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Protein

Catalase

Gene

ektA

Organism
Exiguobacterium oxidotolerans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

hemeUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561UniRule annotation
Active sitei129 – 1291UniRule annotation
Metal bindingi339 – 3391Iron (heme axial ligand)UniRule annotationCombined sources

GO - Molecular functioni

  1. catalase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. hydrogen peroxide catabolic process Source: UniProtKB-KW
  2. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxideUniRule annotation

Keywords - Ligandi

HemeUniRule annotationCombined sources, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CatalaseUniRule annotation (EC:1.11.1.6UniRule annotation)
Gene namesi
Name:ektAImported
OrganismiExiguobacterium oxidotoleransImported
Taxonomic identifieri223958 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2J2MX-ray2.40A/B/C/D1-491[»]
SMRiA2A136. Positions 6-485.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA2A136.

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.UniRule annotation

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNENEKKLTT NQGVPIGDNQ NSRTAGRRGP TLLEDYQLIE KIAHFDRERV
60 70 80 90 100
PERVVHARGF GAHGVFKVKN SMKKYTKAAF LQEEGTEVPV FARFSTVIHG
110 120 130 140 150
THSPETLRDP RGFSVKFYTE EGNWDFVGNN LPVFFIRDAM KFPDMVHSLK
160 170 180 190 200
PDPRTNIQDP DRYWDFMTLR PESTNMLMHI FTDEGIPASY RKMRGSSVHS
210 220 230 240 250
FKWVNAHGNT VYIKLRWVPK EGVHNLSADE ATEVQGKDFN HASNDTFQAI
260 270 280 290 300
ENGDFPEWDL FVQVLDPADV ENFDFDPLDA TKDWFEDVIP FQHVGTMTLN
310 320 330 340 350
KNVDNYFAET ESVGFNPGVL VPGMLPSEDK LLQGRLFSYS DTQRHRIGPN
360 370 380 390 400
YQQLPINCPF AQVNNYQRDG AMPFKQQTSS VNYEPNRYQD EPKQTPEYTE
410 420 430 440 450
DTQPLHDDIH GRLEIEKTNN FGQAGEVYRR MTEEEQMALL NNLVNDLQQV
460 470 480 490
RHENTVLLAI CNFYRADASL GEKLSEALNV DIKPFLQQMQ K
Length:491
Mass (Da):56,523
Last modified:February 20, 2007 - v1
Checksum:i024092394EB49591
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB266484 Genomic DNA. Translation: BAF45371.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB266484 Genomic DNA. Translation: BAF45371.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2J2MX-ray2.40A/B/C/D1-491[»]
SMRiA2A136. Positions 6-485.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiA2A136.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Relationship between the size of the bottleneck 15 A from iron in the main channel and the reactivity of catalase corresponding to the molecular size of substrates."
    Hara I., Ichise N., Kojima K., Kondo H., Ohgiya S., Matsuyama H., Yumoto I.
    Biochemistry 46:11-22(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiA2A136_9BACL
AccessioniPrimary (citable) accession number: A2A136
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: March 4, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.