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A2A288 (ZC12D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ribonuclease ZC3H12D

EC=3.1.-.-
Alternative name(s):
MCP-induced protein 4
Transformed follicular lymphoma
Zinc finger CCCH domain-containing protein 12D
p34
Gene names
Name:ZC3H12D
Synonyms:C6orf95, MCPIP4, TFL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May regulate cell growth likely by suppressing RB1 phosphorylation. May function as RNase and regulate the levels of target RNA species Potential. Serve as a tumor suppressor in certain leukemia cells. Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation. Ref.1 Ref.6

Cofactor

Magnesium Potential.

Subcellular location

Isoform 1: Cytoplasm. Note: Localized as discrete granules. Colocalized with mRNA-processing body markers, AGO2 and DCP1A, but not with a stress granule maker, TIA1, in the cytoplasm. Ref.1

Isoform 3: Cytoplasm. Nucleus Ref.1.

Tissue specificity

Expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines. Ref.1

Induction

By prolonged exposure to bacterial lipopolysaccharides (LPS) in acute monocytic leukemia cell line THP-1 cells. Ref.7

Involvement in disease

A chromosomal aberration involving ZC3H12D may be the cause of the transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL). Translocation t(2;6)(p12;q25) with IGK. Resulting protein may not be expressed.

Sequence similarities

Belongs to the ZC3H12 family. UniProtKB A6QQJ8

Contains 1 C3H1-type zinc finger. UniProtKB A6QQJ8

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.3 (identifier: A2A288-1)

Also known as: P58TFL; TFL1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.3 (identifier: A2A288-3)

The sequence of this isoform differs from the canonical sequence as follows:
     228-527: Missing.
Note: No experimental confirmation available.
Isoform 3 Ref.4 (identifier: A2A288-4)

Also known as: P36TFL; TFL2;

The sequence of this isoform differs from the canonical sequence as follows:
     300-321: GAGAEEQRPPRAPGGSAGARAA → VLPGRPPASARPAAPAAGRTPP
     322-527: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527Probable ribonuclease ZC3H12D
PRO_0000348931

Regions

Zinc finger248 – 27932C3H1-type
Compositional bias357 – 44185Pro-rich

Natural variations

Alternative sequence228 – 527300Missing in isoform 2. Ref.4
VSP_052853
Alternative sequence300 – 32122GAGAE…GARAA → VLPGRPPASARPAAPAAGRT PP in isoform 3.
VSP_040794
Alternative sequence322 – 527206Missing in isoform 3. Ref.3
VSP_040795
Natural variant531P → L. Ref.1 Ref.2 Ref.3
Corresponds to variant rs7747948 [ dbSNP | Ensembl ].
VAR_046199
Natural variant1061K → R in some sporadic lung cancer sample; appears to cause loss of tumor suppressor activity. Ref.6
Corresponds to variant rs61997220 [ dbSNP | Ensembl ].
VAR_046200

Experimental info

Sequence conflict1351S → F in BAH28269. Ref.1
Sequence conflict1401P → S in BAH28269. Ref.1
Sequence conflict1401P → S in BAC87196. Ref.2
Sequence conflict2991P → L in BAH28269. Ref.1
Sequence conflict2991P → L in BAC87196. Ref.2
Sequence conflict4051P → S in AAI57833. Ref.4
Sequence conflict4991A → T in AAI57833. Ref.4
Isoform 3:
Sequence conflict3001V → G in BAH28269. Ref.1
Sequence conflict3011L → V in BAH28269. Ref.1
Sequence conflict3021P → R in BAH28269. Ref.1
Sequence conflict3001V → G in BAC87196. Ref.2
Sequence conflict3011L → V in BAC87196. Ref.2
Sequence conflict3021P → R in BAC87196. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (P58TFL) (TFL1) [UniParc].

Last modified September 1, 2009. Version 3.
Checksum: E330D92548D49DD7

FASTA52758,078
        10         20         30         40         50         60 
MEHPSKMEFF QKLGYDREDV LRVLGKLGEG ALVNDVLQEL IRTGSRPGAL EHPAAPRLVP 

        70         80         90        100        110        120 
RGSCGVPDSA QRGPGTALEE DFRTLASSLR PIVIDGSNVA MSHGNKETFS CRGIKLAVDW 

       130        140        150        160        170        180 
FRDRGHTYIK VFVPSWRKDP PRADTPIREQ HVLAELERQA VLVYTPSRKV HGKRLVCYDD 

       190        200        210        220        230        240 
RYIVKVAYEQ DGVIVSNDNY RDLQSENPEW KWFIEQRLLM FSFVNDRFMP PDDPLGRHGP 

       250        260        270        280        290        300 
SLSNFLSRKP KPPEPSWQHC PYGKKCTYGI KCKFYHPERP HHAQLAVADE LRAKTGARPG 

       310        320        330        340        350        360 
AGAEEQRPPR APGGSAGARA APREPFAHSL PPARGSPDLA ALRGSFSRLA FSDDLGPLGP 

       370        380        390        400        410        420 
PLPVPACSLT PRLGGPDWVS AGGRVPGPLS LPSPESQFSP GDLPPPPGLQ LQPRGEHRPR 

       430        440        450        460        470        480 
DLHGDLLSPR RPPDDPWARP PRSDRFPGRS VWAEPAWGDG ATGGLSVYAT EDDEGDARAR 

       490        500        510        520 
ARIALYSVFP RDQVDRVMAA FPELSDLARL ILLVQRCQSA GAPLGKP 

« Hide

Isoform 2 [UniParc].

