A2A2Y4 (FRMD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FERM domain-containing protein 3

Alternative name(s):
Band 4.1-like protein 4O
Ovary type protein 4.1
Short name=4.1O

Gene names

Name:	FRMD3
Synonyms:	EPB41L4O

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	597 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. Ref.8
Subcellular location	Membrane; Single-pass membrane protein Potential.
Tissue specificity	Ovary-specific. Ref.1
Developmental stage	Expressed in skeletal muscle, lower levels in thymus and brain. Ref.1
Sequence similarities	Contains 1 FERM domain.
Sequence caution	The sequence BAC04321.1 differs from that shown. Reason: Erroneous initiation. The sequence EAW62650.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro cytoskeleton Inferred from electronic annotation. Source: InterPro extrinsic to membrane Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A2A2Y4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A2A2Y4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     553-597: GIDLSFLCEIRQTPEFEQFHYEYYCPLKEWVAGKVHLILYMLGCS → VSMQ

Isoform 3 (identifier: A2A2Y4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-194: Missing.
     195-198: KNEL → MVFR
     553-597: GIDLSFLCEIRQTPEFEQFHYEYYCPLKEWVAGKVHLILYMLGCS → VSMQ

Isoform 4 (identifier: A2A2Y4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-344: Missing.
     345-398: SSKIQREPPE...EQEEELPLGE → MQAEETKGIG...LGSKVTARNT
     553-597: GIDLSFLCEIRQTPEFEQFHYEYYCPLKEWVAGKVHLILYMLGCS → VSMQ

Note: No experimental confirmation available.

Isoform 5 (identifier: A2A2Y4-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: MFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQ → MQLSK

