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Protein

Amino acid transporter

Gene

SLC1A2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

SymportUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Amino acid transporterUniRule annotation
Gene namesi
Name:SLC1A2Imported
ORF Names:hCG_26509Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 58HelicalUniRule annotationAdd BLAST23
Transmembranei79 – 99HelicalUniRule annotationAdd BLAST21
Transmembranei111 – 133HelicalUniRule annotationAdd BLAST23
Transmembranei230 – 247HelicalUniRule annotationAdd BLAST18
Transmembranei267 – 292HelicalUniRule annotationAdd BLAST26
Transmembranei304 – 330HelicalUniRule annotationAdd BLAST27
Transmembranei336 – 359HelicalUniRule annotationAdd BLAST24
Transmembranei424 – 448HelicalUniRule annotationAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSG00000110436.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000278379.

Family & Domainsi

Sequence similaritiesi

Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 2 hits.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A2U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKQVEVRMH DSHLGSEEPK HRHLGLRLCD KLGKNLLLTL TVFGVILGAV
60 70 80 90 100
CGGLLRLASP IHPDVVMLIA FPGDILMRML KMLILPLIIS SLITGLSGLD
110 120 130 140 150
AKASGRLGTR AMVYYMSTTI IAAVLGVILV LAIHPGNPKL KKQLGPGKKN
160 170 180 190 200
DEVSSLDAFL DLIRNLFPEN LVQACFQQIQ TVTKKVLVAP PPDEEANATS
210 220 230 240 250
AVVSLLNETV TEVPEETKMV IKKGLEFKDG MNVLGLIGFF IAFGIAMGKM
260 270 280 290 300
GDQAKLMVDF FNILNEIVMK LVIMIMWYSP LGIACLICGK IIAIKDLEVV
310 320 330 340 350
ARQLGMYMVT VIIGLIIHGG IFLPLIYFVV TRKNPFSFFA GIFQAWITAL
360 370 380 390 400
GTASSAGTLP VTFRCLEENL GIDKRVTRFV LPVGATINMD GTALYEAVAA
410 420 430 440 450
IFIAQMNGVV LDGGQIVTVS LTATLASVGA ASIPSAGLVT MLLILTAVGL
460 470 480 490 500
PTEDISLLVA VDWLLDRMRT SVNVVGDSFG AGIVYHLSKS ELDTIDSQHR
510 520 530 540 550
VHEDIEMTKT QSIYDDMKNH RESNSNQCVY AAHNSVIVDE CKVTLAANGK
560
SADCSVEEEP WKREK
Length:565
Mass (Da):61,228
Last modified:February 20, 2007 - v1
Checksum:iA7286207F550252F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122843 mRNA. Translation: BAG53756.1.
CH471064 Genomic DNA. Translation: EAW68142.1.
RefSeqiNP_001182657.1. NM_001195728.2.
NP_001239581.1. NM_001252652.1.
XP_016873626.1. XM_017018137.1.
XP_016873627.1. XM_017018138.1.
UniGeneiHs.502338.
Hs.661429.

Genome annotation databases

GeneIDi6506.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122843 mRNA. Translation: BAG53756.1.
CH471064 Genomic DNA. Translation: EAW68142.1.
RefSeqiNP_001182657.1. NM_001195728.2.
NP_001239581.1. NM_001252652.1.
XP_016873626.1. XM_017018137.1.
XP_016873627.1. XM_017018138.1.
UniGeneiHs.502338.
Hs.661429.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000278379.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6506.

Organism-specific databases

CTDi6506.

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.

Miscellaneous databases

ChiTaRSiSLC1A2. human.
GenomeRNAii6506.

Gene expression databases

BgeeiENSG00000110436.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 2 hits.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA2A2U1_HUMAN
AccessioniPrimary (citable) accession number: A2A2U1
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.