ACO2

Functionⁱ

GO - Biological processⁱ

metabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Aconitate hydratase, mitochondrialImported
Gene namesⁱ	Name:ACO2Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100412.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:118 ACO2

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000100412

OpenTargetsⁱ

ENSG00000100412

PTM / Processingⁱ

Proteomic databases

EPDⁱ	A2A274
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A2A274
PeptideAtlas More...PeptideAtlasⁱ	A2A274
PRIDEⁱ	A2A274

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000100412
ExpressionAtlasⁱ	A2A274 baseline and differential

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	A2A274 1 interactor.

IntActⁱ

A2A274 1 interactor.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A2A274
SMRⁱ	A2A274
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	67 – 279	AconitaseInterPro annotationAdd BLAST	213
Domainⁱ	303 – 528	AconitaseInterPro annotationAdd BLAST	226
Domainⁱ	608 – 736	Aconitase_CInterPro annotationAdd BLAST	129

Phylogenomic databases

eggNOGⁱ	KOG0453 Eukaryota COG1048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139397
HOGENOMⁱ	HOG000224293
HOVERGENⁱ	HBG000248
OMAⁱ	GCIGMGQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G024R
PhylomeDBⁱ	A2A274

Family and domain databases

Gene3Dⁱ	3.20.19.101 hit 3.30.499.102 hits 3.40.1060.102 hits
InterProⁱ	View protein in InterPro IPR015931 Acnase/IPM_dHydase_lsu_aba_1/3 IPR001030 Acoase/IPM_deHydtase_lsu_aba IPR015928 Aconitase/3IPM_dehydase_swvl IPR018136 Aconitase_4Fe-4S_BS IPR036008 Aconitase_4Fe-4S_dom IPR015932 Aconitase_dom2 IPR000573 AconitaseA/IPMdHydase_ssu_swvl
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00330 Aconitase, 2 hits PF00694 Aconitase_C, 1 hit
PRINTSⁱ	PR00415 ACONITASE
SUPFAMⁱ	SSF53732 SSF53732, 1 hit
PROSITEⁱ	View protein in PROSITE PS00450 ACONITASE_1, 1 hit PS01244 ACONITASE_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A2A274-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAPYSLLVTR LQKALGVRQY HVASVLCQRA KVAMSHFEPN EYIHYDLLEK 
        60         70         80         90        100
NINIVRKRLN RPLTLSEKIV YGHLDDPASQ EIERGKSYLR LRPDRVAMQD 
       110        120        130        140        150
ATAQMAMLQF ISSGLSKVAV PSTIHCDHLI EAQVGGEKDL RRAKDINQEV 
       160        170        180        190        200
YNFLATAGAK YGVGFWKPGS GIIHQIILEN YAYPGVLLIG TDSHTPNGGG 
       210        220        230        240        250
LGGICIGVGG ADAVDVMAGI PWELKCPKVI GVKLTGSLSG WSSPKDVILK 
       260        270        280        290        300
VAGILTVKGG TGAIVEYHGP GVDSISCTGE EGGQATWPLP CAGPDGSPVG 
       310        320        330        340        350
SRSGMATICN MGAEIGATTS VFPYNHRMKK YLSKTGREDI ANLADEFKDH 
       360        370        380        390        400
LVPDPGCHYD QLIEINLSEL KPHINGPFTP DLAHPVAEVG KVAEKEGWPL 
       410        420        430        440        450
DIRVGLIGSC TNSSYEDMGR SAAVAKQALA HGLKCKSQFT ITPGSEQIRA 
       460        470        480        490        500
TIERDGYAQI LRDLGGIVLA NACGPCIGQW DRKDIKKGEK NTIVTSYNRN 
       510        520        530        540        550
FTGRNDANPE THAFVTSPEI VTALAIAGTL KFNPETDYLT GTDGKKFRLE 
       560        570        580        590        600
APDADELPKG EFDPGQDTYQ HPPKDSSGQH VDVSPTSQRL QLLEPFDKWD 
       610        620        630        640        650
GKDLEDLQIL IKVKGKCTTD HISAAGPWLK FRGHLDNISN NLLIGAINIE 
       660        670        680        690        700
NGKANSVRNA VTQEFGPVPD TARYYKKHGI RWVVIGDENY GEGSSREHAA 
       710        720        730        740        750
LEPRHLGGRA IITKSFARIH ETNLKKQGLL PLTFADPADY NKIHPVDKLT 
       760        770        780        790        800
IQGLKDFTPG KPLKCIIKHP NGTQETILLN HTFNETQIEW FRAGSALNRM 