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 597	597	FERM domain-containing protein 3		PRO_0000318098
Regions
	Transmembrane	531 – 551	21	Helical; Potential
	Domain	32 – 312	281	FERM
Amino acid modifications
	Modified residue	415	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 344	344	Missing in isoform 4.		VSP_031162
	Alternative sequence	1 – 194	194	Missing in isoform 3.		VSP_031163
	Alternative sequence	1 – 49	49	MFASC…SCHIQ → MQLSK in isoform 5.		VSP_031164
	Alternative sequence	195 – 198	4	KNEL → MVFR in isoform 3.		VSP_031165
	Alternative sequence	345 – 398	54	SSKIQ…LPLGE → MQAEETKGIGITSMAKCLVK IQTRRSLQLHMVNHCNSNVF VRLLRLGSKVTARNT in isoform 4.		VSP_031166
	Alternative sequence	553 – 597	45	GIDLS…MLGCS → VSMQ in isoform 2, isoform 3 and isoform 4.		VSP_031167
	Natural variant	485	1	D → Y. Corresponds to variant rs4877747 [ dbSNP | Ensembl ].		VAR_048366
Experimental info
	Sequence conflict	248	1	Q → R in AAN52119. Ref.1
	Sequence conflict	554	1	I → V in AAN52119. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 0B11ABBDDDE0AE67	FASTA	597	68,772
	10 20 30 40 50 60 MFASCHCVPR GRRTMKMIHF RSSSVKSLSQ EMRCTIRLLD DSEISCHIQR ETKGQFLIDH 70 80 90 100 110 120 ICNYYSLLEK DYFGIRYVDP EKQRHWLEPN KSIFKQMKTH PPYTMCFRVK FYPHEPLKIK 130 140 150 160 170 180 EELTRYLLYL QIKRDIFHGR LLCSFSDAAY LGACIVQAEL GDYDPDEHPE NYISEFEIFP 190 200 210 220 230 240 KQSQKLERKI VEIHKNELRG QSPPVAEFNL LLKAHTLETY GVDPHPCKDS TGTTTFLGFT 250 260 270 280 290 300 AAGFVVFQGN KRIHLIKWPD VCKLKFEGKT FYVIGTQKEK KAMLAFHTST PAACKHLWKC 310 320 330 340 350 360 GVENQAFYKY AKSSQIKTVS SSKIFFKGSR FRYSGKVAKE VVEASSKIQR EPPEVHRANI 370 380 390 400 410 420 TQSRSSHSLN KQLIINMEPL QPLLPSPSEQ EEELPLGEGV PLPKEENISA PLISSSPVKA 430 440 450 460 470 480 AREYEDPPSE EEDKIKEEPL TISELVYNPS ASLLPTPVDD DEIDMLFDCP SRLELEREDT 490 500 510 520 530 540 DSFEDLEADE NAFLIAEEEE LKEARRALSW SYDILTGHIR VNPLVKSFSR LLVVGLGLLL 550 560 570 580 590 FVFPLLLLLL ESGIDLSFLC EIRQTPEFEQ FHYEYYCPLK EWVAGKVHLI LYMLGCS
	Isoform 2 [UniParc]. Checksum: CD62C83272419CC6	FASTA	556	63,864
	10 20 30 40 50 60 MFASCHCVPR GRRTMKMIHF RSSSVKSLSQ EMRCTIRLLD DSEISCHIQR ETKGQFLIDH 70 80 90 100 110 120 ICNYYSLLEK DYFGIRYVDP EKQRHWLEPN KSIFKQMKTH PPYTMCFRVK FYPHEPLKIK 130 140 150 160 170 180 EELTRYLLYL QIKRDIFHGR LLCSFSDAAY LGACIVQAEL GDYDPDEHPE NYISEFEIFP 190 200 210 220 230 240 KQSQKLERKI VEIHKNELRG QSPPVAEFNL LLKAHTLETY GVDPHPCKDS TGTTTFLGFT 250 260 270 280 290 300 AAGFVVFQGN KRIHLIKWPD VCKLKFEGKT FYVIGTQKEK KAMLAFHTST PAACKHLWKC 310 320 330 340 350 360 GVENQAFYKY AKSSQIKTVS SSKIFFKGSR FRYSGKVAKE VVEASSKIQR EPPEVHRANI 370 380 390 400 410 420 TQSRSSHSLN KQLIINMEPL QPLLPSPSEQ EEELPLGEGV PLPKEENISA PLISSSPVKA 430 440 450 460 470 480 AREYEDPPSE EEDKIKEEPL TISELVYNPS ASLLPTPVDD DEIDMLFDCP SRLELEREDT 490 500 510 520 530 540 DSFEDLEADE NAFLIAEEEE LKEARRALSW SYDILTGHIR VNPLVKSFSR LLVVGLGLLL 550 FVFPLLLLLL ESVSMQ
	Isoform 3 [UniParc]. Checksum: B91E6436B98ECC42	FASTA	362	40,685
	10 20 30 40 50 60 MVFRRGQSPP VAEFNLLLKA HTLETYGVDP HPCKDSTGTT TFLGFTAAGF VVFQGNKRIH 70 80 90 100 110 120 LIKWPDVCKL KFEGKTFYVI GTQKEKKAML AFHTSTPAAC KHLWKCGVEN QAFYKYAKSS 130 140 150 160 170 180 QIKTVSSSKI FFKGSRFRYS GKVAKEVVEA SSKIQREPPE VHRANITQSR SSHSLNKQLI 190 200 210 220 230 240 INMEPLQPLL PSPSEQEEEL PLGEGVPLPK EENISAPLIS SSPVKAAREY EDPPSEEEDK 250 260 270 280 290 300 IKEEPLTISE LVYNPSASLL PTPVDDDEID MLFDCPSRLE LEREDTDSFE DLEADENAFL 310 320 330 340 350 360 IAEEEELKEA RRALSWSYDI LTGHIRVNPL VKSFSRLLVV GLGLLLFVFP LLLLLLESVS MQ
	Isoform 4 [UniParc]. Checksum: BEAE61103185D1D1	FASTA	213	23,923
	10 20 30 40 50 60 MQAEETKGIG ITSMAKCLVK IQTRRSLQLH MVNHCNSNVF VRLLRLGSKV TARNTGVPLP 70 80 90 100 110 120 KEENISAPLI SSSPVKAARE YEDPPSEEED KIKEEPLTIS ELVYNPSASL LPTPVDDDEI 130 140 150 160 170 180 DMLFDCPSRL ELEREDTDSF EDLEADENAF LIAEEEELKE ARRALSWSYD ILTGHIRVNP 190 200 210 LVKSFSRLLV VGLGLLLFVF PLLLLLLESV SMQ
	Isoform 5 [UniParc]. Checksum: 38AD8ADC22D97EE8	FASTA	553	63,664
