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Protein
Submitted name:

Aconitate hydratase, mitochondrial

Gene

ACO2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Aconitate hydratase, mitochondrialImported
Gene namesi
Name:ACO2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100412.15
HGNCiHGNC:118 ACO2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100412

PTM / Processingi

Proteomic databases

EPDiA2A274
MaxQBiA2A274
PeptideAtlasiA2A274
PRIDEiA2A274

Expressioni

Gene expression databases

BgeeiENSG00000100412
ExpressionAtlasiA2A274 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiA2A274 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliA2A274
SMRiA2A274
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 279AconitaseInterPro annotationAdd BLAST213
Domaini303 – 528AconitaseInterPro annotationAdd BLAST226
Domaini608 – 736Aconitase_CInterPro annotationAdd BLAST129

Phylogenomic databases

eggNOGiKOG0453 Eukaryota
COG1048 LUCA
GeneTreeiENSGT00890000139397
HOGENOMiHOG000224293
HOVERGENiHBG000248
OMAiGCIGMGQ
OrthoDBiEOG091G024R
PhylomeDBiA2A274

Family and domain databases

Gene3Di3.20.19.101 hit
3.30.499.102 hits
3.40.1060.102 hits
InterProiView protein in InterPro
IPR015931 Acnase/IPM_dHydase_lsu_aba_1/3
IPR001030 Acoase/IPM_deHydtase_lsu_aba
IPR015928 Aconitase/3IPM_dehydase_swvl
IPR018136 Aconitase_4Fe-4S_BS
IPR036008 Aconitase_4Fe-4S_dom
IPR015932 Aconitase_dom2
IPR000573 AconitaseA/IPMdHydase_ssu_swvl
PfamiView protein in Pfam
PF00330 Aconitase, 2 hits
PF00694 Aconitase_C, 1 hit
PRINTSiPR00415 ACONITASE
SUPFAMiSSF53732 SSF53732, 1 hit
PROSITEiView protein in PROSITE
PS00450 ACONITASE_1, 1 hit
PS01244 ACONITASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A2A274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPYSLLVTR LQKALGVRQY HVASVLCQRA KVAMSHFEPN EYIHYDLLEK
60 70 80 90 100
NINIVRKRLN RPLTLSEKIV YGHLDDPASQ EIERGKSYLR LRPDRVAMQD
110 120 130 140 150
ATAQMAMLQF ISSGLSKVAV PSTIHCDHLI EAQVGGEKDL RRAKDINQEV
160 170 180 190 200
YNFLATAGAK YGVGFWKPGS GIIHQIILEN YAYPGVLLIG TDSHTPNGGG
210 220 230 240 250
LGGICIGVGG ADAVDVMAGI PWELKCPKVI GVKLTGSLSG WSSPKDVILK
260 270 280 290 300
VAGILTVKGG TGAIVEYHGP GVDSISCTGE EGGQATWPLP CAGPDGSPVG
310 320 330 340 350
SRSGMATICN MGAEIGATTS VFPYNHRMKK YLSKTGREDI ANLADEFKDH
360 370 380 390 400
LVPDPGCHYD QLIEINLSEL KPHINGPFTP DLAHPVAEVG KVAEKEGWPL
410 420 430 440 450
DIRVGLIGSC TNSSYEDMGR SAAVAKQALA HGLKCKSQFT ITPGSEQIRA
460 470 480 490 500
TIERDGYAQI LRDLGGIVLA NACGPCIGQW DRKDIKKGEK NTIVTSYNRN
510 520 530 540 550
FTGRNDANPE THAFVTSPEI VTALAIAGTL KFNPETDYLT GTDGKKFRLE
560 570 580 590 600
APDADELPKG EFDPGQDTYQ HPPKDSSGQH VDVSPTSQRL QLLEPFDKWD
610 620 630 640 650
GKDLEDLQIL IKVKGKCTTD HISAAGPWLK FRGHLDNISN NLLIGAINIE
660 670 680 690 700
NGKANSVRNA VTQEFGPVPD TARYYKKHGI RWVVIGDENY GEGSSREHAA
710 720 730 740 750
LEPRHLGGRA IITKSFARIH ETNLKKQGLL PLTFADPADY NKIHPVDKLT
760 770 780 790 800
IQGLKDFTPG KPLKCIIKHP NGTQETILLN HTFNETQIEW FRAGSALNRM

KELQQ
Length:805
Mass (Da):87,820
Last modified:February 20, 2007 - v1
Checksum:i8584824DB3C3EAD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL008582 Genomic DNA No translation available.
AL023553 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000396512; ENSP00000379769; ENSG00000100412
UCSCiuc062eqp.1 human

Similar proteinsi

Entry informationi

Entry nameiA2A274_HUMAN
AccessioniPrimary (citable) accession number: A2A274
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: April 25, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported