SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A2A288

- ZC12D_HUMAN

UniProt

A2A288 - ZC12D_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Probable ribonuclease ZC3H12D
Gene
ZC3H12D, C6orf95, MCPIP4, TFL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May regulate cell growth likely by suppressing RB1 phosphorylation. May function as RNase and regulate the levels of target RNA species Reviewed prediction. Serve as a tumor suppressor in certain leukemia cells. Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation.2 Publications

Cofactori

Magnesium Reviewed prediction.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri248 – 27932C3H1-type
Add
BLAST

GO - Molecular functioni

  1. endonuclease activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
  2. negative regulation of cell growth Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ribonuclease ZC3H12D (EC:3.1.-.-)
Alternative name(s):
MCP-induced protein 4
Transformed follicular lymphoma
Zinc finger CCCH domain-containing protein 12D
p34
Gene namesi
Name:ZC3H12D
Synonyms:C6orf95, MCPIP4, TFL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21175. ZC3H12D.

Subcellular locationi

Isoform 1 : Cytoplasm
Note: Localized as discrete granules. Colocalized with mRNA-processing body markers, AGO2 and DCP1A, but not with a stress granule maker, TIA1, in the cytoplasm.1 Publication
Isoform 3 : Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving ZC3H12D may be the cause of the transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL). Translocation t(2;6)(p12;q25) with IGK. Resulting protein may not be expressed.

Organism-specific databases

PharmGKBiPA134867170.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Probable ribonuclease ZC3H12D
PRO_0000348931Add
BLAST

Proteomic databases

MaxQBiA2A288.
PaxDbiA2A288.
PRIDEiA2A288.

PTM databases

PhosphoSiteiA2A288.

Expressioni

Tissue specificityi

Expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines.1 Publication

Inductioni

By prolonged exposure to bacterial lipopolysaccharides (LPS) in acute monocytic leukemia cell line THP-1 cells.1 Publication

Gene expression databases

ArrayExpressiA2A288.
BgeeiA2A288.
CleanExiHS_ZC3H12D.
GenevestigatoriA2A288.

Organism-specific databases

HPAiHPA036897.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000374592.

Structurei

3D structure databases

ProteinModelPortaliA2A288.
SMRiA2A288. Positions 89-250.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi357 – 44185Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the ZC3H12 family.By similarity
Contains 1 C3H1-type zinc finger.By similarity

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG259385.
HOGENOMiHOG000060218.
HOVERGENiHBG108759.
InParanoidiA2A288.
OMAiRPPDDPW.
OrthoDBiEOG7NSB2F.
PhylomeDBiA2A288.
TreeFamiTF315783.

Family and domain databases

InterProiIPR021869. RNase_Zc3h12.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF11977. RNase_Zc3h12a. 1 hit.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: A2A288-1) [UniParc]FASTAAdd to Basket

Also known as: P58TFL, TFL1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEHPSKMEFF QKLGYDREDV LRVLGKLGEG ALVNDVLQEL IRTGSRPGAL    50
EHPAAPRLVP RGSCGVPDSA QRGPGTALEE DFRTLASSLR PIVIDGSNVA 100
MSHGNKETFS CRGIKLAVDW FRDRGHTYIK VFVPSWRKDP PRADTPIREQ 150
HVLAELERQA VLVYTPSRKV HGKRLVCYDD RYIVKVAYEQ DGVIVSNDNY 200
RDLQSENPEW KWFIEQRLLM FSFVNDRFMP PDDPLGRHGP SLSNFLSRKP 250
KPPEPSWQHC PYGKKCTYGI KCKFYHPERP HHAQLAVADE LRAKTGARPG 300
AGAEEQRPPR APGGSAGARA APREPFAHSL PPARGSPDLA ALRGSFSRLA 350
FSDDLGPLGP PLPVPACSLT PRLGGPDWVS AGGRVPGPLS LPSPESQFSP 400
GDLPPPPGLQ LQPRGEHRPR DLHGDLLSPR RPPDDPWARP PRSDRFPGRS 450
VWAEPAWGDG ATGGLSVYAT EDDEGDARAR ARIALYSVFP RDQVDRVMAA 500
FPELSDLARL ILLVQRCQSA GAPLGKP 527
Length:527
Mass (Da):58,078
Last modified:September 1, 2009 - v3
Checksum:iE330D92548D49DD7
GO
Isoform 21 Publication (identifier: A2A288-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-527: Missing.

Note: No experimental confirmation available.

Show »
Length:227
Mass (Da):25,951
Checksum:i5267FCB7B992C467
GO
Isoform 31 Publication (identifier: A2A288-4) [UniParc]FASTAAdd to Basket

Also known as: P36TFL, TFL2

The sequence of this isoform differs from the canonical sequence as follows:
     300-321: GAGAEEQRPPRAPGGSAGARAA → VLPGRPPASARPAAPAAGRTPP
     322-527: Missing.