	10 20 30 40 50 60 MQLSKRETKG QFLIDHICNY YSLLEKDYFG IRYVDPEKQR HWLEPNKSIF KQMKTHPPYT 70 80 90 100 110 120 MCFRVKFYPH EPLKIKEELT RYLLYLQIKR DIFHGRLLCS FSDAAYLGAC IVQAELGDYD 130 140 150 160 170 180 PDEHPENYIS EFEIFPKQSQ KLERKIVEIH KNELRGQSPP VAEFNLLLKA HTLETYGVDP 190 200 210 220 230 240 HPCKDSTGTT TFLGFTAAGF VVFQGNKRIH LIKWPDVCKL KFEGKTFYVI GTQKEKKAML 250 260 270 280 290 300 AFHTSTPAAC KHLWKCGVEN QAFYKYAKSS QIKTVSSSKI FFKGSRFRYS GKVAKEVVEA 310 320 330 340 350 360 SSKIQREPPE VHRANITQSR SSHSLNKQLI INMEPLQPLL PSPSEQEEEL PLGEGVPLPK 370 380 390 400 410 420 EENISAPLIS SSPVKAAREY EDPPSEEEDK IKEEPLTISE LVYNPSASLL PTPVDDDEID 430 440 450 460 470 480 MLFDCPSRLE LEREDTDSFE DLEADENAFL IAEEEELKEA RRALSWSYDI LTGHIRVNPL 490 500 510 520 530 540 VKSFSRLLVV GLGLLLFVFP LLLLLLESGI DLSFLCEIRQ TPEFEQFHYE YYCPLKEWVA 550 GKVHLILYML GCS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of the protein 4.1O gene, a novel member of the protein 4.1 family with focal expression in ovary." Ni X., Ji C., Cao G., Cheng H., Guo L., Gu S., Ying K., Zhao R.C., Mao Y. J. Hum. Genet. 48:101-106(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Fetal brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-597 (ISOFORM 2). Tissue: Cerebellum.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4). Tissue: Brain and Placenta.
[7]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-597 (ISOFORM 1). Tissue: Kidney.
[8]	"FRMD3, a novel putative tumour suppressor in NSCLC." Haase D., Meister M., Muley T., Hess J., Teurich S., Schnabel P., Hartenstein B., Angel P. Oncogene 26:4464-4468(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY137774 mRNA. Translation: AAN52119.1. AK094281 mRNA. Translation: BAC04321.1. Different initiation. AK297722 mRNA. Translation: BAG60076.1. EF560742 mRNA. Translation: ABQ59052.1. AL161786, AL137847 Genomic DNA. Translation: CAH72749.1. AL161786, AL137847, AL450026 Genomic DNA. Translation: CAH72750.2. AL137847, AL161786 Genomic DNA. Translation: CAI40734.1. AL137847, AL161786, AL450026 Genomic DNA. Translation: CAI40735.2. AL137847 Genomic DNA. Translation: CAI40736.1. AL161786, AL137847, AL450026 Genomic DNA. Translation: CAM17460.1. AL450026, AL137847, AL161786 Genomic DNA. Translation: CAM19643.1. AL450026, AL137847, AL161786 Genomic DNA. Translation: CAM19644.1. AL137847, AL161786, AL450026 Genomic DNA. Translation: CAM19673.1. CH471089 Genomic DNA. Translation: EAW62647.1. CH471089 Genomic DNA. Translation: EAW62649.1. CH471089 Genomic DNA. Translation: EAW62650.1. Different initiation. CH471089 Genomic DNA. Translation: EAW62651.1. BC023560 mRNA. Translation: AAH23560.1. BC037253 mRNA. Translation: AAH37253.1. AK223597 mRNA. Translation: BAD97317.1.
IPI	IPI00184358. IPI00217088. IPI00642471. IPI00657701. IPI00885145.
RefSeq	NP_001231888.1. NM_001244959.1. NP_001231889.1. NM_001244960.1. NP_001231890.1. NM_001244961.1. NP_001231891.1. NM_001244962.1. NP_777598.3. NM_174938.5.
UniGene	Hs.127535. Hs.743606.
3D structure databases
ProteinModelPortal	A2A2Y4.
ModBase	Search...
PTM databases
PhosphoSite	A2A2Y4.
Proteomic databases
PaxDb	A2A2Y4.
PRIDE	A2A2Y4.
Protocols and materials databases
DNASU	257019.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304195; ENSP00000303508; ENSG00000172159. ENST00000328788; ENSP00000328615; ENSG00000172159. ENST00000376434; ENSP00000365617; ENSG00000172159. ENST00000376438; ENSP00000365621; ENSG00000172159.
GeneID	257019.
KEGG	hsa:257019.
UCSC	uc004amq.1. human. uc004amr.1. human. uc004ams.2. human. uc022biz.1. human. uc022bja.1. human.
Organism-specific databases
CTD	257019.
GeneCards	GC09M085857.
H-InvDB	HIX0023043.
HGNC	HGNC:24125. FRMD3.
MIM	607619. gene.
neXtProt	NX_A2A2Y4.
PharmGKB	PA134903920.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG331698.
HOVERGEN	HBG057180.
InParanoid	A2A2Y4.
OMA	FLCEIRQ.
Gene expression databases
ArrayExpress	A2A2Y4.
Bgee	A2A2Y4.
Genevestigator	A2A2Y4.
Family and domain databases
Gene3D	1.20.80.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR019749. Band_41_domain. IPR019750. Band_41_fam. IPR000798. Ez/rad/moesin_like. IPR014847. FERM-adjacent. IPR014352. FERM/acyl-CoA-bd_prot_3-hlx. IPR019748. FERM_central. IPR019747. FERM_CS. IPR000299. FERM_domain. IPR018979. FERM_N. IPR018980. FERM_PH-like_C. IPR011993. PH_like_dom. [Graphical view]
Pfam	PF08736. FA. 1 hit. PF09380. FERM_C. 1 hit. PF00373. FERM_M. 1 hit. PF09379. FERM_N. 1 hit. [Graphical view]
PRINTS	PR00935. BAND41. PR00661. ERMFAMILY.
SMART	SM00295. B41. 1 hit. [Graphical view]
SUPFAM	SSF47031. FERM_3-hlx. 1 hit.
PROSITE	PS00660. FERM_1. 1 hit. PS00661. FERM_2. False negative. PS50057. FERM_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	257019.
NextBio	92903.
SOURCE	Search...

Entry information

Entry name

FRMD3_HUMAN

Accession

Primary (citable) accession number: A2A2Y4
Secondary accession number(s): A8MQB0 , B4DN14, Q53EP2, Q5JV59, Q5VZA1, Q86WP8, Q8IZ44, Q8N3Y5, Q8N9L2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 20, 2007
Last modified:	May 29, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.