A2A114 (A2A114_NEOCA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Apical membrane antigen 1 EMBL BAF45372.1

Gene names

Name:

AMA1 EMBL BAF45372.1

Organism

Neospora caninum (Coccidian parasite) EMBL BAF45372.1

Taxonomic identifier

29176 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Apicomplexa › Conoidasida › Coccidia › Eucoccidiorida › Eimeriorina › Sarcocystidae › Neospora

Protein attributes

Sequence length	564 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 4APL
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular_component	membrane Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A2A114 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: F2E5FA8F903E0F9E	FASTA	564	62,813
	10 20 30 40 50 60 MGSWRRERPA RPSDQQWITE WRQIGIVGVA ILLVLVAESS LLATGINPKT RSGGSQTLSA 70 80 90 100 110 120 STPQNPFQTP ELKAFLERYN VTLHHQSGVN VDLGQDKEVD GKLYREAAGL CPVWGKYIQL 130 140 150 160 170 180 HQPNRPPYKN NFLEDIPTEA EYQKSGNPLP GGFNMNFVTP AGQRISPYPM ELLEKSSKIK 190 200 210 220 230 240 ASTELGKCAE FAYKTTAMDK SNQATQYRYP FVYDSKRRLC YILSVSMQRM EGSKYCSTND 250 260 270 280 290 300 DPVNLTWYCF EPQKSPTANH NLIFGSAYVG KDPDAFLTKC PNQALKGYRF GHWTNGRCHD 310 320 330 340 350 360 YTELADSWIE AVDSKAQCWV KTFTNDEVAS DQPRTYPLTS QHSWNDWWPV HEKDQPHSGG 370 380 390 400 410 420 DGRNYGFFYF DSNGKGKCAL SHKAPDCLVS DSKAVSYTAL GSLSEETPDI IIPSNPSVNP 430 440 450 460 470 480 STPDEALQCR SSEFPETFGS CDVQACKRQK TSCVGGQIQS TSVDCTAEEQ NDCGSNTALI 490 500 510 520 530 540 AGMAIGGVLI MGLLAGSGYY YSKRLNTNQG VPAVDHDHEF QTQRNAQKKR PSDLMQEAEP 550 560 SFWDEAEENI DQSGETQVLV EGDY

References

[1]

"Apical membrane antigen 1 is a cross-reactive antigen between Neospora caninum and Toxoplasma gondii, and the anti-NcAMA1 antibody inhibits host cell invasion by both parasites." Zhang H., Compaore M.K., Lee E.G., Liao M., Zhang G., Sugimoto C., Fujisaki K., Nishikawa Y., Xuan X. Mol. Biochem. Parasitol. 151:205-212(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: NC-1 EMBL BAF45372.1.

[2]

"Babesia divergens and Neospora caninum apical membrane antigen 1 structures reveal selectivity and plasticity in apicomplexan parasite host cell invasion." Tonkin M.L., Crawford J., Lebrun M.L., Boulanger M.J. Protein Sci. 22:114-127(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 59-478.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB265823 mRNA. Translation: BAF45372.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4APL	X-ray	2.90	A/B/D/E	59-478	[»]

ModBase

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Protocols and materials databases

StructuralBiologyKnowledgebase

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Family and domain databases

InterPro

IPR003298. Apmem_Ag1.
[Graphical view]

Pfam

PF02430. AMA-1. 2 hits.
[Graphical view]

PRINTS

PR01361. MEROZOITESA.

SMART

SM00815. AMA-1. 1 hit.
[Graphical view]

ProtoNet

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Entry information

Entry name

A2A114_NEOCA

Accession

Primary (citable) accession number: A2A114

Entry history

Integrated into UniProtKB/TrEMBL:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	May 1, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)