ACO2

Functionⁱ

GO - Biological processⁱ

metabolic process Source: InterPro

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Aconitate hydratase, mitochondrialImported
Gene namesⁱ	Name:ACO2Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

HGNCⁱ

HGNC:118. ACO2.

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000100412.

OpenTargetsⁱ

ENSG00000100412.

PTM / Processingⁱ

Proteomic databases

EPDⁱ	A2A274.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A2A274.
PaxDbⁱ	A2A274.
PeptideAtlas More...PeptideAtlasⁱ	A2A274.
PRIDEⁱ	A2A274.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000100412.
ExpressionAtlasⁱ	A2A274. baseline and differential.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A2A274.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	67 – 279	AconitaseInterPro annotationAdd BLAST	213
Domainⁱ	303 – 528	AconitaseInterPro annotationAdd BLAST	226
Domainⁱ	608 – 736	Aconitase_CInterPro annotationAdd BLAST	129

Phylogenomic databases

eggNOGⁱ	KOG0453. Eukaryota. COG1048. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000138030.
HOGENOMⁱ	HOG000224293.
HOVERGENⁱ	HBG000248.
OMAⁱ	GCIGMGQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G024R.
PhylomeDBⁱ	A2A274.

Family and domain databases

Gene3Dⁱ	3.20.19.10. 1 hit. 3.30.499.10. 2 hits. 3.40.1060.10. 2 hits.
InterProⁱ	View protein in InterPro IPR015931. Acnase/IPM_dHydase_lsu_aba_1/3. IPR001030. Acoase/IPM_deHydtase_lsu_aba. IPR015928. Aconitase/3IPM_dehydase_swvl. IPR015932. Aconitase/IPMdHydase_lsu_aba_2. IPR018136. Aconitase_4Fe-4S_BS. IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00330. Aconitase. 2 hits. PF00694. Aconitase_C. 1 hit.
PRINTSⁱ	PR00415. ACONITASE.
SUPFAMⁱ	SSF52016. SSF52016. 1 hit. SSF53732. SSF53732. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00450. ACONITASE_1. 1 hit. PS01244. ACONITASE_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A2A274-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAPYSLLVTR LQKALGVRQY HVASVLCQRA KVAMSHFEPN EYIHYDLLEK 
        60         70         80         90        100
NINIVRKRLN RPLTLSEKIV YGHLDDPASQ EIERGKSYLR LRPDRVAMQD 
       110        120        130        140        150
ATAQMAMLQF ISSGLSKVAV PSTIHCDHLI EAQVGGEKDL RRAKDINQEV 
       160        170        180        190        200
YNFLATAGAK YGVGFWKPGS GIIHQIILEN YAYPGVLLIG TDSHTPNGGG 
       210        220        230        240        250
LGGICIGVGG ADAVDVMAGI PWELKCPKVI GVKLTGSLSG WSSPKDVILK 
       260        270        280        290        300
VAGILTVKGG TGAIVEYHGP GVDSISCTGE EGGQATWPLP CAGPDGSPVG 
       310        320        330        340        350
SRSGMATICN MGAEIGATTS VFPYNHRMKK YLSKTGREDI ANLADEFKDH 
       360        370        380        390        400
LVPDPGCHYD QLIEINLSEL KPHINGPFTP DLAHPVAEVG KVAEKEGWPL 
       410        420        430        440        450
DIRVGLIGSC TNSSYEDMGR SAAVAKQALA HGLKCKSQFT ITPGSEQIRA 
       460        470        480        490        500
TIERDGYAQI LRDLGGIVLA NACGPCIGQW DRKDIKKGEK NTIVTSYNRN 
       510        520        530        540        550
FTGRNDANPE THAFVTSPEI VTALAIAGTL KFNPETDYLT GTDGKKFRLE 
       560        570        580        590        600
APDADELPKG EFDPGQDTYQ HPPKDSSGQH VDVSPTSQRL QLLEPFDKWD 
       610        620        630        640        650
GKDLEDLQIL IKVKGKCTTD HISAAGPWLK FRGHLDNISN NLLIGAINIE 
       660        670        680        690        700
NGKANSVRNA VTQEFGPVPD TARYYKKHGI RWVVIGDENY GEGSSREHAA 
       710        720        730        740        750
LEPRHLGGRA IITKSFARIH ETNLKKQGLL PLTFADPADY NKIHPVDKLT 
       760        770        780        790        800
IQGLKDFTPG KPLKCIIKHP NGTQETILLN HTFNETQIEW FRAGSALNRM 

KELQQ

Length:805

Mass (Da):87,820

Last modified:February 20, 2007 - v1

Checksum:ⁱ8584824DB3C3EAD0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL008582 Genomic DNA. No translation available. AL023553 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL008582 Genomic DNA. No translation available.
AL023553 Genomic DNA. No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000396512; ENSP00000379769; ENSG00000100412.
UCSC genome browser More...UCSCⁱ	uc062eqp.1. human.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL008582 Genomic DNA. No translation available. AL023553 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL008582 Genomic DNA. No translation available.
AL023553 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalⁱ	A2A274.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

EPDⁱ	A2A274.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A2A274.
PaxDbⁱ	A2A274.
PeptideAtlas More...PeptideAtlasⁱ	A2A274.
PRIDEⁱ	A2A274.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000396512; ENSP00000379769; ENSG00000100412.
UCSC genome browser More...UCSCⁱ	uc062eqp.1. human.

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:118. ACO2.
Open Targets More...OpenTargetsⁱ	ENSG00000100412.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0453. Eukaryota. COG1048. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000138030.
HOGENOMⁱ	HOG000224293.
HOVERGENⁱ	HBG000248.
OMAⁱ	GCIGMGQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G024R.
PhylomeDBⁱ	A2A274.

Miscellaneous databases

ChiTaRSⁱ	ACO2. human.

ChiTaRSⁱ

ACO2. human.

Gene expression databases

Bgeeⁱ	ENSG00000100412.
ExpressionAtlasⁱ	A2A274. baseline and differential.

Family and domain databases

Gene3Dⁱ	3.20.19.10. 1 hit. 3.30.499.10. 2 hits. 3.40.1060.10. 2 hits.
InterProⁱ	View protein in InterPro IPR015931. Acnase/IPM_dHydase_lsu_aba_1/3. IPR001030. Acoase/IPM_deHydtase_lsu_aba. IPR015928. Aconitase/3IPM_dehydase_swvl. IPR015932. Aconitase/IPMdHydase_lsu_aba_2. IPR018136. Aconitase_4Fe-4S_BS. IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00330. Aconitase. 2 hits. PF00694. Aconitase_C. 1 hit.
PRINTSⁱ	PR00415. ACONITASE.
SUPFAMⁱ	SSF52016. SSF52016. 1 hit. SSF53732. SSF53732. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00450. ACONITASE_1. 1 hit. PS01244. ACONITASE_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A2A274_HUMAN
Accessionⁱ	A2A274Primary (citable) accession number: A2A274
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 20, 2007
	Last sequence update:	February 20, 2007
	Last modified:	July 5, 2017
	This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB - A2A274 (A2A274_HUMAN)

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Aconitate hydratase, mitochondrial

Select a section on the left to see content.

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Organism-specific databases

Pathology & Biotechⁱ

Organism-specific databases

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Caution

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A2A274 (A2A274_HUMAN)

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Aconitate hydratase, mitochondrial

ACO2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