Unreviewed, UniProtKB/TrEMBL A2A284 (A2A284_HUMAN)

Names and origin

Protein names

Submitted name:
    Phospholipase C, gamma 1 EMBL CAM28260.1
Submitted name:
    Phospholipase C, gamma 1, isoform CRA_b EMBL EAW75990.1

Gene names

Name:	PLCG1 EMBL CAM28260.1
ORF Names:	RP3-511B24.2-013 EMBL CAM28260.1, hCG_2018597 EMBL EAW75990.1

Organism

Homo sapiens (Human) EMBL CAM28260.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1291 AA.
Sequence status	Complete.
Protein existence	Predicted.

General annotation (Comments)

Sequence similarities

Contains 1 C2 domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC Y-box domain. Contains 1 SH3 domain. Contains 3 PH domains.

Ontologies

Keywords
Domain	SH3 domain RuleBase RU003338V3
Ligand	Calcium RuleBase RU000331V1
Molecular function	Transducer Spearmint SPM001192
Gene Ontology (GO)
Biological process	T cell receptor signaling pathway Inferred from electronic annotation. Source: Compara calcium ion transport Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara inositol trisphosphate biosynthetic process Inferred from electronic annotation. Source: Compara intracellular signaling cascade Inferred from electronic annotation. Source: InterPro phospholipid catabolic process Inferred from electronic annotation. Source: InterPro positive regulation of calcium ion transport via store-operated calcium channel activity Inferred from electronic annotation. Source: Compara positive regulation of epithelial cell migration Inferred from electronic annotation. Source: Compara response to gravity Inferred from electronic annotation. Source: Compara response to hydrogen peroxide Inferred from electronic annotation. Source: Compara response to morphine Inferred from electronic annotation. Source: Compara response to organic nitrogen Inferred from electronic annotation. Source: Compara vesicle-mediated transport Inferred from electronic annotation. Source: Compara
Cellular component	neuron projection Inferred from electronic annotation. Source: Compara
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW glutamate receptor binding Inferred from electronic annotation. Source: Compara insulin receptor binding Inferred from electronic annotation. Source: Compara phosphoinositide phospholipase C activity Inferred from electronic annotation. Source: InterPro phosphoprotein binding Inferred from electronic annotation. Source: Compara signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A2A284-1 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: EDDBB8D4E49B2F3E	FASTA	1,291	148,660
	10 20 30 40 50 60 MAGAASPCAN GCGPGAPSDA EVLHLCRSLE VGTVMTLFYS KKSQRPERKT FQVKLETRQI 70 80 90 100 110 120 TWSRGADKIE GAIDIREIKE IRPGKTSRDF DRYQEDPAFR PDQSHCFVIL YGMEFRLKTL 130 140 150 160 170 180 SLQATSEDEV NMWIKGLTWL MEDTLQAPTP LQIERWLRKQ FYSVDRNRED RISAKDLKNM 190 200 210 220 230 240 LSQVNYRVPN MRFLRERLTD LEQRSGDITY GQFAQLYRSL MYSAQKTMDL PFLEASTLRA 250 260 270 280 290 300 GERPELCRVS LPEFQQFLLD YQGELWAVDR LQVQEFMLSF LRDPLREIEE PYFFLDEFVT 310 320 330 340 350 360 FLFSKENSVW NSQLDAVCPD TMNNPLSHYW ISSSHNTYLT GDQFSSESSL EAYARCLRMG 370 380 390 400 410 420 CRCIELDCWD GPDGMPVIYH GHTLTTKIKF SDVLHTIKEH AFVASEYPVI LSIEDHCSIA 430 440 450 460 470 480 QQRNMAQYFK KVLGDTLLTK PVEISADGLP SPNQLKRKIL IKHKKLAEGS AYEEVPTSMM 490 500 510 520 530 540 YSENDISNSI KNGILYLEDP VNHEWYPHYF VLTSSKIYYS EETSSDQGNE DEEEPKEVSS 550 560 570 580 590 600 STELHSNEKW FHGKLGAGRD GRHIAERLLT EYCIETGAPD GSFLVRESET FVGDYTLSFW 610 620 630 640 650 660 RNGKVQHCRI HSRQDAGTPK FFLTDNLVFD SLYDLITHYQ QVPLRCNEFE MRLSEPVPQT 670 680 690 700 710 720 NAHESKEWYH ASLTRAQAEH MLMRVPRDGA FLVRKRNEPN SYAISFRAEG KIKHCRVQQE 730 740 750 760 770 780 GQTVMLGNSE FDSLVDLISY YEKHPLYRKM KLRYPINEEA LEKIGTAEPD YGALYEGRNP 790 800 810 820 830 840 GFYVEANPMP TFKCAVKALF DYKAQREDEL TFIKSAIIQN VEKQEGGWWR GDYGGKKQLW 850 860 870 880 890 900 FPSNYVEEMV NPVALEPERE HLDENSPLGD LLRGVLDVPA CQIAIRPEGK NNRLFVFSIS 910 920 930 940 950 960 MASVAHWSLD VAADSQEELQ DWVKKIREVA QTADARLTEG KIMERRKKIA LELSELVVYC 970 980 990 1000 1010 1020 RPVPFDEEKI GTERACYRDM SSFPETKAEK YVNKAKGKKF LQYNRLQLSR IYPKGQRLDS 1030 1040 1050 1060 1070 1080 SNYDPLPMWI CGSQLVALNF QTPDKPMQMN QALFMTGRHC GYVLQPSTMR DEAFDPFDKS 1090 1100 1110 1120 1130 1140 SLRGLEPCAI SIEVLGARHL PKNGRGIVCP FVEIEVAGAE YDSTKQKTEF VVDNGLNPVW 1150 1160 1170 1180 1190 1200 PAKPFHFQIS NPEFAFLRFV VYEEDMFSDQ NFLAQATFPV KGLKTGYRAV PLKNNYSEDL 1210 1220 1230 1240 1250 1260 ELASLLIKID IFPAKQENGD LSPFSGTSLR ERGSDASGQL FHGRAREGSF ESRYQQPFED 1270 1280 1290 FRISQEHLAD HFDSRERRAP RRTRVNGDNR L

