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A2A114

- A2A114_NEOCA

UniProt

A2A114 - A2A114_NEOCA

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Protein
Submitted name:

Apical membrane antigen 1

Gene

AMA1

Organism
Neospora caninum (Coccidian parasite)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Apical membrane antigen 1Imported
Gene namesi
Name:AMA1Imported
OrganismiNeospora caninum (Coccidian parasite)Imported
Taxonomic identifieri29176 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeNeospora

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4APLX-ray2.90A/B/D/E59-478[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiIPR003298. Apmem_Ag1.
[Graphical view]
PfamiPF02430. AMA-1. 2 hits.
[Graphical view]
PRINTSiPR01361. MEROZOITESA.
SMARTiSM00815. AMA-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2A114 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MGSWRRERPA RPSDQQWITE WRQIGIVGVA ILLVLVAESS LLATGINPKT
60 70 80 90 100
RSGGSQTLSA STPQNPFQTP ELKAFLERYN VTLHHQSGVN VDLGQDKEVD
110 120 130 140 150
GKLYREAAGL CPVWGKYIQL HQPNRPPYKN NFLEDIPTEA EYQKSGNPLP
160 170 180 190 200
GGFNMNFVTP AGQRISPYPM ELLEKSSKIK ASTELGKCAE FAYKTTAMDK
210 220 230 240 250
SNQATQYRYP FVYDSKRRLC YILSVSMQRM EGSKYCSTND DPVNLTWYCF
260 270 280 290 300
EPQKSPTANH NLIFGSAYVG KDPDAFLTKC PNQALKGYRF GHWTNGRCHD
310 320 330 340 350
YTELADSWIE AVDSKAQCWV KTFTNDEVAS DQPRTYPLTS QHSWNDWWPV
360 370 380 390 400
HEKDQPHSGG DGRNYGFFYF DSNGKGKCAL SHKAPDCLVS DSKAVSYTAL
410 420 430 440 450
GSLSEETPDI IIPSNPSVNP STPDEALQCR SSEFPETFGS CDVQACKRQK
460 470 480 490 500
TSCVGGQIQS TSVDCTAEEQ NDCGSNTALI AGMAIGGVLI MGLLAGSGYY
510 520 530 540 550
YSKRLNTNQG VPAVDHDHEF QTQRNAQKKR PSDLMQEAEP SFWDEAEENI
560
DQSGETQVLV EGDY
Length:564
Mass (Da):62,813
Last modified:February 20, 2007 - v1
Checksum:iF2E5FA8F903E0F9E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB265823 mRNA. Translation: BAF45372.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB265823 mRNA. Translation: BAF45372.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4APL X-ray 2.90 A/B/D/E 59-478 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR003298. Apmem_Ag1.
[Graphical view ]
Pfami PF02430. AMA-1. 2 hits.
[Graphical view ]
PRINTSi PR01361. MEROZOITESA.
SMARTi SM00815. AMA-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Apical membrane antigen 1 is a cross-reactive antigen between Neospora caninum and Toxoplasma gondii, and the anti-NcAMA1 antibody inhibits host cell invasion by both parasites."
    Zhang H., Compaore M.K., Lee E.G., Liao M., Zhang G., Sugimoto C., Fujisaki K., Nishikawa Y., Xuan X.
    Mol. Biochem. Parasitol. 151:205-212(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NC-1Imported.
  2. "Babesia divergens and Neospora caninum apical membrane antigen 1 structures reveal selectivity and plasticity in apicomplexan parasite host cell invasion."
    Tonkin M.L., Crawford J., Lebrun M.L., Boulanger M.J.
    Protein Sci. 22:114-127(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 59-478.

Entry informationi

Entry nameiA2A114_NEOCA
AccessioniPrimary (citable) accession number: A2A114
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 1, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3