. DR EMBL; CH471089; EAW62651.1; -; Genomic_DNA. DR EMBL; BC023560; AAH23560.1; -; mRNA. DR EMBL; BC037253; AAH37253.1; -; mRNA. DR EMBL; AK223597; BAD97317.1; -; mRNA. DR CCDS; CCDS43840.1; -. [A2A2Y4-1] DR CCDS; CCDS59131.1; -. [A2A2Y4-4] DR CCDS; CCDS59132.1; -. [A2A2Y4-3] DR CCDS; CCDS59133.1; -. [A2A2Y4-2] DR CCDS; CCDS75852.1; -. [A2A2Y4-5] DR RefSeq; NP_001231888.1; NM_001244959.1. [A2A2Y4-2] DR RefSeq; NP_001231889.1; NM_001244960.1. [A2A2Y4-5] DR RefSeq; NP_001231890.1; NM_001244961.1. [A2A2Y4-3] DR RefSeq; NP_001231891.1; NM_001244962.1. [A2A2Y4-4] DR RefSeq; NP_777598.3; NM_174938.5. [A2A2Y4-1] DR AlphaFoldDB; A2A2Y4; -. DR SMR; A2A2Y4; -. DR BioGRID; 129190; 24. DR IntAct; A2A2Y4; 24. DR STRING; 9606.ENSP00000303508; -. DR iPTMnet; A2A2Y4; -. DR PhosphoSitePlus; A2A2Y4; -. DR BioMuta; FRMD3; -. DR jPOST; A2A2Y4; -. DR MassIVE; A2A2Y4; -. DR MaxQB; A2A2Y4; -. DR PaxDb; 9606-ENSP00000303508; -. DR PeptideAtlas; A2A2Y4; -. DR ProteomicsDB; 234; -. [A2A2Y4-1] DR ProteomicsDB; 235; -. [A2A2Y4-2] DR ProteomicsDB; 236; -. [A2A2Y4-3] DR ProteomicsDB; 237; -. [A2A2Y4-4] DR ProteomicsDB; 238; -. [A2A2Y4-5] DR Antibodypedia; 27519; 155 antibodies from 22 providers. DR DNASU; 257019; -. DR Ensembl; ENST00000304195.8; ENSP00000303508.3; ENSG00000172159.16. [A2A2Y4-1] DR Ensembl; ENST00000328788.5; ENSP00000328615.1; ENSG00000172159.16. [A2A2Y4-4] DR Ensembl; ENST00000376434.5; ENSP00000365617.1; ENSG00000172159.16. [A2A2Y4-3] DR Ensembl; ENST00000376438.5; ENSP00000365621.1; ENSG00000172159.16. [A2A2Y4-2] DR Ensembl; ENST00000621208.4; ENSP00000484839.1; ENSG00000172159.16. [A2A2Y4-5] DR GeneID; 257019; -. DR KEGG; hsa:257019; -. DR MANE-Select; ENST00000304195.8; ENSP00000303508.3; NM_174938.6; NP_777598.3. DR UCSC; uc004amq.1; human. [A2A2Y4-1] DR AGR; HGNC:24125; -. DR CTD; 257019; -. DR DisGeNET; 257019; -. DR GeneCards; FRMD3; -. DR HGNC; HGNC:24125; FRMD3. DR HPA; ENSG00000172159; Tissue enhanced (heart muscle, skeletal muscle, tongue). DR MIM; 607619; gene. DR neXtProt; NX_A2A2Y4; -. DR OpenTargets; ENSG00000172159; -. DR PharmGKB; PA134903920; -. DR VEuPathDB; HostDB:ENSG00000172159; -. DR eggNOG; KOG3530; Eukaryota. DR GeneTree; ENSGT00940000158577; -. DR HOGENOM; CLU_113149_0_0_1; -. DR InParanoid; A2A2Y4; -. DR OMA; CPLRQWM; -. DR OrthoDB; 2912597at2759; -. DR PhylomeDB; A2A2Y4; -. DR TreeFam; TF343477; -. DR PathwayCommons; A2A2Y4; -. DR SignaLink; A2A2Y4; -. DR BioGRID-ORCS; 257019; 16 hits in 1149 CRISPR screens. DR ChiTaRS; FRMD3; human. DR GenomeRNAi; 257019; -. DR Pharos; A2A2Y4; Tbio. DR PRO; PR:A2A2Y4; -. DR Proteomes; UP000005640; Chromosome 9. DR RNAct; A2A2Y4; Protein. DR Bgee; ENSG00000172159; Expressed in secondary oocyte and 194 other cell types or tissues. DR ExpressionAtlas; A2A2Y4; baseline and differential. DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro. DR GO; GO:0031032; P:actomyosin structure organization; IBA:GO_Central. DR CDD; cd14473; FERM_B-lobe; 1. DR CDD; cd17102; FERM_F1_FRMD3; 1. DR Gene3D; 1.20.80.10; -; 1. DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1. DR InterPro; IPR019749; Band_41_domain. DR InterPro; IPR000798; Ez/rad/moesin-like. DR InterPro; IPR014847; FA. DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf. DR