Checksum: 5267FCB7B992C467
Show »

FASTA22725,951
Isoform 3 (P36TFL) (TFL2) [UniParc].

Checksum: 268B27A7F6375628
Show »

FASTA32136,199

References

« Hide 'large scale' references
[1]"Inhibition of G(1) to S phase progression by a novel zinc finger protein P58(TFL) at P-bodies."
Minagawa K., Katayama Y., Nishikawa S., Yamamoto K., Sada A., Okamura A., Shimoyama M., Matsui T.
Mol. Cancer Res. 7:880-889(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT LEU-53.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT LEU-53.
Tissue: Spleen.
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain cortex.
[5]"Deregulation of a possible tumour suppressor gene, ZC3H12D, by translocation of IGK@ in transformed follicular lymphoma with t(2;6)(p12;q25)."
Minagawa K., Yamamoto K., Nishikawa S., Ito M., Sada A., Yakushijin K., Okamura A., Shimoyama M., Katayama Y., Matsui T.
Br. J. Haematol. 139:161-163(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: CHROMOSOMAL TRANSLOCATION, INVOLVEMENT IN DIFFUSE LARGE B-CELL LYMPHOMA.
[6]"Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1."
Wang M., Vikis H.G., Wang Y., Jia D., Wang D., Bierut L.J., Bailey-Wilson J.E., Amos C.I., Pinney S.M., Petersen G.M., de Andrade M., Yang P., Wiest J.S., Fain P.R., Schwartz A.G., Gazdar A., Minna J., Gaba C. expand/collapse author list , Rothschild H., Mandal D., Kupert E., Seminara D., Liu Y., Viswanathan A., Govindan R., Anderson M.W., You M.
Cancer Res. 67:93-99(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, VARIANT ARG-106.
[7]"A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages."
Liang J., Wang J., Azfer A., Song W., Tromp G., Kolattukudy P.E., Fu M.
J. Biol. Chem. 283:6337-6346(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB458221 mRNA. Translation: BAH28268.1.
AB458222 mRNA. Translation: BAH28269.1.
AK127932 mRNA. Translation: BAC87196.1.
AL031133 Genomic DNA. Translation: CAM28211.2.
BC127762 mRNA. Translation: AAI27763.1.
BC157832 mRNA. Translation: AAI57833.1.
RefSeqNP_997243.2. NM_207360.2. [A2A288-1]
UniGeneHs.632618.

3D structure databases

ProteinModelPortalA2A288.
SMRA2A288. Positions 89-250.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000374592.

PTM databases

PhosphoSiteA2A288.

Proteomic databases

MaxQBA2A288.
PaxDbA2A288.
PRIDEA2A288.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000389942; ENSP00000374592; ENSG00000178199. [A2A288-1]
ENST00000409806; ENSP00000386616; ENSG00000178199. [A2A288-1]
ENST00000542614; ENSP00000440813; ENSG00000178199. [A2A288-4]
GeneID340152.
KEGGhsa:340152.
UCSCuc003qmn.1. human. [A2A288-3]
uc010kid.3. human. [A2A288-1]

Organism-specific databases

CTD340152.
GeneCardsGC06M149811.
HGNCHGNC:21175. ZC3H12D.
HPAHPA036897.
MIM611106. gene.
neXtProtNX_A2A288.
PharmGKBPA134867170.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG259385.
HOGENOMHOG000060218.
HOVERGENHBG108759.
InParanoidA2A288.
OMARPPDDPW.
OrthoDBEOG7NSB2F.
PhylomeDBA2A288.
TreeFamTF315783.

Gene expression databases

ArrayExpressA2A288.
BgeeA2A288.
CleanExHS_ZC3H12D.
GenevestigatorA2A288.

Family and domain databases

InterProIPR021869. RNase_Zc3h12.
IPR000571. Znf_CCCH.
[Graphical view]
PfamPF11977. RNase_Zc3h12a. 1 hit.
[Graphical view]
PROSITEPS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi340152.
NextBio97711.
PROA2A288.
SOURCESearch...

Entry information

Entry nameZC12D_HUMAN
AccessionPrimary (citable) accession number: A2A288
Secondary accession number(s): A1L178 expand/collapse secondary AC list , B2RXF4, B7WNU7, B9ZZP9, B9ZZQ0, Q6ZRW2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 1, 2009
Last modified: May 14, 2014
This is version 65 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM