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A2A114

- A2A114_NEOCA

UniProt

A2A114 - A2A114_NEOCA

Protein
Submitted name:

Apical membrane antigen 1

Gene

AMA1

Organism
Neospora caninum (Coccidian parasite)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 11 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Apical membrane antigen 1Imported
    Gene namesi
    Name:AMA1Imported
    OrganismiNeospora caninum (Coccidian parasite)Imported
    Taxonomic identifieri29176 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeNeospora

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4APLX-ray2.90A/B/D/E59-478[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    InterProiIPR003298. Apmem_Ag1.
    [Graphical view]
    PfamiPF02430. AMA-1. 2 hits.
    [Graphical view]
    PRINTSiPR01361. MEROZOITESA.
    SMARTiSM00815. AMA-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2A114-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSWRRERPA RPSDQQWITE WRQIGIVGVA ILLVLVAESS LLATGINPKT    50
    RSGGSQTLSA STPQNPFQTP ELKAFLERYN VTLHHQSGVN VDLGQDKEVD 100
    GKLYREAAGL CPVWGKYIQL HQPNRPPYKN NFLEDIPTEA EYQKSGNPLP 150
    GGFNMNFVTP AGQRISPYPM ELLEKSSKIK ASTELGKCAE FAYKTTAMDK 200
    SNQATQYRYP FVYDSKRRLC YILSVSMQRM EGSKYCSTND DPVNLTWYCF 250
    EPQKSPTANH NLIFGSAYVG KDPDAFLTKC PNQALKGYRF GHWTNGRCHD 300
    YTELADSWIE AVDSKAQCWV KTFTNDEVAS DQPRTYPLTS QHSWNDWWPV 350
    HEKDQPHSGG DGRNYGFFYF DSNGKGKCAL SHKAPDCLVS DSKAVSYTAL 400
    GSLSEETPDI IIPSNPSVNP STPDEALQCR SSEFPETFGS CDVQACKRQK 450
    TSCVGGQIQS TSVDCTAEEQ NDCGSNTALI AGMAIGGVLI MGLLAGSGYY 500
    YSKRLNTNQG VPAVDHDHEF QTQRNAQKKR PSDLMQEAEP SFWDEAEENI 550
    DQSGETQVLV EGDY 564
    Length:564
    Mass (Da):62,813
    Last modified:February 20, 2007 - v1
    Checksum:iF2E5FA8F903E0F9E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB265823 mRNA. Translation: BAF45372.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB265823 mRNA. Translation: BAF45372.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4APL X-ray 2.90 A/B/D/E 59-478 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR003298. Apmem_Ag1.
    [Graphical view ]
    Pfami PF02430. AMA-1. 2 hits.
    [Graphical view ]
    PRINTSi PR01361. MEROZOITESA.
    SMARTi SM00815. AMA-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Apical membrane antigen 1 is a cross-reactive antigen between Neospora caninum and Toxoplasma gondii, and the anti-NcAMA1 antibody inhibits host cell invasion by both parasites."
      Zhang H., Compaore M.K., Lee E.G., Liao M., Zhang G., Sugimoto C., Fujisaki K., Nishikawa Y., Xuan X.
      Mol. Biochem. Parasitol. 151:205-212(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NC-1Imported.
    2. "Babesia divergens and Neospora caninum apical membrane antigen 1 structures reveal selectivity and plasticity in apicomplexan parasite host cell invasion."
      Tonkin M.L., Crawford J., Lebrun M.L., Boulanger M.J.
      Protein Sci. 22:114-127(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 59-478.

    Entry informationi

    Entry nameiA2A114_NEOCA
    AccessioniPrimary (citable) accession number: A2A114
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 11 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3