InterPro; IPR035963; FERM_2. DR InterPro; IPR019748; FERM_central. DR InterPro; IPR019747; FERM_CS. DR InterPro; IPR000299; FERM_domain. DR InterPro; IPR018979; FERM_N. DR InterPro; IPR018980; FERM_PH-like_C. DR InterPro; IPR011993; PH-like_dom_sf. DR InterPro; IPR029071; Ubiquitin-like_domsf. DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1. DR PANTHER; PTHR23280:SF8; FERM DOMAIN-CONTAINING PROTEIN 3; 1. DR Pfam; PF08736; FA; 1. DR Pfam; PF09380; FERM_C; 1. DR Pfam; PF00373; FERM_M; 1. DR Pfam; PF09379; FERM_N; 1. DR PRINTS; PR00935; BAND41. DR PRINTS; PR00661; ERMFAMILY. DR SMART; SM00295; B41; 1. DR SMART; SM01195; FA; 1. DR SMART; SM01196; FERM_C; 1. DR SUPFAM; SSF50729; PH domain-like; 1. DR SUPFAM; SSF47031; Second domain of FERM; 1. DR SUPFAM; SSF54236; Ubiquitin-like; 1. DR PROSITE; PS00660; FERM_1; 1. DR PROSITE; PS50057; FERM_3; 1. DR Genevisible; A2A2Y4; HS. PE 1: Evidence at protein level; KW Alternative splicing; Membrane; Reference proteome; Transmembrane; KW Transmembrane helix. FT CHAIN 1..597 FT /note="FERM domain-containing protein 3" FT /id="PRO_0000318098" FT TRANSMEM 531..551 FT /note="Helical" FT /evidence="ECO:0000255" FT DOMAIN 32..312 FT /note="FERM" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00084" FT REGION 383..403 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 1..344 FT /note="Missing (in isoform 4)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_031162" FT VAR_SEQ 1..194 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_031163" FT VAR_SEQ 1..49 FT /note="MFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQ -> FT MQLSK (in isoform 5)" FT /evidence="ECO:0000303|PubMed:12601556" FT /id="VSP_031164" FT VAR_SEQ 195..198 FT /note="KNEL -> MVFR (in isoform 3)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_031165" FT VAR_SEQ 345..398 FT /note="SSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPLQPLLPSPSEQEEELPL FT GE -> MQAEETKGIGITSMAKCLVKIQTRRSLQLHMVNHCNSNVFVRLLRLGSKVTAR FT NT (in isoform 4)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_031166" FT VAR_SEQ 553..597 FT /note="GIDLSFLCEIRQTPEFEQFHYEYYCPLKEWVAGKVHLILYMLGCS -> VSM FT Q (in isoform 2, isoform 3 and isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:15489334" FT /id="VSP_031167" FT VARIANT 485 FT /note="D -> Y (in dbSNP:rs4877747)" FT /id="VAR_048366" FT CONFLICT 248 FT /note="Q -> R (in Ref. 1; AAN52119)" FT /evidence="ECO:0000305" FT CONFLICT 554 FT /note="I -> V (in Ref. 1; AAN52119)" FT /evidence="ECO:0000305" SQ SEQUENCE 597 AA; 68772 MW; 0B11ABBDDDE0AE67 CRC64; MFASCHCVPR GRRTMKMIHF RSSSVKSLSQ EMRCTIRLLD DSEISCHIQR ETKGQFLIDH ICNYYSLLEK DYFGIRYVDP EKQRHWLEPN KSIFKQMKTH PPYTMCFRVK FYPHEPLKIK EELTRYLLYL QIKRDIFHGR LLCSFSDAAY LGACIVQAEL GDYDPDEHPE NYISEFEIFP KQSQKLERKI VEIHKNELRG QSPPVAEFNL LLKAHTLETY GVDPHPCKDS TGTTTFLGFT AAGFVVFQGN KRIHLIKWPD VCKLKFEGKT FYVIGTQKEK KAMLAFHTST PAACKHLWKC GVENQAFYKY AKSSQIKTVS SSKIFFKGSR FRYSGKVAKE VVEASSKIQR EPPEVHRANI TQSRSSHSLN KQLIINMEPL QPLLPSPSEQ EEELPLGEGV PLPKEENISA PLISSSPVKA AREYEDPPSE EEDKIKEEPL TISELVYNPS ASLLPTPVDD DEIDMLFDCP SRLELEREDT DSFEDLEADE NAFLIAEEEE LKEARRALSW SYDILTGHIR VNPLVKSFSR LLVVGLGLLL FVFPLLLLLL ESGIDLSFLC EIRQTPEFEQ FHYEYYCPLK EWVAGKVHLI LYMLGCS //