KELQQ

Length:805

Mass (Da):87,820

Last modified:February 20, 2007 - v1

Checksum:ⁱ8584824DB3C3EAD0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL008582 Genomic DNA No translation available. AL023553 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL008582 Genomic DNA No translation available.
AL023553 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000396512; ENSP00000379769; ENSG00000100412
UCSC genome browser More...UCSCⁱ	uc062eqp.1 human

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A2A274	B4DEC3	Homo sapiens (Human)	805	UniRef100_A2A274	Cluster: Aconitate hydratase, mitochondrial	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A2A274	G1MB13 B4DEC3 A0A2J8TWR2 A0A2J8LN43 A0A2K6NBJ6 D2I290 A0A1D5QB91 A0A2K5R085 A0A2K5DQK8 L8HTI2 +11	Ailuropoda melanoleuca (Giant panda) Homo sapiens (Human) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan troglodytes (Chimpanzee) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Macaca mulatta (Rhesus macaque) Cebus capucinus imitator Aotus nancymaae (Ma's night monkey) Bos mutus (wild yak) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) And more	805	UniRef90_G1MB13	Cluster: Aconitase 2	22

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A2A274	Q99798 UPI00024CEDDD UPI0005224998 UPI000521C3D7 UPI0007712124 UPI000771190F UPI0005216F5D UPI0005327552 UPI000CDA4B9F UPI000529FCE0 +612	Homo sapiens (Human) Opisthocomus hoazin (Hoatzin) (Phasianus hoazin) Dryobates pubescens (Downy woodpecker) (Picoides pubescens) Parus major (Great tit) Charadrius vociferus (Killdeer) (Aegialitis vocifera) Balearica regulorum gibbericeps (East African grey crowned-crane) Cyanistes caeruleus (Eurasian blue tit) (Parus caeruleus) Chlamydotis macqueenii (Macqueen's bustard) Aptenodytes forsteri (Emperor penguin) Struthio camelus australis And more	780	UniRef50_Q99798	Cluster: Aconitate hydratase, mitochondrial	623

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL008582 Genomic DNA No translation available. AL023553 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL008582 Genomic DNA No translation available.
AL023553 Genomic DNA No translation available.

3D structure databases

ProteinModelPortalⁱ	A2A274
SMRⁱ	A2A274
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	A2A274 1 interactor.

IntActⁱ

A2A274 1 interactor.

Proteomic databases

EPDⁱ	A2A274
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A2A274
PeptideAtlas More...PeptideAtlasⁱ	A2A274
PRIDEⁱ	A2A274

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000396512; ENSP00000379769; ENSG00000100412
UCSC genome browser More...UCSCⁱ	uc062eqp.1 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100412.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:118 ACO2
Open Targets More...OpenTargetsⁱ	ENSG00000100412
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0453 Eukaryota COG1048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139397
HOGENOMⁱ	HOG000224293
HOVERGENⁱ	HBG000248
OMAⁱ	GCIGMGQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G024R
PhylomeDBⁱ	A2A274

Miscellaneous databases

ChiTaRSⁱ	ACO2 human

ChiTaRSⁱ

ACO2 human

Gene expression databases

Bgeeⁱ	ENSG00000100412
ExpressionAtlasⁱ	A2A274 baseline and differential

Family and domain databases

Gene3Dⁱ	3.20.19.101 hit 3.30.499.102 hits 3.40.1060.102 hits
InterProⁱ	View protein in InterPro IPR015931 Acnase/IPM_dHydase_lsu_aba_1/3 IPR001030 Acoase/IPM_deHydtase_lsu_aba IPR015928 Aconitase/3IPM_dehydase_swvl IPR018136 Aconitase_4Fe-4S_BS IPR036008 Aconitase_4Fe-4S_dom IPR015932 Aconitase_dom2 IPR000573 AconitaseA/IPMdHydase_ssu_swvl
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00330 Aconitase, 2 hits PF00694 Aconitase_C, 1 hit
PRINTSⁱ	PR00415 ACONITASE
SUPFAMⁱ	SSF53732 SSF53732, 1 hit
PROSITEⁱ	View protein in PROSITE PS00450 ACONITASE_1, 1 hit PS01244 ACONITASE_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A2A274_HUMAN
Accessionⁱ	A2A274Primary (citable) accession number: A2A274
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 20, 2007
	Last sequence update:	February 20, 2007
	Last modified:	April 25, 2018
	This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A2A274 (A2A274_HUMAN)

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Aconitate hydratase, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