Show »
Length:321
Mass (Da):36,199
Checksum:i268B27A7F6375628
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531P → L.3 Publications
Corresponds to variant rs7747948 [ dbSNP | Ensembl ].
VAR_046199
Natural varianti106 – 1061K → R in some sporadic lung cancer sample; appears to cause loss of tumor suppressor activity. 1 Publication
Corresponds to variant rs61997220 [ dbSNP | Ensembl ].
VAR_046200

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei228 – 527300Missing in isoform 2. 1 Publication
VSP_052853Add
BLAST
Alternative sequencei300 – 32122GAGAE…GARAA → VLPGRPPASARPAAPAAGRT PP in isoform 3.
VSP_040794Add
BLAST
Alternative sequencei322 – 527206Missing in isoform 3. 1 Publication
VSP_040795Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351S → F in BAH28269. 1 Publication
Sequence conflicti140 – 1401P → S in BAH28269. 1 Publication
Sequence conflicti140 – 1401P → S in BAC87196. 1 Publication
Sequence conflicti299 – 2991P → L in BAH28269. 1 Publication
Sequence conflicti299 – 2991P → L in BAC87196. 1 Publication
Sequence conflicti405 – 4051P → S in AAI57833. 1 Publication
Sequence conflicti499 – 4991A → T in AAI57833. 1 Publication
Isoform 31 Publication (identifier: A2A288-4)
Sequence conflicti300 – 3001V → G in BAH28269. 1 Publication
Sequence conflicti300 – 3001V → G in BAC87196. 1 Publication
Sequence conflicti301 – 3011L → V in BAH28269. 1 Publication
Sequence conflicti301 – 3011L → V in BAC87196. 1 Publication
Sequence conflicti302 – 3021P → R in BAH28269. 1 Publication
Sequence conflicti302 – 3021P → R in BAC87196. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB458221 mRNA. Translation: BAH28268.1.
AB458222 mRNA. Translation: BAH28269.1.
AK127932 mRNA. Translation: BAC87196.1.
AL031133 Genomic DNA. Translation: CAM28211.2.
BC127762 mRNA. Translation: AAI27763.1.
BC157832 mRNA. Translation: AAI57833.1.
RefSeqiNP_997243.2. NM_207360.2. [A2A288-1]
UniGeneiHs.632618.

Genome annotation databases

EnsembliENST00000389942; ENSP00000374592; ENSG00000178199. [A2A288-1]
ENST00000409806; ENSP00000386616; ENSG00000178199. [A2A288-1]
ENST00000542614; ENSP00000440813; ENSG00000178199. [A2A288-4]
GeneIDi340152.
KEGGihsa:340152.
UCSCiuc003qmn.1. human. [A2A288-3]
uc010kid.3. human. [A2A288-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB458221 mRNA. Translation: BAH28268.1 .
AB458222 mRNA. Translation: BAH28269.1 .
AK127932 mRNA. Translation: BAC87196.1 .
AL031133 Genomic DNA. Translation: CAM28211.2 .
BC127762 mRNA. Translation: AAI27763.1 .
BC157832 mRNA. Translation: AAI57833.1 .
RefSeqi NP_997243.2. NM_207360.2. [A2A288-1 ]
UniGenei Hs.632618.

3D structure databases

ProteinModelPortali A2A288.
SMRi A2A288. Positions 89-250.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000374592.

PTM databases

PhosphoSitei A2A288.

Proteomic databases

MaxQBi A2A288.
PaxDbi A2A288.
PRIDEi A2A288.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000389942 ; ENSP00000374592 ; ENSG00000178199 . [A2A288-1 ]
ENST00000409806 ; ENSP00000386616 ; ENSG00000178199 . [A2A288-1 ]
ENST00000542614 ; ENSP00000440813 ; ENSG00000178199 . [A2A288-4 ]
GeneIDi 340152.
KEGGi hsa:340152.
UCSCi uc003qmn.1. human. [A2A288-3 ]
uc010kid.3. human. [A2A288-1 ]

Organism-specific databases

CTDi 340152.
GeneCardsi GC06M149811.
HGNCi HGNC:21175. ZC3H12D.
HPAi HPA036897.
MIMi 611106. gene.
neXtProti NX_A2A288.
PharmGKBi PA134867170.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG259385.
HOGENOMi HOG000060218.
HOVERGENi HBG108759.
InParanoidi A2A288.
OMAi RPPDDPW.
OrthoDBi EOG7NSB2F.
PhylomeDBi A2A288.
TreeFami TF315783.

Miscellaneous databases

GenomeRNAii 340152.
NextBioi 97711.
PROi A2A288.
SOURCEi Search...

Gene expression databases

ArrayExpressi A2A288.
Bgeei A2A288.
CleanExi HS_ZC3H12D.
Genevestigatori A2A288.

Family and domain databases

InterProi IPR021869. RNase_Zc3h12.
IPR000571. Znf_CCCH.
[Graphical view ]
Pfami PF11977. RNase_Zc3h12a. 1 hit.
[Graphical view ]
PROSITEi PS50103. ZF_C3H1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Inhibition of G(1) to S phase progression by a novel zinc finger protein P58(TFL) at P-bodies."
    Minagawa K., Katayama Y., Nishikawa S., Yamamoto K., Sada A., Okamura A., Shimoyama M., Matsui T.
    Mol. Cancer Res. 7:880-889(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT LEU-53.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT LEU-53.
    Tissue: Spleen.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain cortex.
  5. "Deregulation of a possible tumour suppressor gene, ZC3H12D, by translocation of IGK@ in transformed follicular lymphoma with t(2;6)(p12;q25)."
    Minagawa K., Yamamoto K., Nishikawa S., Ito M., Sada A., Yakushijin K., Okamura A., Shimoyama M., Katayama Y., Matsui T.
    Br. J. Haematol. 139:161-163(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION, INVOLVEMENT IN DIFFUSE LARGE B-CELL LYMPHOMA.
  6. Cited for: FUNCTION, VARIANT ARG-106.
  7. "A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages."
    Liang J., Wang J., Azfer A., Song W., Tromp G., Kolattukudy P.E., Fu M.
    J. Biol. Chem. 283:6337-6346(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiZC12D_HUMAN
AccessioniPrimary (citable) accession number: A2A288
Secondary accession number(s): A1L178
, B2RXF4, B7WNU7, B9ZZP9, B9ZZQ0, Q6ZRW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 1, 2009
Last modified: May 14, 2014
This is version 65 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi