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A2A114

- A2A114_NEOCA

UniProt

A2A114 - A2A114_NEOCA

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Protein
Submitted name:

Apical membrane antigen 1

Gene
AMA1
Organism
Neospora caninum (Coccidian parasite)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Apical membrane antigen 1Imported
Gene namesi
Name:AMA1Imported
OrganismiNeospora caninum (Coccidian parasite)Imported
Taxonomic identifieri29176 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeNeospora

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4APLX-ray2.90A/B/D/E59-478[»]

Family & Domainsi

Family and domain databases

InterProiIPR003298. Apmem_Ag1.
[Graphical view]
PfamiPF02430. AMA-1. 2 hits.
[Graphical view]
PRINTSiPR01361. MEROZOITESA.
SMARTiSM00815. AMA-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A114-1 [UniParc]FASTAAdd to Basket

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MGSWRRERPA RPSDQQWITE WRQIGIVGVA ILLVLVAESS LLATGINPKT    50
RSGGSQTLSA STPQNPFQTP ELKAFLERYN VTLHHQSGVN VDLGQDKEVD 100
GKLYREAAGL CPVWGKYIQL HQPNRPPYKN NFLEDIPTEA EYQKSGNPLP 150
GGFNMNFVTP AGQRISPYPM ELLEKSSKIK ASTELGKCAE FAYKTTAMDK 200
SNQATQYRYP FVYDSKRRLC YILSVSMQRM EGSKYCSTND DPVNLTWYCF 250
EPQKSPTANH NLIFGSAYVG KDPDAFLTKC PNQALKGYRF GHWTNGRCHD 300
YTELADSWIE AVDSKAQCWV KTFTNDEVAS DQPRTYPLTS QHSWNDWWPV 350
HEKDQPHSGG DGRNYGFFYF DSNGKGKCAL SHKAPDCLVS DSKAVSYTAL 400
GSLSEETPDI IIPSNPSVNP STPDEALQCR SSEFPETFGS CDVQACKRQK 450
TSCVGGQIQS TSVDCTAEEQ NDCGSNTALI AGMAIGGVLI MGLLAGSGYY 500
YSKRLNTNQG VPAVDHDHEF QTQRNAQKKR PSDLMQEAEP SFWDEAEENI 550
DQSGETQVLV EGDY 564
Length:564
Mass (Da):62,813
Last modified:February 20, 2007 - v1
Checksum:iF2E5FA8F903E0F9E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB265823 mRNA. Translation: BAF45372.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB265823 mRNA. Translation: BAF45372.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4APL X-ray 2.90 A/B/D/E 59-478 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR003298. Apmem_Ag1.
[Graphical view ]
Pfami PF02430. AMA-1. 2 hits.
[Graphical view ]
PRINTSi PR01361. MEROZOITESA.
SMARTi SM00815. AMA-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Apical membrane antigen 1 is a cross-reactive antigen between Neospora caninum and Toxoplasma gondii, and the anti-NcAMA1 antibody inhibits host cell invasion by both parasites."
    Zhang H., Compaore M.K., Lee E.G., Liao M., Zhang G., Sugimoto C., Fujisaki K., Nishikawa Y., Xuan X.
    Mol. Biochem. Parasitol. 151:205-212(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NC-1Imported.
  2. "Babesia divergens and Neospora caninum apical membrane antigen 1 structures reveal selectivity and plasticity in apicomplexan parasite host cell invasion."
    Tonkin M.L., Crawford J., Lebrun M.L., Boulanger M.J.
    Protein Sci. 22:114-127(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 59-478.

Entry informationi

Entry nameiA2A114_NEOCA
AccessioniPrimary (citable) accession number: A2A114
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: May 1, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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