References

[1]	Bridgeman A. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL022394 Genomic DNA. Translation: CAM28260.1. CH471077 Genomic DNA. Translation: EAW75990.1.
IPI	IPI00383849.
RefSeq	NP_002651.2.
UniGene	Hs.268177
3D structure databases
SMR	A2A284. Positions 489-553, 542-658, 663-759, 790-852, 851-933.
ModBase	Search...
Protein-protein interaction databases
STRING	A2A284.
Proteomic databases
PRIDE	A2A284.
Genome annotation databases
Ensembl	ENST00000244007; ENSP00000244007; ENSG00000124181; Homo sapiens. [Genome view] ENST00000373272; ENSP00000362369; ENSG00000124181; Homo sapiens. [Genome view]
GeneID	5335.
KEGG	hsa:5335.
UCSC	uc002xjo.1. human.
Organism-specific databases
CTD	5335.
HGNC	HGNC:9065. PLCG1.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08759.
HOGENOM	HBG402919.
HOVERGEN	A2A284.
OMA	DKIEGAI.
OrthoDB	EOG937V0B.
PhylomeDB	A2A284.
Gene expression databases
Bgee	A2A284.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR018247. EF_Hand_1_Ca_BS. IPR018249. EF_HAND_2. IPR011993. PH_type. IPR015359. Phospholipase_C_EF-hand-like. IPR001192. Phospholipase_C_Pinositol-sp_C. IPR001711. Phospholipase_C_Pinositol-sp_Y. IPR016279. PLC-gamma. IPR017946. PLC-like_Pdiesterase_TIM-brl. IPR001849. Pleckstrin_homology. IPR000909. PLipase_C_PInositol-sp_X_dom. IPR000980. SH2. IPR001452. SH3_domain. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit. G3DSA:3.20.20.190. PLC-like_Pdiesterase_TIM-brl. 1 hit.
Pfam	PF00168. C2. 1 hit. PF09279. efhand_like. 1 hit. PF00169. PH. 1 hit. PF00388. PI-PLC-X. 1 hit. PF00387. PI-PLC-Y. 1 hit. PF00017. SH2. 2 hits. PF00018. SH3_1. 1 hit. [Graphical view]
PIRSF	PIRSF000952. PLC-gamma. 1 hit.
PRINTS	PR00390. PHPHLIPASEC. PR00401. SH2DOMAIN.
SMART	SM00239. C2. 1 hit. SM00233. PH. 3 hits. SM00148. PLCXc. 1 hit. SM00149. PLCYc. 1 hit. SM00252. SH2. 2 hits. SM00326. SH3. 1 hit. [Graphical view]
PROSITE	PS50004. C2. 1 hit. PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 1 hit. PS50003. PH_DOMAIN. 2 hits. PS50007. PIPLC_X_DOMAIN. 1 hit. PS50008. PIPLC_Y_DOMAIN. 1 hit. PS50001. SH2. 2 hits. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	20662.

Entry information

Entry name

A2A284_HUMAN

Accession

Primary (citable) accession number: A2A284

Entry history

Integrated into UniProtKB/TrEMBL:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	February 9, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.